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A Baraka - One of the best experts on this subject based on the ideXlab platform.
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Suxamethonium-INDUCED MUSCLE CONTRACTURE FOLLOWING TRAUMATIC DENERVATION IN MAN
2016Co-Authors: A BarakaAbstract:The effects of the systemic and of the i.v. regional administration of Suxamethonium were investi-gated in 23 patients with traumatic nerve injury. Following the systemic administration of suxa-methonium 100 mg, normally innervated muscles showed muscle fasciculations initially, followed by muscular relaxation. On the other hand, denervated muscles did not fasciculate and, in 21 patients, manifested Suxamethonium-induced contractures. In the other two patients no response was observed. In 10 of the patients, the i.v. regional administration of Suxamethonium 5 mg was fol-lowed by a contracture of the denervated muscle which was maintained until the tourniquet was deflated. No systemic reaction to Suxamethonium, other than mild ptosis, followed the release of the tourniquet. In normal muscles, the administration of the depolarizing muscle relaxant Suxamethonium pro-duces neuromuscular block, usually preceded by muscle fasciculation. Experimental investigations in animals have shown that, in denervated muscles, contracture can occu
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effect of Suxamethonium vs rocuronium on onset of oxygen desaturation during apnoea following rapid sequence induction
Anaesthesia, 2010Co-Authors: Samar K Taha, Mohamad F Elkhatib, A Baraka, Y A Haidar, Faraj W Abdallah, R A Zbeidy, Sahar M SiddiksayyidAbstract:This study investigates the effect of Suxamethonium vs rocuronium on the onset of haemoglobin desaturation during apnoea, following rapid sequence induction of anaesthesia. Sixty patients were randomly allocated to one of three groups. Anaesthesia was induced with lidocaine 1.5 mg.kg(-1), fentanyl 2 microg.kg(-1) and propofol 2 mg.kg(-1), followed by either rocuronium 1 mg.kg(-1) (Group R) or Suxamethonium 1.5 mg.kg(-1) (Group S). The third group received propofol 2 mg.kg(-1) and Suxamethonium 1.5 mg.kg(-1) only (Group SO). The median (IQR [range]) time to reach S(p)O(2) of 95% was significantly shorter in Group S (358 (311-373 [245-430]) s) [corrected] than in Group R (378 (370-393 [366-420]) s; p = 0.003), and shorter in Group SO (242 (225-258 [189-270]) s) [corrected] than in both Group R (p < 0.001) and Group S (p < 0.001). When Suxamethonium is administered for rapid sequence induction of anaesthesia, a faster onset of oxygen desaturation is observed during the subsequent apnoea compared with rocuronium. However, time to desaturation is prolonged whenever lidocaine and fentanyl precede Suxamethonium.
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effect of Suxamethonium vs rocuronium on onset of oxygen desaturation during apnoea following rapid sequence induction
Anaesthesia, 2010Co-Authors: Samar K Taha, Mohamad F Elkhatib, A Baraka, Y A Haidar, Faraj W Abdallah, R A Zbeidy, Sahar M SiddiksayyidAbstract:Summary This study investigates the effect of Suxamethonium vs rocuronium on the onset of haemoglobin desaturation during apnoea, following rapid sequence induction of anaesthesia. Sixty patients were randomly allocated to one of three groups. Anaesthesia was induced with lidocaine 1.5 mg.kg−1, fentanyl 2 μg.kg−1 and propofol 2 mg.kg−1, followed by either rocuronium 1 mg.kg−1 (Group R) or Suxamethonium 1.5 mg.kg−1 (Group S). The third group received propofol 2 mg.kg−1 and Suxamethonium 1.5 mg.kg−1 only (Group SO). The median (IQR [range]) time to reach SpO2 of 95% was significantly shorter in Group S (358 (311–373 [215–430]) s) than in Group R (378 (370–393 [366–420]) s; p = 0.003), and shorter in Group SO (242 (225–258 [189–370]) s) than in both Group R (p < 0.001) and Group S (p < 0.001). When Suxamethonium is administered for rapid sequence induction of anaesthesia, a faster onset of oxygen desaturation is observed during the subsequent apnoea compared with rocuronium. However, time to desaturation is prolonged whenever lidocaine and fentanyl precede Suxamethonium.
G Putensenhimmer - One of the best experts on this subject based on the ideXlab platform.
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comparison of intubating conditions after rocuronium and Suxamethonium following rapid sequence induction with thiopentone in elective cases
Acta Anaesthesiologica Scandinavica, 1996Co-Authors: H J Sparr, T J Luger, Thomas Heidegger, G PutensenhimmerAbstract:Background: Rocuronium (Org 9426) was shown to have the fastest onset of action of all currently available non-depolarizing neuromuscular blocking drugs and to provide intubating conditions similar to those of Suxamethonium 60 to 90 s after administration. We compared the intubating conditions after rocuronium and Suxamethonium following rapid-sequence induction of anaesthesia. Methods: Fifty unpremedicated patients of ASA physical status I or II, scheduled for elective surgery were studied. Anaesthesia was induced with thiopentone 6 mg kg-1 followed randomly by Suxamethonium 1 mg kg-1 or rocuronium 0.6 mg kg-1 and, 45 s later, intubation was commenced. Muscle fasciculations, intubating conditions and intubation time, haemodynamic variables and oxygenation were assessed. Results: Intubation time did not differ between Suxamethonium (9.8±2.2 s) (mean±SD) and rocuronium (10.5±2.9 s), respectively. Intubating conditions were clinically acceptable (good or excellent) in all patients given Suxamethonium and in 96% of the patients given rocuronium. However, the condition of the vocal cords was better (P<0.05) and diaphragmatic response to intubation was less pronounced with Suxamethonium (P<0.05). Changes in heart rate and arterial blood pressure were similar in both groups. Conclusion: The authors conclude that rocuronium is a suitable alternative to Suxamethonium for rapid tracheal intubation even under unsupplemented thiopentone anaesthesia, at least in elective, otherwise healthy patients. Its use for rapid-sequence induction under emergency conditions, however, needs further investigation.
Sahar M Siddiksayyid - One of the best experts on this subject based on the ideXlab platform.
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effect of Suxamethonium vs rocuronium on onset of oxygen desaturation during apnoea following rapid sequence induction
Anaesthesia, 2010Co-Authors: Samar K Taha, Mohamad F Elkhatib, A Baraka, Y A Haidar, Faraj W Abdallah, R A Zbeidy, Sahar M SiddiksayyidAbstract:This study investigates the effect of Suxamethonium vs rocuronium on the onset of haemoglobin desaturation during apnoea, following rapid sequence induction of anaesthesia. Sixty patients were randomly allocated to one of three groups. Anaesthesia was induced with lidocaine 1.5 mg.kg(-1), fentanyl 2 microg.kg(-1) and propofol 2 mg.kg(-1), followed by either rocuronium 1 mg.kg(-1) (Group R) or Suxamethonium 1.5 mg.kg(-1) (Group S). The third group received propofol 2 mg.kg(-1) and Suxamethonium 1.5 mg.kg(-1) only (Group SO). The median (IQR [range]) time to reach S(p)O(2) of 95% was significantly shorter in Group S (358 (311-373 [245-430]) s) [corrected] than in Group R (378 (370-393 [366-420]) s; p = 0.003), and shorter in Group SO (242 (225-258 [189-270]) s) [corrected] than in both Group R (p < 0.001) and Group S (p < 0.001). When Suxamethonium is administered for rapid sequence induction of anaesthesia, a faster onset of oxygen desaturation is observed during the subsequent apnoea compared with rocuronium. However, time to desaturation is prolonged whenever lidocaine and fentanyl precede Suxamethonium.
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effect of Suxamethonium vs rocuronium on onset of oxygen desaturation during apnoea following rapid sequence induction
Anaesthesia, 2010Co-Authors: Samar K Taha, Mohamad F Elkhatib, A Baraka, Y A Haidar, Faraj W Abdallah, R A Zbeidy, Sahar M SiddiksayyidAbstract:Summary This study investigates the effect of Suxamethonium vs rocuronium on the onset of haemoglobin desaturation during apnoea, following rapid sequence induction of anaesthesia. Sixty patients were randomly allocated to one of three groups. Anaesthesia was induced with lidocaine 1.5 mg.kg−1, fentanyl 2 μg.kg−1 and propofol 2 mg.kg−1, followed by either rocuronium 1 mg.kg−1 (Group R) or Suxamethonium 1.5 mg.kg−1 (Group S). The third group received propofol 2 mg.kg−1 and Suxamethonium 1.5 mg.kg−1 only (Group SO). The median (IQR [range]) time to reach SpO2 of 95% was significantly shorter in Group S (358 (311–373 [215–430]) s) than in Group R (378 (370–393 [366–420]) s; p = 0.003), and shorter in Group SO (242 (225–258 [189–370]) s) than in both Group R (p < 0.001) and Group S (p < 0.001). When Suxamethonium is administered for rapid sequence induction of anaesthesia, a faster onset of oxygen desaturation is observed during the subsequent apnoea compared with rocuronium. However, time to desaturation is prolonged whenever lidocaine and fentanyl precede Suxamethonium.
Klaus T. Olkkola - One of the best experts on this subject based on the ideXlab platform.
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comparison of rocuronium and Suxamethonium for use during rapid sequence induction of anaesthesia
Anaesthesia, 1998Co-Authors: K C Mccourt, Leena Salmela, M T Carroll, M T Makinen, Maija Kansanaho, Gerben J De Roest, Charles R. Kerr, Rajinder K. Mirakhur, Klaus T. OlkkolaAbstract:This study was designed to compare the tracheal intubating conditions during a rapid sequence induction of anaesthesia using rocuronium 0.6 (n = 61) or 1.0 mg.kg−1 (n = 130) or Suxamethonium 1.0 mg.kg−1 (n = 127) as the neuromuscular blocking drugs. Anaesthesia was induced with fentanyl 1–2 μg.kg−1 and thiopentone 5 mg.kg−1 (median dose) and intubating conditions were assessed 60 s after the administration of the neuromuscular blocking drug by an observer unaware of which drug had been given. Intubating conditions were graded on a three-point scale as excellent, good or poor, the first two being considered clinically acceptable. The study was carried out in two parts. At the end of the first part a comparison between the two doses of rocuronium was carried out when at least 50 patients had been enrolled in each group. The results showed the intubating conditions to be significantly superior with the 1.0 mg.kg−1 dose of rocuronium (p < 0.01). Final comparison between the 1.0 mg.kg−1 doses of rocuronium and Suxamethonium showed no significant difference in the incidence of acceptable intubations (96 and 97%, respectively). The incidence of excellent grade of intubations was, however, significantly higher with Suxamethonium (80% vs. 65%; p = 0.02). It is concluded that rocuronium 1.0 mg.kg−1 can be used as an alternative to Suxamethonium 1.0 mg.kg−1 as part of a rapid sequence induction provided there is no anticipated difficulty in intubation. The clinical duration of this dose of rocuronium is, however, 50–60 min.
Rajinder K. Mirakhur - One of the best experts on this subject based on the ideXlab platform.
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comparison of rocuronium and Suxamethonium for use during rapid sequence induction of anaesthesia
Anaesthesia, 1998Co-Authors: K C Mccourt, Leena Salmela, M T Carroll, M T Makinen, Maija Kansanaho, Gerben J De Roest, Charles R. Kerr, Rajinder K. Mirakhur, Klaus T. OlkkolaAbstract:This study was designed to compare the tracheal intubating conditions during a rapid sequence induction of anaesthesia using rocuronium 0.6 (n = 61) or 1.0 mg.kg−1 (n = 130) or Suxamethonium 1.0 mg.kg−1 (n = 127) as the neuromuscular blocking drugs. Anaesthesia was induced with fentanyl 1–2 μg.kg−1 and thiopentone 5 mg.kg−1 (median dose) and intubating conditions were assessed 60 s after the administration of the neuromuscular blocking drug by an observer unaware of which drug had been given. Intubating conditions were graded on a three-point scale as excellent, good or poor, the first two being considered clinically acceptable. The study was carried out in two parts. At the end of the first part a comparison between the two doses of rocuronium was carried out when at least 50 patients had been enrolled in each group. The results showed the intubating conditions to be significantly superior with the 1.0 mg.kg−1 dose of rocuronium (p < 0.01). Final comparison between the 1.0 mg.kg−1 doses of rocuronium and Suxamethonium showed no significant difference in the incidence of acceptable intubations (96 and 97%, respectively). The incidence of excellent grade of intubations was, however, significantly higher with Suxamethonium (80% vs. 65%; p = 0.02). It is concluded that rocuronium 1.0 mg.kg−1 can be used as an alternative to Suxamethonium 1.0 mg.kg−1 as part of a rapid sequence induction provided there is no anticipated difficulty in intubation. The clinical duration of this dose of rocuronium is, however, 50–60 min.
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comparison of intubating conditions after administration of org 9426 rocuronium and Suxamethonium
BJA: British Journal of Anaesthesia, 1992Co-Authors: R Cooper, Rajinder K. Mirakhur, R S J Clarke, Z BoulesAbstract:We have assessed intubating conditions after administration of Org 9426 (rocuronium) 600 fig kg−1 at 60 or 90s in groups of 20 patients anaesthetized with thiopentone, nitrous oxide in oxygen and small doses of fentanyl, and compared the data with those obtained after Suxamethonium 1 mg kg−1 in similar groups of patients. The influence of prior Suxamethonium administration on the potency of Org 9426 was studied also by constructing a dose-response curve. Intubating conditions after Org 9426 were found to be clinically acceptable (good or excellent) in 95% of patients at 60 s and in all patients at 90 s and in all patients at both times after Suxamethonium. The average time for the onset of block following Org 9426 at this dose was 89 s (which is shorter than with any of the currently available non-depolarizing neuromuscular blocking drugs); the duration of clinical relaxation (25% recovery of twitch height) 30 min. Prior administration of Suxamethonium did not appear to influence the potency of Org 9426.
