The Experts below are selected from a list of 31644 Experts worldwide ranked by ideXlab platform
Kyle N Kaneko - One of the best experts on this subject based on the ideXlab platform.
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long term outcome of pars plana vitrectomy and sutured scleral fixated posterior chamber intraocular lens implantation or repositioning
American Journal of Ophthalmology, 2018Co-Authors: Gregg T Kokame, Ryan Yanagihara, Jessica G Shantha, Kyle N KanekoAbstract:Purpose To assess the long-term stability of sutured scleral-fixated posterior chamber intraocular lenses (PCIOLs) performed in combination with pars plana vitrectomy. Design Retrospective, consecutive, interventional case series. Methods Retrospective single-surgeon study of 118 eyes of 111 patients seen at Retina Consultants of Hawaii, who underwent sutured scleral fixation of at least 1 haptic of a posterior chamber intraocular lens with 10-0 polypropylene combined with a pars plana vitrectomy. The fixation knot-tying technique required 2 separate 10-0 polypropylene Sutures tied into 1 combined knot—1 suture closed the fixation sclerotomy and created the scleral fixation, and 1 suture looped together around the haptic of the PCIOL, securing the haptic to the scleral fixation site. The primary outcomes were position of the PCIOL at last follow-up, dislocation of either 1 or both haptics of the PCIOL, and breakage of the 10-0 polypropylene fixation suture. Results PCIOLs remained well stabilized and positioned at last follow-up in 116 of 118 eyes (98.3%), with a mean follow-up of 6.0 years. The maximum stable follow-up with 2 intact fixation Sutures was 24.75 years. There were 4 cases of redislocation (3.4%), but 2 cases were owing to unstable residual capsular support. There was 1 case of suture breakage in 214 fixation Sutures (0.47%) and 1 case of haptic breakage. Conclusions Scleral fixation Sutures with 10-0 polypropylene provide excellent long-term fixation of PCIOLs, with a less than 0.5% incidence of suture breakage and documented suture stability for up to 24+ years.
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long term outcome of pars plana vitrectomy and sutured scleral fixated posterior chamber intraocular lens implantation or repositioning
American Journal of Ophthalmology, 2018Co-Authors: Gregg T Kokame, Ryan Yanagihara, Jessica G Shantha, Kyle N KanekoAbstract:Abstract Purpose To assess the long-term stability of sutured scleral-fixated posterior chamber intraocular lenses (PC IOL) performed in combination with pars plana vitrectomy. Design Retrospective, consecutive, interventional case series Methods Retrospective single-surgeon study of 118 eyes of 111 patients seen at Retina Consultants of Hawaii, who underwent sutured scleral fixation of at least one haptic of a posterior chamber intraocular lens with 10-0 polypropylene combined with a pars plana vitrectomy. The fixation knot tying technique required two separate 10-0 polypropylene Sutures tied into one combined knot – one suture closed the fixation sclerotomy and created the scleral fixation, and one suture looped together around the haptic of the PC IOL securing the haptic to the scleral fixation site. The primary outcomes were: position of the PCIOL at last follow-up, dislocation of either one or both haptics of the PCIOL, and breakage of the 10-0 polypropylene fixation suture. Results PCIOLs remained well stabilized and positioned at last follow-up in 116 of 118 eyes (98.3%) with a mean follow-up of 6.0 years. The maximum stable follow-up with two intact fixation Sutures was 24.75 years. There were 4 cases of redislocation (3.4%), but 2 cases were due to unstable residual capsular support. There was one case of suture breakage in 214 fixation Sutures (0.47%), and one case of haptic breakage. Conclusions Scleral fixation Sutures with 10-0 polypropylene provide excellent long term fixation of PC IOLs with a less than 0.5% incidence of suture breakage and documented suture stability for up to over 24 years.
Gregg T Kokame - One of the best experts on this subject based on the ideXlab platform.
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long term outcome of pars plana vitrectomy and sutured scleral fixated posterior chamber intraocular lens implantation or repositioning
American Journal of Ophthalmology, 2018Co-Authors: Gregg T Kokame, Ryan Yanagihara, Jessica G Shantha, Kyle N KanekoAbstract:Purpose To assess the long-term stability of sutured scleral-fixated posterior chamber intraocular lenses (PCIOLs) performed in combination with pars plana vitrectomy. Design Retrospective, consecutive, interventional case series. Methods Retrospective single-surgeon study of 118 eyes of 111 patients seen at Retina Consultants of Hawaii, who underwent sutured scleral fixation of at least 1 haptic of a posterior chamber intraocular lens with 10-0 polypropylene combined with a pars plana vitrectomy. The fixation knot-tying technique required 2 separate 10-0 polypropylene Sutures tied into 1 combined knot—1 suture closed the fixation sclerotomy and created the scleral fixation, and 1 suture looped together around the haptic of the PCIOL, securing the haptic to the scleral fixation site. The primary outcomes were position of the PCIOL at last follow-up, dislocation of either 1 or both haptics of the PCIOL, and breakage of the 10-0 polypropylene fixation suture. Results PCIOLs remained well stabilized and positioned at last follow-up in 116 of 118 eyes (98.3%), with a mean follow-up of 6.0 years. The maximum stable follow-up with 2 intact fixation Sutures was 24.75 years. There were 4 cases of redislocation (3.4%), but 2 cases were owing to unstable residual capsular support. There was 1 case of suture breakage in 214 fixation Sutures (0.47%) and 1 case of haptic breakage. Conclusions Scleral fixation Sutures with 10-0 polypropylene provide excellent long-term fixation of PCIOLs, with a less than 0.5% incidence of suture breakage and documented suture stability for up to 24+ years.
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long term outcome of pars plana vitrectomy and sutured scleral fixated posterior chamber intraocular lens implantation or repositioning
American Journal of Ophthalmology, 2018Co-Authors: Gregg T Kokame, Ryan Yanagihara, Jessica G Shantha, Kyle N KanekoAbstract:Abstract Purpose To assess the long-term stability of sutured scleral-fixated posterior chamber intraocular lenses (PC IOL) performed in combination with pars plana vitrectomy. Design Retrospective, consecutive, interventional case series Methods Retrospective single-surgeon study of 118 eyes of 111 patients seen at Retina Consultants of Hawaii, who underwent sutured scleral fixation of at least one haptic of a posterior chamber intraocular lens with 10-0 polypropylene combined with a pars plana vitrectomy. The fixation knot tying technique required two separate 10-0 polypropylene Sutures tied into one combined knot – one suture closed the fixation sclerotomy and created the scleral fixation, and one suture looped together around the haptic of the PC IOL securing the haptic to the scleral fixation site. The primary outcomes were: position of the PCIOL at last follow-up, dislocation of either one or both haptics of the PCIOL, and breakage of the 10-0 polypropylene fixation suture. Results PCIOLs remained well stabilized and positioned at last follow-up in 116 of 118 eyes (98.3%) with a mean follow-up of 6.0 years. The maximum stable follow-up with two intact fixation Sutures was 24.75 years. There were 4 cases of redislocation (3.4%), but 2 cases were due to unstable residual capsular support. There was one case of suture breakage in 214 fixation Sutures (0.47%), and one case of haptic breakage. Conclusions Scleral fixation Sutures with 10-0 polypropylene provide excellent long term fixation of PC IOLs with a less than 0.5% incidence of suture breakage and documented suture stability for up to over 24 years.
Jessica G Shantha - One of the best experts on this subject based on the ideXlab platform.
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long term outcome of pars plana vitrectomy and sutured scleral fixated posterior chamber intraocular lens implantation or repositioning
American Journal of Ophthalmology, 2018Co-Authors: Gregg T Kokame, Ryan Yanagihara, Jessica G Shantha, Kyle N KanekoAbstract:Purpose To assess the long-term stability of sutured scleral-fixated posterior chamber intraocular lenses (PCIOLs) performed in combination with pars plana vitrectomy. Design Retrospective, consecutive, interventional case series. Methods Retrospective single-surgeon study of 118 eyes of 111 patients seen at Retina Consultants of Hawaii, who underwent sutured scleral fixation of at least 1 haptic of a posterior chamber intraocular lens with 10-0 polypropylene combined with a pars plana vitrectomy. The fixation knot-tying technique required 2 separate 10-0 polypropylene Sutures tied into 1 combined knot—1 suture closed the fixation sclerotomy and created the scleral fixation, and 1 suture looped together around the haptic of the PCIOL, securing the haptic to the scleral fixation site. The primary outcomes were position of the PCIOL at last follow-up, dislocation of either 1 or both haptics of the PCIOL, and breakage of the 10-0 polypropylene fixation suture. Results PCIOLs remained well stabilized and positioned at last follow-up in 116 of 118 eyes (98.3%), with a mean follow-up of 6.0 years. The maximum stable follow-up with 2 intact fixation Sutures was 24.75 years. There were 4 cases of redislocation (3.4%), but 2 cases were owing to unstable residual capsular support. There was 1 case of suture breakage in 214 fixation Sutures (0.47%) and 1 case of haptic breakage. Conclusions Scleral fixation Sutures with 10-0 polypropylene provide excellent long-term fixation of PCIOLs, with a less than 0.5% incidence of suture breakage and documented suture stability for up to 24+ years.
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long term outcome of pars plana vitrectomy and sutured scleral fixated posterior chamber intraocular lens implantation or repositioning
American Journal of Ophthalmology, 2018Co-Authors: Gregg T Kokame, Ryan Yanagihara, Jessica G Shantha, Kyle N KanekoAbstract:Abstract Purpose To assess the long-term stability of sutured scleral-fixated posterior chamber intraocular lenses (PC IOL) performed in combination with pars plana vitrectomy. Design Retrospective, consecutive, interventional case series Methods Retrospective single-surgeon study of 118 eyes of 111 patients seen at Retina Consultants of Hawaii, who underwent sutured scleral fixation of at least one haptic of a posterior chamber intraocular lens with 10-0 polypropylene combined with a pars plana vitrectomy. The fixation knot tying technique required two separate 10-0 polypropylene Sutures tied into one combined knot – one suture closed the fixation sclerotomy and created the scleral fixation, and one suture looped together around the haptic of the PC IOL securing the haptic to the scleral fixation site. The primary outcomes were: position of the PCIOL at last follow-up, dislocation of either one or both haptics of the PCIOL, and breakage of the 10-0 polypropylene fixation suture. Results PCIOLs remained well stabilized and positioned at last follow-up in 116 of 118 eyes (98.3%) with a mean follow-up of 6.0 years. The maximum stable follow-up with two intact fixation Sutures was 24.75 years. There were 4 cases of redislocation (3.4%), but 2 cases were due to unstable residual capsular support. There was one case of suture breakage in 214 fixation Sutures (0.47%), and one case of haptic breakage. Conclusions Scleral fixation Sutures with 10-0 polypropylene provide excellent long term fixation of PC IOLs with a less than 0.5% incidence of suture breakage and documented suture stability for up to over 24 years.
Ryan Yanagihara - One of the best experts on this subject based on the ideXlab platform.
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long term outcome of pars plana vitrectomy and sutured scleral fixated posterior chamber intraocular lens implantation or repositioning
American Journal of Ophthalmology, 2018Co-Authors: Gregg T Kokame, Ryan Yanagihara, Jessica G Shantha, Kyle N KanekoAbstract:Purpose To assess the long-term stability of sutured scleral-fixated posterior chamber intraocular lenses (PCIOLs) performed in combination with pars plana vitrectomy. Design Retrospective, consecutive, interventional case series. Methods Retrospective single-surgeon study of 118 eyes of 111 patients seen at Retina Consultants of Hawaii, who underwent sutured scleral fixation of at least 1 haptic of a posterior chamber intraocular lens with 10-0 polypropylene combined with a pars plana vitrectomy. The fixation knot-tying technique required 2 separate 10-0 polypropylene Sutures tied into 1 combined knot—1 suture closed the fixation sclerotomy and created the scleral fixation, and 1 suture looped together around the haptic of the PCIOL, securing the haptic to the scleral fixation site. The primary outcomes were position of the PCIOL at last follow-up, dislocation of either 1 or both haptics of the PCIOL, and breakage of the 10-0 polypropylene fixation suture. Results PCIOLs remained well stabilized and positioned at last follow-up in 116 of 118 eyes (98.3%), with a mean follow-up of 6.0 years. The maximum stable follow-up with 2 intact fixation Sutures was 24.75 years. There were 4 cases of redislocation (3.4%), but 2 cases were owing to unstable residual capsular support. There was 1 case of suture breakage in 214 fixation Sutures (0.47%) and 1 case of haptic breakage. Conclusions Scleral fixation Sutures with 10-0 polypropylene provide excellent long-term fixation of PCIOLs, with a less than 0.5% incidence of suture breakage and documented suture stability for up to 24+ years.
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long term outcome of pars plana vitrectomy and sutured scleral fixated posterior chamber intraocular lens implantation or repositioning
American Journal of Ophthalmology, 2018Co-Authors: Gregg T Kokame, Ryan Yanagihara, Jessica G Shantha, Kyle N KanekoAbstract:Abstract Purpose To assess the long-term stability of sutured scleral-fixated posterior chamber intraocular lenses (PC IOL) performed in combination with pars plana vitrectomy. Design Retrospective, consecutive, interventional case series Methods Retrospective single-surgeon study of 118 eyes of 111 patients seen at Retina Consultants of Hawaii, who underwent sutured scleral fixation of at least one haptic of a posterior chamber intraocular lens with 10-0 polypropylene combined with a pars plana vitrectomy. The fixation knot tying technique required two separate 10-0 polypropylene Sutures tied into one combined knot – one suture closed the fixation sclerotomy and created the scleral fixation, and one suture looped together around the haptic of the PC IOL securing the haptic to the scleral fixation site. The primary outcomes were: position of the PCIOL at last follow-up, dislocation of either one or both haptics of the PCIOL, and breakage of the 10-0 polypropylene fixation suture. Results PCIOLs remained well stabilized and positioned at last follow-up in 116 of 118 eyes (98.3%) with a mean follow-up of 6.0 years. The maximum stable follow-up with two intact fixation Sutures was 24.75 years. There were 4 cases of redislocation (3.4%), but 2 cases were due to unstable residual capsular support. There was one case of suture breakage in 214 fixation Sutures (0.47%), and one case of haptic breakage. Conclusions Scleral fixation Sutures with 10-0 polypropylene provide excellent long term fixation of PC IOLs with a less than 0.5% incidence of suture breakage and documented suture stability for up to over 24 years.
Michael T Longaker - One of the best experts on this subject based on the ideXlab platform.
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apoptosis in a rodent model of cranial suture fusion in situ imaging and gene expression analysis
Plastic and Reconstructive Surgery, 2004Co-Authors: Kenton Fong, Randall P. Nacamuli, Hanjoon M Song, Tony D Fang, Stephen M Warren, Benjamin L Franc, Carina Mari, Christopher H Contag, Francis G Blankenberg, Michael T LongakerAbstract:Craniosynostosis, the premature fusion of cranial Sutures, is one of the most common craniofacial anomalies, with a reported incidence of up to one in 2500 live births. Despite its prevalence, the cause of craniosynostosis remains unknown. Previously, apoptosis has been postulated to be a contributing factor in the pathogenesis of craniosynostosis, although the role of programmed cell death in cranial Sutures is poorly understood. To address this problem, the authors used an established rodent model of posterior-frontal suture fusion and sagittal suture patency to globally examine apoptosis in cranial Sutures. Apoptosis was evaluated by systemically coinjecting Sprague-Dawley rats with both fluorescent and technetium-99m-labeled annexin V at time points before, during, and after the period of predicted posterior-frontal suture fusion to determine the magnitude and time course of overall apoptotic activity in both fusing and patent Sutures. Using these novel in situ imaging techniques, the authors observed a significant increase in the overall levels of apoptosis in both the posterior-frontal and sagittal suture complexes during the period of predicted posterior-frontal suture fusion. To further explore this increase in apoptotic activity, they used microarray technology to study apoptosis-related genes within the suture complex. Interestingly, there was activation of distinct apoptotic pathways in the posterior-frontal and sagittal Sutures during the period of predicted posterior-frontal suture fusion. Whereas increased transcription of genes associated with the mitochondria-mediated apoptotic pathway occurred in the posterior-frontal suture during fusion, activation of genes associated with the death receptor-mediated apoptotic pathway predominated in the patent sagittal suture during the same time period. These data suggest that although overall apoptotic activity in rat patent and fusing Sutures is similar, the pathways mediating apoptosis within each suture are distinct.
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in vitro murine posterior frontal suture fate is age dependent implications for cranial suture biology
Plastic and Reconstructive Surgery, 2004Co-Authors: Hanjoon M Song, Randall P. Nacamuli, Kenton Fong, Tony D Fang, Oliver Aalami, Jonathan A Mathy, Stephen M Warren, David E. Sahar, Michael T LongakerAbstract:In CD-1 mice, the posterior frontal suture (analogous to the human metopic suture) fuses while all other cranial Sutures remain patent. In an in vitro organ culture model, the authors previously demonstrated that posterior frontal Sutures explanted immediately before the onset of suture fusion (at 2
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increased igf i and igf ii mrna and igf i peptide in fusing rat cranial Sutures suggest evidence for a paracrine role of insulin like growth factors in suture fusion
Plastic and Reconstructive Surgery, 1999Co-Authors: James P. Bradley, Douglas A Roth, Joseph G. Mccarthy, Jamie P. Levine, Victor K M Han, Michael T LongakerAbstract:Premature cranial suture fusion, or craniosynostosis, can result in gross aberrations of craniofacial growth. The biology underlying cranial suture fusion remains poorly understood. Previous studies of the Sprague-Dawley rat posterior frontal suture, which fuses at between 12 and 20 days, have suggested that the regional dura mater beneath the cranial suture directs the overlying suture's fusion. To address the dura-suture paracrine signaling that results in osteogenic differentiation and suture fusion, the authors investigated the possible role of insulin-like growth factors (IGF) I and II. The authors studied the temporal and spatial patterns of the expression of IGF-I and IGF-II mRNA and IGF-I peptide and osteocalcin (bone morphogenetic protein-4) protein in fusing posterior frontal rat Sutures, and they compared them with patent coronal (control) Sutures. Ten Sprague-Dawley rats were studied at the following time points: 16, 18, and 20 days of gestation and 2, 5, 10, 15, 20, 30, 50, and 80 days after birth (n = 110). Posterior frontal and coronal (patent, control) Sutures were analyzed for IGF-I and IGF-II mRNA expression by in situ hybridization by using 35S-labeled IGF-I and IGF-II antisense riboprobes. Levels of IGF-I and IGF-II mRNA were quantified by counting the number of autoradiograph signals per cell. IGF-I and osteocalcin immunoreactivity were identified by avidin-biotin peroxidase immunohistochemistry. IGF-I and IGF-II mRNA were expressed in dural cells beneath fusing Sutures, and the relative mRNA abundance increased between 2 and 10 days before initiation of fusion. Subsequently, IGF-I and IGF-II mRNA were detected in the suture connective tissue cells at 15 and 20 days during the time of active fusion. In contrast, within large osteoblasts of the osteogenic front, the expression of IGF-I and IGF-II mRNA was minimal. However, IGF-I peptide and osteocalcin protein were intensely immunoreactive within these osteoblasts at 15 days (during the period of suture fusion). These data suggest that the dura-suture interaction may be signaled in a paracrine fashion by dura-derived growth factors, such as IGF-I and IGF-II. These peptides, in turn, stimulate nearby osteoblasts to produce bone-promoting growth factors, such as osteocalcin.
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studies in cranial suture biology regional dura mater determines overlying suture biology
Plastic and Reconstructive Surgery, 1998Co-Authors: Jamie P. Levine, Douglas A Roth, James P. Bradley, Joseph G. Mccarthy, Michael T LongakerAbstract:The influence of dura mater on adjacent cranial Sutures is significant. By better understanding the mechanisms of normal suture fusion and the role of the dura mater, it may be possible to delineate the events responsible for the premature suture fusion seen in craniosynostosis. In the Sprague-Dawley rat, the posterior frontal suture normally fuses between 12 and 20 days of postnatal life and has proved to be an excellent model to describe normal suture fusion. The purpose of this study was to document the critical role that the dura mater-suture complex may play on cranial suture biology. Forty Sprague-Dawley rats at 8 days of age were divided into two groups of 20 animals each. The control group (group A) had surgical disruption of the dura mater-calvarial interface. This was accomplished by elevating a strip of cranium inclusive of the posterior frontal and sagittal Sutures and replacement of the cranial strip back to its anatomic position, all with the dura mater left intact. The experimental group (group B) had the same calvarial elevation (strip craniectomy), but the sutural anatomy/ alignment was rotated 180 degrees. This rotation placed the posterior frontal suture into the sagittal suture's anatomic position and the sagittal suture into the posterior frontal suture's anatomic position. All of these procedures were accomplished by leaving the underlying dura mater intact. Animals were killed at 20, 30, 40, and 50 days (12, 22, 32, and 42 days postoperatively), and tissue sections were examined with hematoxylin and eosin staining. Group A (control) showed normal but delayed suture activity. The posterior frontal suture fused, and the sagittal suture remained patent. Fusion was delayed, not beginning before 20 days (12 days postoperative) and showing complete fusion between 30 and 40 days. Group B (180-degree calvarial rotation) demonstrated that the suture in the posterior frontal anatomic position (actual sagittal suture) fused between 20 and 40 days, whereas the suture in the sagittal anatomic position (actual posterior-frontal suture) remained patent throughout the study. This study demonstrates that the location of the dura mater-suture complex is important in determining either suture patency or closure in this model. Normal closure of the suture overlying the posterior frontal dura mater demonstrates that the dura mater itself, or forces derived in specific cranial locations, determines the overlying suture biology.
