The Experts below are selected from a list of 45 Experts worldwide ranked by ideXlab platform
A C G Egberts - One of the best experts on this subject based on the ideXlab platform.
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analysis of low concentration Sufentanil Citrate bupivacaine hydrochloride admixtures using solid phase extraction followed by high performance liquid chromatography
Journal of Pharmaceutical and Biomedical Analysis, 1999Co-Authors: Kris L L Movig, M C J Langen, A C G EgbertsAbstract:A method has been developed for the quantitative determination of low concentrations of Sufentanil Citrate (1.0 μg/ml), in the presence of bupivacaine hydrochloride (0.125%), in the quality control of pharmaceutical preparations. The main problem in analysis of this combination is the low concentration of Sufentanil Citrate in the presence of relatively high concentrations of bupivacaine hydrochloride. This paper describes the validation of a HPLC method of Sufentanil Citrate in an admixture with bupivacaine hydrochloride using solid phase extraction (SPE). The optimized method shows good linearity, precision and accuracy. The limits of detection (0.09 μg/l) and quantification (0.29 μg/l) for Sufentanil Citrate are lower than the maximal accepted limits. This method is currently used in stability studies.
P J Roos - One of the best experts on this subject based on the ideXlab platform.
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effect of glucose 5 solution and bupivacaine hydrochloride on absorption of Sufentanil Citrate in a portable pump reservoir during storage and simulated infusion by an epidural catheter
Pharmacy World & Science, 1993Co-Authors: P J Roos, J H Glerum, M J H SchroedersAbstract:The stability of Sufentanil (5 micrograms/ml as Citrate) in admixtures with glucose 5% or bupivacaine hydrochloride (2 mg/ml) in 100 ml polyvinyl chloride portable pump reservoirs was investigated during simulated infusion by an epidural catheter at 32 degrees C for 48 h and during storage at 4 degrees C and 32 degrees C for 30 days. During both experiments a small decrease (< 5%) in concentration of Sufentanil and bupivacaine was observed. No loss of Sufentanil or bupivacaine could be detected (in both experiments) in the portable pump reservoirs when stored at 4 degrees C for 30 days. A significant decrease of Sufentanil was observed when stored at 32 degrees C after 30 days when diluted with glucose (9.2%) or in combination with bupivacaine (8.9%); also, the bupivacaine concentration decreased significantly (4.1%). It is concluded that Sufentanil in portable pump reservoirs can be used under patient conditions at 32 degrees C for 7 days when diluted with glucose 5% or 3 days in combination with bupivacaine hydrochloride.
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effect of ph on absorption of Sufentanil Citrate in a portable pump reservoir during storage and administration under simulated epidural conditions
Pharmacy World & Science, 1993Co-Authors: P J Roos, J H Glerum, J W Meilink, L ZwangAbstract:Sufentanil (5μg/ml as Citrate) was investigated for its stability when diluted with sodium chloride 0.9%, in 100 ml polyvinyl chloride portable pump reservoirs during administration under simulated epidural conditions at 32°C for 48 h. Sufentanil was absorbed into the polyvinyl chloride, resulting in a reduction of 10.9% of the concentration after 48 h. The absorption of Sufentanil (5μg/ml as Citrate), alone and in combination with bupivacaine hydrochloride (2 mg/ml), was investigated when diluted with sodium chloride 0.9% in combination with a Citrate buffer (pH 4.6), in the same reservoirs under similar conditions. There was no loss of Sufentanil after 48 h in both experiments. The effect of the pH on the absorption of Sufentanil in polyvinyl chloride was investigated at different pH values. After storage for 21 days at 32°C there was 5.1% loss of Sufentanil at pH 4 and 80.6% loss at pH 6. The Citrate buffer at the optimum pH (4.6) has a low, acceptable buffer capacity for epidural administration.
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stability of Sufentanil Citrate in a portable pump reservoir a glass container and a polyethylene container
Pharmacy World & Science, 1992Co-Authors: P J Roos, J H Glerum, J W MeilinkAbstract:The stability of Sufentanil Citrate (100 ml, 5μg/ml) in an admixture with sodium chloride 0.9% injection was investigated when filled in a portable pump reservoir with PVC wall, a glass container and a polyethylene container, at 32°C, 4°C and −20°C for up to 21 days. No change in colour was visually observed in any of the samples during the 21-day storage period. A slight precipitation was noticed in three out of nine portable pump reservoirs, one at each storage temperature. There was a slight rise in pH at each storage temperature in all samples. There was approximately 13% loss of Sufentanil Citrate in the portable pump reservoirs stored at 32°C during 2 days and 60% loss after 21 days, due to absorption of Sufentanil Citrate in the reservoir wall. No loss of Sufentanil Citrate could be detected in the portable pump reservoirs when stored at −20°C and 4°C. However, a serious inhomogeneity of the Sufentanil Citrate solution occurred after thawing at room temperature in the portable pump reservoirs which had been kept at −20°C. The homogeneity could be restored by shaking for approximately 10 min. There was no change in the Sufentanil Citrate concentrations in the glass containers and polyethylene containers stored at the three temperatures. The portable pump reservoirs stored at 32°C also showed a significant loss of vehicle due to evaporation (1.0±0.1 ml a week). This could not be detected in any of the other samples.
Kris L L Movig - One of the best experts on this subject based on the ideXlab platform.
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analysis of low concentration Sufentanil Citrate bupivacaine hydrochloride admixtures using solid phase extraction followed by high performance liquid chromatography
Journal of Pharmaceutical and Biomedical Analysis, 1999Co-Authors: Kris L L Movig, M C J Langen, A C G EgbertsAbstract:A method has been developed for the quantitative determination of low concentrations of Sufentanil Citrate (1.0 μg/ml), in the presence of bupivacaine hydrochloride (0.125%), in the quality control of pharmaceutical preparations. The main problem in analysis of this combination is the low concentration of Sufentanil Citrate in the presence of relatively high concentrations of bupivacaine hydrochloride. This paper describes the validation of a HPLC method of Sufentanil Citrate in an admixture with bupivacaine hydrochloride using solid phase extraction (SPE). The optimized method shows good linearity, precision and accuracy. The limits of detection (0.09 μg/l) and quantification (0.29 μg/l) for Sufentanil Citrate are lower than the maximal accepted limits. This method is currently used in stability studies.
J H Glerum - One of the best experts on this subject based on the ideXlab platform.
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effect of glucose 5 solution and bupivacaine hydrochloride on absorption of Sufentanil Citrate in a portable pump reservoir during storage and simulated infusion by an epidural catheter
Pharmacy World & Science, 1993Co-Authors: P J Roos, J H Glerum, M J H SchroedersAbstract:The stability of Sufentanil (5 micrograms/ml as Citrate) in admixtures with glucose 5% or bupivacaine hydrochloride (2 mg/ml) in 100 ml polyvinyl chloride portable pump reservoirs was investigated during simulated infusion by an epidural catheter at 32 degrees C for 48 h and during storage at 4 degrees C and 32 degrees C for 30 days. During both experiments a small decrease (< 5%) in concentration of Sufentanil and bupivacaine was observed. No loss of Sufentanil or bupivacaine could be detected (in both experiments) in the portable pump reservoirs when stored at 4 degrees C for 30 days. A significant decrease of Sufentanil was observed when stored at 32 degrees C after 30 days when diluted with glucose (9.2%) or in combination with bupivacaine (8.9%); also, the bupivacaine concentration decreased significantly (4.1%). It is concluded that Sufentanil in portable pump reservoirs can be used under patient conditions at 32 degrees C for 7 days when diluted with glucose 5% or 3 days in combination with bupivacaine hydrochloride.
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effect of ph on absorption of Sufentanil Citrate in a portable pump reservoir during storage and administration under simulated epidural conditions
Pharmacy World & Science, 1993Co-Authors: P J Roos, J H Glerum, J W Meilink, L ZwangAbstract:Sufentanil (5μg/ml as Citrate) was investigated for its stability when diluted with sodium chloride 0.9%, in 100 ml polyvinyl chloride portable pump reservoirs during administration under simulated epidural conditions at 32°C for 48 h. Sufentanil was absorbed into the polyvinyl chloride, resulting in a reduction of 10.9% of the concentration after 48 h. The absorption of Sufentanil (5μg/ml as Citrate), alone and in combination with bupivacaine hydrochloride (2 mg/ml), was investigated when diluted with sodium chloride 0.9% in combination with a Citrate buffer (pH 4.6), in the same reservoirs under similar conditions. There was no loss of Sufentanil after 48 h in both experiments. The effect of the pH on the absorption of Sufentanil in polyvinyl chloride was investigated at different pH values. After storage for 21 days at 32°C there was 5.1% loss of Sufentanil at pH 4 and 80.6% loss at pH 6. The Citrate buffer at the optimum pH (4.6) has a low, acceptable buffer capacity for epidural administration.
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stability of Sufentanil Citrate in a portable pump reservoir a glass container and a polyethylene container
Pharmacy World & Science, 1992Co-Authors: P J Roos, J H Glerum, J W MeilinkAbstract:The stability of Sufentanil Citrate (100 ml, 5μg/ml) in an admixture with sodium chloride 0.9% injection was investigated when filled in a portable pump reservoir with PVC wall, a glass container and a polyethylene container, at 32°C, 4°C and −20°C for up to 21 days. No change in colour was visually observed in any of the samples during the 21-day storage period. A slight precipitation was noticed in three out of nine portable pump reservoirs, one at each storage temperature. There was a slight rise in pH at each storage temperature in all samples. There was approximately 13% loss of Sufentanil Citrate in the portable pump reservoirs stored at 32°C during 2 days and 60% loss after 21 days, due to absorption of Sufentanil Citrate in the reservoir wall. No loss of Sufentanil Citrate could be detected in the portable pump reservoirs when stored at −20°C and 4°C. However, a serious inhomogeneity of the Sufentanil Citrate solution occurred after thawing at room temperature in the portable pump reservoirs which had been kept at −20°C. The homogeneity could be restored by shaking for approximately 10 min. There was no change in the Sufentanil Citrate concentrations in the glass containers and polyethylene containers stored at the three temperatures. The portable pump reservoirs stored at 32°C also showed a significant loss of vehicle due to evaporation (1.0±0.1 ml a week). This could not be detected in any of the other samples.
J W Meilink - One of the best experts on this subject based on the ideXlab platform.
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effect of ph on absorption of Sufentanil Citrate in a portable pump reservoir during storage and administration under simulated epidural conditions
Pharmacy World & Science, 1993Co-Authors: P J Roos, J H Glerum, J W Meilink, L ZwangAbstract:Sufentanil (5μg/ml as Citrate) was investigated for its stability when diluted with sodium chloride 0.9%, in 100 ml polyvinyl chloride portable pump reservoirs during administration under simulated epidural conditions at 32°C for 48 h. Sufentanil was absorbed into the polyvinyl chloride, resulting in a reduction of 10.9% of the concentration after 48 h. The absorption of Sufentanil (5μg/ml as Citrate), alone and in combination with bupivacaine hydrochloride (2 mg/ml), was investigated when diluted with sodium chloride 0.9% in combination with a Citrate buffer (pH 4.6), in the same reservoirs under similar conditions. There was no loss of Sufentanil after 48 h in both experiments. The effect of the pH on the absorption of Sufentanil in polyvinyl chloride was investigated at different pH values. After storage for 21 days at 32°C there was 5.1% loss of Sufentanil at pH 4 and 80.6% loss at pH 6. The Citrate buffer at the optimum pH (4.6) has a low, acceptable buffer capacity for epidural administration.
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stability of Sufentanil Citrate in a portable pump reservoir a glass container and a polyethylene container
Pharmacy World & Science, 1992Co-Authors: P J Roos, J H Glerum, J W MeilinkAbstract:The stability of Sufentanil Citrate (100 ml, 5μg/ml) in an admixture with sodium chloride 0.9% injection was investigated when filled in a portable pump reservoir with PVC wall, a glass container and a polyethylene container, at 32°C, 4°C and −20°C for up to 21 days. No change in colour was visually observed in any of the samples during the 21-day storage period. A slight precipitation was noticed in three out of nine portable pump reservoirs, one at each storage temperature. There was a slight rise in pH at each storage temperature in all samples. There was approximately 13% loss of Sufentanil Citrate in the portable pump reservoirs stored at 32°C during 2 days and 60% loss after 21 days, due to absorption of Sufentanil Citrate in the reservoir wall. No loss of Sufentanil Citrate could be detected in the portable pump reservoirs when stored at −20°C and 4°C. However, a serious inhomogeneity of the Sufentanil Citrate solution occurred after thawing at room temperature in the portable pump reservoirs which had been kept at −20°C. The homogeneity could be restored by shaking for approximately 10 min. There was no change in the Sufentanil Citrate concentrations in the glass containers and polyethylene containers stored at the three temperatures. The portable pump reservoirs stored at 32°C also showed a significant loss of vehicle due to evaporation (1.0±0.1 ml a week). This could not be detected in any of the other samples.
