The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform
Lindsay M. Jaacks - One of the best experts on this subject based on the ideXlab platform.
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Synthetic Chemical Trade as a Potential Driver of Global Health Disparities and Data Gaps on Synthetic Chemicals in Vulnerable Populations
Current Environmental Health Reports, 2020Co-Authors: Dina Goodman, Nicholas Arisco, Lindsay M. JaacksAbstract:Purpose of Review Most research on toxic exposures in vulnerable populations focuses on air pollution. Synthetic Chemical production, however, is a multi-billion-dollar industry that lacks appropriate international regulation to protect those exposed to toxic Chemicals. This paper aims to describe the country-level import and export of key groups of Synthetic Chemicals using data from the United Nations Comtrade Database and provide a narrative review of the evidence from January 2018 to August 2019 on exposure to, health effects of, and interventions to reduce Synthetic Chemicals in vulnerable populations around the world. Recent Findings Generally, a small number of high-income countries export the majority of Synthetic Chemicals, while most low-income countries import more Chemicals than they export, which may contribute to higher levels of Synthetic Chemicals in those settings. However, few studies have quantified exposures to Synthetic Chemicals in low- and middle-income countries, the health effects of such exposures, or interventions to mitigate exposures. Summary Synthetic Chemicals continue to enter markets despite our limited knowledge of their effects on human health, particularly in the most vulnerable populations. We need more research to understand the health impacts of these pervasive exposures.
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Synthetic Chemical Trade as a Potential Driver of Global Health Disparities and Data Gaps on Synthetic Chemicals in Vulnerable Populations.
Current environmental health reports, 2020Co-Authors: Dina Goodman, Nicholas Arisco, Lindsay M. JaacksAbstract:Most research on toxic exposures in vulnerable populations focuses on air pollution. Synthetic Chemical production, however, is a multi-billion-dollar industry that lacks appropriate international regulation to protect those exposed to toxic Chemicals. This paper aims to describe the country-level import and export of key groups of Synthetic Chemicals using data from the United Nations Comtrade Database and provide a narrative review of the evidence from January 2018 to August 2019 on exposure to, health effects of, and interventions to reduce Synthetic Chemicals in vulnerable populations around the world. Generally, a small number of high-income countries export the majority of Synthetic Chemicals, while most low-income countries import more Chemicals than they export, which may contribute to higher levels of Synthetic Chemicals in those settings. However, few studies have quantified exposures to Synthetic Chemicals in low- and middle-income countries, the health effects of such exposures, or interventions to mitigate exposures. Synthetic Chemicals continue to enter markets despite our limited knowledge of their effects on human health, particularly in the most vulnerable populations. We need more research to understand the health impacts of these pervasive exposures.
Dina Goodman - One of the best experts on this subject based on the ideXlab platform.
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Synthetic Chemical Trade as a Potential Driver of Global Health Disparities and Data Gaps on Synthetic Chemicals in Vulnerable Populations
Current Environmental Health Reports, 2020Co-Authors: Dina Goodman, Nicholas Arisco, Lindsay M. JaacksAbstract:Purpose of Review Most research on toxic exposures in vulnerable populations focuses on air pollution. Synthetic Chemical production, however, is a multi-billion-dollar industry that lacks appropriate international regulation to protect those exposed to toxic Chemicals. This paper aims to describe the country-level import and export of key groups of Synthetic Chemicals using data from the United Nations Comtrade Database and provide a narrative review of the evidence from January 2018 to August 2019 on exposure to, health effects of, and interventions to reduce Synthetic Chemicals in vulnerable populations around the world. Recent Findings Generally, a small number of high-income countries export the majority of Synthetic Chemicals, while most low-income countries import more Chemicals than they export, which may contribute to higher levels of Synthetic Chemicals in those settings. However, few studies have quantified exposures to Synthetic Chemicals in low- and middle-income countries, the health effects of such exposures, or interventions to mitigate exposures. Summary Synthetic Chemicals continue to enter markets despite our limited knowledge of their effects on human health, particularly in the most vulnerable populations. We need more research to understand the health impacts of these pervasive exposures.
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Synthetic Chemical Trade as a Potential Driver of Global Health Disparities and Data Gaps on Synthetic Chemicals in Vulnerable Populations.
Current environmental health reports, 2020Co-Authors: Dina Goodman, Nicholas Arisco, Lindsay M. JaacksAbstract:Most research on toxic exposures in vulnerable populations focuses on air pollution. Synthetic Chemical production, however, is a multi-billion-dollar industry that lacks appropriate international regulation to protect those exposed to toxic Chemicals. This paper aims to describe the country-level import and export of key groups of Synthetic Chemicals using data from the United Nations Comtrade Database and provide a narrative review of the evidence from January 2018 to August 2019 on exposure to, health effects of, and interventions to reduce Synthetic Chemicals in vulnerable populations around the world. Generally, a small number of high-income countries export the majority of Synthetic Chemicals, while most low-income countries import more Chemicals than they export, which may contribute to higher levels of Synthetic Chemicals in those settings. However, few studies have quantified exposures to Synthetic Chemicals in low- and middle-income countries, the health effects of such exposures, or interventions to mitigate exposures. Synthetic Chemicals continue to enter markets despite our limited knowledge of their effects on human health, particularly in the most vulnerable populations. We need more research to understand the health impacts of these pervasive exposures.
Emily S. Barrett - One of the best experts on this subject based on the ideXlab platform.
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Joint Impact of Synthetic Chemical and Non-Chemical Stressors on Children’s Health
Current Environmental Health Reports, 2019Co-Authors: Emily S. Barrett, Amy M. PadulaAbstract:Purpose of Review Pregnant women are exposed to numerous Synthetic Chemicals (e.g., pesticides, phthalates, polychlorinated biphenyls) in their daily lives as well as a range of non-Chemical stressors, including poverty, depression, discrimination, and stressful life events. Although many studies have examined individual exposures to Chemical and non-Chemical stressors in relation to child health outcomes, very few studies have considered these exposures together. Here, we review the recent epidemiologic literature on the joint impact of Chemical and non-Chemical stressors on child outcomes. Recent Findings Considerable co-exposure to Chemical and non-Chemical stressors occurs in vulnerable populations. Non-Chemical stressors may modify the impact of Chemical exposures on children’s health, typically exacerbating their negative impact, but associations differ considerably by the Chemicals and populations of interest. Summary Additional research is urgently needed to better understand the cumulative risks of multiple stressors on children’s health and the underlying physiological mechanisms.
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Joint Impact of Synthetic Chemical and Non-Chemical Stressors on Children's Health.
Current environmental health reports, 2019Co-Authors: Emily S. Barrett, Amy PadulaAbstract:Pregnant women are exposed to numerous Synthetic Chemicals (e.g., pesticides, phthalates, polychlorinated biphenyls) in their daily lives as well as a range of non-Chemical stressors, including poverty, depression, discrimination, and stressful life events. Although many studies have examined individual exposures to Chemical and non-Chemical stressors in relation to child health outcomes, very few studies have considered these exposures together. Here, we review the recent epidemiologic literature on the joint impact of Chemical and non-Chemical stressors on child outcomes. Considerable co-exposure to Chemical and non-Chemical stressors occurs in vulnerable populations. Non-Chemical stressors may modify the impact of Chemical exposures on children’s health, typically exacerbating their negative impact, but associations differ considerably by the Chemicals and populations of interest. Additional research is urgently needed to better understand the cumulative risks of multiple stressors on children’s health and the underlying physiological mechanisms.
W. Clark Still - One of the best experts on this subject based on the ideXlab platform.
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Complex Synthetic Chemical Libraries Indexed with Molecular Tags
Proceedings of the National Academy of Sciences of the United States of America, 2017Co-Authors: Michael H J Ohlmeyer, Robert N. Swanson, Lawrence W Dillard, Gigi Asoulinet, Ryuji Kobayashit, Michael Wiglert, C. John, W. Clark StillAbstract:Combinatorial methods of Chemical synthesis allow the creation of molecular libraries having immense diversity. The utility of such ibraries is dependednt upon identifiying hte structures of teh molecules so prepared. We describe the construction of a peptide combinatorial library, baving 117,649 different members, synthesized on beads and indexed with intert Chemical tags. These tags are used as a binary code to record the reaction history of each bead. The code can be read directly from a single bead by electron capture capillary gas chromatography. We demonstrate the correct seletion of members of the library on the absis of binding to a monoclonal antibody.
Eoin M. Scanlan - One of the best experts on this subject based on the ideXlab platform.
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recent advances in the development of Synthetic Chemical probes for glycosidase enzymes
Chemical Communications, 2015Co-Authors: Helen Burke, Thorfinnur Gunnlaugsson, Eoin M. ScanlanAbstract:The emergence of Synthetic glycoconjugates as Chemical probes for the detection of glycosidase enzymes has resulted in the development of a range of useful Chemical tools with applications in glycobiology, biotechnology, medical and industrial research. Critical to the function of these probes is the preparation of substrates containing a glycosidic linkage that when activated by a specific enzyme or group of enzymes, irreversibly releases a reporter molecule that can be detected. Starting from the earliest examples of colourimetric probes, increasingly sensitive and sophisticated substrates have been reported. In this review we present an overview of the recent advances in this field, covering an array of strategies including chromogenic and fluorogenic substrates, lanthanide complexes, gels and nanoparticles. The applications of these substrates for the detection of various glycosidases and the scope and limitations for each approach are discussed.
