The Experts below are selected from a list of 261 Experts worldwide ranked by ideXlab platform
Servet Inci - One of the best experts on this subject based on the ideXlab platform.
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Treatment of a Superior Sagittal Sinus dural arteriovenous fistula with Onyx: technical case report.
Neurosurgery, 2006Co-Authors: Anil Arat, Servet InciAbstract:Objective The endovascular treatment of a complex Superior Sagittal Sinus dural arteriovenous fistula with ethylene vinyl alcohol copolymer (Onyx) in one session is described. Clinical presentation A 54-year-old man presented with dizziness and a bruit. A cerebral angiogram demonstrated a Superior Sagittal Sinus dural arteriovenous fistula with a patent Superior Sagittal Sinus that was supplied via multiple branches of the external carotid arteries bilaterally and the left anterior and middle cerebral arteries. Drainage was mainly through the Superior Sagittal Sinus and, only in part, retrogradely through the cortical veins. A decision was made to proceed with endovascular treatment followed by surgery. Intervention Transarterial injection of one pedicle of middle meningeal artery on both sides with Onyx resulted in complete obliteration of the dural supply and some of the pial supply to the malformation without complications. The Superior Sagittal Sinus remained patent. Based on this result, surgical treatment was cancelled. The residual pial supply had disappeared by the 10-month angiographic follow-up examination and the patient remained neurologically intact and without symptoms. Conclusion Definitive treatment may be attained with Onyx in dural arteriovenous fistulas. The potential of Onyx for use as a permanent embolic agent in dural arteriovenous fistulae needs to be investigated.
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Treatment of a Superior Sagittal Sinus dural arteriovenous fistula with Onyx: technical case report.
Neurosurgery, 2006Co-Authors: Anil Arat, Servet InciAbstract:The endovascular treatment of a complex Superior Sagittal Sinus dural arteriovenous fistula with ethylene vinyl alcohol copolymer (Onyx) in one session is described. A 54-year-old man presented with dizziness and a bruit. A cerebral angiogram demonstrated a Superior Sagittal Sinus dural arteriovenous fistula with a patent Superior Sagittal Sinus that was supplied via multiple branches of the external carotid arteries bilaterally and the left anterior and middle cerebral arteries. Drainage was mainly through the Superior Sagittal Sinus and, only in part, retrogradely through the cortical veins. A decision was made to proceed with endovascular treatment followed by surgery. Transarterial injection of one pedicle of middle meningeal artery on both sides with Onyx resulted in complete obliteration of the dural supply and some of the pial supply to the malformation without complications. The Superior Sagittal Sinus remained patent. Based on this result, surgical treatment was cancelled. The residual pial supply had disappeared by the 10-month angiographic follow-up examination and the patient remained neurologically intact and without symptoms. Definitive treatment may be attained with Onyx in dural arteriovenous fistulas. The potential of Onyx for use as a permanent embolic agent in dural arteriovenous fistulae needs to be investigated.
Yuchuan Ding - One of the best experts on this subject based on the ideXlab platform.
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A new thrombosis model of the Superior Sagittal Sinus involving cortical veins.
World neurosurgery, 2012Co-Authors: Xianwei Zeng, Tony Wang, Mohammed Hussain, Changhong Ren, Jian Chen, Chaitanya Sikhram, Vance Fredrickson, Yuchuan DingAbstract:Patients with cerebral Sinus and cortical venous thrombosis develop venous infarcts in approximately 50% of cases, resulting in serious clinical symptoms. An animal model is needed to further clarify the underlying mechanisms and consequences surrounding cerebral venous Sinus thrombosis, particularly for severe ones. Adult male Sprague-Dawley rats were used to develop a new Superior Sagittal Sinus thrombosis model involving cortical veins. The Superior Sagittal Sinus was exposed and ligated. A microcatheter was inserted into the Sinus, then both common carotid arteries were temporary occluded to reduce cerebral blood flow, and thrombin was injected into the Sinus. Twenty-four hours later, after evaluating neurological function and obtaining a magnetic resonance imaging, animals were sacrificed and data pertaining to brain water content, infarct volume, and tissue histology was collected. Superior Sagittal Sinus thrombosis and brain infarction were detected in all rats (100%). Hemorrhagic infarction, when present, and brain edema were observed in the brain parenchyma of the parietal lobe. The rate of hemorrhage was 59%, which is similar to that seen clinically in patients with Superior Sagittal Sinus thrombosis. Brain edema, as measured by brain water content percentage, was significantly increased in thrombosed animals compared with sham-operated animals (80.8% ± 0.55% vs. 78.8% ± 0.14%, P < 0.05). Infarct volumes were 53.02 ± 7.91 mm(3). We suggest that our modified model of Superior Sagittal Sinus thrombosis, involving cortical veins, is suitable for the study of its underlying mechanisms, as well as therapeutic approaches directed at the disease. Copyright © 2014 Elsevier Inc. All rights reserved.
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A new thrombosis model of the Superior Sagittal Sinus involving cortical veins.
World Neurosurgery, 2012Co-Authors: Xianwei Zeng, Vance L Fredrickson, Tony Wang, Mohammed Hussain, Changhong Ren, Jian Chen, Chaitanya Sikhram, Yuchuan DingAbstract:Objective Patients with cerebral Sinus and cortical venous thrombosis develop venous infarcts in approximately 50% of cases, resulting in serious clinical symptoms. An animal model is needed to further clarify the underlying mechanisms and consequences surrounding cerebral venous Sinus thrombosis, particularly for severe ones. Methods Adult male Sprague-Dawley rats were used to develop a new Superior Sagittal Sinus thrombosis model involving cortical veins. The Superior Sagittal Sinus was exposed and ligated. A microcatheter was inserted into the Sinus, then both common carotid arteries were temporary occluded to reduce cerebral blood flow, and thrombin was injected into the Sinus. Twenty-four hours later, after evaluating neurological function and obtaining a magnetic resonance imaging, animals were sacrificed and data pertaining to brain water content, infarct volume, and tissue histology was collected. Results Superior Sagittal Sinus thrombosis and brain infarction were detected in all rats (100%). Hemorrhagic infarction, when present, and brain edema were observed in the brain parenchyma of the parietal lobe. The rate of hemorrhage was 59%, which is similar to that seen clinically in patients with Superior Sagittal Sinus thrombosis. Brain edema, as measured by brain water content percentage, was significantly increased in thrombosed animals compared with sham-operated animals (80.8% ± 0.55% vs. 78.8% ± 0.14%, P 3 . Conclusions We suggest that our modified model of Superior Sagittal Sinus thrombosis, involving cortical veins, is suitable for the study of its underlying mechanisms, as well as therapeutic approaches directed at the disease.
Anil Arat - One of the best experts on this subject based on the ideXlab platform.
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Treatment of a Superior Sagittal Sinus dural arteriovenous fistula with Onyx: technical case report.
Neurosurgery, 2006Co-Authors: Anil Arat, Servet InciAbstract:Objective The endovascular treatment of a complex Superior Sagittal Sinus dural arteriovenous fistula with ethylene vinyl alcohol copolymer (Onyx) in one session is described. Clinical presentation A 54-year-old man presented with dizziness and a bruit. A cerebral angiogram demonstrated a Superior Sagittal Sinus dural arteriovenous fistula with a patent Superior Sagittal Sinus that was supplied via multiple branches of the external carotid arteries bilaterally and the left anterior and middle cerebral arteries. Drainage was mainly through the Superior Sagittal Sinus and, only in part, retrogradely through the cortical veins. A decision was made to proceed with endovascular treatment followed by surgery. Intervention Transarterial injection of one pedicle of middle meningeal artery on both sides with Onyx resulted in complete obliteration of the dural supply and some of the pial supply to the malformation without complications. The Superior Sagittal Sinus remained patent. Based on this result, surgical treatment was cancelled. The residual pial supply had disappeared by the 10-month angiographic follow-up examination and the patient remained neurologically intact and without symptoms. Conclusion Definitive treatment may be attained with Onyx in dural arteriovenous fistulas. The potential of Onyx for use as a permanent embolic agent in dural arteriovenous fistulae needs to be investigated.
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Treatment of a Superior Sagittal Sinus dural arteriovenous fistula with Onyx: technical case report.
Neurosurgery, 2006Co-Authors: Anil Arat, Servet InciAbstract:The endovascular treatment of a complex Superior Sagittal Sinus dural arteriovenous fistula with ethylene vinyl alcohol copolymer (Onyx) in one session is described. A 54-year-old man presented with dizziness and a bruit. A cerebral angiogram demonstrated a Superior Sagittal Sinus dural arteriovenous fistula with a patent Superior Sagittal Sinus that was supplied via multiple branches of the external carotid arteries bilaterally and the left anterior and middle cerebral arteries. Drainage was mainly through the Superior Sagittal Sinus and, only in part, retrogradely through the cortical veins. A decision was made to proceed with endovascular treatment followed by surgery. Transarterial injection of one pedicle of middle meningeal artery on both sides with Onyx resulted in complete obliteration of the dural supply and some of the pial supply to the malformation without complications. The Superior Sagittal Sinus remained patent. Based on this result, surgical treatment was cancelled. The residual pial supply had disappeared by the 10-month angiographic follow-up examination and the patient remained neurologically intact and without symptoms. Definitive treatment may be attained with Onyx in dural arteriovenous fistulas. The potential of Onyx for use as a permanent embolic agent in dural arteriovenous fistulae needs to be investigated.
Xianwei Zeng - One of the best experts on this subject based on the ideXlab platform.
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A new thrombosis model of the Superior Sagittal Sinus involving cortical veins.
World neurosurgery, 2012Co-Authors: Xianwei Zeng, Tony Wang, Mohammed Hussain, Changhong Ren, Jian Chen, Chaitanya Sikhram, Vance Fredrickson, Yuchuan DingAbstract:Patients with cerebral Sinus and cortical venous thrombosis develop venous infarcts in approximately 50% of cases, resulting in serious clinical symptoms. An animal model is needed to further clarify the underlying mechanisms and consequences surrounding cerebral venous Sinus thrombosis, particularly for severe ones. Adult male Sprague-Dawley rats were used to develop a new Superior Sagittal Sinus thrombosis model involving cortical veins. The Superior Sagittal Sinus was exposed and ligated. A microcatheter was inserted into the Sinus, then both common carotid arteries were temporary occluded to reduce cerebral blood flow, and thrombin was injected into the Sinus. Twenty-four hours later, after evaluating neurological function and obtaining a magnetic resonance imaging, animals were sacrificed and data pertaining to brain water content, infarct volume, and tissue histology was collected. Superior Sagittal Sinus thrombosis and brain infarction were detected in all rats (100%). Hemorrhagic infarction, when present, and brain edema were observed in the brain parenchyma of the parietal lobe. The rate of hemorrhage was 59%, which is similar to that seen clinically in patients with Superior Sagittal Sinus thrombosis. Brain edema, as measured by brain water content percentage, was significantly increased in thrombosed animals compared with sham-operated animals (80.8% ± 0.55% vs. 78.8% ± 0.14%, P < 0.05). Infarct volumes were 53.02 ± 7.91 mm(3). We suggest that our modified model of Superior Sagittal Sinus thrombosis, involving cortical veins, is suitable for the study of its underlying mechanisms, as well as therapeutic approaches directed at the disease. Copyright © 2014 Elsevier Inc. All rights reserved.
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A new thrombosis model of the Superior Sagittal Sinus involving cortical veins.
World Neurosurgery, 2012Co-Authors: Xianwei Zeng, Vance L Fredrickson, Tony Wang, Mohammed Hussain, Changhong Ren, Jian Chen, Chaitanya Sikhram, Yuchuan DingAbstract:Objective Patients with cerebral Sinus and cortical venous thrombosis develop venous infarcts in approximately 50% of cases, resulting in serious clinical symptoms. An animal model is needed to further clarify the underlying mechanisms and consequences surrounding cerebral venous Sinus thrombosis, particularly for severe ones. Methods Adult male Sprague-Dawley rats were used to develop a new Superior Sagittal Sinus thrombosis model involving cortical veins. The Superior Sagittal Sinus was exposed and ligated. A microcatheter was inserted into the Sinus, then both common carotid arteries were temporary occluded to reduce cerebral blood flow, and thrombin was injected into the Sinus. Twenty-four hours later, after evaluating neurological function and obtaining a magnetic resonance imaging, animals were sacrificed and data pertaining to brain water content, infarct volume, and tissue histology was collected. Results Superior Sagittal Sinus thrombosis and brain infarction were detected in all rats (100%). Hemorrhagic infarction, when present, and brain edema were observed in the brain parenchyma of the parietal lobe. The rate of hemorrhage was 59%, which is similar to that seen clinically in patients with Superior Sagittal Sinus thrombosis. Brain edema, as measured by brain water content percentage, was significantly increased in thrombosed animals compared with sham-operated animals (80.8% ± 0.55% vs. 78.8% ± 0.14%, P 3 . Conclusions We suggest that our modified model of Superior Sagittal Sinus thrombosis, involving cortical veins, is suitable for the study of its underlying mechanisms, as well as therapeutic approaches directed at the disease.
Mohammed Hussain - One of the best experts on this subject based on the ideXlab platform.
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A new thrombosis model of the Superior Sagittal Sinus involving cortical veins.
World neurosurgery, 2012Co-Authors: Xianwei Zeng, Tony Wang, Mohammed Hussain, Changhong Ren, Jian Chen, Chaitanya Sikhram, Vance Fredrickson, Yuchuan DingAbstract:Patients with cerebral Sinus and cortical venous thrombosis develop venous infarcts in approximately 50% of cases, resulting in serious clinical symptoms. An animal model is needed to further clarify the underlying mechanisms and consequences surrounding cerebral venous Sinus thrombosis, particularly for severe ones. Adult male Sprague-Dawley rats were used to develop a new Superior Sagittal Sinus thrombosis model involving cortical veins. The Superior Sagittal Sinus was exposed and ligated. A microcatheter was inserted into the Sinus, then both common carotid arteries were temporary occluded to reduce cerebral blood flow, and thrombin was injected into the Sinus. Twenty-four hours later, after evaluating neurological function and obtaining a magnetic resonance imaging, animals were sacrificed and data pertaining to brain water content, infarct volume, and tissue histology was collected. Superior Sagittal Sinus thrombosis and brain infarction were detected in all rats (100%). Hemorrhagic infarction, when present, and brain edema were observed in the brain parenchyma of the parietal lobe. The rate of hemorrhage was 59%, which is similar to that seen clinically in patients with Superior Sagittal Sinus thrombosis. Brain edema, as measured by brain water content percentage, was significantly increased in thrombosed animals compared with sham-operated animals (80.8% ± 0.55% vs. 78.8% ± 0.14%, P < 0.05). Infarct volumes were 53.02 ± 7.91 mm(3). We suggest that our modified model of Superior Sagittal Sinus thrombosis, involving cortical veins, is suitable for the study of its underlying mechanisms, as well as therapeutic approaches directed at the disease. Copyright © 2014 Elsevier Inc. All rights reserved.
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A new thrombosis model of the Superior Sagittal Sinus involving cortical veins.
World Neurosurgery, 2012Co-Authors: Xianwei Zeng, Vance L Fredrickson, Tony Wang, Mohammed Hussain, Changhong Ren, Jian Chen, Chaitanya Sikhram, Yuchuan DingAbstract:Objective Patients with cerebral Sinus and cortical venous thrombosis develop venous infarcts in approximately 50% of cases, resulting in serious clinical symptoms. An animal model is needed to further clarify the underlying mechanisms and consequences surrounding cerebral venous Sinus thrombosis, particularly for severe ones. Methods Adult male Sprague-Dawley rats were used to develop a new Superior Sagittal Sinus thrombosis model involving cortical veins. The Superior Sagittal Sinus was exposed and ligated. A microcatheter was inserted into the Sinus, then both common carotid arteries were temporary occluded to reduce cerebral blood flow, and thrombin was injected into the Sinus. Twenty-four hours later, after evaluating neurological function and obtaining a magnetic resonance imaging, animals were sacrificed and data pertaining to brain water content, infarct volume, and tissue histology was collected. Results Superior Sagittal Sinus thrombosis and brain infarction were detected in all rats (100%). Hemorrhagic infarction, when present, and brain edema were observed in the brain parenchyma of the parietal lobe. The rate of hemorrhage was 59%, which is similar to that seen clinically in patients with Superior Sagittal Sinus thrombosis. Brain edema, as measured by brain water content percentage, was significantly increased in thrombosed animals compared with sham-operated animals (80.8% ± 0.55% vs. 78.8% ± 0.14%, P 3 . Conclusions We suggest that our modified model of Superior Sagittal Sinus thrombosis, involving cortical veins, is suitable for the study of its underlying mechanisms, as well as therapeutic approaches directed at the disease.
