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Jennifer Linn - One of the best experts on this subject based on the ideXlab platform.
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cortical Superficial Siderosis detection and clinical significance in cerebral amyloid angiopathy and related conditions
Brain, 2015Co-Authors: Meike W Vernooij, Andreas Charidimou, Jennifer Linn, Christian Opherk, Saloua Akoudad, Jeanclaude Baron, Steven M Greenberg, Hans Rolf Jager, David J WerringAbstract:Cortical Superficial Siderosis describes a distinct pattern of blood-breakdown product deposition limited to cortical sulci over the convexities of the cerebral hemispheres, sparing the brainstem, cerebellum and spinal cord. Although cortical Superficial Siderosis has many possible causes, it is emerging as a key feature of cerebral amyloid angiopathy, a common and important age-related cerebral small vessel disorder leading to intracerebral haemorrhage and dementia. In cerebral amyloid angiopathy cohorts, cortical Superficial Siderosis is associated with characteristic clinical symptoms, including transient focal neurological episodes; preliminary data also suggest an association with a high risk of future intracerebral haemorrhage, with potential implications for antithrombotic treatment decisions. Thus, cortical Superficial Siderosis is of relevance to neurologists working in neurovascular, memory and epilepsy clinics, and neurovascular emergency services, emphasizing the need for appropriate blood-sensitive magnetic resonance sequences to be routinely acquired in these clinical settings. In this review we focus on recent developments in neuroimaging and detection, aetiology, prevalence, pathophysiology and clinical significance of cortical Superficial Siderosis, with a particular emphasis on cerebral amyloid angiopathy. We also highlight important areas for future investigation and propose standards for evaluating cortical Superficial Siderosis in research studies. * Abbreviations : CAA : cerebral amyloid angiopathy cSAH : convexity subarachnoid haemorrhage cSS : cortical Superficial Siderosis GRE : gradient recalled echo ICH : intracerebral haemorrhage SWI : susceptibility-weighted imaging
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Cortical Superficial Siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions.
Brain : a journal of neurology, 2015Co-Authors: Andreas Charidimou, Meike W Vernooij, Jennifer Linn, Christian Opherk, Saloua Akoudad, Jeanclaude Baron, Steven M Greenberg, Hans Rolf Jager, David J WerringAbstract:Cortical Superficial Siderosis describes a distinct pattern of blood-breakdown product deposition limited to cortical sulci over the convexities of the cerebral hemispheres, sparing the brainstem, cerebellum and spinal cord. Although cortical Superficial Siderosis has many possible causes, it is emerging as a key feature of cerebral amyloid angiopathy, a common and important age-related cerebral small vessel disorder leading to intracerebral haemorrhage and dementia. In cerebral amyloid angiopathy cohorts, cortical Superficial Siderosis is associated with characteristic clinical symptoms, including transient focal neurological episodes; preliminary data also suggest an association with a high risk of future intracerebral haemorrhage, with potential implications for antithrombotic treatment decisions. Thus, cortical Superficial Siderosis is of relevance to neurologists working in neurovascular, memory and epilepsy clinics, and neurovascular emergency services, emphasizing the need for appropriate blood-sensitive magnetic resonance sequences to be routinely acquired in these clinical settings. In this review we focus on recent developments in neuroimaging and detection, aetiology, prevalence, pathophysiology and clinical significance of cortical Superficial Siderosis, with a particular emphasis on cerebral amyloid angiopathy. We also highlight important areas for future investigation and propose standards for evaluating cortical Superficial Siderosis in research studies.
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prevalence of Superficial Siderosis following singular acute aneurysmal subarachnoid hemorrhage
Neuroradiology, 2015Co-Authors: N Lummel, C Bernau, Niklas Thon, Katja Bochmann, Jennifer LinnAbstract:Superficial Siderosis is presumably a consequence of recurrent bleeding into the subarachnoid space. The objective of this study was to assess the prevalence of Superficial Siderosis after singular, aneurysmal subarachnoid hemorrhage (SAH) in the long term. We retrospectively identified all patients who presented with a singular, acute, aneurysmal SAH at our institution between 2010 and 2013 and in whom a magnetic resonance imaging (MRI) including T2*-weighted imaging was available at least 4 months after the acute bleeding event. MRI scans were judged concerning the presence and distribution of Superficial Siderosis. Influence of clinical data, Fisher grade, localization, and cause of SAH as well as the impact of neurosurgical interventions on the occurrence of Superficial Siderosis was tested. Seventy-two patients with a total of 117 MRIs were included. Mean delay between SAH and the last available MRI was 47.4 months (range 4–129). SAH was Fisher grade 1 in 2 cases, 2 in 4 cases, 3 in 10 cases, and 4 in 56 cases. Superficial Siderosis was detected in 39 patients (54.2 %). In all patients with more than one MRI scan, localization and distribution of Superficial Siderosis did not change over time. Older age (p = 0.02) and higher degree of SAH (p = 0.03) were significantly associated with the development of Superficial Siderosis. Superficial Siderosis develops in approximately half of patients after singular, aneurysmal SAH and might be more common in patients with an older age and a greater amount of blood. However, additional factors must play a role in whether a patient is prone to develop Superficial Siderosis or not.
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Prevalence of Superficial Siderosis following singular, acute aneurysmal subarachnoid hemorrhage
Neuroradiology, 2015Co-Authors: N Lummel, C Bernau, Niklas Thon, Katja Bochmann, Jennifer LinnAbstract:Introduction Superficial Siderosis is presumably a consequence of recurrent bleeding into the subarachnoid space. The objective of this study was to assess the prevalence of Superficial Siderosis after singular, aneurysmal subarachnoid hemorrhage (SAH) in the long term. Methods We retrospectively identified all patients who presented with a singular, acute, aneurysmal SAH at our institution between 2010 and 2013 and in whom a magnetic resonance imaging (MRI) including T2*-weighted imaging was available at least 4 months after the acute bleeding event. MRI scans were judged concerning the presence and distribution of Superficial Siderosis. Influence of clinical data, Fisher grade, localization, and cause of SAH as well as the impact of neurosurgical interventions on the occurrence of Superficial Siderosis was tested. Results Seventy-two patients with a total of 117 MRIs were included. Mean delay between SAH and the last available MRI was 47.4 months (range 4–129). SAH was Fisher grade 1 in 2 cases, 2 in 4 cases, 3 in 10 cases, and 4 in 56 cases. Superficial Siderosis was detected in 39 patients (54.2 %). In all patients with more than one MRI scan, localization and distribution of Superficial Siderosis did not change over time. Older age ( p = 0.02) and higher degree of SAH ( p = 0.03) were significantly associated with the development of Superficial Siderosis. Conclusion Superficial Siderosis develops in approximately half of patients after singular, aneurysmal SAH and might be more common in patients with an older age and a greater amount of blood. However, additional factors must play a role in whether a patient is prone to develop Superficial Siderosis or not.
N Lummel - One of the best experts on this subject based on the ideXlab platform.
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prevalence of Superficial Siderosis following singular acute aneurysmal subarachnoid hemorrhage
Neuroradiology, 2015Co-Authors: N Lummel, C Bernau, Niklas Thon, Katja Bochmann, Jennifer LinnAbstract:Superficial Siderosis is presumably a consequence of recurrent bleeding into the subarachnoid space. The objective of this study was to assess the prevalence of Superficial Siderosis after singular, aneurysmal subarachnoid hemorrhage (SAH) in the long term. We retrospectively identified all patients who presented with a singular, acute, aneurysmal SAH at our institution between 2010 and 2013 and in whom a magnetic resonance imaging (MRI) including T2*-weighted imaging was available at least 4 months after the acute bleeding event. MRI scans were judged concerning the presence and distribution of Superficial Siderosis. Influence of clinical data, Fisher grade, localization, and cause of SAH as well as the impact of neurosurgical interventions on the occurrence of Superficial Siderosis was tested. Seventy-two patients with a total of 117 MRIs were included. Mean delay between SAH and the last available MRI was 47.4 months (range 4–129). SAH was Fisher grade 1 in 2 cases, 2 in 4 cases, 3 in 10 cases, and 4 in 56 cases. Superficial Siderosis was detected in 39 patients (54.2 %). In all patients with more than one MRI scan, localization and distribution of Superficial Siderosis did not change over time. Older age (p = 0.02) and higher degree of SAH (p = 0.03) were significantly associated with the development of Superficial Siderosis. Superficial Siderosis develops in approximately half of patients after singular, aneurysmal SAH and might be more common in patients with an older age and a greater amount of blood. However, additional factors must play a role in whether a patient is prone to develop Superficial Siderosis or not.
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Prevalence of Superficial Siderosis following singular, acute aneurysmal subarachnoid hemorrhage
Neuroradiology, 2015Co-Authors: N Lummel, C Bernau, Niklas Thon, Katja Bochmann, Jennifer LinnAbstract:Introduction Superficial Siderosis is presumably a consequence of recurrent bleeding into the subarachnoid space. The objective of this study was to assess the prevalence of Superficial Siderosis after singular, aneurysmal subarachnoid hemorrhage (SAH) in the long term. Methods We retrospectively identified all patients who presented with a singular, acute, aneurysmal SAH at our institution between 2010 and 2013 and in whom a magnetic resonance imaging (MRI) including T2*-weighted imaging was available at least 4 months after the acute bleeding event. MRI scans were judged concerning the presence and distribution of Superficial Siderosis. Influence of clinical data, Fisher grade, localization, and cause of SAH as well as the impact of neurosurgical interventions on the occurrence of Superficial Siderosis was tested. Results Seventy-two patients with a total of 117 MRIs were included. Mean delay between SAH and the last available MRI was 47.4 months (range 4–129). SAH was Fisher grade 1 in 2 cases, 2 in 4 cases, 3 in 10 cases, and 4 in 56 cases. Superficial Siderosis was detected in 39 patients (54.2 %). In all patients with more than one MRI scan, localization and distribution of Superficial Siderosis did not change over time. Older age ( p = 0.02) and higher degree of SAH ( p = 0.03) were significantly associated with the development of Superficial Siderosis. Conclusion Superficial Siderosis develops in approximately half of patients after singular, aneurysmal SAH and might be more common in patients with an older age and a greater amount of blood. However, additional factors must play a role in whether a patient is prone to develop Superficial Siderosis or not.
Katja Bochmann - One of the best experts on this subject based on the ideXlab platform.
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prevalence of Superficial Siderosis following singular acute aneurysmal subarachnoid hemorrhage
Neuroradiology, 2015Co-Authors: N Lummel, C Bernau, Niklas Thon, Katja Bochmann, Jennifer LinnAbstract:Superficial Siderosis is presumably a consequence of recurrent bleeding into the subarachnoid space. The objective of this study was to assess the prevalence of Superficial Siderosis after singular, aneurysmal subarachnoid hemorrhage (SAH) in the long term. We retrospectively identified all patients who presented with a singular, acute, aneurysmal SAH at our institution between 2010 and 2013 and in whom a magnetic resonance imaging (MRI) including T2*-weighted imaging was available at least 4 months after the acute bleeding event. MRI scans were judged concerning the presence and distribution of Superficial Siderosis. Influence of clinical data, Fisher grade, localization, and cause of SAH as well as the impact of neurosurgical interventions on the occurrence of Superficial Siderosis was tested. Seventy-two patients with a total of 117 MRIs were included. Mean delay between SAH and the last available MRI was 47.4 months (range 4–129). SAH was Fisher grade 1 in 2 cases, 2 in 4 cases, 3 in 10 cases, and 4 in 56 cases. Superficial Siderosis was detected in 39 patients (54.2 %). In all patients with more than one MRI scan, localization and distribution of Superficial Siderosis did not change over time. Older age (p = 0.02) and higher degree of SAH (p = 0.03) were significantly associated with the development of Superficial Siderosis. Superficial Siderosis develops in approximately half of patients after singular, aneurysmal SAH and might be more common in patients with an older age and a greater amount of blood. However, additional factors must play a role in whether a patient is prone to develop Superficial Siderosis or not.
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Prevalence of Superficial Siderosis following singular, acute aneurysmal subarachnoid hemorrhage
Neuroradiology, 2015Co-Authors: N Lummel, C Bernau, Niklas Thon, Katja Bochmann, Jennifer LinnAbstract:Introduction Superficial Siderosis is presumably a consequence of recurrent bleeding into the subarachnoid space. The objective of this study was to assess the prevalence of Superficial Siderosis after singular, aneurysmal subarachnoid hemorrhage (SAH) in the long term. Methods We retrospectively identified all patients who presented with a singular, acute, aneurysmal SAH at our institution between 2010 and 2013 and in whom a magnetic resonance imaging (MRI) including T2*-weighted imaging was available at least 4 months after the acute bleeding event. MRI scans were judged concerning the presence and distribution of Superficial Siderosis. Influence of clinical data, Fisher grade, localization, and cause of SAH as well as the impact of neurosurgical interventions on the occurrence of Superficial Siderosis was tested. Results Seventy-two patients with a total of 117 MRIs were included. Mean delay between SAH and the last available MRI was 47.4 months (range 4–129). SAH was Fisher grade 1 in 2 cases, 2 in 4 cases, 3 in 10 cases, and 4 in 56 cases. Superficial Siderosis was detected in 39 patients (54.2 %). In all patients with more than one MRI scan, localization and distribution of Superficial Siderosis did not change over time. Older age ( p = 0.02) and higher degree of SAH ( p = 0.03) were significantly associated with the development of Superficial Siderosis. Conclusion Superficial Siderosis develops in approximately half of patients after singular, aneurysmal SAH and might be more common in patients with an older age and a greater amount of blood. However, additional factors must play a role in whether a patient is prone to develop Superficial Siderosis or not.
Niklas Thon - One of the best experts on this subject based on the ideXlab platform.
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prevalence of Superficial Siderosis following singular acute aneurysmal subarachnoid hemorrhage
Neuroradiology, 2015Co-Authors: N Lummel, C Bernau, Niklas Thon, Katja Bochmann, Jennifer LinnAbstract:Superficial Siderosis is presumably a consequence of recurrent bleeding into the subarachnoid space. The objective of this study was to assess the prevalence of Superficial Siderosis after singular, aneurysmal subarachnoid hemorrhage (SAH) in the long term. We retrospectively identified all patients who presented with a singular, acute, aneurysmal SAH at our institution between 2010 and 2013 and in whom a magnetic resonance imaging (MRI) including T2*-weighted imaging was available at least 4 months after the acute bleeding event. MRI scans were judged concerning the presence and distribution of Superficial Siderosis. Influence of clinical data, Fisher grade, localization, and cause of SAH as well as the impact of neurosurgical interventions on the occurrence of Superficial Siderosis was tested. Seventy-two patients with a total of 117 MRIs were included. Mean delay between SAH and the last available MRI was 47.4 months (range 4–129). SAH was Fisher grade 1 in 2 cases, 2 in 4 cases, 3 in 10 cases, and 4 in 56 cases. Superficial Siderosis was detected in 39 patients (54.2 %). In all patients with more than one MRI scan, localization and distribution of Superficial Siderosis did not change over time. Older age (p = 0.02) and higher degree of SAH (p = 0.03) were significantly associated with the development of Superficial Siderosis. Superficial Siderosis develops in approximately half of patients after singular, aneurysmal SAH and might be more common in patients with an older age and a greater amount of blood. However, additional factors must play a role in whether a patient is prone to develop Superficial Siderosis or not.
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Prevalence of Superficial Siderosis following singular, acute aneurysmal subarachnoid hemorrhage
Neuroradiology, 2015Co-Authors: N Lummel, C Bernau, Niklas Thon, Katja Bochmann, Jennifer LinnAbstract:Introduction Superficial Siderosis is presumably a consequence of recurrent bleeding into the subarachnoid space. The objective of this study was to assess the prevalence of Superficial Siderosis after singular, aneurysmal subarachnoid hemorrhage (SAH) in the long term. Methods We retrospectively identified all patients who presented with a singular, acute, aneurysmal SAH at our institution between 2010 and 2013 and in whom a magnetic resonance imaging (MRI) including T2*-weighted imaging was available at least 4 months after the acute bleeding event. MRI scans were judged concerning the presence and distribution of Superficial Siderosis. Influence of clinical data, Fisher grade, localization, and cause of SAH as well as the impact of neurosurgical interventions on the occurrence of Superficial Siderosis was tested. Results Seventy-two patients with a total of 117 MRIs were included. Mean delay between SAH and the last available MRI was 47.4 months (range 4–129). SAH was Fisher grade 1 in 2 cases, 2 in 4 cases, 3 in 10 cases, and 4 in 56 cases. Superficial Siderosis was detected in 39 patients (54.2 %). In all patients with more than one MRI scan, localization and distribution of Superficial Siderosis did not change over time. Older age ( p = 0.02) and higher degree of SAH ( p = 0.03) were significantly associated with the development of Superficial Siderosis. Conclusion Superficial Siderosis develops in approximately half of patients after singular, aneurysmal SAH and might be more common in patients with an older age and a greater amount of blood. However, additional factors must play a role in whether a patient is prone to develop Superficial Siderosis or not.
C Bernau - One of the best experts on this subject based on the ideXlab platform.
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prevalence of Superficial Siderosis following singular acute aneurysmal subarachnoid hemorrhage
Neuroradiology, 2015Co-Authors: N Lummel, C Bernau, Niklas Thon, Katja Bochmann, Jennifer LinnAbstract:Superficial Siderosis is presumably a consequence of recurrent bleeding into the subarachnoid space. The objective of this study was to assess the prevalence of Superficial Siderosis after singular, aneurysmal subarachnoid hemorrhage (SAH) in the long term. We retrospectively identified all patients who presented with a singular, acute, aneurysmal SAH at our institution between 2010 and 2013 and in whom a magnetic resonance imaging (MRI) including T2*-weighted imaging was available at least 4 months after the acute bleeding event. MRI scans were judged concerning the presence and distribution of Superficial Siderosis. Influence of clinical data, Fisher grade, localization, and cause of SAH as well as the impact of neurosurgical interventions on the occurrence of Superficial Siderosis was tested. Seventy-two patients with a total of 117 MRIs were included. Mean delay between SAH and the last available MRI was 47.4 months (range 4–129). SAH was Fisher grade 1 in 2 cases, 2 in 4 cases, 3 in 10 cases, and 4 in 56 cases. Superficial Siderosis was detected in 39 patients (54.2 %). In all patients with more than one MRI scan, localization and distribution of Superficial Siderosis did not change over time. Older age (p = 0.02) and higher degree of SAH (p = 0.03) were significantly associated with the development of Superficial Siderosis. Superficial Siderosis develops in approximately half of patients after singular, aneurysmal SAH and might be more common in patients with an older age and a greater amount of blood. However, additional factors must play a role in whether a patient is prone to develop Superficial Siderosis or not.
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Prevalence of Superficial Siderosis following singular, acute aneurysmal subarachnoid hemorrhage
Neuroradiology, 2015Co-Authors: N Lummel, C Bernau, Niklas Thon, Katja Bochmann, Jennifer LinnAbstract:Introduction Superficial Siderosis is presumably a consequence of recurrent bleeding into the subarachnoid space. The objective of this study was to assess the prevalence of Superficial Siderosis after singular, aneurysmal subarachnoid hemorrhage (SAH) in the long term. Methods We retrospectively identified all patients who presented with a singular, acute, aneurysmal SAH at our institution between 2010 and 2013 and in whom a magnetic resonance imaging (MRI) including T2*-weighted imaging was available at least 4 months after the acute bleeding event. MRI scans were judged concerning the presence and distribution of Superficial Siderosis. Influence of clinical data, Fisher grade, localization, and cause of SAH as well as the impact of neurosurgical interventions on the occurrence of Superficial Siderosis was tested. Results Seventy-two patients with a total of 117 MRIs were included. Mean delay between SAH and the last available MRI was 47.4 months (range 4–129). SAH was Fisher grade 1 in 2 cases, 2 in 4 cases, 3 in 10 cases, and 4 in 56 cases. Superficial Siderosis was detected in 39 patients (54.2 %). In all patients with more than one MRI scan, localization and distribution of Superficial Siderosis did not change over time. Older age ( p = 0.02) and higher degree of SAH ( p = 0.03) were significantly associated with the development of Superficial Siderosis. Conclusion Superficial Siderosis develops in approximately half of patients after singular, aneurysmal SAH and might be more common in patients with an older age and a greater amount of blood. However, additional factors must play a role in whether a patient is prone to develop Superficial Siderosis or not.
