The Experts below are selected from a list of 14526 Experts worldwide ranked by ideXlab platform
Jieshan Qiu - One of the best experts on this subject based on the ideXlab platform.
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an aerobic and very fast pd c catalyzed ligand free and aqueous Suzuki Reaction under mild conditions
ChemInform, 2013Co-Authors: Chun Liu, Xiaofeng Rao, Jieshan Qiu, Yixia Zhang, Zilin JinAbstract:A very simple, green, efficient, and mild protocol for the title Reaction is presented with short Reaction times.
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an aerobic and very fast pd c catalyzed ligand free and aqueous Suzuki Reaction under mild conditions
European Journal of Organic Chemistry, 2013Co-Authors: Chun Liu, Xiaofeng Rao, Jieshan Qiu, Yixia Zhang, Zilin JinAbstract:An aerobic, ligand-free Suzuki Reaction catalyzed by Pd/C in aqueous media has been developed. This method is a very simple, efficient and mild protocol for the cross-coupling of aryl bromides with arylboronic acids, and the Reactions proceeded smoothly in excellent yields within short Reaction times. Control experiments demonstrated that the Pd/C-cata
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a simple and efficient approach for the palladium catalyzed ligand free Suzuki Reaction in water
Green Chemistry, 2012Co-Authors: Chun Liu, Ning Liu, Yixia Zhang, Jieshan QiuAbstract:A general and efficient protocol is described for the palladium-catalyzed ligand-free and aerobic Suzuki Reaction in water in the absence of any additive. The results demonstrate that the base played a crucial role in the high efficiency. The Pd(OAc)2/(i-Pr)2NH/H2O system showed the highest catalytic activity towards the Suzuki Reaction of a wide range of aryl halides bearing hydrophilic or hydrophobic groups.
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Oxygen-Promoted PdCl2-Catalyzed Ligand-Free Suzuki Reaction in Aqueous Media.
ChemInform, 2011Co-Authors: Chun Liu, Jieshan QiuAbstract:Investigations in different solvents reveal that an aerobic atmosphere could accelerate the Suzuki Reaction in aqueous media.
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Oxygen-promoted PdCl2-catalyzed ligand-free Suzuki Reaction in aqueous media
Organic & biomolecular chemistry, 2010Co-Authors: Chun Liu, Jieshan QiuAbstract:A simple and efficient protocol has been developed for the PdCl2-catalyzed ligand-free and aerobic Suzuki Reaction of aryl bromides or nitrogen-based heteroaryl bromides with arylboronic acids in good to excellent yields in aqueous ethanol. A systematic investigation on the effect of different atmospheres on the reactivity of the palladium-catalyzed Suzuki Reaction has been carried out, the results show that an aerobic atmosphere demonstrates a positive effect on the reactivity of the Suzuki Reaction in an aqueous media and a negative effect in a pure organic solvent, which exhibits that the water plays a crucial role for the function of the atmosphere on the palladium-catalyzed ligand-free Suzuki Reaction.
Chun Liu - One of the best experts on this subject based on the ideXlab platform.
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an aerobic and very fast pd c catalyzed ligand free and aqueous Suzuki Reaction under mild conditions
ChemInform, 2013Co-Authors: Chun Liu, Xiaofeng Rao, Jieshan Qiu, Yixia Zhang, Zilin JinAbstract:A very simple, green, efficient, and mild protocol for the title Reaction is presented with short Reaction times.
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an aerobic and very fast pd c catalyzed ligand free and aqueous Suzuki Reaction under mild conditions
European Journal of Organic Chemistry, 2013Co-Authors: Chun Liu, Xiaofeng Rao, Jieshan Qiu, Yixia Zhang, Zilin JinAbstract:An aerobic, ligand-free Suzuki Reaction catalyzed by Pd/C in aqueous media has been developed. This method is a very simple, efficient and mild protocol for the cross-coupling of aryl bromides with arylboronic acids, and the Reactions proceeded smoothly in excellent yields within short Reaction times. Control experiments demonstrated that the Pd/C-cata
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a simple and efficient approach for the palladium catalyzed ligand free Suzuki Reaction in water
Green Chemistry, 2012Co-Authors: Chun Liu, Ning Liu, Yixia Zhang, Jieshan QiuAbstract:A general and efficient protocol is described for the palladium-catalyzed ligand-free and aerobic Suzuki Reaction in water in the absence of any additive. The results demonstrate that the base played a crucial role in the high efficiency. The Pd(OAc)2/(i-Pr)2NH/H2O system showed the highest catalytic activity towards the Suzuki Reaction of a wide range of aryl halides bearing hydrophilic or hydrophobic groups.
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poly ethylene glycol functionalized imidazolium salts palladium catalyzed Suzuki Reaction in water
ChemInform, 2012Co-Authors: Ning Liu, Chun Liu, Zilin JinAbstract:A novel PEG-functionalized imidazolium salt is prepared and successfully used as a water-soluble ligand in the palladium-catalyzed Suzuki Reaction.
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poly ethylene glycol functionalized imidazolium salts palladium catalyzed Suzuki Reaction in water
Green Chemistry, 2012Co-Authors: Ning Liu, Chun Liu, Zilin JinAbstract:Three water-soluble imidazolium salts bearing poly(ethylene glycol) moieties directly attached to an N-atom of imidazole have been synthesized via a simple synthetic method, which could be served as N-heterocyclic carbene precursors for the palladium-catalyzed Suzuki Reaction. The catalytic system generated in situ from a source of Pd(OAc)2, a precursor of imidazolium salt, and a base of triethylamine is able to smoothly perform the Suzuki Reaction of a variety of substrates in water.
Zilin Jin - One of the best experts on this subject based on the ideXlab platform.
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an aerobic and very fast pd c catalyzed ligand free and aqueous Suzuki Reaction under mild conditions
ChemInform, 2013Co-Authors: Chun Liu, Xiaofeng Rao, Jieshan Qiu, Yixia Zhang, Zilin JinAbstract:A very simple, green, efficient, and mild protocol for the title Reaction is presented with short Reaction times.
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an aerobic and very fast pd c catalyzed ligand free and aqueous Suzuki Reaction under mild conditions
European Journal of Organic Chemistry, 2013Co-Authors: Chun Liu, Xiaofeng Rao, Jieshan Qiu, Yixia Zhang, Zilin JinAbstract:An aerobic, ligand-free Suzuki Reaction catalyzed by Pd/C in aqueous media has been developed. This method is a very simple, efficient and mild protocol for the cross-coupling of aryl bromides with arylboronic acids, and the Reactions proceeded smoothly in excellent yields within short Reaction times. Control experiments demonstrated that the Pd/C-cata
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poly ethylene glycol functionalized imidazolium salts palladium catalyzed Suzuki Reaction in water
ChemInform, 2012Co-Authors: Ning Liu, Chun Liu, Zilin JinAbstract:A novel PEG-functionalized imidazolium salt is prepared and successfully used as a water-soluble ligand in the palladium-catalyzed Suzuki Reaction.
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poly ethylene glycol functionalized imidazolium salts palladium catalyzed Suzuki Reaction in water
Green Chemistry, 2012Co-Authors: Ning Liu, Chun Liu, Zilin JinAbstract:Three water-soluble imidazolium salts bearing poly(ethylene glycol) moieties directly attached to an N-atom of imidazole have been synthesized via a simple synthetic method, which could be served as N-heterocyclic carbene precursors for the palladium-catalyzed Suzuki Reaction. The catalytic system generated in situ from a source of Pd(OAc)2, a precursor of imidazolium salt, and a base of triethylamine is able to smoothly perform the Suzuki Reaction of a variety of substrates in water.
Qijian Ni - One of the best experts on this subject based on the ideXlab platform.
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a simple and efficient protocol for a palladium catalyzed ligand free Suzuki Reaction at room temperature in aqueous dmf
Green Chemistry, 2011Co-Authors: Qijian NiAbstract:A convenient, effective and mild protocol has been developed for the palladium-catalyzed ligand-free Suzuki Reaction of aryl bromides with arylboronic acids in aqueous N,N-dimethylformamide (DMF) in the presence of K2CO3 and a catalytic amount of PdCl2 in air at room temperature. It is noteworthy that the volume ratio of water–DMF and base play important roles in the Reaction, and various functional groups are tolerated under the optimized conditions. Furthermore, this protocol could be extended to the cross-couplings of nitrogen-based heteroaryl halides with arylboronic acids in moderate to excellent yields.
David R Spring - One of the best experts on this subject based on the ideXlab platform.
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synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino heck Suzuki Reaction
ChemInform, 2015Co-Authors: Esther Alza, Luca Laraia, Brett M Ibbeson, Suil Collins, Warren R J D Galloway, Jamie E Stokes, Ashok R Venkitaraman, David R SpringAbstract:13 Title compounds of type (III) are prepared and screened for their antimitotic properties.
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synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino heck Suzuki Reaction
Chemical Science, 2015Co-Authors: Esther Alza, Luca Laraia, Brett M Ibbeson, Suil Collins, Warren R J D Galloway, Jamie E Stokes, Ashok R Venkitaraman, David R SpringAbstract:The synthesis of a previously undescribed sp3-rich 6-5-5-6 tetracyclic ring scaffold using a palladium catalysed domino Heck-Suzuki Reaction is reported. This Reaction is high-yielding, selective for the domino process over the direct Suzuki Reaction and tolerant towards a variety of boronic acids. The novel scaffold can also be accessed via domino Heck-Stille and radical cyclisations. Compounds based around this scaffold were found to be effective antimitotic agents in a human cancer cell line. Detailed phenotypic profiling showed that the compounds affected the congression of chromosomes to give mitotic arrest and apoptotic cell death. Thus, a novel structural class of antimitotic agents that does not disrupt the tubulin network has been identified.
