The Experts below are selected from a list of 96 Experts worldwide ranked by ideXlab platform
Kitlam Chan - One of the best experts on this subject based on the ideXlab platform.
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a novel simultaneous hplc assay for serum paracetamol and Sulfapyridine as markers of gastric emptying and orocecal transit
Drug Development and Industrial Pharmacy, 1997Co-Authors: Kahhay Yuen, Kok Khiang Peh, Yinlynn Quah, Kitlam ChanAbstract:AbstractA simple high-peqormance liquid chromatography method is described for the simultaneous determination of two marker drugs, namely paracetamol and Sulfapyridine, in serum. indirectly indicative of gastric emptying and orocecal transit, respectively. Extraction of the drugs from serum was achieved with chloroform:isopropyl alcohol (7:3). Analysis was peqormed with a mobile phase comprising 1.9% tetrahydrofuran in 0.01 M sodium acetate bufSer adjusted to pH 4.5, through a YMC-Packed C18 column at a flow rate of 1.0 ml/min and ultraviolet detection at 254 nm. The detection limit is approximately 0.2 μg/ml for paracetamol and 0.1 μg/ml for Sulfapyridine. This method is applicable to monitoring gastric emptying and orocecal transit following oral administration of paracetamol and sulfasalazine, the latter being hydrolyzed in the large bowel and absorbed as Sulfapyridine.
Kahhay Yuen - One of the best experts on this subject based on the ideXlab platform.
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a novel simultaneous hplc assay for serum paracetamol and Sulfapyridine as markers of gastric emptying and orocecal transit
Drug Development and Industrial Pharmacy, 1997Co-Authors: Kahhay Yuen, Kok Khiang Peh, Yinlynn Quah, Kitlam ChanAbstract:AbstractA simple high-peqormance liquid chromatography method is described for the simultaneous determination of two marker drugs, namely paracetamol and Sulfapyridine, in serum. indirectly indicative of gastric emptying and orocecal transit, respectively. Extraction of the drugs from serum was achieved with chloroform:isopropyl alcohol (7:3). Analysis was peqormed with a mobile phase comprising 1.9% tetrahydrofuran in 0.01 M sodium acetate bufSer adjusted to pH 4.5, through a YMC-Packed C18 column at a flow rate of 1.0 ml/min and ultraviolet detection at 254 nm. The detection limit is approximately 0.2 μg/ml for paracetamol and 0.1 μg/ml for Sulfapyridine. This method is applicable to monitoring gastric emptying and orocecal transit following oral administration of paracetamol and sulfasalazine, the latter being hydrolyzed in the large bowel and absorbed as Sulfapyridine.
Charles Caulin - One of the best experts on this subject based on the ideXlab platform.
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Orocecal transit time in humans assessed by Sulfapyridine appearance in saliva after sulfasalazine intake.
Clinical pharmacology and therapeutics, 1995Co-Authors: Robin Dhote, Jean-françois Bergmann, Patrick Leglise, Olivier Chassany, David Elkharrat, Ornella Conort, Charles CaulinAbstract:Purpose We propose a noninvasive method for the measurement of orocecal transit time assessed by the Sulfapyridine appearance time in saliva after ingestion of sulfasalazine. Method In 12 healthy volunteers, we studied the correlation between plasma and saliva Sulfapyridine appearance times and then the Sulfapyridine appearance times in saliva under various experimental conditions to assess the reproducibility, the effects of meals, the role of the formulation, and the effects of gastrointestinal kinetic drugs. Results The correlation between saliva and plasma Sulfapyridine appearance times was strong (r = 0.84; p = 0.0004). The Sulfapyridine saliva appearance time was significantly delayed by the meal. Compared with placebo, the saliva Sulfapyridine appearance time was reduced by cisapride (312 ± 128 versus 551 ± 97 minutes; p = 0.0001) and increased by loperamide (674 ± 267 versus 501 ± 131 minutes; p = 0.044). Conclusion We propose the salivary sample method as a validated simplification of the plasma sulfasalazine-Sulfapyridine test for the measurement of orocecal transit time. Clinical Pharmacology & Therapeutics (1995) 57, 461–470; doi:
Kok Khiang Peh - One of the best experts on this subject based on the ideXlab platform.
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a novel simultaneous hplc assay for serum paracetamol and Sulfapyridine as markers of gastric emptying and orocecal transit
Drug Development and Industrial Pharmacy, 1997Co-Authors: Kahhay Yuen, Kok Khiang Peh, Yinlynn Quah, Kitlam ChanAbstract:AbstractA simple high-peqormance liquid chromatography method is described for the simultaneous determination of two marker drugs, namely paracetamol and Sulfapyridine, in serum. indirectly indicative of gastric emptying and orocecal transit, respectively. Extraction of the drugs from serum was achieved with chloroform:isopropyl alcohol (7:3). Analysis was peqormed with a mobile phase comprising 1.9% tetrahydrofuran in 0.01 M sodium acetate bufSer adjusted to pH 4.5, through a YMC-Packed C18 column at a flow rate of 1.0 ml/min and ultraviolet detection at 254 nm. The detection limit is approximately 0.2 μg/ml for paracetamol and 0.1 μg/ml for Sulfapyridine. This method is applicable to monitoring gastric emptying and orocecal transit following oral administration of paracetamol and sulfasalazine, the latter being hydrolyzed in the large bowel and absorbed as Sulfapyridine.
Yinlynn Quah - One of the best experts on this subject based on the ideXlab platform.
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a novel simultaneous hplc assay for serum paracetamol and Sulfapyridine as markers of gastric emptying and orocecal transit
Drug Development and Industrial Pharmacy, 1997Co-Authors: Kahhay Yuen, Kok Khiang Peh, Yinlynn Quah, Kitlam ChanAbstract:AbstractA simple high-peqormance liquid chromatography method is described for the simultaneous determination of two marker drugs, namely paracetamol and Sulfapyridine, in serum. indirectly indicative of gastric emptying and orocecal transit, respectively. Extraction of the drugs from serum was achieved with chloroform:isopropyl alcohol (7:3). Analysis was peqormed with a mobile phase comprising 1.9% tetrahydrofuran in 0.01 M sodium acetate bufSer adjusted to pH 4.5, through a YMC-Packed C18 column at a flow rate of 1.0 ml/min and ultraviolet detection at 254 nm. The detection limit is approximately 0.2 μg/ml for paracetamol and 0.1 μg/ml for Sulfapyridine. This method is applicable to monitoring gastric emptying and orocecal transit following oral administration of paracetamol and sulfasalazine, the latter being hydrolyzed in the large bowel and absorbed as Sulfapyridine.
