The Experts below are selected from a list of 3930 Experts worldwide ranked by ideXlab platform
Peter Wipf - One of the best experts on this subject based on the ideXlab platform.
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Total synthesis of (-)-CP 2 -disorazole C 1
2011Co-Authors: Cd Hopkins, John C. Schmitz, Edward Chu, Peter WipfAbstract:The total synthesis of a bis-cyclopropane analog of the antimitotic natural product (-)-disorazole C1 was accomplished in 23 steps and 1.1% overall yield. A vinyl cyclopropane cross-metathesis reaction generated a key (E)-alkene segment of the target molecule. IC50 determinations of (-)-CP2-disorazole C1 in human colon cancer cell lines indicated low nanomolar cytotoxic properties. Accordingly, this synthetic bioisostere represents the first biologically active disorazole analog not containing a conjugated diene or polyene Substructure Element. © 2011 American Chemical Society.
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Total Synthesis of (−)-CP2-Disorazole C1
Organic letters, 2011Co-Authors: Chad D. Hopkins, John C. Schmitz, Edward Chu, Peter WipfAbstract:The total synthesis of a bis-cyclopropane analog of the antimitotic natural product (−)-disorazole C1 was accomplished in 23 steps and 1.1% overall yield. A vinyl cyclopropane cross-metathesis reaction generated a key (E)-alkene segment of the target molecule. IC50 determinations of (−)-CP2-disorazole C1 in human colon cancer cell lines indicated low nanomolar cytotoxic properties. Accordingly, this synthetic bioisostere represents the first biologically active disorazole analog not containing a conjugated diene or polyene Substructure Element.
António J.m. Ferreira - One of the best experts on this subject based on the ideXlab platform.
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In-plane vibration analysis of plates in curvilinear domains by a differential quadrature hierarchical finite Element method
Meccanica, 2016Co-Authors: Cuiyun Liu, Bo Liu, Yufeng Xing, J. N. Reddy, A. M. A. Neves, António J.m. FerreiraAbstract:Free in-plane vibration analysis of plates is carried out by a differential quadrature hierarchical finite Element method (DQHFEM). The NURBS (Non-Uniform Rational B-Splines) patches of geometries were first transformed into differential quadrature hierarchical (DQH) patches, and then the elastic field was discretized by the same DQH basis. The DQHFEM solved the compatibility problem caused by different parametrization of neighbouring patches of isogeometric analysis using NURBS. And mesh refinement in DQHFEM does not propagate from patch to patch. The DQHFEM matrices also have the embedding property as the hierarchical finite Element method (HFEM). In-plane vibration analyses of plates of several planforms showed that the DQHFEM is similar as the fixed interface mode synthesis method that can analyse a structure using a few nodes on the boundary of Substructure Elements and only several clamped modes inside each Substructure Element, but the DQHFEM does not need modal analysis and is of high accuracy. The accuracy and convergence of the DQHFEM were validated through comparison with exact and approximate results in literatures and computed by the authors.
John C. Schmitz - One of the best experts on this subject based on the ideXlab platform.
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Total synthesis of (-)-CP 2 -disorazole C 1
2011Co-Authors: Cd Hopkins, John C. Schmitz, Edward Chu, Peter WipfAbstract:The total synthesis of a bis-cyclopropane analog of the antimitotic natural product (-)-disorazole C1 was accomplished in 23 steps and 1.1% overall yield. A vinyl cyclopropane cross-metathesis reaction generated a key (E)-alkene segment of the target molecule. IC50 determinations of (-)-CP2-disorazole C1 in human colon cancer cell lines indicated low nanomolar cytotoxic properties. Accordingly, this synthetic bioisostere represents the first biologically active disorazole analog not containing a conjugated diene or polyene Substructure Element. © 2011 American Chemical Society.
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Total Synthesis of (−)-CP2-Disorazole C1
Organic letters, 2011Co-Authors: Chad D. Hopkins, John C. Schmitz, Edward Chu, Peter WipfAbstract:The total synthesis of a bis-cyclopropane analog of the antimitotic natural product (−)-disorazole C1 was accomplished in 23 steps and 1.1% overall yield. A vinyl cyclopropane cross-metathesis reaction generated a key (E)-alkene segment of the target molecule. IC50 determinations of (−)-CP2-disorazole C1 in human colon cancer cell lines indicated low nanomolar cytotoxic properties. Accordingly, this synthetic bioisostere represents the first biologically active disorazole analog not containing a conjugated diene or polyene Substructure Element.
Edward Chu - One of the best experts on this subject based on the ideXlab platform.
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Total synthesis of (-)-CP 2 -disorazole C 1
2011Co-Authors: Cd Hopkins, John C. Schmitz, Edward Chu, Peter WipfAbstract:The total synthesis of a bis-cyclopropane analog of the antimitotic natural product (-)-disorazole C1 was accomplished in 23 steps and 1.1% overall yield. A vinyl cyclopropane cross-metathesis reaction generated a key (E)-alkene segment of the target molecule. IC50 determinations of (-)-CP2-disorazole C1 in human colon cancer cell lines indicated low nanomolar cytotoxic properties. Accordingly, this synthetic bioisostere represents the first biologically active disorazole analog not containing a conjugated diene or polyene Substructure Element. © 2011 American Chemical Society.
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Total Synthesis of (−)-CP2-Disorazole C1
Organic letters, 2011Co-Authors: Chad D. Hopkins, John C. Schmitz, Edward Chu, Peter WipfAbstract:The total synthesis of a bis-cyclopropane analog of the antimitotic natural product (−)-disorazole C1 was accomplished in 23 steps and 1.1% overall yield. A vinyl cyclopropane cross-metathesis reaction generated a key (E)-alkene segment of the target molecule. IC50 determinations of (−)-CP2-disorazole C1 in human colon cancer cell lines indicated low nanomolar cytotoxic properties. Accordingly, this synthetic bioisostere represents the first biologically active disorazole analog not containing a conjugated diene or polyene Substructure Element.
Chad D. Hopkins - One of the best experts on this subject based on the ideXlab platform.
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Total Synthesis of (−)-CP2-Disorazole C1
Organic letters, 2011Co-Authors: Chad D. Hopkins, John C. Schmitz, Edward Chu, Peter WipfAbstract:The total synthesis of a bis-cyclopropane analog of the antimitotic natural product (−)-disorazole C1 was accomplished in 23 steps and 1.1% overall yield. A vinyl cyclopropane cross-metathesis reaction generated a key (E)-alkene segment of the target molecule. IC50 determinations of (−)-CP2-disorazole C1 in human colon cancer cell lines indicated low nanomolar cytotoxic properties. Accordingly, this synthetic bioisostere represents the first biologically active disorazole analog not containing a conjugated diene or polyene Substructure Element.
