The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Arthas Flabouris - One of the best experts on this subject based on the ideXlab platform.
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Respiratory rate: The neglected vital sign
Medical Journal of Australia, 2008Co-Authors: Michelle A. Cretikos, Rinaldo Bellomo, Jack Chen, Simon Finfer, Ken Hillman, Arthas FlabourisAbstract:The level of documentation of vital signs in many hospitals is extremely poor, and respiratory rate, in particular, is often not recorded. There is Substantial Evidence that an abnormal respiratory rate is a predictor of potentially serious clinical events. Nurses and doctors need to be more aware of the importance of an abnormal respiratory rate as a marker of serious illness. Hospital systems that encourage appropriate responses to an elevated respiratory rate and other abnormal vital signs can be rapidly implemented. Such systems help to raise and sustain awareness of the importance of vital signs.
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respiratory rate the neglected vital sign commentary
The Medical Journal of Australia, 2008Co-Authors: James D Cooper, Michelle A. Cretikos, Rinaldo Bellomo, Jack Chen, Simon Finfer, Ken Hillman, Michael Buist, Arthas FlabourisAbstract:• The level of documentation of vital signs in many hospitals is extremely poor, and respiratory rate, in particular, is often not recorded. • There is Substantial Evidence that an abnormal respiratory rate is a predictor of potentially serious clinical events. • Nurses and doctors need to be more aware of the importance of an abnormal respiratory rate as a marker of serious illness. • Hospital systems that encourage appropriate responses to an elevated respiratory rate and other abnormal vital signs can be rapidly implemented. Such systems help to raise and sustain awareness of the importance of vital signs.
Andras Tilcsik - One of the best experts on this subject based on the ideXlab platform.
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scaling down inequality rating scales gender bias and the architecture of evaluation
American Sociological Review, 2019Co-Authors: Lauren A Rivera, Andras TilcsikAbstract:Quantitative performance ratings are ubiquitous in modern organizations—from businesses to universities—yet there is Substantial Evidence of bias against women in such ratings. This study examines ...
Nigel J Pyne - One of the best experts on this subject based on the ideXlab platform.
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Sphingosine Kinases as Druggable Targets.
Handbook of experimental pharmacology, 2018Co-Authors: Susan Pyne, David R. Adams, Nigel J PyneAbstract:There is Substantial Evidence that the enzymes, sphingosine kinase 1 and 2, which catalyse the formation of the bioactive lipid sphingosine 1-phosphate, are involved in pathophysiological processes. In this chapter, we appraise the Evidence that both enzymes are druggable and describe how isoform-specific inhibitors can be developed based on the plasticity of the sphingosine-binding site. This is contextualised with the effect of sphingosine kinase inhibitors in cancer, pulmonary hypertension, neurodegeneration, inflammation and sickling.
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Sphingosine 1-phosphate and cancer
Nature Reviews Cancer, 2010Co-Authors: Nigel J Pyne, Susan PyneAbstract:There is Substantial Evidence that sphingosine 1-phosphate (S1P) is involved in cancer. S1P regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival. This occurs at multiple levels and involves S1P receptors, sphingosine kinases, S1P phosphatases and S1P lyase. This Review summarizes current research findings and examines the potential for new therapeutics designed to alter S1P signalling and function in cancer.
Michelle A. Cretikos - One of the best experts on this subject based on the ideXlab platform.
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Respiratory rate: The neglected vital sign
Medical Journal of Australia, 2008Co-Authors: Michelle A. Cretikos, Rinaldo Bellomo, Jack Chen, Simon Finfer, Ken Hillman, Arthas FlabourisAbstract:The level of documentation of vital signs in many hospitals is extremely poor, and respiratory rate, in particular, is often not recorded. There is Substantial Evidence that an abnormal respiratory rate is a predictor of potentially serious clinical events. Nurses and doctors need to be more aware of the importance of an abnormal respiratory rate as a marker of serious illness. Hospital systems that encourage appropriate responses to an elevated respiratory rate and other abnormal vital signs can be rapidly implemented. Such systems help to raise and sustain awareness of the importance of vital signs.
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respiratory rate the neglected vital sign commentary
The Medical Journal of Australia, 2008Co-Authors: James D Cooper, Michelle A. Cretikos, Rinaldo Bellomo, Jack Chen, Simon Finfer, Ken Hillman, Michael Buist, Arthas FlabourisAbstract:• The level of documentation of vital signs in many hospitals is extremely poor, and respiratory rate, in particular, is often not recorded. • There is Substantial Evidence that an abnormal respiratory rate is a predictor of potentially serious clinical events. • Nurses and doctors need to be more aware of the importance of an abnormal respiratory rate as a marker of serious illness. • Hospital systems that encourage appropriate responses to an elevated respiratory rate and other abnormal vital signs can be rapidly implemented. Such systems help to raise and sustain awareness of the importance of vital signs.
Susan Pyne - One of the best experts on this subject based on the ideXlab platform.
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Sphingosine Kinases as Druggable Targets.
Handbook of experimental pharmacology, 2018Co-Authors: Susan Pyne, David R. Adams, Nigel J PyneAbstract:There is Substantial Evidence that the enzymes, sphingosine kinase 1 and 2, which catalyse the formation of the bioactive lipid sphingosine 1-phosphate, are involved in pathophysiological processes. In this chapter, we appraise the Evidence that both enzymes are druggable and describe how isoform-specific inhibitors can be developed based on the plasticity of the sphingosine-binding site. This is contextualised with the effect of sphingosine kinase inhibitors in cancer, pulmonary hypertension, neurodegeneration, inflammation and sickling.
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Sphingosine 1-phosphate and cancer
Nature Reviews Cancer, 2010Co-Authors: Nigel J Pyne, Susan PyneAbstract:There is Substantial Evidence that sphingosine 1-phosphate (S1P) is involved in cancer. S1P regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival. This occurs at multiple levels and involves S1P receptors, sphingosine kinases, S1P phosphatases and S1P lyase. This Review summarizes current research findings and examines the potential for new therapeutics designed to alter S1P signalling and function in cancer.
