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Saida Haider - One of the best experts on this subject based on the ideXlab platform.
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curcumin restores rotenone induced depressive like symptoms in animal model of neurotoxicity assessment by social interaction Test and Sucrose Preference Test
Metabolic Brain Disease, 2019Co-Authors: Syeda Madiha, Saida HaiderAbstract:Environmental toxin rotenone has been associated to with increased Parkinson's disease (PD) prevalence in population. Depression is one of the main non-motor symptoms of PD. Curcumin exhibits neuroprotective action in neurodegenerative diseases. In the study we investigated the effect of pre- and post-treatment of curcumin on rotenone-induced depressive-like behaviors and neurotransmitter alterations in rat model of PD. In pre-treatment phase rats were administered with curcumin (100 mg/kg/day, p.o.) for 2 weeks. After curcumin treatment rotenone (1.5 mg/kg/day, s.c.) was administered in Pre-Cur + Rot group and rotenone alone group for 8 days. Meanwhile, in Post-Cur + Rot group rotenone was injected for 8 days in order to develop PD-like symptoms. After rotenone administration curcumin (100 mg/kg/day, p.o.) was administered in Post-Cur + Rot group for 2 weeks. Depressive-like behaviors were monitored by the forced swim Test (FST), open field Test (OFT), Sucrose Preference Test (SPT) and social interaction Test (SIT). Animals were decapitated after behavioral analysis, striatum and hippocampus were dissected out for neurochemical estimations. Results showed that the rotenone administration significantly (p < 0.01) produced depressive-like symptoms in all depression-related behavioral Test. All these behavioral deficits were accompanied by the reduction of striatal and hippocampal neurotransmitter levels following rotenone administration. Pre- and post-treatment with curcumin significantly (p < 0.01) reversed the depressive-like behavior induced by rotenone and significantly (p < 0.01) improved neurotransmitter levels as compared to rotenone injected rats. Our results strongly suggest that normalization of neurotransmitter levels particularly highlights the antidepressant effect of curcumin against rotenone-induced depressive behavior.
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Curcumin restores rotenone induced depressive-like symptoms in animal model of neurotoxicity: assessment by social interaction Test and Sucrose Preference Test
Metabolic Brain Disease, 2018Co-Authors: Syeda Madiha, Saida HaiderAbstract:Environmental toxin rotenone has been associated to with increased Parkinson’s disease (PD) prevalence in population. Depression is one of the main non-motor symptoms of PD. Curcumin exhibits neuroprotective action in neurodegenerative diseases. In the study we investigated the effect of pre- and post-treatment of curcumin on rotenone-induced depressive-like behaviors and neurotransmitter alterations in rat model of PD. In pre-treatment phase rats were administered with curcumin (100 mg/kg/day, p.o.) for 2 weeks. After curcumin treatment rotenone (1.5 mg/kg/day, s.c.) was administered in Pre-Cur + Rot group and rotenone alone group for 8 days. Meanwhile, in Post-Cur + Rot group rotenone was injected for 8 days in order to develop PD-like symptoms. After rotenone administration curcumin (100 mg/kg/day, p.o.) was administered in Post-Cur + Rot group for 2 weeks. Depressive-like behaviors were monitored by the forced swim Test (FST), open field Test (OFT), Sucrose Preference Test (SPT) and social interaction Test (SIT). Animals were decapitated after behavioral analysis, striatum and hippocampus were dissected out for neurochemical estimations. Results showed that the rotenone administration significantly (p
Kenji Hashimoto - One of the best experts on this subject based on the ideXlab platform.
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Lack of dopamine D1 receptors in the antidepressant actions of (R)-ketamine in a chronic social defeat stress model.
European Archives of Psychiatry and Clinical Neuroscience, 2019Co-Authors: Lijia Chang, Kai Zhang, Yaoyu Pu, Youge Qu, Siming Wang, Zhongwei Xiong, Yukihiko Shirayama, Kenji HashimotoAbstract:It is reported that dopamine D1 receptors in the medial prefrontal cortex play a role in the antidepressant actions of (R,S)-ketamine. However, its role in the antidepressant actions of (R)-ketamine, which is more potent than (S)-ketamine, is unknown. In the locomotion Test, tail suspension Test, forced swimming Test and 1% Sucrose Preference Test, pretreatment with dopamine D1 receptor antagonist SCH-23390 did not block the antidepressant effects of (R)-ketamine in the susceptible mice after chronic social defeat stress. These findings suggest that dopamine D1 receptors may not play a major role in the antidepressant actions of (R)-ketamine.
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Lack of Antidepressant Effects of Low-Voltage-Sensitive T-Type Calcium Channel Blocker Ethosuximide in a Chronic Social Defeat Stress Model: Comparison with (R)-Ketamine.
The International Journal of Neuropsychopharmacology, 2018Co-Authors: Zheng Tian, Chao Dong, Kai Zhang, Lijia Chang, Kenji HashimotoAbstract:Background: A recent study demonstrated that low-voltage-sensitive T-type calcium channel blocker ethosuximide shows rapid antidepressant actions. This study was conducted to compare the antidepressant actions of ethosuximide and (R)-ketamine in a chronic social defeat stress model. Methods: Ethosuximide (100, 200, or 400 mg/kg), (R)-ketamine (10 mg/kg), or saline was administered i.p. to chronic social defeat stress-susceptible mice. Subsequently, locomotion Test, tail suspension Test, forced swimming Test, and 1% Sucrose Preference Test were performed. Results: (R)-ketamine showed rapid and long-lasting antidepressant actions in chronic social defeat stress-susceptible mice. In contrast, ethosuximide did not attenuate the increased immobility time of tail suspension Test and forced swimming Test in chronic social defeat stress-susceptible mice. In the Sucrose Preference Test, ethosuximide did not improve decreased Sucrose Preference in chronic social defeat stress-susceptible mice. Conclusions: Unlike (R)-ketamine, ethosuximide did not show rapid and sustained antidepressant effects in a chronic social defeat stress model. Therefore, it is unlikely that low-voltage-sensitive T-type calcium channel inhibitors may have ketamine-like robust antidepressant actions.
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5-Hydroxytryptamine-Independent Antidepressant Actions of (R)-Ketamine in a Chronic Social Defeat Stress Model.
The International Journal of Neuropsychopharmacology, 2017Co-Authors: Kai Zhang, Chao Dong, Yuko Fujita, Atsuhiro Fujita, Kenji HashimotoAbstract:Background: Previous reports suggest that 5-hydroxytryptamine might play a role in the antidepressant actions of (R,S)-ketamine. However, its role in the antidepressant actions of (R)-ketamine, which is more potent than (S)-ketamine, is unknown. This study was conducted to examine whether 5-hydroxytryptamine depletion affects the antidepressant actions of (R)-ketamine in a chronic social defeat stress model. Methods: An inhibitor of 5-hydroxytryptamine synthesis, para-chlorophenylalanine methyl ester hydrochloride (300 mg/kg, twice daily for 3 consecutive days), or vehicle was administered to control and chronic social defeat stress-susceptible mice. Levels of 5-hydroxytryptamine and its metabolite, 5-hydroxyindoleacetic acid, in mouse brain regions were measured using high-performance liquid chromatography. Furthermore, antidepressant effects of (R)-ketamine (10 mg/kg) in the vehicle- and para-chlorophenylalanine methyl ester hydrochloride-treated susceptible mice were assessed using tail suspension Test and 1% Sucrose Preference Test. Results: para-Chlorophenylalanine methyl ester hydrochloride treatment caused marked reductions of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the brain regions of control and chronic social defeat stress susceptible mice. In the tail suspension Test, (R)-ketamine significantly attenuated the increased immobility time in the chronic social defeat stress-susceptible mice with or without 5-hydroxytryptamine depletion. In the Sucrose Preference Test (2 and 5 days after a single dose), (R)-ketamine significantly enhanced reduced Sucrose consumption in the chronic social defeat stress-susceptible mice with or without 5-hydroxytryptamine depletion. Conclusions: These findings show that 5-hydroxytryptamine depletion did not affect the antidepressant effects of (R)-ketamine in a chronic social defeat stress model. Therefore, it is unlikely that 5-hydroxytryptamine plays a major role in the antidepressant actions of (R)-ketamine.
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Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model.
The International Journal of Neuropsychopharmacology, 2016Co-Authors: Bangkun Yang, Min Ma, Qian-xue Chen, Kenji HashimotoAbstract:Background: Current data on antidepressant action of the N -methyl-D-aspartate receptor antagonist, (+)-MK-801, is inconsistent. This study was conducted to examine the effects of (+)-MK-801 and its less potent stereoisomer, (-)-MK-801, in the social defeat stress model of depression. Methods: The antidepressant effects of (+)-MK-801 (0.1mg/kg) and (-)-MK-801 (0.1mg/kg) in the social defeat stress model were examined. Results: In the tail suspension and forced swimming Tests, both stereoisomers significantly attenuated increased immobility time in susceptible mice. In the Sucrose Preference Test, (+)-MK-801, but not (-)-MK-801, significantly enhanced reduced Sucrose consumption 2 or 4 days after a single dose. However, no antianhedonia effects were detected 7 days after a single dose of either stereoisomer. Conclusions: Both stereoisomers of MK-801 induced rapid antidepressant effects in the social defeat stress model, although neither produced a long-lasting effect (7 days).
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Antidepressant Effects of Ketamine on Depression-like Behavior in Juvenile Mice after Neonatal Dexamethasone Exposure.
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2014Co-Authors: Su-xia Li, Ji-chun Zhang, Jin Wu, Kenji HashimotoAbstract:OBJECTIVE: Pediatric depression is associated with significant functional impairment at school and at work. Recently, we reported on depression-like behavior in juvenile mice neonatally exposed to dexamethasone (DEX) as a potential animal model for pediatric depression. The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has promoted rapid and long-lasting antidepressant effects in patients with treatment-resistant major depression. This study was conducted to examine whether ketamine had antidepressant effects in juvenile mice after neonatal DEX exposure. METHODS: A single dose (10 mg/kg) of ketamine or vehicle was injected into juvenile mice at days 29-32 after neonatal DEX (or saline) exposure (days 1-3). The Sucrose Preference Test, tail suspension Test, and forced swimming Test were performed 24, 40, and 46 hours, respectively, after injection of ketamine. RESULTS: Ketamine (10 mg/kg) significantly improved depression-like behavior in DEX-treated juvenile mice. CONCLUSION: This finding suggests that ketamine confers antidepressant effects in an animal model of pediatric depression.
Syeda Madiha - One of the best experts on this subject based on the ideXlab platform.
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curcumin restores rotenone induced depressive like symptoms in animal model of neurotoxicity assessment by social interaction Test and Sucrose Preference Test
Metabolic Brain Disease, 2019Co-Authors: Syeda Madiha, Saida HaiderAbstract:Environmental toxin rotenone has been associated to with increased Parkinson's disease (PD) prevalence in population. Depression is one of the main non-motor symptoms of PD. Curcumin exhibits neuroprotective action in neurodegenerative diseases. In the study we investigated the effect of pre- and post-treatment of curcumin on rotenone-induced depressive-like behaviors and neurotransmitter alterations in rat model of PD. In pre-treatment phase rats were administered with curcumin (100 mg/kg/day, p.o.) for 2 weeks. After curcumin treatment rotenone (1.5 mg/kg/day, s.c.) was administered in Pre-Cur + Rot group and rotenone alone group for 8 days. Meanwhile, in Post-Cur + Rot group rotenone was injected for 8 days in order to develop PD-like symptoms. After rotenone administration curcumin (100 mg/kg/day, p.o.) was administered in Post-Cur + Rot group for 2 weeks. Depressive-like behaviors were monitored by the forced swim Test (FST), open field Test (OFT), Sucrose Preference Test (SPT) and social interaction Test (SIT). Animals were decapitated after behavioral analysis, striatum and hippocampus were dissected out for neurochemical estimations. Results showed that the rotenone administration significantly (p < 0.01) produced depressive-like symptoms in all depression-related behavioral Test. All these behavioral deficits were accompanied by the reduction of striatal and hippocampal neurotransmitter levels following rotenone administration. Pre- and post-treatment with curcumin significantly (p < 0.01) reversed the depressive-like behavior induced by rotenone and significantly (p < 0.01) improved neurotransmitter levels as compared to rotenone injected rats. Our results strongly suggest that normalization of neurotransmitter levels particularly highlights the antidepressant effect of curcumin against rotenone-induced depressive behavior.
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Curcumin restores rotenone induced depressive-like symptoms in animal model of neurotoxicity: assessment by social interaction Test and Sucrose Preference Test
Metabolic Brain Disease, 2018Co-Authors: Syeda Madiha, Saida HaiderAbstract:Environmental toxin rotenone has been associated to with increased Parkinson’s disease (PD) prevalence in population. Depression is one of the main non-motor symptoms of PD. Curcumin exhibits neuroprotective action in neurodegenerative diseases. In the study we investigated the effect of pre- and post-treatment of curcumin on rotenone-induced depressive-like behaviors and neurotransmitter alterations in rat model of PD. In pre-treatment phase rats were administered with curcumin (100 mg/kg/day, p.o.) for 2 weeks. After curcumin treatment rotenone (1.5 mg/kg/day, s.c.) was administered in Pre-Cur + Rot group and rotenone alone group for 8 days. Meanwhile, in Post-Cur + Rot group rotenone was injected for 8 days in order to develop PD-like symptoms. After rotenone administration curcumin (100 mg/kg/day, p.o.) was administered in Post-Cur + Rot group for 2 weeks. Depressive-like behaviors were monitored by the forced swim Test (FST), open field Test (OFT), Sucrose Preference Test (SPT) and social interaction Test (SIT). Animals were decapitated after behavioral analysis, striatum and hippocampus were dissected out for neurochemical estimations. Results showed that the rotenone administration significantly (p
Qigang Zhou - One of the best experts on this subject based on the ideXlab platform.
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Sucrose Preference Test for measurement of stress induced anhedonia in mice
Nature Protocols, 2018Co-Authors: Chu Xu, Hongshan Chen, Qigang ZhouAbstract:Anhedonia is the inability to experience pleasure from rewarding or enjoyable activities and is a core symptom of depression in humans. Here, we describe a protocol for the measurement of anhedonia in mice, in which anhedonia is measured by a Sucrose Preference Test (SPT) based on a two-bottle choice paradigm. A reduction in the Sucrose Preference ratio in experimental relative to control mice is indicative of anhedonia. To date, inconsistent and variable results have been reported following the use of the SPT by different groups, probably due to the use of different protocols and equipment. In this protocol, we describe how to set up a clearly defined apparatus for SPT and provide a detailed protocol to ensure greater consistency when carrying out SPT. This optimized protocol is highly sensitive, reliable, and adaptable for evaluation of chronic stress–related anhedonia, as well as morphine-induced dependence. The whole SPT, including adaptation, baseline measurement, and Testing, takes 8 d. This protocol describes how to carry out the Sucrose Preference Test (SPT) in a standardized way to reduce data variability. The SPT is a widely used behavioral assay to monitor depression-related behavior in rodents.
Nandkishor R. Kotagale - One of the best experts on this subject based on the ideXlab platform.
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Agmatine attenuates chronic unpredictable mild stress induced behavioral alteration in mice
European Journal of Pharmacology, 2013Co-Authors: Brijesh G. Taksande, Manish M. Aglawe, Dharmesh S. Faldu, Madhura P. Dixit, Jay N. Sakaria, Milind J. Umekar, Nandkishor R. KotagaleAbstract:Chronic stress exposure and resulting dysregulation of the hypothalamic pituitary adrenal axis develops susceptibility to variety of neurological and psychiatric disorders. Agmatine, a putative neurotransmitter has been reported to be released in response to various stressful stimuli to maintain the homeostasis. Present study investigated the role of agmatine on chronic unpredictable mild stress (CUMS) induced behavioral and biochemical alteration in mice. Exposure of mice to CUMS protocol for 28 days resulted in diminished performance in Sucrose Preference Test, splash Test, forced swim Test and marked elevation in plasma corticosterone levels. Chronic agmatine (5 and10 mg/kg, ip, once daily) treatment started on day-15 and continued till the end of the CUMS protocol significantly increased Sucrose Preference, improved self-care and motivational behavior in the splash Test and decreased duration of immobility in the forced swim Test. Agmatine treatment also normalized the elevated corticosterone levels and prevented the body weight changes in chronically stressed animals. The pharmacological effect of agmatine was comparable to selective serotonin reuptake inhibitor, fluoxetine (10 mg/kg, ip). Results of present study clearly demonstrated the anti-depressant like effect of agmatine in chronic unpredictable mild stress induced depression in mice. Thus the development of drugs based on brain agmatinergic modulation may represent a new potential approach for the treatment of stress related mood disorders like depression. © 2013 Elsevier B.V. All rights reserved.
