The Experts below are selected from a list of 1299 Experts worldwide ranked by ideXlab platform
Yun Liang - One of the best experts on this subject based on the ideXlab platform.
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copper catalyzed c sp3 s bond and c sp2 s bond cross coupling of 2 2 iodobenzoyl substituted or 2 2 iodobenzyl substituted 1 2 3 4 tetrahydroisoquinolines with potassium sulfide synthesis of isoquinoline fused 1 3 benzothiazine scaffolds
Journal of Organic Chemistry, 2017Co-Authors: Pan Dang, Zhilei Zheng, Yun LiangAbstract:The Sulfuration reaction of 2-(2-iodobenzoyl) substituted, or 2-(2-iodobenzyl) substituted 1,2,3,4-tetrahydroisoquinolines with potassium sulfide proceeded in the presence of copper catalysts to give tetrahydroisoquinoline-fused 1,3-benzothiazine scaffolds in moderate to appropriate yields. This protocol provided an efficient and simple strategy to construct the corresponding benzothiazine derivatives via formation of C(sp3)-S bond and C(sp2)-S bond, which the C-S bonds formed via different routes in this reaction (traditional cross-coupling reaction via the cleavage of C-I bond and oxidative cross-coupling reaction via C(sp3)-H bond functionalization).
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Copper-Catalyzed C(sp3)–S Bond and C(sp2)–S Bond Cross-Coupling of 2‑(2-Iodobenzoyl) Substituted or 2‑(2-Iodobenzyl) Substituted 1,2,3,4-Tetrahydroisoquinolines with Potassium Sulfide: Synthesis of Isoquinoline-Fused 1,3-Benzothiazine Scaffolds
2017Co-Authors: Pan Dang, Zhilei Zheng, Yun LiangAbstract:The Sulfuration reaction of 2-(2-iodobenzoyl) substituted, or 2-(2-iodobenzyl) substituted 1,2,3,4-tetrahydroisoquinolines with potassium sulfide proceeded in the presence of copper catalysts to give tetrahydroisoquinoline-fused 1,3-benzothiazine scaffolds in moderate to appropriate yields. This protocol provided an efficient and simple strategy to construct the corresponding benzothiazine derivatives via formation of C(sp3)–S bond and C(sp2)–S bond, which the C–S bonds formed via different routes in this reaction (traditional cross-coupling reaction via the cleavage of C–I bond and oxidative cross-coupling reaction via C(sp3)–H bond functionalization)
Pan Dang - One of the best experts on this subject based on the ideXlab platform.
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copper catalyzed c sp3 s bond and c sp2 s bond cross coupling of 2 2 iodobenzoyl substituted or 2 2 iodobenzyl substituted 1 2 3 4 tetrahydroisoquinolines with potassium sulfide synthesis of isoquinoline fused 1 3 benzothiazine scaffolds
Journal of Organic Chemistry, 2017Co-Authors: Pan Dang, Zhilei Zheng, Yun LiangAbstract:The Sulfuration reaction of 2-(2-iodobenzoyl) substituted, or 2-(2-iodobenzyl) substituted 1,2,3,4-tetrahydroisoquinolines with potassium sulfide proceeded in the presence of copper catalysts to give tetrahydroisoquinoline-fused 1,3-benzothiazine scaffolds in moderate to appropriate yields. This protocol provided an efficient and simple strategy to construct the corresponding benzothiazine derivatives via formation of C(sp3)-S bond and C(sp2)-S bond, which the C-S bonds formed via different routes in this reaction (traditional cross-coupling reaction via the cleavage of C-I bond and oxidative cross-coupling reaction via C(sp3)-H bond functionalization).
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Copper-Catalyzed C(sp3)–S Bond and C(sp2)–S Bond Cross-Coupling of 2‑(2-Iodobenzoyl) Substituted or 2‑(2-Iodobenzyl) Substituted 1,2,3,4-Tetrahydroisoquinolines with Potassium Sulfide: Synthesis of Isoquinoline-Fused 1,3-Benzothiazine Scaffolds
2017Co-Authors: Pan Dang, Zhilei Zheng, Yun LiangAbstract:The Sulfuration reaction of 2-(2-iodobenzoyl) substituted, or 2-(2-iodobenzyl) substituted 1,2,3,4-tetrahydroisoquinolines with potassium sulfide proceeded in the presence of copper catalysts to give tetrahydroisoquinoline-fused 1,3-benzothiazine scaffolds in moderate to appropriate yields. This protocol provided an efficient and simple strategy to construct the corresponding benzothiazine derivatives via formation of C(sp3)–S bond and C(sp2)–S bond, which the C–S bonds formed via different routes in this reaction (traditional cross-coupling reaction via the cleavage of C–I bond and oxidative cross-coupling reaction via C(sp3)–H bond functionalization)
Ning Jiao - One of the best experts on this subject based on the ideXlab platform.
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cu catalyzed aerobic oxidative Sulfuration annulation approach to thiazoles via multiple csp3 h bond cleavage
Organic Letters, 2018Co-Authors: Xiaoyang Wang, Xu Qiu, Jialiang Wei, Jianzhong Liu, Song Song, Wen Wang, Ning JiaoAbstract:A novel and practical Cu-catalyzed aerobic oxidative synthesis of thiazoles was developed. This chemistry for the first time achieved thiazole construction from simple aldehydes, amines, and element sulfur through multiple Csp3–H bond cleavage processes. Molecular oxygen was used as a green oxidant in this oxidative protocol. The substrate scope is broad with the tolerance of aliphatic amines. The mechanistic study might promote the reaction design for a new Sulfuration/annulation reaction with readily available element sulfur.
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Cu-Catalyzed Aerobic Oxidative Sulfuration/Annulation Approach to Thiazoles via Multiple Csp3–H Bond Cleavage
2018Co-Authors: Xiaoyang Wang, Xu Qiu, Jialiang Wei, Jianzhong Liu, Song Song, Wen Wang, Ning JiaoAbstract:A novel and practical Cu-catalyzed aerobic oxidative synthesis of thiazoles was developed. This chemistry for the first time achieved thiazole construction from simple aldehydes, amines, and element sulfur through multiple Csp3–H bond cleavage processes. Molecular oxygen was used as a green oxidant in this oxidative protocol. The substrate scope is broad with the tolerance of aliphatic amines. The mechanistic study might promote the reaction design for a new Sulfuration/annulation reaction with readily available element sulfur
Zhilei Zheng - One of the best experts on this subject based on the ideXlab platform.
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copper catalyzed c sp3 s bond and c sp2 s bond cross coupling of 2 2 iodobenzoyl substituted or 2 2 iodobenzyl substituted 1 2 3 4 tetrahydroisoquinolines with potassium sulfide synthesis of isoquinoline fused 1 3 benzothiazine scaffolds
Journal of Organic Chemistry, 2017Co-Authors: Pan Dang, Zhilei Zheng, Yun LiangAbstract:The Sulfuration reaction of 2-(2-iodobenzoyl) substituted, or 2-(2-iodobenzyl) substituted 1,2,3,4-tetrahydroisoquinolines with potassium sulfide proceeded in the presence of copper catalysts to give tetrahydroisoquinoline-fused 1,3-benzothiazine scaffolds in moderate to appropriate yields. This protocol provided an efficient and simple strategy to construct the corresponding benzothiazine derivatives via formation of C(sp3)-S bond and C(sp2)-S bond, which the C-S bonds formed via different routes in this reaction (traditional cross-coupling reaction via the cleavage of C-I bond and oxidative cross-coupling reaction via C(sp3)-H bond functionalization).
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Copper-Catalyzed C(sp3)–S Bond and C(sp2)–S Bond Cross-Coupling of 2‑(2-Iodobenzoyl) Substituted or 2‑(2-Iodobenzyl) Substituted 1,2,3,4-Tetrahydroisoquinolines with Potassium Sulfide: Synthesis of Isoquinoline-Fused 1,3-Benzothiazine Scaffolds
2017Co-Authors: Pan Dang, Zhilei Zheng, Yun LiangAbstract:The Sulfuration reaction of 2-(2-iodobenzoyl) substituted, or 2-(2-iodobenzyl) substituted 1,2,3,4-tetrahydroisoquinolines with potassium sulfide proceeded in the presence of copper catalysts to give tetrahydroisoquinoline-fused 1,3-benzothiazine scaffolds in moderate to appropriate yields. This protocol provided an efficient and simple strategy to construct the corresponding benzothiazine derivatives via formation of C(sp3)–S bond and C(sp2)–S bond, which the C–S bonds formed via different routes in this reaction (traditional cross-coupling reaction via the cleavage of C–I bond and oxidative cross-coupling reaction via C(sp3)–H bond functionalization)
Qiuling Song - One of the best experts on this subject based on the ideXlab platform.
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rh ii phosphine cocatalyzed synthesis of dithioketal derivatives from diazo compounds through simultaneous construction of two different c s bonds
Chemical Communications, 2018Co-Authors: Changqing Rao, Shaoyu Mai, Qiuling SongAbstract:Rhodium(II)/phosphine-cocatalyzed bis-Sulfuration of α-diazocarbonyl compounds using thiosulfonates as the sulfenylating agent, which provided two sulfur-containing moieties, was developed via simultaneous inter- and intra-molecular C–S bond formation. This novel protocol provides a rapid synthetic route to dithioketal derivatives in moderate to good yields in an atom-economic process. The transformation is proposed to proceed through phosphine ylide formation followed by S(O2)–S bond cleavage and rearrangement.
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thiocarbamate directed tandem olefination intramolecular Sulfuration of two ortho c h bonds application to synthesis of a cox 2 inhibitor
Organic Letters, 2018Co-Authors: Yingwei Zhao, Shaoyu Mai, Qiuling SongAbstract:A palladium-catalyzed dual ortho C–H bond activation of aryl thiocarbamates is developed. This tandem reaction initiates by thiocarbamate-directed ortho C–H palladation, which leads to favorable olefin insertion rather than reductive elimination. The oxidative Heck reaction followed by another C–H activation and Sulfuration affords the dual-functionalized products. This reaction provides a concise route to the S,O,C multisubstituted benzene skeleton which could be successfully applied for the synthesis of a COX-2 inhibitor.
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Thiocarbamate-Directed Tandem Olefination–Intramolecular Sulfuration of Two Ortho C–H Bonds: Application to Synthesis of a COX‑2 Inhibitor
2018Co-Authors: Yingwei Zhao, Shaoyu Mai, Qiuling SongAbstract:A palladium-catalyzed dual ortho C–H bond activation of aryl thiocarbamates is developed. This tandem reaction initiates by thiocarbamate-directed ortho C–H palladation, which leads to favorable olefin insertion rather than reductive elimination. The oxidative Heck reaction followed by another C–H activation and Sulfuration affords the dual-functionalized products. This reaction provides a concise route to the S,O,C multisubstituted benzene skeleton which could be successfully applied for the synthesis of a COX-2 inhibitor
