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A. López-castellano - One of the best experts on this subject based on the ideXlab platform.
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Elastic vesicles of Sumatriptan Succinate for transdermal administration: characterization and in vitro permeation studies.
Journal of liposome research, 2010Co-Authors: C. Balaguer-fernández, A. Femenía-font, Virginia Merino, Damián Cordoba-diaz, María A. Elorza-barroeta, A. López-castellano, Manuel Cordoba-diazAbstract:Elastic liposomes, including Sumatriptan Succinate, were prepared for their transdermal administration. Lipid vesicles containing 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) or l-α-phosphatidylcholine dilauroyl (DLPC) phospholipids were characterized for various parameters, including size, particle-size distribution (i.e., polydispersity index), and elasticity. In vitro transdermal experiments for the study of the skin penetration of Sumatriptan Succinate contained in liposomes were performed by using flow-through diffusion cells. The diameter of Sumatriptan liposomes with different lipid compositions varied between 279 and 282 nm, and the polydispersity index value for the size distribution of liposomal formulations was
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Development and evaluation of occlusive systems employing polyvinyl alcohol for transdermal delivery of Sumatriptan Succinate.
Drug delivery, 2010Co-Authors: C. Balaguer-fernández, A. Femenía-font, Virginia Merino, Cristina Padula, Patrizia Santi, A. López-castellanoAbstract:The aim of the present study was to develop a Sumatriptan Succinate transdermal system for applying migraine treatments efficiently and easily. For this system polyvinyl alcohol was employed as a matrix and Azone® was added as a permeability enhancer. The physical characteristics, mechanical properties, and in vivo bioadhesion of the systems were evaluated, as was in vitro permeation across porcine skin. A uniform distribution of the drug in the matrix was observed, and moisture uptake values were constant. With regard to mechanical parameters, occlusive layer inclusion made the system more resistant, and no significant differences were detected with respect to other systems. Although Azone® reduced the bioadhesivity of the systems, adherence to skin was maintained 24 h after application. Permeation studies showed that the systems formulated with Azone® provided the highest permeability profiles for Sumatriptan Succinate.
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Sumatriptan Succinate transdermal delivery systems for the treatment of migraine.
Journal of pharmaceutical sciences, 2008Co-Authors: C. Balaguer-fernández, A. Femenía-font, Virginia Merino, S. Del Rio-sancho, A. López-castellanoAbstract:Abstract We have successfully obtained Sumatriptan transdermal systems with different polymer compositions: methyl cellulose (MC), polyvinyl pyrrolidone (PVP) and a polyvinyl pyrrolidone (PVP)-polyvinyl alcohol (PVA) mixture. The systems contained 1,2-propilenglycol (MC) or sorbitol as a plasticizer (PVP and PVP-PVA), methacrylate copolymer as an adhesive agent, and an occlusive liner. Azone® (5%, w/w) was incorporated into all the systems as a percutaneous enhancer. Transdermal systems are thin, transparent and non-adhesive when in a dry state. The permeation of Sumatriptan Succinate across pig ear skin was studied using the systems prepared. The formulation with MC polymer produced a statistically significant increment with respect to the PVP and PVP-PVA formulations ( p p
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Effect of chemical enhancers on the in vitro percutaneous absorption of Sumatriptan Succinate
European Journal of Pharmaceutics and Biopharmaceutics, 2005Co-Authors: A. Femenía-font, C. Balaguer-fernández, Virginia Merino, Vicente Rodilla, A. López-castellanoAbstract:The effects of percutaneous enhancers on the transdermal absorption of Sumatriptan Succinate were investigated by in vitro permeation studies. Pretreatment of porcine skin with ethanol (vehicle), polyethylene glycol 600, Span 20, oleic acid, R-(+)-limonene, alpha-bisabolol and 1,8-cineole (at 5% in ethanol, w/w) produced in all cases an increase in the flux of Sumatriptan. The amount of Sumatriptan retained in the skin was also determined. Ethanol has showed a low but significant increment on the drug transdermal flux. Treatment of the skin with alpha-bisabolol shows the same enhancer effect than ethanol. Span 20, oleic acid, and polyethylene glycol 600 have shown a moderate enhancing activity on transdermal flux of Sumatriptan. R-(+)-limonene showed the greatest ability to enhance the flux of Sumatriptan.
C. Balaguer-fernández - One of the best experts on this subject based on the ideXlab platform.
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Elastic vesicles of Sumatriptan Succinate for transdermal administration: characterization and in vitro permeation studies.
Journal of liposome research, 2010Co-Authors: C. Balaguer-fernández, A. Femenía-font, Virginia Merino, Damián Cordoba-diaz, María A. Elorza-barroeta, A. López-castellano, Manuel Cordoba-diazAbstract:Elastic liposomes, including Sumatriptan Succinate, were prepared for their transdermal administration. Lipid vesicles containing 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) or l-α-phosphatidylcholine dilauroyl (DLPC) phospholipids were characterized for various parameters, including size, particle-size distribution (i.e., polydispersity index), and elasticity. In vitro transdermal experiments for the study of the skin penetration of Sumatriptan Succinate contained in liposomes were performed by using flow-through diffusion cells. The diameter of Sumatriptan liposomes with different lipid compositions varied between 279 and 282 nm, and the polydispersity index value for the size distribution of liposomal formulations was
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Development and evaluation of occlusive systems employing polyvinyl alcohol for transdermal delivery of Sumatriptan Succinate.
Drug delivery, 2010Co-Authors: C. Balaguer-fernández, A. Femenía-font, Virginia Merino, Cristina Padula, Patrizia Santi, A. López-castellanoAbstract:The aim of the present study was to develop a Sumatriptan Succinate transdermal system for applying migraine treatments efficiently and easily. For this system polyvinyl alcohol was employed as a matrix and Azone® was added as a permeability enhancer. The physical characteristics, mechanical properties, and in vivo bioadhesion of the systems were evaluated, as was in vitro permeation across porcine skin. A uniform distribution of the drug in the matrix was observed, and moisture uptake values were constant. With regard to mechanical parameters, occlusive layer inclusion made the system more resistant, and no significant differences were detected with respect to other systems. Although Azone® reduced the bioadhesivity of the systems, adherence to skin was maintained 24 h after application. Permeation studies showed that the systems formulated with Azone® provided the highest permeability profiles for Sumatriptan Succinate.
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Sumatriptan Succinate transdermal delivery systems for the treatment of migraine.
Journal of pharmaceutical sciences, 2008Co-Authors: C. Balaguer-fernández, A. Femenía-font, Virginia Merino, S. Del Rio-sancho, A. López-castellanoAbstract:Abstract We have successfully obtained Sumatriptan transdermal systems with different polymer compositions: methyl cellulose (MC), polyvinyl pyrrolidone (PVP) and a polyvinyl pyrrolidone (PVP)-polyvinyl alcohol (PVA) mixture. The systems contained 1,2-propilenglycol (MC) or sorbitol as a plasticizer (PVP and PVP-PVA), methacrylate copolymer as an adhesive agent, and an occlusive liner. Azone® (5%, w/w) was incorporated into all the systems as a percutaneous enhancer. Transdermal systems are thin, transparent and non-adhesive when in a dry state. The permeation of Sumatriptan Succinate across pig ear skin was studied using the systems prepared. The formulation with MC polymer produced a statistically significant increment with respect to the PVP and PVP-PVA formulations ( p p
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Effect of chemical enhancers on the in vitro percutaneous absorption of Sumatriptan Succinate
European Journal of Pharmaceutics and Biopharmaceutics, 2005Co-Authors: A. Femenía-font, C. Balaguer-fernández, Virginia Merino, Vicente Rodilla, A. López-castellanoAbstract:The effects of percutaneous enhancers on the transdermal absorption of Sumatriptan Succinate were investigated by in vitro permeation studies. Pretreatment of porcine skin with ethanol (vehicle), polyethylene glycol 600, Span 20, oleic acid, R-(+)-limonene, alpha-bisabolol and 1,8-cineole (at 5% in ethanol, w/w) produced in all cases an increase in the flux of Sumatriptan. The amount of Sumatriptan retained in the skin was also determined. Ethanol has showed a low but significant increment on the drug transdermal flux. Treatment of the skin with alpha-bisabolol shows the same enhancer effect than ethanol. Span 20, oleic acid, and polyethylene glycol 600 have shown a moderate enhancing activity on transdermal flux of Sumatriptan. R-(+)-limonene showed the greatest ability to enhance the flux of Sumatriptan.
Virginia Merino - One of the best experts on this subject based on the ideXlab platform.
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elastic vesicles of Sumatriptan Succinate for transdermal administration characterization and in vitro permeation studies
Journal of Liposome Research, 2011Co-Authors: C Balaguerfernandez, Virginia Merino, A Femeniafont, Damian Cordobadiaz, Maria A Elorzabarroeta, A Lopezcastellano, Manuel CordobadiazAbstract:Elastic liposomes, including Sumatriptan Succinate, were prepared for their transdermal administration. Lipid vesicles containing 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) or l-α-phosphatidylcholine dilauroyl (DLPC) phospholipids were characterized for various parameters, including size, particle-size distribution (i.e., polydispersity index), and elasticity. In vitro transdermal experiments for the study of the skin penetration of Sumatriptan Succinate contained in liposomes were performed by using flow-through diffusion cells. The diameter of Sumatriptan liposomes with different lipid compositions varied between 279 and 282 nm, and the polydispersity index value for the size distribution of liposomal formulations was <0.5. DLPC vesicles proved to be more elastic and provided a higher Sumatriptan transdermal flux than vesicles formulated with DOPC phospolipid.
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Elastic vesicles of Sumatriptan Succinate for transdermal administration: characterization and in vitro permeation studies.
Journal of liposome research, 2010Co-Authors: C. Balaguer-fernández, A. Femenía-font, Virginia Merino, Damián Cordoba-diaz, María A. Elorza-barroeta, A. López-castellano, Manuel Cordoba-diazAbstract:Elastic liposomes, including Sumatriptan Succinate, were prepared for their transdermal administration. Lipid vesicles containing 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) or l-α-phosphatidylcholine dilauroyl (DLPC) phospholipids were characterized for various parameters, including size, particle-size distribution (i.e., polydispersity index), and elasticity. In vitro transdermal experiments for the study of the skin penetration of Sumatriptan Succinate contained in liposomes were performed by using flow-through diffusion cells. The diameter of Sumatriptan liposomes with different lipid compositions varied between 279 and 282 nm, and the polydispersity index value for the size distribution of liposomal formulations was
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Development and evaluation of occlusive systems employing polyvinyl alcohol for transdermal delivery of Sumatriptan Succinate.
Drug delivery, 2010Co-Authors: C. Balaguer-fernández, A. Femenía-font, Virginia Merino, Cristina Padula, Patrizia Santi, A. López-castellanoAbstract:The aim of the present study was to develop a Sumatriptan Succinate transdermal system for applying migraine treatments efficiently and easily. For this system polyvinyl alcohol was employed as a matrix and Azone® was added as a permeability enhancer. The physical characteristics, mechanical properties, and in vivo bioadhesion of the systems were evaluated, as was in vitro permeation across porcine skin. A uniform distribution of the drug in the matrix was observed, and moisture uptake values were constant. With regard to mechanical parameters, occlusive layer inclusion made the system more resistant, and no significant differences were detected with respect to other systems. Although Azone® reduced the bioadhesivity of the systems, adherence to skin was maintained 24 h after application. Permeation studies showed that the systems formulated with Azone® provided the highest permeability profiles for Sumatriptan Succinate.
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Sumatriptan Succinate transdermal delivery systems for the treatment of migraine.
Journal of pharmaceutical sciences, 2008Co-Authors: C. Balaguer-fernández, A. Femenía-font, Virginia Merino, S. Del Rio-sancho, A. López-castellanoAbstract:Abstract We have successfully obtained Sumatriptan transdermal systems with different polymer compositions: methyl cellulose (MC), polyvinyl pyrrolidone (PVP) and a polyvinyl pyrrolidone (PVP)-polyvinyl alcohol (PVA) mixture. The systems contained 1,2-propilenglycol (MC) or sorbitol as a plasticizer (PVP and PVP-PVA), methacrylate copolymer as an adhesive agent, and an occlusive liner. Azone® (5%, w/w) was incorporated into all the systems as a percutaneous enhancer. Transdermal systems are thin, transparent and non-adhesive when in a dry state. The permeation of Sumatriptan Succinate across pig ear skin was studied using the systems prepared. The formulation with MC polymer produced a statistically significant increment with respect to the PVP and PVP-PVA formulations ( p p
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Effect of chemical enhancers on the in vitro percutaneous absorption of Sumatriptan Succinate
European Journal of Pharmaceutics and Biopharmaceutics, 2005Co-Authors: A. Femenía-font, C. Balaguer-fernández, Virginia Merino, Vicente Rodilla, A. López-castellanoAbstract:The effects of percutaneous enhancers on the transdermal absorption of Sumatriptan Succinate were investigated by in vitro permeation studies. Pretreatment of porcine skin with ethanol (vehicle), polyethylene glycol 600, Span 20, oleic acid, R-(+)-limonene, alpha-bisabolol and 1,8-cineole (at 5% in ethanol, w/w) produced in all cases an increase in the flux of Sumatriptan. The amount of Sumatriptan retained in the skin was also determined. Ethanol has showed a low but significant increment on the drug transdermal flux. Treatment of the skin with alpha-bisabolol shows the same enhancer effect than ethanol. Span 20, oleic acid, and polyethylene glycol 600 have shown a moderate enhancing activity on transdermal flux of Sumatriptan. R-(+)-limonene showed the greatest ability to enhance the flux of Sumatriptan.
Shailendra Kumar Singh - One of the best experts on this subject based on the ideXlab platform.
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A Comparative Study of Orally Delivered PBCA and ApoE Coupled BSA Nanoparticles for Brain Targeting of Sumatriptan Succinate in Therapeutic Management of Migraine.
Pharmaceutical research, 2016Co-Authors: Priti Girotra, Shailendra Kumar SinghAbstract:Purpose The present investigation aimed at brain targeting of Sumatriptan Succinate (SS) for its optimal therapeutic effect in migraine through nanoparticulate drug delivery system using poly (butyl cyanoacrylate) (PBCA) and bovine serum albumin linked with apolipoprotein E3 (BSA-ApoE).
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Sumatriptan Succinate loaded chitosan solid lipid nanoparticles for enhanced anti-migraine potential.
International journal of biological macromolecules, 2015Co-Authors: Girotra Priti Hansraj, Shailendra Kumar Singh, Pawan KumarAbstract:The objective of the present investigation was to prepare chitosan solid lipid nanoparticles (SLN), containing Sumatriptan Succinate using solvent injection method and to optimize the formulations for brain targeting potential. The formulation optimization was performed using three factor two level full factorial design so as to minimize the particle size and zeta potential, maximize the entrapment efficiency as well as maximize the concentration of drug in brain with maximized brain/plasma ratio of the drug. The particle size, zeta potential and entrapment efficiency for all the batches were in the range of 192-301.4nm, 30.2-51.4mV and 76.3-91.1% respectively. The optimized formulation showed a 4.54-fold increase in brain/blood ratio of drug after 2h of drug administration in male Wistar rats. The optimized nanoparticles were characterized by FT-IR spectroscopy, DSC, TGA, powder X-ray diffraction study and TEM analysis. It could be elucidated from the experimental in vivo and behavioral studies that the formulations successfully crossed the blood brain barrier and significantly exhibited its anti-migraine activity. Present investigation indicated that the hydrophilic drug Sumatriptan Succinate, loaded in chitosan SLN, can be successfully targeted to brain via oral delivery and thus present an effective approach for the therapeutic management of migraine.
A. Femenía-font - One of the best experts on this subject based on the ideXlab platform.
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Elastic vesicles of Sumatriptan Succinate for transdermal administration: characterization and in vitro permeation studies.
Journal of liposome research, 2010Co-Authors: C. Balaguer-fernández, A. Femenía-font, Virginia Merino, Damián Cordoba-diaz, María A. Elorza-barroeta, A. López-castellano, Manuel Cordoba-diazAbstract:Elastic liposomes, including Sumatriptan Succinate, were prepared for their transdermal administration. Lipid vesicles containing 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) or l-α-phosphatidylcholine dilauroyl (DLPC) phospholipids were characterized for various parameters, including size, particle-size distribution (i.e., polydispersity index), and elasticity. In vitro transdermal experiments for the study of the skin penetration of Sumatriptan Succinate contained in liposomes were performed by using flow-through diffusion cells. The diameter of Sumatriptan liposomes with different lipid compositions varied between 279 and 282 nm, and the polydispersity index value for the size distribution of liposomal formulations was
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Development and evaluation of occlusive systems employing polyvinyl alcohol for transdermal delivery of Sumatriptan Succinate.
Drug delivery, 2010Co-Authors: C. Balaguer-fernández, A. Femenía-font, Virginia Merino, Cristina Padula, Patrizia Santi, A. López-castellanoAbstract:The aim of the present study was to develop a Sumatriptan Succinate transdermal system for applying migraine treatments efficiently and easily. For this system polyvinyl alcohol was employed as a matrix and Azone® was added as a permeability enhancer. The physical characteristics, mechanical properties, and in vivo bioadhesion of the systems were evaluated, as was in vitro permeation across porcine skin. A uniform distribution of the drug in the matrix was observed, and moisture uptake values were constant. With regard to mechanical parameters, occlusive layer inclusion made the system more resistant, and no significant differences were detected with respect to other systems. Although Azone® reduced the bioadhesivity of the systems, adherence to skin was maintained 24 h after application. Permeation studies showed that the systems formulated with Azone® provided the highest permeability profiles for Sumatriptan Succinate.
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Sumatriptan Succinate transdermal delivery systems for the treatment of migraine.
Journal of pharmaceutical sciences, 2008Co-Authors: C. Balaguer-fernández, A. Femenía-font, Virginia Merino, S. Del Rio-sancho, A. López-castellanoAbstract:Abstract We have successfully obtained Sumatriptan transdermal systems with different polymer compositions: methyl cellulose (MC), polyvinyl pyrrolidone (PVP) and a polyvinyl pyrrolidone (PVP)-polyvinyl alcohol (PVA) mixture. The systems contained 1,2-propilenglycol (MC) or sorbitol as a plasticizer (PVP and PVP-PVA), methacrylate copolymer as an adhesive agent, and an occlusive liner. Azone® (5%, w/w) was incorporated into all the systems as a percutaneous enhancer. Transdermal systems are thin, transparent and non-adhesive when in a dry state. The permeation of Sumatriptan Succinate across pig ear skin was studied using the systems prepared. The formulation with MC polymer produced a statistically significant increment with respect to the PVP and PVP-PVA formulations ( p p
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Effect of chemical enhancers on the in vitro percutaneous absorption of Sumatriptan Succinate
European Journal of Pharmaceutics and Biopharmaceutics, 2005Co-Authors: A. Femenía-font, C. Balaguer-fernández, Virginia Merino, Vicente Rodilla, A. López-castellanoAbstract:The effects of percutaneous enhancers on the transdermal absorption of Sumatriptan Succinate were investigated by in vitro permeation studies. Pretreatment of porcine skin with ethanol (vehicle), polyethylene glycol 600, Span 20, oleic acid, R-(+)-limonene, alpha-bisabolol and 1,8-cineole (at 5% in ethanol, w/w) produced in all cases an increase in the flux of Sumatriptan. The amount of Sumatriptan retained in the skin was also determined. Ethanol has showed a low but significant increment on the drug transdermal flux. Treatment of the skin with alpha-bisabolol shows the same enhancer effect than ethanol. Span 20, oleic acid, and polyethylene glycol 600 have shown a moderate enhancing activity on transdermal flux of Sumatriptan. R-(+)-limonene showed the greatest ability to enhance the flux of Sumatriptan.
