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Agustin Ibanez - One of the best experts on this subject based on the ideXlab platform.
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Corrigendum: Detaching from the negative by reappraisal: the role of right Superior Frontal Gyrus (BA9/32)
Frontiers in Behavioral Neuroscience, 2014Co-Authors: Rosalux Falquez, Blas Couto, Agustin Ibanez, Martin T Freitag, Elisabeth A Arens, Simone Lang, Moritz C. Berger, Sven BarnowAbstract:We noticed an error in one of our presented analyses. One mismatched brain image was accidentally included in the voxel-based-morphometry (VBM) analysis. Thus, arousal and valence values were consecutively not properly assigned to the morphological brain data of the other included participants. Of three analyses implemented in this study (VSLM, ROI-based), only the VBM analysis was affected but the others remain untouched. Therefore, we re-conducted the whole VBM analysis with the correct allocation of data. The corrected results showed changes in the whole-brain and regional correlations compared to the originally presented results. However, the correlations in the expected areas of the original manuscript remain significant for arousal and valence difference scores. Fortunately, these results do not impact the main implications and neither invalidate the conclusions derived from the study nor introduce differing directions of inference. The right Superior Frontal Gyrus (SFG/BA9) and anterior cingulate cortex (ACC/BA32) remain significant at whole-brain p < 0.001 uncorrected level, and the ROI analysis still showed significant correlations with gray matter intensities in the right SFG (BA9). The corrected results affect Figures Figures6,6, ,7,7, Tables Tables5,5, ,6,6, and small parts in results and discussion which are attached below. Figure 6 Whole brain patterns of gray matter volumes correlated with task performance in controls. (A) Arousal rating differences and (B) Valence rating differences (presented at a level of p < 0.001 unc). Figure 7 Graphic display of regional gray matter patterns of volume using the ROI depicted by the VLSM analysis (BA9/32) correlated with task performance in controls for (A) Arousal and (B) Valence rating differences (presented at a level of p < 0.05 unc) ... Table 5 Whole brain Patterns of GM volume correlated with task performance in controls. Table 6 Regional brain Patterns of GM volume correlated with task performance in controls. The authors deeply regret this error and apologize for any confusion it might have caused.
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corrigendum detaching from the negative by reappraisal the role of right Superior Frontal Gyrus ba9 32
Frontiers in Behavioral Neuroscience, 2014Co-Authors: Rosalux Falquez, Blas Couto, Agustin Ibanez, Martin T Freitag, Elisabeth A Arens, Moritz C. Berger, Simone LangAbstract:We noticed an error in one of our presented analyses. One mismatched brain image was accidentally included in the voxel-based-morphometry (VBM) analysis. Thus, arousal and valence values were consecutively not properly assigned to the morphological brain data of the other included participants. Of three analyses implemented in this study (VSLM, ROI-based), only the VBM analysis was affected but the others remain untouched. Therefore, we re-conducted the whole VBM analysis with the correct allocation of data. The corrected results showed changes in the whole-brain and regional correlations compared to the originally presented results. However, the correlations in the expected areas of the original manuscript remain significant for arousal and valence difference scores. Fortunately, these results do not impact the main implications and neither invalidate the conclusions derived from the study nor introduce differing directions of inference. The right Superior Frontal Gyrus (SFG/BA9) and anterior cingulate cortex (ACC/BA32) remain significant at whole-brain p < 0.001 uncorrected level, and the ROI analysis still showed significant correlations with gray matter intensities in the right SFG (BA9). The corrected results affect Figures Figures6,6, ,7,7, Tables Tables5,5, ,6,6, and small parts in results and discussion which are attached below. Figure 6 Whole brain patterns of gray matter volumes correlated with task performance in controls. (A) Arousal rating differences and (B) Valence rating differences (presented at a level of p < 0.001 unc). Figure 7 Graphic display of regional gray matter patterns of volume using the ROI depicted by the VLSM analysis (BA9/32) correlated with task performance in controls for (A) Arousal and (B) Valence rating differences (presented at a level of p < 0.05 unc) ... Table 5 Whole brain Patterns of GM volume correlated with task performance in controls. Table 6 Regional brain Patterns of GM volume correlated with task performance in controls. The authors deeply regret this error and apologize for any confusion it might have caused.
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detaching from the negative by reappraisal the role of right Superior Frontal Gyrus ba9 32
Frontiers in Behavioral Neuroscience, 2014Co-Authors: Rosalux Falquez, Blas Couto, Agustin Ibanez, Martin T Freitag, Moritz Berger, Elisabeth A Arens, Simone Lang, Sven BarnowAbstract:The ability to reappraise the emotional impact of events is related to long-term mental health. Self-focused reappraisal (REAPPself), i.e., reducing the personal relevance of the negative events, has been previously associated with neural activity in regions near right medial preFrontal cortex, but rarely investigated among brain-damaged individuals. Thus, we aimed to examine the REAPPself ability of brain-damaged patients and healthy controls considering structural atrophies and grey matter intensities, respectively. Twenty patients with well-defined cortex lesions due to an acquired circumscribed tumor or cyst and 23 healthy controls performed a REAPPself task, in which they had to either observe negative stimuli or decrease emotional responding by REAPPself. Next, they rated the impact of negative arousal and valence. REAPPself ability scores were calculated by subtracting the negative picture ratings after applying REAPPself from the ratings of the observing condition. The scores of the patients were included in a voxel-based lesion-symptom mapping (VLSM) analysis to identify deficit related areas (ROI). Then, a ROI group-wise comparison was performed. Additionally, a whole-brain voxel-based-morphometry (VBM) analysis was run, in which healthy participant’s REAPPself ability scores were correlated with grey matter intensities. Results showed that 1) regions in the right Superior Frontal Gyrus (SFG), comprising the right dorsolateral preFrontal cortex (BA9) and the right dorsal anterior cingulate cortex (BA32), were associated with patient’s impaired down-regulation of arousal, 2) a lesion in the depicted ROI occasioned significant REAPPself impairments, 3) REAPPself ability of controls was linked with increased grey matter intensities in the ROI regions. Our findings show for the first time that the neural integrity and the structural volume of right SFG regions (BA9/32) might be indispensable for REAPPself. Implications for neurofeedback research are discussed.
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Detaching from the negative by reappraisal: the role of right Superior Frontal Gyrus (BA9/32).
Frontiers in behavioral neuroscience, 2014Co-Authors: Rosalux Falquez, Blas Couto, Agustin Ibanez, Martin T Freitag, Elisabeth A Arens, Simone Lang, Moritz C. Berger, Sven BarnowAbstract:The ability to reappraise the emotional impact of events is related to long-term mental health. Self-focused reappraisal (REAPPself), i.e., reducing the personal relevance of the negative events, has been previously associated with neural activity in regions near right medial preFrontal cortex, but rarely investigated among brain-damaged individuals. Thus, we aimed to examine the REAPPself ability of brain-damaged patients and healthy controls considering structural atrophies and grey matter intensities, respectively. Twenty patients with well-defined cortex lesions due to an acquired circumscribed tumor or cyst and 23 healthy controls performed a REAPPself task, in which they had to either observe negative stimuli or decrease emotional responding by REAPPself. Next, they rated the impact of negative arousal and valence. REAPPself ability scores were calculated by subtracting the negative picture ratings after applying REAPPself from the ratings of the observing condition. The scores of the patients were included in a voxel-based lesion-symptom mapping (VLSM) analysis to identify deficit related areas (ROI). Then, a ROI group-wise comparison was performed. Additionally, a whole-brain voxel-based-morphometry (VBM) analysis was run, in which healthy participant’s REAPPself ability scores were correlated with grey matter intensities. Results showed that 1) regions in the right Superior Frontal Gyrus (SFG), comprising the right dorsolateral preFrontal cortex (BA9) and the right dorsal anterior cingulate cortex (BA32), were associated with patient’s impaired down-regulation of arousal, 2) a lesion in the depicted ROI occasioned significant REAPPself impairments, 3) REAPPself ability of controls was linked with increased grey matter intensities in the ROI regions. Our findings show for the first time that the neural integrity and the structural volume of right SFG regions (BA9/32) might be indispensable for REAPPself. Implications for neurofeedback research are discussed.
Sven Barnow - One of the best experts on this subject based on the ideXlab platform.
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Corrigendum: Detaching from the negative by reappraisal: the role of right Superior Frontal Gyrus (BA9/32)
Frontiers in Behavioral Neuroscience, 2014Co-Authors: Rosalux Falquez, Blas Couto, Agustin Ibanez, Martin T Freitag, Elisabeth A Arens, Simone Lang, Moritz C. Berger, Sven BarnowAbstract:We noticed an error in one of our presented analyses. One mismatched brain image was accidentally included in the voxel-based-morphometry (VBM) analysis. Thus, arousal and valence values were consecutively not properly assigned to the morphological brain data of the other included participants. Of three analyses implemented in this study (VSLM, ROI-based), only the VBM analysis was affected but the others remain untouched. Therefore, we re-conducted the whole VBM analysis with the correct allocation of data. The corrected results showed changes in the whole-brain and regional correlations compared to the originally presented results. However, the correlations in the expected areas of the original manuscript remain significant for arousal and valence difference scores. Fortunately, these results do not impact the main implications and neither invalidate the conclusions derived from the study nor introduce differing directions of inference. The right Superior Frontal Gyrus (SFG/BA9) and anterior cingulate cortex (ACC/BA32) remain significant at whole-brain p < 0.001 uncorrected level, and the ROI analysis still showed significant correlations with gray matter intensities in the right SFG (BA9). The corrected results affect Figures Figures6,6, ,7,7, Tables Tables5,5, ,6,6, and small parts in results and discussion which are attached below. Figure 6 Whole brain patterns of gray matter volumes correlated with task performance in controls. (A) Arousal rating differences and (B) Valence rating differences (presented at a level of p < 0.001 unc). Figure 7 Graphic display of regional gray matter patterns of volume using the ROI depicted by the VLSM analysis (BA9/32) correlated with task performance in controls for (A) Arousal and (B) Valence rating differences (presented at a level of p < 0.05 unc) ... Table 5 Whole brain Patterns of GM volume correlated with task performance in controls. Table 6 Regional brain Patterns of GM volume correlated with task performance in controls. The authors deeply regret this error and apologize for any confusion it might have caused.
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detaching from the negative by reappraisal the role of right Superior Frontal Gyrus ba9 32
Frontiers in Behavioral Neuroscience, 2014Co-Authors: Rosalux Falquez, Blas Couto, Agustin Ibanez, Martin T Freitag, Moritz Berger, Elisabeth A Arens, Simone Lang, Sven BarnowAbstract:The ability to reappraise the emotional impact of events is related to long-term mental health. Self-focused reappraisal (REAPPself), i.e., reducing the personal relevance of the negative events, has been previously associated with neural activity in regions near right medial preFrontal cortex, but rarely investigated among brain-damaged individuals. Thus, we aimed to examine the REAPPself ability of brain-damaged patients and healthy controls considering structural atrophies and grey matter intensities, respectively. Twenty patients with well-defined cortex lesions due to an acquired circumscribed tumor or cyst and 23 healthy controls performed a REAPPself task, in which they had to either observe negative stimuli or decrease emotional responding by REAPPself. Next, they rated the impact of negative arousal and valence. REAPPself ability scores were calculated by subtracting the negative picture ratings after applying REAPPself from the ratings of the observing condition. The scores of the patients were included in a voxel-based lesion-symptom mapping (VLSM) analysis to identify deficit related areas (ROI). Then, a ROI group-wise comparison was performed. Additionally, a whole-brain voxel-based-morphometry (VBM) analysis was run, in which healthy participant’s REAPPself ability scores were correlated with grey matter intensities. Results showed that 1) regions in the right Superior Frontal Gyrus (SFG), comprising the right dorsolateral preFrontal cortex (BA9) and the right dorsal anterior cingulate cortex (BA32), were associated with patient’s impaired down-regulation of arousal, 2) a lesion in the depicted ROI occasioned significant REAPPself impairments, 3) REAPPself ability of controls was linked with increased grey matter intensities in the ROI regions. Our findings show for the first time that the neural integrity and the structural volume of right SFG regions (BA9/32) might be indispensable for REAPPself. Implications for neurofeedback research are discussed.
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Detaching from the negative by reappraisal: the role of right Superior Frontal Gyrus (BA9/32).
Frontiers in behavioral neuroscience, 2014Co-Authors: Rosalux Falquez, Blas Couto, Agustin Ibanez, Martin T Freitag, Elisabeth A Arens, Simone Lang, Moritz C. Berger, Sven BarnowAbstract:The ability to reappraise the emotional impact of events is related to long-term mental health. Self-focused reappraisal (REAPPself), i.e., reducing the personal relevance of the negative events, has been previously associated with neural activity in regions near right medial preFrontal cortex, but rarely investigated among brain-damaged individuals. Thus, we aimed to examine the REAPPself ability of brain-damaged patients and healthy controls considering structural atrophies and grey matter intensities, respectively. Twenty patients with well-defined cortex lesions due to an acquired circumscribed tumor or cyst and 23 healthy controls performed a REAPPself task, in which they had to either observe negative stimuli or decrease emotional responding by REAPPself. Next, they rated the impact of negative arousal and valence. REAPPself ability scores were calculated by subtracting the negative picture ratings after applying REAPPself from the ratings of the observing condition. The scores of the patients were included in a voxel-based lesion-symptom mapping (VLSM) analysis to identify deficit related areas (ROI). Then, a ROI group-wise comparison was performed. Additionally, a whole-brain voxel-based-morphometry (VBM) analysis was run, in which healthy participant’s REAPPself ability scores were correlated with grey matter intensities. Results showed that 1) regions in the right Superior Frontal Gyrus (SFG), comprising the right dorsolateral preFrontal cortex (BA9) and the right dorsal anterior cingulate cortex (BA32), were associated with patient’s impaired down-regulation of arousal, 2) a lesion in the depicted ROI occasioned significant REAPPself impairments, 3) REAPPself ability of controls was linked with increased grey matter intensities in the ROI regions. Our findings show for the first time that the neural integrity and the structural volume of right SFG regions (BA9/32) might be indispensable for REAPPself. Implications for neurofeedback research are discussed.
Peter R. Dodd - One of the best experts on this subject based on the ideXlab platform.
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Identifying changes in the synaptic proteome of cirrhotic alcoholic Superior Frontal Gyrus.
Current neuropharmacology, 2011Co-Authors: Naomi Etheridge, R. D. Mayfield, R. A. Harris, Peter R. DoddAbstract:Hepatic complications are a common side-effect of alcoholism. Without the detoxification capabilities of the liver, alcohol misuse induces changes in gene and protein expression throughout the body. A global proteomics approach was used to identify these protein changes in the brain. We utilised human autopsy tissue from the Superior Frontal Gyrus (SFG) of six cirrhotic alcoholics, six alcoholics without comorbid disease, and six non-alcoholic non-cirrhotic controls. Synaptic proteins were isolated and used in two-dimensional differential in-gel electrophoresis coupled with mass spectrometry. Many expression differences were confined to one or other alcoholic sub-group. Cirrhotic alcoholics showed 99 differences in protein expression levels from controls, of which half also differed from non-comorbid alcoholics. This may reflect differences in disease severity between the sub-groups of alcoholics, or differences in patterns of harmful drinking. Alternatively, the protein profiles may result from differences between cirrhotic and non-comorbid alcoholics in subjects' responses to alcohol misuse. Ten proteins were identified in at least two spots on the 2D gel; they were involved in basal energy metabolism, synaptic vesicle recycling, and chaperoning. These post-translationally modified isoforms were differentially regulated in cirrhotic alcoholics, indicating a level of epigenetic control not previously observed in this disorder.
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synaptic proteome changes in the Superior Frontal Gyrus and occipital cortex of the alcoholic brain
Proteomics Clinical Applications, 2009Co-Authors: Naomi Etheridge, J M Lewohl, Dayne R Mayfield, Adron R Harris, Peter R. DoddAbstract:Cognitive deficits and behavioral changes that result from chronic alcohol abuse are a consequence of neuropathological changes which alter signal transmission through the neural network. To focus on the changes that occur at the point of connection between the neural network cells, synaptosomal preparations from post-mortem human brain of six chronic alcoholics and six non-alcoholic controls were compared using 2D-DIGE. Functionally affected and spared regions (Superior Frontal Gyrus, SFG, and occipital cortex, OC, respectively) were analyzed from both groups to further investigate the specific pathological response that alcoholism has on the brain. Forty-nine proteins were differentially regulated between the SFG of alcoholics and the SFG of controls and 94 proteins were regulated in the OC with an overlap of 23 proteins. Additionally, the SFG was compared to the OC within each group (alcoholics or controls) to identify region specific differences. A selection were identified by MALDI-TOF mass spectrometry revealing proteins involved in vesicle transport, metabolism, folding and trafficking, and signal transduction, all of which have the potential to influence synaptic activity. A number of proteins identified in this study have been previously related to alcoholism; however, the focus on synaptic proteins has also uncovered novel alcoholism-affected proteins. Further exploration of these proteins will illuminate the mechanisms altering synaptic plasticity, and thus neuronal signaling and response, in the alcoholic brain.
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Synaptic proteome changes in the Superior Frontal Gyrus and occipital cortex of the alcoholic brain.
Proteomics. Clinical applications, 2009Co-Authors: Naomi Etheridge, R. D. Mayfield, R. A. Harris, J M Lewohl, Peter R. DoddAbstract:Cognitive deficits and behavioral changes that result from chronic alcohol abuse are a consequence of neuropathological changes which alter signal transmission through the neural network. To focus on the changes that occur at the point of connection between the neural network cells, synaptosomal preparations from post-mortem human brain of six chronic alcoholics and six non-alcoholic controls were compared using 2D-DIGE. Functionally affected and spared regions (Superior Frontal Gyrus, SFG, and occipital cortex, OC, respectively) were analyzed from both groups to further investigate the specific pathological response that alcoholism has on the brain. Forty-nine proteins were differentially regulated between the SFG of alcoholics and the SFG of controls and 94 proteins were regulated in the OC with an overlap of 23 proteins. Additionally, the SFG was compared to the OC within each group (alcoholics or controls) to identify region specific differences. A selection were identified by MALDI-TOF mass spectrometry revealing proteins involved in vesicle transport, metabolism, folding and trafficking, and signal transduction, all of which have the potential to influence synaptic activity. A number of proteins identified in this study have been previously related to alcoholism; however, the focus on synaptic proteins has also uncovered novel alcoholism-affected proteins. Further exploration of these proteins will illuminate the mechanisms altering synaptic plasticity, and thus neuronal signaling and response, in the alcoholic brain.
Yasuyoshi Watanabe - One of the best experts on this subject based on the ideXlab platform.
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Two types of mental fatigue affect spontaneous oscillatory brain activities in different ways
Behavioral and Brain Functions, 2013Co-Authors: Yoshihito Shigihara, Masaaki Tanaka, Akira Ishii, Etsuko Kanai, Masami Funakura, Yasuyoshi WatanabeAbstract:Background Fatigue has a multi-factorial nature. We examined the effects of two types of mental fatigue on spontaneous oscillatory brain activity using magnetoencephalography (MEG). Methods Participants were randomly assigned to two groups in a single-blinded, crossover fashion to perform two types of mental fatigue-inducing experiments. Each experiment consisted of a 30-min fatigue-inducing 0- or 2-back test session and two evaluation sessions performed just before and after the fatigue-inducing mental task session. Results After the 0-back test, decreased alpha power was indicated in the right angular Gyrus and increased levels in the left middle and Superior temporal Gyrus, left postcentral Gyrus, right Superior Frontal Gyrus, left inferior Frontal Gyrus, and right medial Frontal Gyrus. After the 2-back test, decreased alpha power was indicated in the right middle and Superior Frontal Gyrus and increased levels in the left inferior parietal and Superior parietal lobules, right parahippocampal Gyrus, right uncus, left postcentral Gyrus, left middle Frontal Gyrus, and right inferior Frontal Gyrus. For beta power, increased power following the 0-back test was indicated in the left middle temporal Gyrus, left Superior Frontal Gyrus, left cingulate Gyrus, and left precentral Gyrus. After the 2-back test, decreased power was suggested in the left Superior Frontal Gyrus and increased levels in the left middle temporal Gyrus and left inferior parietal lobule. Some of these brain regions might be associated with task performance during the fatigue-inducing trials. Conclusions Two types of mental fatigue may produce different alterations of the spontaneous oscillatory MEG activities. Our findings would provide new perspectives on the neural mechanisms underlying mental fatigue.
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Two types of mental fatigue affect spontaneous oscillatory brain activities in different ways
Behavioral and brain functions : BBF, 2013Co-Authors: Yoshihito Shigihara, Masaaki Tanaka, Akira Ishii, Etsuko Kanai, Masami Funakura, Yasuyoshi WatanabeAbstract:Fatigue has a multi-factorial nature. We examined the effects of two types of mental fatigue on spontaneous oscillatory brain activity using magnetoencephalography (MEG). Participants were randomly assigned to two groups in a single-blinded, crossover fashion to perform two types of mental fatigue-inducing experiments. Each experiment consisted of a 30-min fatigue-inducing 0- or 2-back test session and two evaluation sessions performed just before and after the fatigue-inducing mental task session. After the 0-back test, decreased alpha power was indicated in the right angular Gyrus and increased levels in the left middle and Superior temporal Gyrus, left postcentral Gyrus, right Superior Frontal Gyrus, left inferior Frontal Gyrus, and right medial Frontal Gyrus. After the 2-back test, decreased alpha power was indicated in the right middle and Superior Frontal Gyrus and increased levels in the left inferior parietal and Superior parietal lobules, right parahippocampal Gyrus, right uncus, left postcentral Gyrus, left middle Frontal Gyrus, and right inferior Frontal Gyrus. For beta power, increased power following the 0-back test was indicated in the left middle temporal Gyrus, left Superior Frontal Gyrus, left cingulate Gyrus, and left precentral Gyrus. After the 2-back test, decreased power was suggested in the left Superior Frontal Gyrus and increased levels in the left middle temporal Gyrus and left inferior parietal lobule. Some of these brain regions might be associated with task performance during the fatigue-inducing trials. Two types of mental fatigue may produce different alterations of the spontaneous oscillatory MEG activities. Our findings would provide new perspectives on the neural mechanisms underlying mental fatigue.
Blas Couto - One of the best experts on this subject based on the ideXlab platform.
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Corrigendum: Detaching from the negative by reappraisal: the role of right Superior Frontal Gyrus (BA9/32)
Frontiers in Behavioral Neuroscience, 2014Co-Authors: Rosalux Falquez, Blas Couto, Agustin Ibanez, Martin T Freitag, Elisabeth A Arens, Simone Lang, Moritz C. Berger, Sven BarnowAbstract:We noticed an error in one of our presented analyses. One mismatched brain image was accidentally included in the voxel-based-morphometry (VBM) analysis. Thus, arousal and valence values were consecutively not properly assigned to the morphological brain data of the other included participants. Of three analyses implemented in this study (VSLM, ROI-based), only the VBM analysis was affected but the others remain untouched. Therefore, we re-conducted the whole VBM analysis with the correct allocation of data. The corrected results showed changes in the whole-brain and regional correlations compared to the originally presented results. However, the correlations in the expected areas of the original manuscript remain significant for arousal and valence difference scores. Fortunately, these results do not impact the main implications and neither invalidate the conclusions derived from the study nor introduce differing directions of inference. The right Superior Frontal Gyrus (SFG/BA9) and anterior cingulate cortex (ACC/BA32) remain significant at whole-brain p < 0.001 uncorrected level, and the ROI analysis still showed significant correlations with gray matter intensities in the right SFG (BA9). The corrected results affect Figures Figures6,6, ,7,7, Tables Tables5,5, ,6,6, and small parts in results and discussion which are attached below. Figure 6 Whole brain patterns of gray matter volumes correlated with task performance in controls. (A) Arousal rating differences and (B) Valence rating differences (presented at a level of p < 0.001 unc). Figure 7 Graphic display of regional gray matter patterns of volume using the ROI depicted by the VLSM analysis (BA9/32) correlated with task performance in controls for (A) Arousal and (B) Valence rating differences (presented at a level of p < 0.05 unc) ... Table 5 Whole brain Patterns of GM volume correlated with task performance in controls. Table 6 Regional brain Patterns of GM volume correlated with task performance in controls. The authors deeply regret this error and apologize for any confusion it might have caused.
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corrigendum detaching from the negative by reappraisal the role of right Superior Frontal Gyrus ba9 32
Frontiers in Behavioral Neuroscience, 2014Co-Authors: Rosalux Falquez, Blas Couto, Agustin Ibanez, Martin T Freitag, Elisabeth A Arens, Moritz C. Berger, Simone LangAbstract:We noticed an error in one of our presented analyses. One mismatched brain image was accidentally included in the voxel-based-morphometry (VBM) analysis. Thus, arousal and valence values were consecutively not properly assigned to the morphological brain data of the other included participants. Of three analyses implemented in this study (VSLM, ROI-based), only the VBM analysis was affected but the others remain untouched. Therefore, we re-conducted the whole VBM analysis with the correct allocation of data. The corrected results showed changes in the whole-brain and regional correlations compared to the originally presented results. However, the correlations in the expected areas of the original manuscript remain significant for arousal and valence difference scores. Fortunately, these results do not impact the main implications and neither invalidate the conclusions derived from the study nor introduce differing directions of inference. The right Superior Frontal Gyrus (SFG/BA9) and anterior cingulate cortex (ACC/BA32) remain significant at whole-brain p < 0.001 uncorrected level, and the ROI analysis still showed significant correlations with gray matter intensities in the right SFG (BA9). The corrected results affect Figures Figures6,6, ,7,7, Tables Tables5,5, ,6,6, and small parts in results and discussion which are attached below. Figure 6 Whole brain patterns of gray matter volumes correlated with task performance in controls. (A) Arousal rating differences and (B) Valence rating differences (presented at a level of p < 0.001 unc). Figure 7 Graphic display of regional gray matter patterns of volume using the ROI depicted by the VLSM analysis (BA9/32) correlated with task performance in controls for (A) Arousal and (B) Valence rating differences (presented at a level of p < 0.05 unc) ... Table 5 Whole brain Patterns of GM volume correlated with task performance in controls. Table 6 Regional brain Patterns of GM volume correlated with task performance in controls. The authors deeply regret this error and apologize for any confusion it might have caused.
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detaching from the negative by reappraisal the role of right Superior Frontal Gyrus ba9 32
Frontiers in Behavioral Neuroscience, 2014Co-Authors: Rosalux Falquez, Blas Couto, Agustin Ibanez, Martin T Freitag, Moritz Berger, Elisabeth A Arens, Simone Lang, Sven BarnowAbstract:The ability to reappraise the emotional impact of events is related to long-term mental health. Self-focused reappraisal (REAPPself), i.e., reducing the personal relevance of the negative events, has been previously associated with neural activity in regions near right medial preFrontal cortex, but rarely investigated among brain-damaged individuals. Thus, we aimed to examine the REAPPself ability of brain-damaged patients and healthy controls considering structural atrophies and grey matter intensities, respectively. Twenty patients with well-defined cortex lesions due to an acquired circumscribed tumor or cyst and 23 healthy controls performed a REAPPself task, in which they had to either observe negative stimuli or decrease emotional responding by REAPPself. Next, they rated the impact of negative arousal and valence. REAPPself ability scores were calculated by subtracting the negative picture ratings after applying REAPPself from the ratings of the observing condition. The scores of the patients were included in a voxel-based lesion-symptom mapping (VLSM) analysis to identify deficit related areas (ROI). Then, a ROI group-wise comparison was performed. Additionally, a whole-brain voxel-based-morphometry (VBM) analysis was run, in which healthy participant’s REAPPself ability scores were correlated with grey matter intensities. Results showed that 1) regions in the right Superior Frontal Gyrus (SFG), comprising the right dorsolateral preFrontal cortex (BA9) and the right dorsal anterior cingulate cortex (BA32), were associated with patient’s impaired down-regulation of arousal, 2) a lesion in the depicted ROI occasioned significant REAPPself impairments, 3) REAPPself ability of controls was linked with increased grey matter intensities in the ROI regions. Our findings show for the first time that the neural integrity and the structural volume of right SFG regions (BA9/32) might be indispensable for REAPPself. Implications for neurofeedback research are discussed.
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Detaching from the negative by reappraisal: the role of right Superior Frontal Gyrus (BA9/32).
Frontiers in behavioral neuroscience, 2014Co-Authors: Rosalux Falquez, Blas Couto, Agustin Ibanez, Martin T Freitag, Elisabeth A Arens, Simone Lang, Moritz C. Berger, Sven BarnowAbstract:The ability to reappraise the emotional impact of events is related to long-term mental health. Self-focused reappraisal (REAPPself), i.e., reducing the personal relevance of the negative events, has been previously associated with neural activity in regions near right medial preFrontal cortex, but rarely investigated among brain-damaged individuals. Thus, we aimed to examine the REAPPself ability of brain-damaged patients and healthy controls considering structural atrophies and grey matter intensities, respectively. Twenty patients with well-defined cortex lesions due to an acquired circumscribed tumor or cyst and 23 healthy controls performed a REAPPself task, in which they had to either observe negative stimuli or decrease emotional responding by REAPPself. Next, they rated the impact of negative arousal and valence. REAPPself ability scores were calculated by subtracting the negative picture ratings after applying REAPPself from the ratings of the observing condition. The scores of the patients were included in a voxel-based lesion-symptom mapping (VLSM) analysis to identify deficit related areas (ROI). Then, a ROI group-wise comparison was performed. Additionally, a whole-brain voxel-based-morphometry (VBM) analysis was run, in which healthy participant’s REAPPself ability scores were correlated with grey matter intensities. Results showed that 1) regions in the right Superior Frontal Gyrus (SFG), comprising the right dorsolateral preFrontal cortex (BA9) and the right dorsal anterior cingulate cortex (BA32), were associated with patient’s impaired down-regulation of arousal, 2) a lesion in the depicted ROI occasioned significant REAPPself impairments, 3) REAPPself ability of controls was linked with increased grey matter intensities in the ROI regions. Our findings show for the first time that the neural integrity and the structural volume of right SFG regions (BA9/32) might be indispensable for REAPPself. Implications for neurofeedback research are discussed.
