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Trd Oskar Wintersteiner - One of the best experts on this subject based on the ideXlab platform.
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STUDIES ON CRYSTALLINE INSULIN’ III. FURTHER OBSERVATIONS ON THE CRYSTALLIZA- TION OF INSULIN AND ON THE NATURE OF THE Sulfur Linkage. THE ISOLATION OF CYSTINE AND TYROSINE FROM HYDROLYZED CRYSTALLINE
2016Co-Authors: Vincent Du Vigneaud, H Jensen, Trd Oskar WintersteinerAbstract:In a previous publication by one of us (1), evidence was pre-sented that the Sulfur of insulin is present as the disulfide Linkage, and that the labile Sulfur arises from the breaking down of this Linkage. Evidence was also presented which strongly indicated that insulin is a derivative of cystine in which the latter is most likely linked to the rest of the molecule by a peptide Linkage. As the insulin used in this previous investigation, although highly purified, was not a crystalline preparation, there remained a remote possibffity that the results obtained might have been in-fluenced by some impurity in the material. With insulin ob-tainable in crystalline form, it was hoped that the evidence could be placed on a more substantial basis and that possibly cystine itself could be isolated from the molecule. The previous work involving the Sulfur of insulin has been taken up elsewhere (1) and will therefore not be discussed here. Although the color reactions and the general behavior of crystalline insulin are strongly suggestive of a protein-like sub
Vincent Du Vigneaud - One of the best experts on this subject based on the ideXlab platform.
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STUDIES ON CRYSTALLINE INSULIN’ III. FURTHER OBSERVATIONS ON THE CRYSTALLIZA- TION OF INSULIN AND ON THE NATURE OF THE Sulfur Linkage. THE ISOLATION OF CYSTINE AND TYROSINE FROM HYDROLYZED CRYSTALLINE
2016Co-Authors: Vincent Du Vigneaud, H Jensen, Trd Oskar WintersteinerAbstract:In a previous publication by one of us (1), evidence was pre-sented that the Sulfur of insulin is present as the disulfide Linkage, and that the labile Sulfur arises from the breaking down of this Linkage. Evidence was also presented which strongly indicated that insulin is a derivative of cystine in which the latter is most likely linked to the rest of the molecule by a peptide Linkage. As the insulin used in this previous investigation, although highly purified, was not a crystalline preparation, there remained a remote possibffity that the results obtained might have been in-fluenced by some impurity in the material. With insulin ob-tainable in crystalline form, it was hoped that the evidence could be placed on a more substantial basis and that possibly cystine itself could be isolated from the molecule. The previous work involving the Sulfur of insulin has been taken up elsewhere (1) and will therefore not be discussed here. Although the color reactions and the general behavior of crystalline insulin are strongly suggestive of a protein-like sub
H Jensen - One of the best experts on this subject based on the ideXlab platform.
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STUDIES ON CRYSTALLINE INSULIN’ III. FURTHER OBSERVATIONS ON THE CRYSTALLIZA- TION OF INSULIN AND ON THE NATURE OF THE Sulfur Linkage. THE ISOLATION OF CYSTINE AND TYROSINE FROM HYDROLYZED CRYSTALLINE
2016Co-Authors: Vincent Du Vigneaud, H Jensen, Trd Oskar WintersteinerAbstract:In a previous publication by one of us (1), evidence was pre-sented that the Sulfur of insulin is present as the disulfide Linkage, and that the labile Sulfur arises from the breaking down of this Linkage. Evidence was also presented which strongly indicated that insulin is a derivative of cystine in which the latter is most likely linked to the rest of the molecule by a peptide Linkage. As the insulin used in this previous investigation, although highly purified, was not a crystalline preparation, there remained a remote possibffity that the results obtained might have been in-fluenced by some impurity in the material. With insulin ob-tainable in crystalline form, it was hoped that the evidence could be placed on a more substantial basis and that possibly cystine itself could be isolated from the molecule. The previous work involving the Sulfur of insulin has been taken up elsewhere (1) and will therefore not be discussed here. Although the color reactions and the general behavior of crystalline insulin are strongly suggestive of a protein-like sub
Isamu Kinoshita - One of the best experts on this subject based on the ideXlab platform.
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manganese ii nickel ii and palladium ii complexes of a terpyridine like ligand containing a Sulfur Linkage and an analogous ncn pincer palladium ii complex synthesis characterization and pd catalyzed reactions
ChemInform, 2011Co-Authors: Masakazu Hirotsu, Yuhei Tsukahara, Isamu KinoshitaAbstract:Coordination properties of new polypyridines containing a single Sulfur Linkage, 6-(2′′-pyridylthio)-2,2′-bipyridine (L1) and 1-(2′-pyridyl)-3-(2′′-pyridylthio)benzene (HL2), are described. The man...
Masakazu Hirotsu - One of the best experts on this subject based on the ideXlab platform.
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manganese ii nickel ii and palladium ii complexes of a terpyridine like ligand containing a Sulfur Linkage and an analogous ncn pincer palladium ii complex synthesis characterization and pd catalyzed reactions
ChemInform, 2011Co-Authors: Masakazu Hirotsu, Yuhei Tsukahara, Isamu KinoshitaAbstract:Coordination properties of new polypyridines containing a single Sulfur Linkage, 6-(2′′-pyridylthio)-2,2′-bipyridine (L1) and 1-(2′-pyridyl)-3-(2′′-pyridylthio)benzene (HL2), are described. The man...
