The Experts below are selected from a list of 17370 Experts worldwide ranked by ideXlab platform
Jens Ledet Jensen - One of the best experts on this subject based on the ideXlab platform.
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Synaptic Contact number and size in stratum radiatum ca1 of app ps1δe9 transgenic mice
Neurobiology of Aging, 2009Co-Authors: Mark J. West, Georg Bach, Andreas Søderman, Jens Ledet JensenAbstract:Synaptic changes occur early in the course of Alzheimer's disease and are key to understanding the initial events in associated neurodegenerative processes. The quantitative analysis of Synaptic morphology in transgenic mouse models of Alzheimer's disease can provide important insights into these processes. To this end, the total number and the distribution of the diameters of Synaptic Contacts in the stratum radiatum of the CA1 region of the hippocampus of 12-month-old APP/PS1ΔE9 transgenic mice and wild type littermates have been evaluated by applying design-based stereological methods to material prepared for electron microscopy. Although there were no differences in the size of the Synaptic Contacts, the total number of Synaptic Contacts was significantly larger in the transgenic mice, suggesting that the transgenic effect at this age is synaptotrophic and that the presence of amyloid plaques and an elevated Abeta42/40 ratio are not necessarily detrimental to populations of synapses. The potential of this type of data in evaluating Synaptic changes related to Alzheimer's disease is discussed and the methodology described in detail.
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Synaptic Contact number and size in stratum radiatum CA1 of APP/PS1ΔE9 transgenic mice
Neurobiology of aging, 2008Co-Authors: Mark J. West, Georg Bach, Andreas Søderman, Jens Ledet JensenAbstract:Synaptic changes occur early in the course of Alzheimer's disease and are key to understanding the initial events in associated neurodegenerative processes. The quantitative analysis of Synaptic morphology in transgenic mouse models of Alzheimer's disease can provide important insights into these processes. To this end, the total number and the distribution of the diameters of Synaptic Contacts in the stratum radiatum of the CA1 region of the hippocampus of 12-month-old APP/PS1ΔE9 transgenic mice and wild type littermates have been evaluated by applying design-based stereological methods to material prepared for electron microscopy. Although there were no differences in the size of the Synaptic Contacts, the total number of Synaptic Contacts was significantly larger in the transgenic mice, suggesting that the transgenic effect at this age is synaptotrophic and that the presence of amyloid plaques and an elevated Abeta42/40 ratio are not necessarily detrimental to populations of synapses. The potential of this type of data in evaluating Synaptic changes related to Alzheimer's disease is discussed and the methodology described in detail.
Noboru Mizuno - One of the best experts on this subject based on the ideXlab platform.
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morphological evidence for gaba glycine cocontaining terminals in Synaptic Contact with neurokinin 1 receptor expressing neurons in the sacral dorsal commissural nucleus of the rat
Neuroscience Letters, 2005Co-Authors: Yu-peng Feng, Wen Wang, Tao Chen, Ryuichi Shigemoto, Noboru MizunoAbstract:Previous studies have shown that neurons in the sacral dorsal commissural nucleus (SDCN) express neurokinin-1 receptor (NK1R) and can be modulated by the co-release of GABA and glycine (Gly) from single preSynaptic terminal. These results raise the possibility that GABA/Gly-cocontaining terminals might make Synaptic Contacts with NK1R-expressing neurons in the SDCN. In order to provide morphological evidence for this hypothesis, the triple-immunohistochemical studies were performed in the SDCN. Triple-immunofluorescence histochemical study showed that some axon terminals in close association with NK1R-immunopositive (NK1R-ip) neurons in the SDCN were immunopositive for both glutamic acid decarboxylase (GAD) and glycine transporter 2 (GlyT2). In electron microscopic dual- and triple-immunohistochemistry for GAD/GlyT2, GAD/NK1R, GlyT2/NK1R, or GAD/GlyT2/NK1R also revealed dually labeled (GAD/GlyT2-ip) Synaptic terminals upon SDCN neurons, as well as GAD- and/or GlyT2-ip axon terminals in Synaptic Contact with NK1R-ip SDCN neurons. These results suggested that some Synaptic terminals upon NK1R-expressing SDCN neurons co-released both GABA and Gly.
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Morphological evidence for GABA/glycine-cocontaining terminals in Synaptic Contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat.
Neuroscience letters, 2005Co-Authors: Yu-peng Feng, Wen Wang, Tao Chen, Ryuichi Shigemoto, Noboru MizunoAbstract:Previous studies have shown that neurons in the sacral dorsal commissural nucleus (SDCN) express neurokinin-1 receptor (NK1R) and can be modulated by the co-release of GABA and glycine (Gly) from single preSynaptic terminal. These results raise the possibility that GABA/Gly-cocontaining terminals might make Synaptic Contacts with NK1R-expressing neurons in the SDCN. In order to provide morphological evidence for this hypothesis, the triple-immunohistochemical studies were performed in the SDCN. Triple-immunofluorescence histochemical study showed that some axon terminals in close association with NK1R-immunopositive (NK1R-ip) neurons in the SDCN were immunopositive for both glutamic acid decarboxylase (GAD) and glycine transporter 2 (GlyT2). In electron microscopic dual- and triple-immunohistochemistry for GAD/GlyT2, GAD/NK1R, GlyT2/NK1R, or GAD/GlyT2/NK1R also revealed dually labeled (GAD/GlyT2-ip) Synaptic terminals upon SDCN neurons, as well as GAD- and/or GlyT2-ip axon terminals in Synaptic Contact with NK1R-ip SDCN neurons. These results suggested that some Synaptic terminals upon NK1R-expressing SDCN neurons co-released both GABA and Gly.
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Glutamic acid decarboxylase-like immunoreactive axon terminals in Synaptic Contact with mesencephalic trigeminal nucleus neurons in the rat.
Neuroscience letters, 2001Co-Authors: P Chen, Noboru MizunoAbstract:The purpose of the present study was to obtain reliable evidence for the presence of γ-aminobutyric acid-ergic (GABAergic) synapses upon mesencephalic trigeminal nucleus (MTN) neurons in the rat. For confocal laser-scanning microscopy, phosphate-activated glutaminase-like immunoreactivity (-IR) of MTN neurons was visualized with red fluorescence of Texas Red, while glutamic acid decarboxylase (GAD)-IR of GABA axons was visualized with green fluorescence of dichlorotriazinyl aminofluorescein. Many GAD-axon terminals were in close apposition to the cell bodies of MTN neurons. For electron microscopy, MTN neurons were labeled with wheat germ agglutinin-horseradish peroxidase injected into the masseter nerve, while axon terminals were labeled with GAD-IR. GAD-axon terminals were in symmetric Synaptic Contact with the cell bodies of MTN neurons. Primary proprioceptive neurons in the orofacial regions might be regulated post-Synaptically by GABA neurons.
Mark J. West - One of the best experts on this subject based on the ideXlab platform.
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Synaptic Contact number and size in stratum radiatum ca1 of app ps1δe9 transgenic mice
Neurobiology of Aging, 2009Co-Authors: Mark J. West, Georg Bach, Andreas Søderman, Jens Ledet JensenAbstract:Synaptic changes occur early in the course of Alzheimer's disease and are key to understanding the initial events in associated neurodegenerative processes. The quantitative analysis of Synaptic morphology in transgenic mouse models of Alzheimer's disease can provide important insights into these processes. To this end, the total number and the distribution of the diameters of Synaptic Contacts in the stratum radiatum of the CA1 region of the hippocampus of 12-month-old APP/PS1ΔE9 transgenic mice and wild type littermates have been evaluated by applying design-based stereological methods to material prepared for electron microscopy. Although there were no differences in the size of the Synaptic Contacts, the total number of Synaptic Contacts was significantly larger in the transgenic mice, suggesting that the transgenic effect at this age is synaptotrophic and that the presence of amyloid plaques and an elevated Abeta42/40 ratio are not necessarily detrimental to populations of synapses. The potential of this type of data in evaluating Synaptic changes related to Alzheimer's disease is discussed and the methodology described in detail.
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Synaptic Contact number and size in stratum radiatum CA1 of APP/PS1ΔE9 transgenic mice
Neurobiology of aging, 2008Co-Authors: Mark J. West, Georg Bach, Andreas Søderman, Jens Ledet JensenAbstract:Synaptic changes occur early in the course of Alzheimer's disease and are key to understanding the initial events in associated neurodegenerative processes. The quantitative analysis of Synaptic morphology in transgenic mouse models of Alzheimer's disease can provide important insights into these processes. To this end, the total number and the distribution of the diameters of Synaptic Contacts in the stratum radiatum of the CA1 region of the hippocampus of 12-month-old APP/PS1ΔE9 transgenic mice and wild type littermates have been evaluated by applying design-based stereological methods to material prepared for electron microscopy. Although there were no differences in the size of the Synaptic Contacts, the total number of Synaptic Contacts was significantly larger in the transgenic mice, suggesting that the transgenic effect at this age is synaptotrophic and that the presence of amyloid plaques and an elevated Abeta42/40 ratio are not necessarily detrimental to populations of synapses. The potential of this type of data in evaluating Synaptic changes related to Alzheimer's disease is discussed and the methodology described in detail.
Andreas Søderman - One of the best experts on this subject based on the ideXlab platform.
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Synaptic Contact number and size in stratum radiatum ca1 of app ps1δe9 transgenic mice
Neurobiology of Aging, 2009Co-Authors: Mark J. West, Georg Bach, Andreas Søderman, Jens Ledet JensenAbstract:Synaptic changes occur early in the course of Alzheimer's disease and are key to understanding the initial events in associated neurodegenerative processes. The quantitative analysis of Synaptic morphology in transgenic mouse models of Alzheimer's disease can provide important insights into these processes. To this end, the total number and the distribution of the diameters of Synaptic Contacts in the stratum radiatum of the CA1 region of the hippocampus of 12-month-old APP/PS1ΔE9 transgenic mice and wild type littermates have been evaluated by applying design-based stereological methods to material prepared for electron microscopy. Although there were no differences in the size of the Synaptic Contacts, the total number of Synaptic Contacts was significantly larger in the transgenic mice, suggesting that the transgenic effect at this age is synaptotrophic and that the presence of amyloid plaques and an elevated Abeta42/40 ratio are not necessarily detrimental to populations of synapses. The potential of this type of data in evaluating Synaptic changes related to Alzheimer's disease is discussed and the methodology described in detail.
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Synaptic Contact number and size in stratum radiatum CA1 of APP/PS1ΔE9 transgenic mice
Neurobiology of aging, 2008Co-Authors: Mark J. West, Georg Bach, Andreas Søderman, Jens Ledet JensenAbstract:Synaptic changes occur early in the course of Alzheimer's disease and are key to understanding the initial events in associated neurodegenerative processes. The quantitative analysis of Synaptic morphology in transgenic mouse models of Alzheimer's disease can provide important insights into these processes. To this end, the total number and the distribution of the diameters of Synaptic Contacts in the stratum radiatum of the CA1 region of the hippocampus of 12-month-old APP/PS1ΔE9 transgenic mice and wild type littermates have been evaluated by applying design-based stereological methods to material prepared for electron microscopy. Although there were no differences in the size of the Synaptic Contacts, the total number of Synaptic Contacts was significantly larger in the transgenic mice, suggesting that the transgenic effect at this age is synaptotrophic and that the presence of amyloid plaques and an elevated Abeta42/40 ratio are not necessarily detrimental to populations of synapses. The potential of this type of data in evaluating Synaptic changes related to Alzheimer's disease is discussed and the methodology described in detail.
Georg Bach - One of the best experts on this subject based on the ideXlab platform.
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Synaptic Contact number and size in stratum radiatum ca1 of app ps1δe9 transgenic mice
Neurobiology of Aging, 2009Co-Authors: Mark J. West, Georg Bach, Andreas Søderman, Jens Ledet JensenAbstract:Synaptic changes occur early in the course of Alzheimer's disease and are key to understanding the initial events in associated neurodegenerative processes. The quantitative analysis of Synaptic morphology in transgenic mouse models of Alzheimer's disease can provide important insights into these processes. To this end, the total number and the distribution of the diameters of Synaptic Contacts in the stratum radiatum of the CA1 region of the hippocampus of 12-month-old APP/PS1ΔE9 transgenic mice and wild type littermates have been evaluated by applying design-based stereological methods to material prepared for electron microscopy. Although there were no differences in the size of the Synaptic Contacts, the total number of Synaptic Contacts was significantly larger in the transgenic mice, suggesting that the transgenic effect at this age is synaptotrophic and that the presence of amyloid plaques and an elevated Abeta42/40 ratio are not necessarily detrimental to populations of synapses. The potential of this type of data in evaluating Synaptic changes related to Alzheimer's disease is discussed and the methodology described in detail.
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Synaptic Contact number and size in stratum radiatum CA1 of APP/PS1ΔE9 transgenic mice
Neurobiology of aging, 2008Co-Authors: Mark J. West, Georg Bach, Andreas Søderman, Jens Ledet JensenAbstract:Synaptic changes occur early in the course of Alzheimer's disease and are key to understanding the initial events in associated neurodegenerative processes. The quantitative analysis of Synaptic morphology in transgenic mouse models of Alzheimer's disease can provide important insights into these processes. To this end, the total number and the distribution of the diameters of Synaptic Contacts in the stratum radiatum of the CA1 region of the hippocampus of 12-month-old APP/PS1ΔE9 transgenic mice and wild type littermates have been evaluated by applying design-based stereological methods to material prepared for electron microscopy. Although there were no differences in the size of the Synaptic Contacts, the total number of Synaptic Contacts was significantly larger in the transgenic mice, suggesting that the transgenic effect at this age is synaptotrophic and that the presence of amyloid plaques and an elevated Abeta42/40 ratio are not necessarily detrimental to populations of synapses. The potential of this type of data in evaluating Synaptic changes related to Alzheimer's disease is discussed and the methodology described in detail.
