The Experts below are selected from a list of 45 Experts worldwide ranked by ideXlab platform
Lenuta Profire - One of the best experts on this subject based on the ideXlab platform.
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Article Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing
2016Co-Authors: Oana Maria Dragostin, Sangram Keshari Samal, Florentina Lupascu, Andreea Pânzariu, Peter Dubruel, Dan Lupascu, Cristina Tuchilus, Cornelia Vasile, Lenuta ProfireAbstract:Abstract: The objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (Sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order to enhance the biological effects of chitosan. The morphology and physical properties of functionalized chitosan films as well the antioxidant effects of sulfonamide-chitosan derivatives were investigated. The chitosan-derivative films showed a rough surface and hydrophilic properties, which are very important features for their use as a wound dressing. The film based on chitosan-sulfisoxazol (CS-S6) showed the highest swelling ratio (197%) and the highest biodegradation rate (63.04%) in comparison to chitosan film for which the swelling ratio was 190 % and biodegradation rate was only 10%. Referring to the antioxidant effects the most active was chitosan-sulfamerazine (CS-S5) which was 8.3 times more active than chitosan relate
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Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing
International journal of molecular sciences, 2015Co-Authors: Oana Maria Dragostin, Sangram Keshari Samal, Florentina Lupascu, Andreea Pânzariu, Peter Dubruel, Dan Lupascu, Cristina Tuchilus, Cornelia Vasile, Lenuta ProfireAbstract:The objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (Sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order to enhance the biological effects of chitosan. The morphology and physical properties of functionalized chitosan films as well the antioxidant effects of sulfonamide-chitosan derivatives were investigated. The chitosan-derivative films showed a rough surface and hydrophilic properties, which are very important features for their use as a wound dressing. The film based on chitosan-sulfisoxazol (CS-S6) showed the highest swelling ratio (197%) and the highest biodegradation rate (63.04%) in comparison to chitosan film for which the swelling ratio was 190% and biodegradation rate was only 10%. Referring to the antioxidant effects the most active was chitosan-sulfamerazine (CS-S5) which was 8.3 times more active than chitosan related to DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging ability. This compound showed also a good ferric reducing power and improved total antioxidant capacity.
Oana Maria Dragostin - One of the best experts on this subject based on the ideXlab platform.
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Article Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing
2016Co-Authors: Oana Maria Dragostin, Sangram Keshari Samal, Florentina Lupascu, Andreea Pânzariu, Peter Dubruel, Dan Lupascu, Cristina Tuchilus, Cornelia Vasile, Lenuta ProfireAbstract:Abstract: The objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (Sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order to enhance the biological effects of chitosan. The morphology and physical properties of functionalized chitosan films as well the antioxidant effects of sulfonamide-chitosan derivatives were investigated. The chitosan-derivative films showed a rough surface and hydrophilic properties, which are very important features for their use as a wound dressing. The film based on chitosan-sulfisoxazol (CS-S6) showed the highest swelling ratio (197%) and the highest biodegradation rate (63.04%) in comparison to chitosan film for which the swelling ratio was 190 % and biodegradation rate was only 10%. Referring to the antioxidant effects the most active was chitosan-sulfamerazine (CS-S5) which was 8.3 times more active than chitosan relate
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Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing
International journal of molecular sciences, 2015Co-Authors: Oana Maria Dragostin, Sangram Keshari Samal, Florentina Lupascu, Andreea Pânzariu, Peter Dubruel, Dan Lupascu, Cristina Tuchilus, Cornelia Vasile, Lenuta ProfireAbstract:The objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (Sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order to enhance the biological effects of chitosan. The morphology and physical properties of functionalized chitosan films as well the antioxidant effects of sulfonamide-chitosan derivatives were investigated. The chitosan-derivative films showed a rough surface and hydrophilic properties, which are very important features for their use as a wound dressing. The film based on chitosan-sulfisoxazol (CS-S6) showed the highest swelling ratio (197%) and the highest biodegradation rate (63.04%) in comparison to chitosan film for which the swelling ratio was 190% and biodegradation rate was only 10%. Referring to the antioxidant effects the most active was chitosan-sulfamerazine (CS-S5) which was 8.3 times more active than chitosan related to DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging ability. This compound showed also a good ferric reducing power and improved total antioxidant capacity.
Peter Dubruel - One of the best experts on this subject based on the ideXlab platform.
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Article Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing
2016Co-Authors: Oana Maria Dragostin, Sangram Keshari Samal, Florentina Lupascu, Andreea Pânzariu, Peter Dubruel, Dan Lupascu, Cristina Tuchilus, Cornelia Vasile, Lenuta ProfireAbstract:Abstract: The objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (Sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order to enhance the biological effects of chitosan. The morphology and physical properties of functionalized chitosan films as well the antioxidant effects of sulfonamide-chitosan derivatives were investigated. The chitosan-derivative films showed a rough surface and hydrophilic properties, which are very important features for their use as a wound dressing. The film based on chitosan-sulfisoxazol (CS-S6) showed the highest swelling ratio (197%) and the highest biodegradation rate (63.04%) in comparison to chitosan film for which the swelling ratio was 190 % and biodegradation rate was only 10%. Referring to the antioxidant effects the most active was chitosan-sulfamerazine (CS-S5) which was 8.3 times more active than chitosan relate
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Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing
International journal of molecular sciences, 2015Co-Authors: Oana Maria Dragostin, Sangram Keshari Samal, Florentina Lupascu, Andreea Pânzariu, Peter Dubruel, Dan Lupascu, Cristina Tuchilus, Cornelia Vasile, Lenuta ProfireAbstract:The objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (Sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order to enhance the biological effects of chitosan. The morphology and physical properties of functionalized chitosan films as well the antioxidant effects of sulfonamide-chitosan derivatives were investigated. The chitosan-derivative films showed a rough surface and hydrophilic properties, which are very important features for their use as a wound dressing. The film based on chitosan-sulfisoxazol (CS-S6) showed the highest swelling ratio (197%) and the highest biodegradation rate (63.04%) in comparison to chitosan film for which the swelling ratio was 190% and biodegradation rate was only 10%. Referring to the antioxidant effects the most active was chitosan-sulfamerazine (CS-S5) which was 8.3 times more active than chitosan related to DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging ability. This compound showed also a good ferric reducing power and improved total antioxidant capacity.
Dan Lupascu - One of the best experts on this subject based on the ideXlab platform.
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Article Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing
2016Co-Authors: Oana Maria Dragostin, Sangram Keshari Samal, Florentina Lupascu, Andreea Pânzariu, Peter Dubruel, Dan Lupascu, Cristina Tuchilus, Cornelia Vasile, Lenuta ProfireAbstract:Abstract: The objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (Sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order to enhance the biological effects of chitosan. The morphology and physical properties of functionalized chitosan films as well the antioxidant effects of sulfonamide-chitosan derivatives were investigated. The chitosan-derivative films showed a rough surface and hydrophilic properties, which are very important features for their use as a wound dressing. The film based on chitosan-sulfisoxazol (CS-S6) showed the highest swelling ratio (197%) and the highest biodegradation rate (63.04%) in comparison to chitosan film for which the swelling ratio was 190 % and biodegradation rate was only 10%. Referring to the antioxidant effects the most active was chitosan-sulfamerazine (CS-S5) which was 8.3 times more active than chitosan relate
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Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing
International journal of molecular sciences, 2015Co-Authors: Oana Maria Dragostin, Sangram Keshari Samal, Florentina Lupascu, Andreea Pânzariu, Peter Dubruel, Dan Lupascu, Cristina Tuchilus, Cornelia Vasile, Lenuta ProfireAbstract:The objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (Sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order to enhance the biological effects of chitosan. The morphology and physical properties of functionalized chitosan films as well the antioxidant effects of sulfonamide-chitosan derivatives were investigated. The chitosan-derivative films showed a rough surface and hydrophilic properties, which are very important features for their use as a wound dressing. The film based on chitosan-sulfisoxazol (CS-S6) showed the highest swelling ratio (197%) and the highest biodegradation rate (63.04%) in comparison to chitosan film for which the swelling ratio was 190% and biodegradation rate was only 10%. Referring to the antioxidant effects the most active was chitosan-sulfamerazine (CS-S5) which was 8.3 times more active than chitosan related to DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging ability. This compound showed also a good ferric reducing power and improved total antioxidant capacity.
Florentina Lupascu - One of the best experts on this subject based on the ideXlab platform.
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Article Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing
2016Co-Authors: Oana Maria Dragostin, Sangram Keshari Samal, Florentina Lupascu, Andreea Pânzariu, Peter Dubruel, Dan Lupascu, Cristina Tuchilus, Cornelia Vasile, Lenuta ProfireAbstract:Abstract: The objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (Sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order to enhance the biological effects of chitosan. The morphology and physical properties of functionalized chitosan films as well the antioxidant effects of sulfonamide-chitosan derivatives were investigated. The chitosan-derivative films showed a rough surface and hydrophilic properties, which are very important features for their use as a wound dressing. The film based on chitosan-sulfisoxazol (CS-S6) showed the highest swelling ratio (197%) and the highest biodegradation rate (63.04%) in comparison to chitosan film for which the swelling ratio was 190 % and biodegradation rate was only 10%. Referring to the antioxidant effects the most active was chitosan-sulfamerazine (CS-S5) which was 8.3 times more active than chitosan relate
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Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing
International journal of molecular sciences, 2015Co-Authors: Oana Maria Dragostin, Sangram Keshari Samal, Florentina Lupascu, Andreea Pânzariu, Peter Dubruel, Dan Lupascu, Cristina Tuchilus, Cornelia Vasile, Lenuta ProfireAbstract:The objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (Sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order to enhance the biological effects of chitosan. The morphology and physical properties of functionalized chitosan films as well the antioxidant effects of sulfonamide-chitosan derivatives were investigated. The chitosan-derivative films showed a rough surface and hydrophilic properties, which are very important features for their use as a wound dressing. The film based on chitosan-sulfisoxazol (CS-S6) showed the highest swelling ratio (197%) and the highest biodegradation rate (63.04%) in comparison to chitosan film for which the swelling ratio was 190% and biodegradation rate was only 10%. Referring to the antioxidant effects the most active was chitosan-sulfamerazine (CS-S5) which was 8.3 times more active than chitosan related to DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging ability. This compound showed also a good ferric reducing power and improved total antioxidant capacity.
