The Experts below are selected from a list of 50601 Experts worldwide ranked by ideXlab platform
Yvan Vander Heyden - One of the best experts on this subject based on the ideXlab platform.
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Chromatography: Supercritical Fluid Chromatography
Encyclopedia of Food and Health, 2020Co-Authors: Charlene Muscat Galea, Debby Mangelings, Yvan Vander HeydenAbstract:Supercritical Fluid chromatography is an analytical technique being used in several processes relating to food analysis and health analysis. This article explains the principles of the technique and goes into more detail regarding the analysis of lipids, fat-soluble vitamins, nutraceuticals, pesticides, and medicines. An overview of the technique at preparative scale and of Supercritical Fluid extraction is also included.
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Supercritical Fluid chromatography for the enantioseparation of pharmaceuticals
Journal of Pharmaceutical and Biomedical Analysis, 2012Co-Authors: Katrijn De Klerck, Debby Mangelings, Yvan Vander HeydenAbstract:Chirality has a significant impact on drug discovery and development processes in the pharmaceutical industry. As the number of enantiopure drugs launched onto the market is yearly increasing, the need for fast and performant enantioseparation methods with minimal costs is becoming more compelling. In this context, sub- and Supercritical Fluid chromatography (SFC), being applicable at an analytical, as well as at a preparative scale is gaining more interest. In this review a practical overview is given of the different parameters that are important in Supercritical Fluid chromatographic separations. A comparison is made between the applicability for chiral separations of SFC and conventional high-performance liquid chromatography (HPLC), and illustrated by means of examples. Different aspects of method development and the upscaling feasibility in SFC are discussed. This review aims to give the reader a practical insight in the use of Supercritical Fluid chromatography for the chiral separation of pharmaceutical compounds.
Jerry W King - One of the best experts on this subject based on the ideXlab platform.
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preparative scale Supercritical Fluid extraction Supercritical Fluid chromatography of corn bran
Journal of the American Oil Chemists' Society, 2002Co-Authors: Scott L. Taylor, Jerry W KingAbstract:A preparative-scale Supercritical Fluid extraction/Supercritical Fluid chromatography (SFE/SFC) procedure has been developed for the removal of oil from corn bran to obtain fractions enriched with free sterols and ferulate-phytosterol esters (FPE). Operational parameters from an analytical-scale Supercritical Fluid fractionation technique were translated to and optimized on a home-built, preparatory-scale SFE/SFC apparatus. SFE was performed at 34.5 MPa and 40°C using Supercritical carbon dioxide. These conditions did not result in exhaustive extraction of the corn bran, but yielded about 96% of the available oil. SFC was conducted in three steps, followed by reconditioning of the sorbent bed. Preparative-scale SFE/SFC of corn bran produced a fraction enriched greater than fourfold in free sterols and 10-fold in FPE, suggesting that such a scheme could be used industrially to produce a functional food ingredient.
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Preparative‐scale Supercritical Fluid extraction/Supercritical Fluid chromatography of corn bran
Journal of the American Oil Chemists' Society, 2002Co-Authors: Scott L. Taylor, Jerry W KingAbstract:A preparative-scale Supercritical Fluid extraction/Supercritical Fluid chromatography (SFE/SFC) procedure has been developed for the removal of oil from corn bran to obtain fractions enriched with free sterols and ferulate-phytosterol esters (FPE). Operational parameters from an analytical-scale Supercritical Fluid fractionation technique were translated to and optimized on a home-built, preparatory-scale SFE/SFC apparatus. SFE was performed at 34.5 MPa and 40°C using Supercritical carbon dioxide. These conditions did not result in exhaustive extraction of the corn bran, but yielded about 96% of the available oil. SFC was conducted in three steps, followed by reconditioning of the sorbent bed. Preparative-scale SFE/SFC of corn bran produced a fraction enriched greater than fourfold in free sterols and 10-fold in FPE, suggesting that such a scheme could be used industrially to produce a functional food ingredient.
Carlos M Silva - One of the best experts on this subject based on the ideXlab platform.
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review of kinetic models for Supercritical Fluid extraction
Chemical Engineering Research & Design, 2011Co-Authors: Eduardo L G Oliveira, Armando J D Silvestre, Carlos M SilvaAbstract:Abstract The Supercritical Fluid extraction (SFE) of liquids and solid materials is gaining increasing interest and commercial application in last decades, most particularly under the recent concept of green chemistry and biorefinery. Hence, it is fundamental to provide adequate modeling of the SFE, in order to optimize operating conditions and simulate the global process. This work intends to review the most significant and physically sound models published in the literature for countercurrent liquid-Supercritical Fluid extraction and SFE of solid matrices, such as the linear driving force, shrinking core, broken and intact cells, and the combination of BIC and shrinking core models. The main assumptions and mass transfer expressions are presented and discussed.
Mohammed J. Meziani - One of the best experts on this subject based on the ideXlab platform.
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Supercritical Fluid Technology for Nanotechnology in Drug Delivery
Nanotechnology in Drug Delivery, 2009Co-Authors: Mohammed J. Meziani, Pankaj PathakAbstract:In the past few decades, Supercritical Fluid technology has attracted the attention of both scientists and engineers (McHugh and Krukonis, 1994; Taylor, 1996; Brennecke, 1993; Hutchenson and Foster, 1995; Levelt Sengers, 1991; Kendall et al., 1999). Early studies on the application of Supercritical Fluid technology were primarily in extraction and chromatography. Extensive experimental and theoretical investigations have been aimed toward an understanding of the properties of Supercritical Fluid systems, particularly intermolecular interactions (solute–solvent, solvent– solvent, and solute–solute) in Supercritical Fluid solutions (Tucker, 1999; Jessop and Leitner, 1999; Sun, 2002).Much progress has also beenmade in the use of Supercritical Fluids and mixtures as reaction media for chemical synthesis and as alternative solvent systems for materials processing (Sun, 2002; Poliakoff et al., 1996; Kajimoto, 1999; Savage, 1999; Musie et al., 2001). Recently, several Supercritical Fluid processing techniques have found significant applications in the nanotechnology development for drug formulation and delivery, especially the production of nanosized drugs and pharmaceuticals. In fact, drug formulation and delivery-related applications have emerged as a new frontier in the development of Supercritical Fluid technology. In this chapter, we provide background information on the Supercritical Fluid processing techniques relevant to drug formulation and delivery, highlight the recent advances and novel applications, and discuss the successful development of a new Supercritical Fluid rapid expansion technique for producing exclusively nanoscale drug particles.
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Supercritical Fluid technology for enhanced drug delivery
Expert Opinion on Drug Delivery, 2005Co-Authors: Pankaj Pathak, Mohammed J. MezianiAbstract:The rapid advances in the development of formulation and delivery systems based on micron-sized and nanoscale drug particles will create significant benefits to the pharmaceutical industry. Complementary to traditional methods, Supercritical Fluid techniques have found many useful, and sometimes unique, applications in the production and processing of drug particles. In this article background information is provided on a variety of Supercritical Fluid techniques relevant to drug formulation and delivery, recent advances and novel applications are highlighted, and the successful development of a new Supercritical Fluid rapid expansion technique for producing exclusively nanoscale drug particles will be discussed. Challenges and opportunities for further development and future applications are also reviewed.
Debby Mangelings - One of the best experts on this subject based on the ideXlab platform.
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Chromatography: Supercritical Fluid Chromatography
Encyclopedia of Food and Health, 2020Co-Authors: Charlene Muscat Galea, Debby Mangelings, Yvan Vander HeydenAbstract:Supercritical Fluid chromatography is an analytical technique being used in several processes relating to food analysis and health analysis. This article explains the principles of the technique and goes into more detail regarding the analysis of lipids, fat-soluble vitamins, nutraceuticals, pesticides, and medicines. An overview of the technique at preparative scale and of Supercritical Fluid extraction is also included.
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Supercritical Fluid chromatography for the enantioseparation of pharmaceuticals
Journal of Pharmaceutical and Biomedical Analysis, 2012Co-Authors: Katrijn De Klerck, Debby Mangelings, Yvan Vander HeydenAbstract:Chirality has a significant impact on drug discovery and development processes in the pharmaceutical industry. As the number of enantiopure drugs launched onto the market is yearly increasing, the need for fast and performant enantioseparation methods with minimal costs is becoming more compelling. In this context, sub- and Supercritical Fluid chromatography (SFC), being applicable at an analytical, as well as at a preparative scale is gaining more interest. In this review a practical overview is given of the different parameters that are important in Supercritical Fluid chromatographic separations. A comparison is made between the applicability for chiral separations of SFC and conventional high-performance liquid chromatography (HPLC), and illustrated by means of examples. Different aspects of method development and the upscaling feasibility in SFC are discussed. This review aims to give the reader a practical insight in the use of Supercritical Fluid chromatography for the chiral separation of pharmaceutical compounds.