The Experts below are selected from a list of 103344 Experts worldwide ranked by ideXlab platform
Sandra Johnen - One of the best experts on this subject based on the ideXlab platform.
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biocompatibility of poly ester amide pea microfibrils in ocular tissues
Polymers, 2014Co-Authors: Martina Kropp, Katharinamarie Morawa, George Mihov, Anna Katharina Salz, Nina Harmening, Astrid Franken, Anja Kemp, Aylvin Jorge Angelo Athanasius Dias, Jens Christoph Thies, Sandra JohnenAbstract:Drug delivery systems (DDS) are able to deliver, over long periods of time, therapeutic concentrations of drugs requiring frequent administration. Two classes of DDS are available, biodegradable and non-biodegradable. The larger non-biodegradable implants ensure long-term delivery, but require surgical interventions. Biodegradable biomaterials are smaller, injectable implants, but degrade hydrolytically and release drugs in non-zero order kinetics, which is inefficient for long-term sustained drug release. Biodegradable poly(ester amides) (PEAs) may overcome these difficulties. To assess their ocular biocompatibility and long-term behavior, PEA fibrils were analyzed in vitro and in vivo. In vitro, incubation in vitreous humor changes to PEA structure, suggests degradation by Surface Erosion, enabling drug release with zero order kinetics. Clinical and histological analysis of PEA fibrils implanted subconjunctivally and intravitreally showed the absence of an inflammatory response or other pathological tissue alteration. This study shows that PEA fibrils are biocompatible with ocular environment and degrade by Surface Erosion.
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biocompatibility of poly ester amide pea microfibrils in ocular tissues
Polymers, 2014Co-Authors: Martina Kropp, Katharinamarie Morawa, George Mihov, Anna Katharina Salz, Nina Harmening, Astrid Franken, Anja Kemp, Aylvin Jorge Angelo Athanasius Dias, Jens Christoph Thies, Sandra JohnenAbstract:Drug delivery systems (DDS) are able to deliver, over long periods of time, therapeutic concentrations of drugs requiring frequent administration. Two classes of DDS are available, biodegradable and non-biodegradable. The larger non-biodegradable implants ensure long-term delivery, but require surgical interventions. Biodegradable biomaterials are smaller, injectable implants, but degrade hydrolytically and release drugs in non-zero order kinetics, which is inefficient for long-term sustained drug release. Biodegradable poly(ester amides) (PEAs) may overcome these difficulties. To assess their ocular biocompatibility and long-term behavior, PEA fibrils were analyzed in vitro and in vivo. In vitro, incubation in vitreous humor changes to PEA structure, suggests degradation by Surface Erosion, enabling drug release with zero order kinetics. Clinical and histological analysis of PEA fibrils implanted subconjunctivally and intravitreally showed the absence of an inflammatory response or other pathological tissue alteration. This study shows that PEA fibrils are biocompatible with ocular environment and degrade by Surface Erosion.
Martina Kropp - One of the best experts on this subject based on the ideXlab platform.
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biocompatibility of poly ester amide pea microfibrils in ocular tissues
Polymers, 2014Co-Authors: Martina Kropp, Katharinamarie Morawa, George Mihov, Anna Katharina Salz, Nina Harmening, Astrid Franken, Anja Kemp, Aylvin Jorge Angelo Athanasius Dias, Jens Christoph Thies, Sandra JohnenAbstract:Drug delivery systems (DDS) are able to deliver, over long periods of time, therapeutic concentrations of drugs requiring frequent administration. Two classes of DDS are available, biodegradable and non-biodegradable. The larger non-biodegradable implants ensure long-term delivery, but require surgical interventions. Biodegradable biomaterials are smaller, injectable implants, but degrade hydrolytically and release drugs in non-zero order kinetics, which is inefficient for long-term sustained drug release. Biodegradable poly(ester amides) (PEAs) may overcome these difficulties. To assess their ocular biocompatibility and long-term behavior, PEA fibrils were analyzed in vitro and in vivo. In vitro, incubation in vitreous humor changes to PEA structure, suggests degradation by Surface Erosion, enabling drug release with zero order kinetics. Clinical and histological analysis of PEA fibrils implanted subconjunctivally and intravitreally showed the absence of an inflammatory response or other pathological tissue alteration. This study shows that PEA fibrils are biocompatible with ocular environment and degrade by Surface Erosion.
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biocompatibility of poly ester amide pea microfibrils in ocular tissues
Polymers, 2014Co-Authors: Martina Kropp, Katharinamarie Morawa, George Mihov, Anna Katharina Salz, Nina Harmening, Astrid Franken, Anja Kemp, Aylvin Jorge Angelo Athanasius Dias, Jens Christoph Thies, Sandra JohnenAbstract:Drug delivery systems (DDS) are able to deliver, over long periods of time, therapeutic concentrations of drugs requiring frequent administration. Two classes of DDS are available, biodegradable and non-biodegradable. The larger non-biodegradable implants ensure long-term delivery, but require surgical interventions. Biodegradable biomaterials are smaller, injectable implants, but degrade hydrolytically and release drugs in non-zero order kinetics, which is inefficient for long-term sustained drug release. Biodegradable poly(ester amides) (PEAs) may overcome these difficulties. To assess their ocular biocompatibility and long-term behavior, PEA fibrils were analyzed in vitro and in vivo. In vitro, incubation in vitreous humor changes to PEA structure, suggests degradation by Surface Erosion, enabling drug release with zero order kinetics. Clinical and histological analysis of PEA fibrils implanted subconjunctivally and intravitreally showed the absence of an inflammatory response or other pathological tissue alteration. This study shows that PEA fibrils are biocompatible with ocular environment and degrade by Surface Erosion.
Katharinamarie Morawa - One of the best experts on this subject based on the ideXlab platform.
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biocompatibility of poly ester amide pea microfibrils in ocular tissues
Polymers, 2014Co-Authors: Martina Kropp, Katharinamarie Morawa, George Mihov, Anna Katharina Salz, Nina Harmening, Astrid Franken, Anja Kemp, Aylvin Jorge Angelo Athanasius Dias, Jens Christoph Thies, Sandra JohnenAbstract:Drug delivery systems (DDS) are able to deliver, over long periods of time, therapeutic concentrations of drugs requiring frequent administration. Two classes of DDS are available, biodegradable and non-biodegradable. The larger non-biodegradable implants ensure long-term delivery, but require surgical interventions. Biodegradable biomaterials are smaller, injectable implants, but degrade hydrolytically and release drugs in non-zero order kinetics, which is inefficient for long-term sustained drug release. Biodegradable poly(ester amides) (PEAs) may overcome these difficulties. To assess their ocular biocompatibility and long-term behavior, PEA fibrils were analyzed in vitro and in vivo. In vitro, incubation in vitreous humor changes to PEA structure, suggests degradation by Surface Erosion, enabling drug release with zero order kinetics. Clinical and histological analysis of PEA fibrils implanted subconjunctivally and intravitreally showed the absence of an inflammatory response or other pathological tissue alteration. This study shows that PEA fibrils are biocompatible with ocular environment and degrade by Surface Erosion.
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biocompatibility of poly ester amide pea microfibrils in ocular tissues
Polymers, 2014Co-Authors: Martina Kropp, Katharinamarie Morawa, George Mihov, Anna Katharina Salz, Nina Harmening, Astrid Franken, Anja Kemp, Aylvin Jorge Angelo Athanasius Dias, Jens Christoph Thies, Sandra JohnenAbstract:Drug delivery systems (DDS) are able to deliver, over long periods of time, therapeutic concentrations of drugs requiring frequent administration. Two classes of DDS are available, biodegradable and non-biodegradable. The larger non-biodegradable implants ensure long-term delivery, but require surgical interventions. Biodegradable biomaterials are smaller, injectable implants, but degrade hydrolytically and release drugs in non-zero order kinetics, which is inefficient for long-term sustained drug release. Biodegradable poly(ester amides) (PEAs) may overcome these difficulties. To assess their ocular biocompatibility and long-term behavior, PEA fibrils were analyzed in vitro and in vivo. In vitro, incubation in vitreous humor changes to PEA structure, suggests degradation by Surface Erosion, enabling drug release with zero order kinetics. Clinical and histological analysis of PEA fibrils implanted subconjunctivally and intravitreally showed the absence of an inflammatory response or other pathological tissue alteration. This study shows that PEA fibrils are biocompatible with ocular environment and degrade by Surface Erosion.
Aylvin Jorge Angelo Athanasius Dias - One of the best experts on this subject based on the ideXlab platform.
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biocompatibility of poly ester amide pea microfibrils in ocular tissues
Polymers, 2014Co-Authors: Martina Kropp, Katharinamarie Morawa, George Mihov, Anna Katharina Salz, Nina Harmening, Astrid Franken, Anja Kemp, Aylvin Jorge Angelo Athanasius Dias, Jens Christoph Thies, Sandra JohnenAbstract:Drug delivery systems (DDS) are able to deliver, over long periods of time, therapeutic concentrations of drugs requiring frequent administration. Two classes of DDS are available, biodegradable and non-biodegradable. The larger non-biodegradable implants ensure long-term delivery, but require surgical interventions. Biodegradable biomaterials are smaller, injectable implants, but degrade hydrolytically and release drugs in non-zero order kinetics, which is inefficient for long-term sustained drug release. Biodegradable poly(ester amides) (PEAs) may overcome these difficulties. To assess their ocular biocompatibility and long-term behavior, PEA fibrils were analyzed in vitro and in vivo. In vitro, incubation in vitreous humor changes to PEA structure, suggests degradation by Surface Erosion, enabling drug release with zero order kinetics. Clinical and histological analysis of PEA fibrils implanted subconjunctivally and intravitreally showed the absence of an inflammatory response or other pathological tissue alteration. This study shows that PEA fibrils are biocompatible with ocular environment and degrade by Surface Erosion.
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biocompatibility of poly ester amide pea microfibrils in ocular tissues
Polymers, 2014Co-Authors: Martina Kropp, Katharinamarie Morawa, George Mihov, Anna Katharina Salz, Nina Harmening, Astrid Franken, Anja Kemp, Aylvin Jorge Angelo Athanasius Dias, Jens Christoph Thies, Sandra JohnenAbstract:Drug delivery systems (DDS) are able to deliver, over long periods of time, therapeutic concentrations of drugs requiring frequent administration. Two classes of DDS are available, biodegradable and non-biodegradable. The larger non-biodegradable implants ensure long-term delivery, but require surgical interventions. Biodegradable biomaterials are smaller, injectable implants, but degrade hydrolytically and release drugs in non-zero order kinetics, which is inefficient for long-term sustained drug release. Biodegradable poly(ester amides) (PEAs) may overcome these difficulties. To assess their ocular biocompatibility and long-term behavior, PEA fibrils were analyzed in vitro and in vivo. In vitro, incubation in vitreous humor changes to PEA structure, suggests degradation by Surface Erosion, enabling drug release with zero order kinetics. Clinical and histological analysis of PEA fibrils implanted subconjunctivally and intravitreally showed the absence of an inflammatory response or other pathological tissue alteration. This study shows that PEA fibrils are biocompatible with ocular environment and degrade by Surface Erosion.
Jens Christoph Thies - One of the best experts on this subject based on the ideXlab platform.
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biocompatibility of poly ester amide pea microfibrils in ocular tissues
Polymers, 2014Co-Authors: Martina Kropp, Katharinamarie Morawa, George Mihov, Anna Katharina Salz, Nina Harmening, Astrid Franken, Anja Kemp, Aylvin Jorge Angelo Athanasius Dias, Jens Christoph Thies, Sandra JohnenAbstract:Drug delivery systems (DDS) are able to deliver, over long periods of time, therapeutic concentrations of drugs requiring frequent administration. Two classes of DDS are available, biodegradable and non-biodegradable. The larger non-biodegradable implants ensure long-term delivery, but require surgical interventions. Biodegradable biomaterials are smaller, injectable implants, but degrade hydrolytically and release drugs in non-zero order kinetics, which is inefficient for long-term sustained drug release. Biodegradable poly(ester amides) (PEAs) may overcome these difficulties. To assess their ocular biocompatibility and long-term behavior, PEA fibrils were analyzed in vitro and in vivo. In vitro, incubation in vitreous humor changes to PEA structure, suggests degradation by Surface Erosion, enabling drug release with zero order kinetics. Clinical and histological analysis of PEA fibrils implanted subconjunctivally and intravitreally showed the absence of an inflammatory response or other pathological tissue alteration. This study shows that PEA fibrils are biocompatible with ocular environment and degrade by Surface Erosion.
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biocompatibility of poly ester amide pea microfibrils in ocular tissues
Polymers, 2014Co-Authors: Martina Kropp, Katharinamarie Morawa, George Mihov, Anna Katharina Salz, Nina Harmening, Astrid Franken, Anja Kemp, Aylvin Jorge Angelo Athanasius Dias, Jens Christoph Thies, Sandra JohnenAbstract:Drug delivery systems (DDS) are able to deliver, over long periods of time, therapeutic concentrations of drugs requiring frequent administration. Two classes of DDS are available, biodegradable and non-biodegradable. The larger non-biodegradable implants ensure long-term delivery, but require surgical interventions. Biodegradable biomaterials are smaller, injectable implants, but degrade hydrolytically and release drugs in non-zero order kinetics, which is inefficient for long-term sustained drug release. Biodegradable poly(ester amides) (PEAs) may overcome these difficulties. To assess their ocular biocompatibility and long-term behavior, PEA fibrils were analyzed in vitro and in vivo. In vitro, incubation in vitreous humor changes to PEA structure, suggests degradation by Surface Erosion, enabling drug release with zero order kinetics. Clinical and histological analysis of PEA fibrils implanted subconjunctivally and intravitreally showed the absence of an inflammatory response or other pathological tissue alteration. This study shows that PEA fibrils are biocompatible with ocular environment and degrade by Surface Erosion.
