The Experts below are selected from a list of 153 Experts worldwide ranked by ideXlab platform
Bert Fraserreid - One of the best experts on this subject based on the ideXlab platform.
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a convenient short synthesis of e 1 3 butadienyl tributyl stannane
Synthesis, 1993Co-Authors: Ana M. Gómez, Cristobal J Lopez, Bert FraserreidAbstract:A ready two-step procedure for medium scale preparation of (E)-1,3-butadienyl(tributyl)stannane involves stannylation (Bu 3 SnI-lithium hexamethyldisilazide) of 2,5-dihydrothiophene S,S-dioxide (3-sulfolene) followed by thermal extrusion of sulfur dioxide
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a convenient short synthesis of e 1 3 butadienyl tributyl stannane
Synthesis, 1993Co-Authors: Ana M. Gómez, Cristobal J Lopez, Bert FraserreidAbstract:A ready two-step procedure for medium scale preparation of (E)-1,3-butadienyl(tributyl)stannane involves stannylation (Bu 3 SnI-lithium hexamethyldisilazide) of 2,5-dihydrothiophene S,S-dioxide (3-sulfolene) followed by thermal extrusion of sulfur dioxide
Ana M. Gómez - One of the best experts on this subject based on the ideXlab platform.
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a convenient short synthesis of e 1 3 butadienyl tributyl stannane
Synthesis, 1993Co-Authors: Ana M. Gómez, Cristobal J Lopez, Bert FraserreidAbstract:A ready two-step procedure for medium scale preparation of (E)-1,3-butadienyl(tributyl)stannane involves stannylation (Bu 3 SnI-lithium hexamethyldisilazide) of 2,5-dihydrothiophene S,S-dioxide (3-sulfolene) followed by thermal extrusion of sulfur dioxide
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a convenient short synthesis of e 1 3 butadienyl tributyl stannane
Synthesis, 1993Co-Authors: Ana M. Gómez, Cristobal J Lopez, Bert FraserreidAbstract:A ready two-step procedure for medium scale preparation of (E)-1,3-butadienyl(tributyl)stannane involves stannylation (Bu 3 SnI-lithium hexamethyldisilazide) of 2,5-dihydrothiophene S,S-dioxide (3-sulfolene) followed by thermal extrusion of sulfur dioxide
Babasola A. Fateye - One of the best experts on this subject based on the ideXlab platform.
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therapeutic efficacy and effects of artemether lumefantrine and amodiaquine Sulfalene pyrimethamine on gametocyte carriage in children with uncomplicated plasmodium falciparum malaria in southwestern nigeria
American Journal of Tropical Medicine and Hygiene, 2007Co-Authors: Grace O. Gbotosho, Christian T. Happi, Fatai A. Fehintola, Onikepe A. Folarin, Ernest Tambo, Babasola A. FateyeAbstract:The treatment efficacy and effects of artemether-lumefantrine (AL) and amodiaquine-Sulfalene- pyrimethamine (ASP) on gametocyte carriage were evaluated in 181 children 10 years of age with uncomplicated Plasmodium falciparum malaria randomized to receive either drug combination. All children recovered clinically. Fever clearance times were similar. The rate of P. falciparum reappearance (recrudescence or re-infection) between two and six weeks after the start of therapy was significantly higher in AL-treated children (P 0.01). Parasite clearance was significantly faster in children treated with AL (mean ± SD 1.7 ± 0.6 days, 95% confidence interval 1.58 - 1.83, P 0.0001) but the polymerase chain reaction-corrected cure rate (90 of 91 versus 84 of 90) and the rate of resolution of malaria-related anemia two weeks after treatment began (45 of 50 versus 33 of 46) were higher in children treated with ASP. Gametocyte carriage rates were similar. Both regimens were well tolerated. Artemether-lumefantrine clears parasitemia more rapidly than ASP but both combinations are effective in treatment of uncomplicated P. falciparum malaria in Nigerian children.
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Therapeutic Efficacy and Effects of ArtemetherLumefantrine and Amodiaquine-Sulfalene-Pyrimethamine on Gametocyte Carriage
2007Co-Authors: Grace O. Gbotosho, Fatai A. Fehintola, Onikepe A. Folarin, Ernest Tambo, Babasola A. Fateye, Ahmed A. AdedejiAbstract:Abstract. The treatment efficacy and effects of artemether-lumefantrine (AL) and amodiaquine-Sulfalene-pyrimethamine (ASP) on gametocyte carriage were evaluated in 181 children 10 years of age with uncomplicated Plasmodium falciparum malaria randomized to receive either drug combination. All children recovered clinically. Fever clearance times were similar. The rate of P. falciparum reappearance (recrudescence or re-infection) between two and six weeks after the start of therapy was significantly higher in AL-treated children (P 0.01). Parasite clearance was significantly faster in children treated with AL (mean ± SD 1.7 ± 0.6 days, 95 % confidence interval 1.58 – 1.83, P 0.0001) but the polymerase chain reaction–corrected cure rate (90 of 91 versus 84 of 90) and the rate of resolution of malaria-related anemia two weeks after treatment began (45 of 50 versus 33 of 46) were higher in children treated with ASP. Gametocyte carriage rates were similar. Both regimens were well tolerated. Artemether-lumefantrine clears parasitemia more rapidly than ASP but both combinations are effective in treatment of uncomplicated P. falciparum malaria in Nigerian children
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The effects of artemether-lumefantrine vs amodiaquine-Sulfalene-pyrimethamine on the hepatomegaly associated with Plasmodium falciparum malaria in children.
Parasitology research, 2006Co-Authors: A Sowunmi, Grace O. Gbotosho, Christian T. Happi, Ernest Tambo, Babasola A. Fateye, Ahmed A. Adedeji, A. O. J. AmooAbstract:An open randomized controlled study of artemether-lumefantrine (AL) and amodiaquine-Sulfalene-pyrimethamine (ASP) for the treatment of uncomplicated Plasmodium falciparum malaria was carried out in 181 children. In 79 children, the hepatomegaly reduction ratios (HRR) and the speed of resolution of hepatomegaly, the hepatomegaly resolution rates (HRSR), were calculated and compared between the two treatment groups. HRR and HRSR were similar in the two treatment groups. HRSR was 71% and 62% in AL- and ASP-treated children, respectively, 14 days after commencing treatment. There was no significant correlation between HRR and parasite reduction ratio in the same patient. In children in whom parasitaemia cleared and hepatomegaly resolved within 14 days, recurrence of parasitaemia was associated with reoccurrence of hepatomegaly, suggesting that the propensity for recurrence of infection drives the malaria-attributable hepatomegaly in children from this endemic area. Combination therapy may provide additional beneficial effects on pathophysiological processes and changes associated with falciparum malaria by rapid clearing of asexual parasitaemia and reducing the propensity for recurrence of infection.
Cristobal J Lopez - One of the best experts on this subject based on the ideXlab platform.
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a convenient short synthesis of e 1 3 butadienyl tributyl stannane
Synthesis, 1993Co-Authors: Ana M. Gómez, Cristobal J Lopez, Bert FraserreidAbstract:A ready two-step procedure for medium scale preparation of (E)-1,3-butadienyl(tributyl)stannane involves stannylation (Bu 3 SnI-lithium hexamethyldisilazide) of 2,5-dihydrothiophene S,S-dioxide (3-sulfolene) followed by thermal extrusion of sulfur dioxide
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a convenient short synthesis of e 1 3 butadienyl tributyl stannane
Synthesis, 1993Co-Authors: Ana M. Gómez, Cristobal J Lopez, Bert FraserreidAbstract:A ready two-step procedure for medium scale preparation of (E)-1,3-butadienyl(tributyl)stannane involves stannylation (Bu 3 SnI-lithium hexamethyldisilazide) of 2,5-dihydrothiophene S,S-dioxide (3-sulfolene) followed by thermal extrusion of sulfur dioxide
Robert W Snow - One of the best experts on this subject based on the ideXlab platform.
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Brands, costs and registration status of antimalarial drugs in the Kenyan retail sector
Malaria Journal, 2005Co-Authors: Abdinasir A Amin, Robert W SnowAbstract:Background Although an important source of treatment for fevers, little is known about the structure of the retail sector in Africa with regard to antimalarial drugs. This study aimed to assess the range, costs, sources and registration of antimalarial drugs in the Kenyan retail sector. Methods In 2002, antimalarial drug registration and trade prices were established by triangulating national registration lists, government gazettes and trade price indices. Data on registration status and trade prices were compared with similar data generated through a retail audit undertaken among 880 randomly sampled retailers in four districts of Kenya. Results Two hundred and eighteen antimalarial drugs were in circulation in Kenya in 2002. These included 65 "sulfur"-pyrimethamine (sulfadoxine-pyrimethamine and Sulfalene-pyrimethamine (SP), the first-line recommended drug in 2002) and 33 amodiaquine (AQ, the second-line recommended drug) preparations. Only half of SP and AQ products were registered with the Pharmacy and Poisons Board. Of SP and AQ brands at district level, 40% and 44% were officially within legal registration requirements. 29% of retailers at district level stocked SP and 95% stocked AQ. The retail price of adult doses of SP and AQ were on average 0.38 and 0.76 US dollars, 100% and 347% higher than trade prices from manufacturers and importers. Artemether-lumefantrine, the newly announced first-line recommended antimalarial drug in 2004, was found in less than 1% of all retail outlets at a median cost of 7.6 US dollars. Conclusion There is a need to ensure that all antimalarial drugs are registered with the Pharmacy and Poisons Board to facilitate a more stringent post-marketing surveillance system to ensure drugs are safe and of good quality post-registration.
