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Khader M. Hasan - One of the best experts on this subject based on the ideXlab platform.
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decoding the Superior parietal lobule connections of the Superior Longitudinal Fasciculus arcuate Fasciculus in the human brain
Neuroscience, 2014Co-Authors: Arash Kamali, Haris I. Sair, A. Radmanesh, Khader M. HasanAbstract:Abstract The temporo-parietal (TP) white matter connections between the inferior parietal lobule and Superior temporal gyrus as part of the Superior Longitudinal Fasciculus/arcuate Fasciculus (SLF/AF) or middle Longitudinal Fasciculus (MdLF) have been studied in prior diffusion tensor tractography (DTT) studies. However, few studies have been focusing on the higher TP connections of the Superior parietal lobule with the temporal lobe. These higher TP connections have been shown to have a role in core processes such as attention, memory, emotions, and language. Our most recent study, for the first time, hinted to the possibility of a long white matter connection interconnecting the Superior parietal lobule (SPL) with the posterior temporal lobe in human brain which we call the SLF/AF TP-SPL and for a shorter abbreviation, the TP-SPL. We decided to further investigate this white matter connection using fiber assignment by continuous tracking deterministic tractography and high spatial resolution diffusion tensor imaging on 3T. Five healthy right-handed men (age range 24–37 years) were studied. We delineated the SPL connections of the SLF/AF TP bilaterally in five normal adult human brains. Using a high resolution DTT technique, we demonstrate for the first time, the trajectory of a long fiber bundle connectivity between the SPL and posterior temporal lobe, called the SLF/AF TP-SPL (or the TP-SPL), bilaterally in five healthy adult human brains. We also demonstrate the trajectory of the vertically oriented posterior TP connections, interconnecting the inferior parietal lobule (IPL) with the posterior temporal lobe (TP-IPL) in relation to the TP-SPL, arcuate Fasciculus and other major language pathways. In the current study, for the first time, we categorized the TP connections into the anterior and posterior connectivity groups and subcategorized each one into the SPL or IPL connections.
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Decoding the Superior parietal lobule connections of the Superior Longitudinal Fasciculus/arcuate Fasciculus in the human brain.
Neuroscience, 2014Co-Authors: Arash Kamali, Haris I. Sair, A. Radmanesh, Khader M. HasanAbstract:Abstract The temporo-parietal (TP) white matter connections between the inferior parietal lobule and Superior temporal gyrus as part of the Superior Longitudinal Fasciculus/arcuate Fasciculus (SLF/AF) or middle Longitudinal Fasciculus (MdLF) have been studied in prior diffusion tensor tractography (DTT) studies. However, few studies have been focusing on the higher TP connections of the Superior parietal lobule with the temporal lobe. These higher TP connections have been shown to have a role in core processes such as attention, memory, emotions, and language. Our most recent study, for the first time, hinted to the possibility of a long white matter connection interconnecting the Superior parietal lobule (SPL) with the posterior temporal lobe in human brain which we call the SLF/AF TP-SPL and for a shorter abbreviation, the TP-SPL. We decided to further investigate this white matter connection using fiber assignment by continuous tracking deterministic tractography and high spatial resolution diffusion tensor imaging on 3T. Five healthy right-handed men (age range 24–37 years) were studied. We delineated the SPL connections of the SLF/AF TP bilaterally in five normal adult human brains. Using a high resolution DTT technique, we demonstrate for the first time, the trajectory of a long fiber bundle connectivity between the SPL and posterior temporal lobe, called the SLF/AF TP-SPL (or the TP-SPL), bilaterally in five healthy adult human brains. We also demonstrate the trajectory of the vertically oriented posterior TP connections, interconnecting the inferior parietal lobule (IPL) with the posterior temporal lobe (TP-IPL) in relation to the TP-SPL, arcuate Fasciculus and other major language pathways. In the current study, for the first time, we categorized the TP connections into the anterior and posterior connectivity groups and subcategorized each one into the SPL or IPL connections.
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Tracing Superior Longitudinal Fasciculus connectivity in the human brain using high resolution diffusion tensor tractography.
Brain structure & function, 2013Co-Authors: Arash Kamali, Adam E. Flanders, Joshua Brody, Jill V. Hunter, Khader M. HasanAbstract:The major language pathways such as Superior Longitudinal Fasciculus (SLF) pathways have been outlined by experimental and diffusion tensor imaging (DTI) studies. The SLF I and some of the Superior parietal lobule connections of the SLF pathways have not been depicted by prior DTI studies due to the lack of imaging sensitivity and adequate spatial resolution. In the current study, the trajectory of the SLF fibers has been delineated on five healthy human subjects using diffusion tensor tractography on a 3.0-T scanner at high spatial resolution. We also demonstrate for the first time the trajectory and connectivity of the SLF fibers in relation to other language pathways as well as the Superior parietal lobule connections of the language circuit using high spatial resolution DTI in the healthy adult human brain.
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Superior Longitudinal Fasciculus and cognitive dysfunction in adolescents born preterm and at term
Developmental Medicine & Child Neurology, 2010Co-Authors: Richard E. Frye, Khader M. Hasan, Benjamin Malmberg, Laura Desouza, Paul R. Swank, Karen E. Smith, Susan H. LandryAbstract:Aim To understand the relationship between cognition and white-matter structure in adolescents born preterm without obvious brain injury. Methods Thirty-two adolescents from a Longitudinal study of child development were selected according to risk of developmental disorders at birth (born at term: eight males, five females; median age 16y 1mo, interquartile range 10mo; low risk preterm: four males, five females, median age 16y, range 4mo; high risk preterm: three males, seven females, median age 16y 2mo, range 1y 2mo) and reading ability (good: three males, eight females, median age 16y, range 7mo; average: six males, three females, median age 16y 10mo, range 1y; poor: six males, six females, median age 16y, range 6mo). Preterm birth was defined as a gestational age of 36 weeks or less and a birthweight of 1600g or less. All participants had normal clinical neuroimaging findings. We examined fractional anisotropy, radial diffusivity, and volume of three major white-matter fasciculi. The relationship between structural measures and birth risk, hemisphere, and cognitive ability (attention, lexical and sublexical decoding, auditory phonological awareness, and processing speed) were analysed using mixed-model regression. Results Left-hemisphere Superior Longitudinal Fasciculus (SLF) fractional anisotropy and radial diffusivity were linked to reading-related skills (fractional anisotropy vs letter–word identification, r(30)=−0.37, p<0.05; fractional anisotropy vs phoneme reversal, r(30)=−0.34, p=0.05; radial diffusivity vs letter–word identification, r(30)=0.31, p<0.10; radial diffusivity vs phoneme reversal, r(30)=0.40, p<0.05), whereas right-hemisphere SLF fractional anisotropy was related to attention skills (fractional anisotropy vs inattentiveness, r(30)=−0.38, p<0.05). SLF volume decreased as these skills declined for adolescents born preterm (volume vs phoneme reversal, r(17)=0.58, p<0.01; volume vs inattentiveness, r(17)=−0.69, p<0.01), but not for those born at term. Interpretation The relationship between cognitive skills and SLF volume suggests that in adolescents born preterm, cryptic white-matter injury may exist, possibly related to oligodendrocyte or axonal loss, despite normal clinical neuroimaging.
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Superior Longitudinal Fasciculus and cognitive dysfunction in adolescents born preterm and at term.
Developmental medicine and child neurology, 2010Co-Authors: Richard E. Frye, Khader M. Hasan, Benjamin Malmberg, Laura Desouza, Paul R. Swank, Karen E. Smith, Susan H. LandryAbstract:Aim To understand the relationship between cognition and white-matter structure in adolescents born preterm without obvious brain injury. Methods Thirty-two adolescents from a Longitudinal study of child development were selected according to risk of developmental disorders at birth (born at term: eight males, five females; median age 16y 1mo, interquartile range 10mo; low risk preterm: four males, five females, median age 16y, range 4mo; high risk preterm: three males, seven females, median age 16y 2mo, range 1y 2mo) and reading ability (good: three males, eight females, median age 16y, range 7mo; average: six males, three females, median age 16y 10mo, range 1y; poor: six males, six females, median age 16y, range 6mo). Preterm birth was defined as a gestational age of 36 weeks or less and a birthweight of 1600g or less. All participants had normal clinical neuroimaging findings. We examined fractional anisotropy, radial diffusivity, and volume of three major white-matter fasciculi. The relationship between structural measures and birth risk, hemisphere, and cognitive ability (attention, lexical and sublexical decoding, auditory phonological awareness, and processing speed) were analysed using mixed-model regression. Results Left-hemisphere Superior Longitudinal Fasciculus (SLF) fractional anisotropy and radial diffusivity were linked to reading-related skills (fractional anisotropy vs letter–word identification, r(30)=−0.37, p
Arash Kamali - One of the best experts on this subject based on the ideXlab platform.
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decoding the Superior parietal lobule connections of the Superior Longitudinal Fasciculus arcuate Fasciculus in the human brain
Neuroscience, 2014Co-Authors: Arash Kamali, Haris I. Sair, A. Radmanesh, Khader M. HasanAbstract:Abstract The temporo-parietal (TP) white matter connections between the inferior parietal lobule and Superior temporal gyrus as part of the Superior Longitudinal Fasciculus/arcuate Fasciculus (SLF/AF) or middle Longitudinal Fasciculus (MdLF) have been studied in prior diffusion tensor tractography (DTT) studies. However, few studies have been focusing on the higher TP connections of the Superior parietal lobule with the temporal lobe. These higher TP connections have been shown to have a role in core processes such as attention, memory, emotions, and language. Our most recent study, for the first time, hinted to the possibility of a long white matter connection interconnecting the Superior parietal lobule (SPL) with the posterior temporal lobe in human brain which we call the SLF/AF TP-SPL and for a shorter abbreviation, the TP-SPL. We decided to further investigate this white matter connection using fiber assignment by continuous tracking deterministic tractography and high spatial resolution diffusion tensor imaging on 3T. Five healthy right-handed men (age range 24–37 years) were studied. We delineated the SPL connections of the SLF/AF TP bilaterally in five normal adult human brains. Using a high resolution DTT technique, we demonstrate for the first time, the trajectory of a long fiber bundle connectivity between the SPL and posterior temporal lobe, called the SLF/AF TP-SPL (or the TP-SPL), bilaterally in five healthy adult human brains. We also demonstrate the trajectory of the vertically oriented posterior TP connections, interconnecting the inferior parietal lobule (IPL) with the posterior temporal lobe (TP-IPL) in relation to the TP-SPL, arcuate Fasciculus and other major language pathways. In the current study, for the first time, we categorized the TP connections into the anterior and posterior connectivity groups and subcategorized each one into the SPL or IPL connections.
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Decoding the Superior parietal lobule connections of the Superior Longitudinal Fasciculus/arcuate Fasciculus in the human brain.
Neuroscience, 2014Co-Authors: Arash Kamali, Haris I. Sair, A. Radmanesh, Khader M. HasanAbstract:Abstract The temporo-parietal (TP) white matter connections between the inferior parietal lobule and Superior temporal gyrus as part of the Superior Longitudinal Fasciculus/arcuate Fasciculus (SLF/AF) or middle Longitudinal Fasciculus (MdLF) have been studied in prior diffusion tensor tractography (DTT) studies. However, few studies have been focusing on the higher TP connections of the Superior parietal lobule with the temporal lobe. These higher TP connections have been shown to have a role in core processes such as attention, memory, emotions, and language. Our most recent study, for the first time, hinted to the possibility of a long white matter connection interconnecting the Superior parietal lobule (SPL) with the posterior temporal lobe in human brain which we call the SLF/AF TP-SPL and for a shorter abbreviation, the TP-SPL. We decided to further investigate this white matter connection using fiber assignment by continuous tracking deterministic tractography and high spatial resolution diffusion tensor imaging on 3T. Five healthy right-handed men (age range 24–37 years) were studied. We delineated the SPL connections of the SLF/AF TP bilaterally in five normal adult human brains. Using a high resolution DTT technique, we demonstrate for the first time, the trajectory of a long fiber bundle connectivity between the SPL and posterior temporal lobe, called the SLF/AF TP-SPL (or the TP-SPL), bilaterally in five healthy adult human brains. We also demonstrate the trajectory of the vertically oriented posterior TP connections, interconnecting the inferior parietal lobule (IPL) with the posterior temporal lobe (TP-IPL) in relation to the TP-SPL, arcuate Fasciculus and other major language pathways. In the current study, for the first time, we categorized the TP connections into the anterior and posterior connectivity groups and subcategorized each one into the SPL or IPL connections.
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Tracing Superior Longitudinal Fasciculus connectivity in the human brain using high resolution diffusion tensor tractography.
Brain structure & function, 2013Co-Authors: Arash Kamali, Adam E. Flanders, Joshua Brody, Jill V. Hunter, Khader M. HasanAbstract:The major language pathways such as Superior Longitudinal Fasciculus (SLF) pathways have been outlined by experimental and diffusion tensor imaging (DTI) studies. The SLF I and some of the Superior parietal lobule connections of the SLF pathways have not been depicted by prior DTI studies due to the lack of imaging sensitivity and adequate spatial resolution. In the current study, the trajectory of the SLF fibers has been delineated on five healthy human subjects using diffusion tensor tractography on a 3.0-T scanner at high spatial resolution. We also demonstrate for the first time the trajectory and connectivity of the SLF fibers in relation to other language pathways as well as the Superior parietal lobule connections of the language circuit using high spatial resolution DTI in the healthy adult human brain.
Kai Yuan - One of the best experts on this subject based on the ideXlab platform.
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Right arcuate Fasciculus and Superior Longitudinal Fasciculus abnormalities in primary insomnia
Brain Imaging and Behavior, 2019Co-Authors: Wanye Cai, Dahua Yu, Meng Zhao, Jingjing Liu, Bo Liu, Kai YuanAbstract:Primary insomnia (PI) is a very common phenomenon and associated with functional impairments of attention, memory and mood regulation. However, its neurobiology is poorly understood. To date, the studies about integrity of white matter (WM) tracts in PI patients have been still rare. In the present study, we used Automated Fiber Quantification (AFQ), which reliably and efficiently quantified diffusion measurements at multiple locations along the WM trajectory based on diffusion tensor imaging (DTI), to assess WM diffusion properties differences between 23 PI patients and 32 matched healthy controls in 18 tracts. The relationships between neuroimaging differences and sleep behaviors were explored, including Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index Scale (ISI). Compared with healthy control group, right arcuate Fasciculus (Arc) and Superior Longitudinal Fasciculus (SLF) showed significant higher fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) along tract length in PI patients (FWE corrected, p
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right arcuate Fasciculus and Superior Longitudinal Fasciculus abnormalities in primary insomnia
Brain Imaging and Behavior, 2019Co-Authors: Wanye Cai, Kai Yuan, Meng Zhao, Jingjing Liu, Bo LiuAbstract:Primary insomnia (PI) is a very common phenomenon and associated with functional impairments of attention, memory and mood regulation. However, its neurobiology is poorly understood. To date, the studies about integrity of white matter (WM) tracts in PI patients have been still rare. In the present study, we used Automated Fiber Quantification (AFQ), which reliably and efficiently quantified diffusion measurements at multiple locations along the WM trajectory based on diffusion tensor imaging (DTI), to assess WM diffusion properties differences between 23 PI patients and 32 matched healthy controls in 18 tracts. The relationships between neuroimaging differences and sleep behaviors were explored, including Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index Scale (ISI). Compared with healthy control group, right arcuate Fasciculus (Arc) and Superior Longitudinal Fasciculus (SLF) showed significant higher fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) along tract length in PI patients (FWE corrected, p < 0.01). Axial diffusivity (AD) for PI patients was higher in right Arc and lower in right SLF. Correlation analyses revealed that FA of right Arc and MD of right SLF were negatively correlated with PSQI score in PI patients, and AD of right Arc and FA of right SLF were positively correlated with PSQI score. Negative correlation was observed between FA of right Arc and AD of right SLF and ISI score in PI patients. Our findings can help us to improve the understanding of the neural mechanisms of primary insomnia at abnormalities in WM microstructure.
Chad A. Glenn - One of the best experts on this subject based on the ideXlab platform.
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Parcellation-based tractographic modeling of the dorsal attention network.
Brain and behavior, 2019Co-Authors: Parker G. Allan, Brian D. Maxwell, Cordell M Baker, Goksel Sali, Christen M. O'neal, Joshua D. Burks, Phillip A. Bonney, Andrew K. Conner, Robert G. Briggs, Chad A. GlennAbstract:The dorsal attention network (DAN) is an important mediator of goal-directed attentional processing. Multiple cortical areas, such as the frontal eye fields, intraparietal sulcus, Superior parietal lobule, and visual cortex, have been linked in this processing. However, knowledge of network connectivity has been devoid of structural specificity. Using attention-related task-based fMRI studies, an anatomic likelihood estimation (ALE) of the DAN was generated. Regions of interest corresponding to the cortical parcellation scheme previously published under the Human Connectome Project were co-registered onto the ALE in MNI coordinate space and visually assessed for inclusion in the network. DSI-based fiber tractography was performed to determine the structural connections between relevant cortical areas comprising the network. Twelve cortical regions were found to be part of the DAN: 6a, 7AM, 7PC, AIP, FEF, LIPd, LIPv, MST, MT, PH, V4t, VIP. All regions demonstrated consistent u-shaped interconnections between adjacent parcellations. The Superior Longitudinal Fasciculus connects the frontal, parietal, and occipital areas of the network. We present a tractographic model of the DAN. This model comprises parcellations within the frontal, parietal, and occipital cortices principally linked through the Superior Longitudinal Fasciculus. Future studies may refine this model with the ultimate goal of clinical application. © 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
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Parcellation-based tractographic modeling of the dorsal attention network.
Brain and behavior, 2019Co-Authors: Parker G. Allan, Brian D. Maxwell, Cordell M Baker, Goksel Sali, Christen M. O'neal, Joshua D. Burks, Phillip A. Bonney, Andrew K. Conner, Robert G. Briggs, Chad A. GlennAbstract:INTRODUCTION The dorsal attention network (DAN) is an important mediator of goal-directed attentional processing. Multiple cortical areas, such as the frontal eye fields, intraparietal sulcus, Superior parietal lobule, and visual cortex, have been linked in this processing. However, knowledge of network connectivity has been devoid of structural specificity. METHODS Using attention-related task-based fMRI studies, an anatomic likelihood estimation (ALE) of the DAN was generated. Regions of interest corresponding to the cortical parcellation scheme previously published under the Human Connectome Project were co-registered onto the ALE in MNI coordinate space and visually assessed for inclusion in the network. DSI-based fiber tractography was performed to determine the structural connections between relevant cortical areas comprising the network. RESULTS Twelve cortical regions were found to be part of the DAN: 6a, 7AM, 7PC, AIP, FEF, LIPd, LIPv, MST, MT, PH, V4t, VIP. All regions demonstrated consistent u-shaped interconnections between adjacent parcellations. The Superior Longitudinal Fasciculus connects the frontal, parietal, and occipital areas of the network. CONCLUSIONS We present a tractographic model of the DAN. This model comprises parcellations within the frontal, parietal, and occipital cortices principally linked through the Superior Longitudinal Fasciculus. Future studies may refine this model with the ultimate goal of clinical application.
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A Connectomic Atlas of the Human Cerebrum-Chapter 10: Tractographic Description of the Superior Longitudinal Fasciculus.
Operative Neurosurgery, 2018Co-Authors: Andrew K. Conner, Cordell M Baker, Goksel Sali, Joshua D. Burks, Chad A. Glenn, Robert G. Briggs, Meherzad Rahimi, James D Battiste, Michael E. SughrueAbstract:The Superior Longitudinal Fasciculus/arcuate white matter complex (SLF/AC) is the largest and most complex white matter tract of the human cerebrum with multiple inter-linked connections encompassing multiple cognitive functions such as language, attention, memory, emotion, and visuospatial function. However, little is known regarding the overall connectivity of this complex. Recently, the Human Connectome Project parcellated the human cortex into 180 distinct regions. Utilizing diffusion spectrum magnetic resonance imaging tractography coupled with the human cortex parcellation data presented earlier in this supplement, we aim to describe the macro-connectome of the SLF/AC in relation to the linked parcellations present within the human cortex. The purpose of this study is to present this information in an indexed, illustrated, and tractographically aided series of figures and tables for anatomic and clinical reference.
Haris I. Sair - One of the best experts on this subject based on the ideXlab platform.
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decoding the Superior parietal lobule connections of the Superior Longitudinal Fasciculus arcuate Fasciculus in the human brain
Neuroscience, 2014Co-Authors: Arash Kamali, Haris I. Sair, A. Radmanesh, Khader M. HasanAbstract:Abstract The temporo-parietal (TP) white matter connections between the inferior parietal lobule and Superior temporal gyrus as part of the Superior Longitudinal Fasciculus/arcuate Fasciculus (SLF/AF) or middle Longitudinal Fasciculus (MdLF) have been studied in prior diffusion tensor tractography (DTT) studies. However, few studies have been focusing on the higher TP connections of the Superior parietal lobule with the temporal lobe. These higher TP connections have been shown to have a role in core processes such as attention, memory, emotions, and language. Our most recent study, for the first time, hinted to the possibility of a long white matter connection interconnecting the Superior parietal lobule (SPL) with the posterior temporal lobe in human brain which we call the SLF/AF TP-SPL and for a shorter abbreviation, the TP-SPL. We decided to further investigate this white matter connection using fiber assignment by continuous tracking deterministic tractography and high spatial resolution diffusion tensor imaging on 3T. Five healthy right-handed men (age range 24–37 years) were studied. We delineated the SPL connections of the SLF/AF TP bilaterally in five normal adult human brains. Using a high resolution DTT technique, we demonstrate for the first time, the trajectory of a long fiber bundle connectivity between the SPL and posterior temporal lobe, called the SLF/AF TP-SPL (or the TP-SPL), bilaterally in five healthy adult human brains. We also demonstrate the trajectory of the vertically oriented posterior TP connections, interconnecting the inferior parietal lobule (IPL) with the posterior temporal lobe (TP-IPL) in relation to the TP-SPL, arcuate Fasciculus and other major language pathways. In the current study, for the first time, we categorized the TP connections into the anterior and posterior connectivity groups and subcategorized each one into the SPL or IPL connections.
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Decoding the Superior parietal lobule connections of the Superior Longitudinal Fasciculus/arcuate Fasciculus in the human brain.
Neuroscience, 2014Co-Authors: Arash Kamali, Haris I. Sair, A. Radmanesh, Khader M. HasanAbstract:Abstract The temporo-parietal (TP) white matter connections between the inferior parietal lobule and Superior temporal gyrus as part of the Superior Longitudinal Fasciculus/arcuate Fasciculus (SLF/AF) or middle Longitudinal Fasciculus (MdLF) have been studied in prior diffusion tensor tractography (DTT) studies. However, few studies have been focusing on the higher TP connections of the Superior parietal lobule with the temporal lobe. These higher TP connections have been shown to have a role in core processes such as attention, memory, emotions, and language. Our most recent study, for the first time, hinted to the possibility of a long white matter connection interconnecting the Superior parietal lobule (SPL) with the posterior temporal lobe in human brain which we call the SLF/AF TP-SPL and for a shorter abbreviation, the TP-SPL. We decided to further investigate this white matter connection using fiber assignment by continuous tracking deterministic tractography and high spatial resolution diffusion tensor imaging on 3T. Five healthy right-handed men (age range 24–37 years) were studied. We delineated the SPL connections of the SLF/AF TP bilaterally in five normal adult human brains. Using a high resolution DTT technique, we demonstrate for the first time, the trajectory of a long fiber bundle connectivity between the SPL and posterior temporal lobe, called the SLF/AF TP-SPL (or the TP-SPL), bilaterally in five healthy adult human brains. We also demonstrate the trajectory of the vertically oriented posterior TP connections, interconnecting the inferior parietal lobule (IPL) with the posterior temporal lobe (TP-IPL) in relation to the TP-SPL, arcuate Fasciculus and other major language pathways. In the current study, for the first time, we categorized the TP connections into the anterior and posterior connectivity groups and subcategorized each one into the SPL or IPL connections.
