The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Dongxing Yuan - One of the best experts on this subject based on the ideXlab platform.
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simultaneous underway analysis of nitrate and nitrite in estuarine and coastal waters using an automated integrated Syringe Pump based environmental water analyzer
Analytica Chimica Acta, 2019Co-Authors: Tengyue Fang, Yiyong Jiang, Kunning Lin, Nengwang Chen, Jixin Chen, Dongxing YuanAbstract:Abstract Methods for determining nitrate and nitrite have been comprehensively developed. However, there are few studies of simultaneous shipboard high-frequency monitoring of these two nutrients in estuarine and coastal area. In this study, a multipurpose integrated Syringe-Pump-based environmental-water analyzer (iSEA) was combined with an on-line filtration system for underway analysis of nitrate and nitrite in saline samples. Vanadium chloride was used instead of a toxic cadmium column to reduce nitrate to nitrite, which was measured on the basis of the classic Griess reaction. This fully automated analyzer had a limit of detection of 0.02 μmol L−1 for nitrite and 0.14 μmol L−1 for nitrate. The sample throughput was 12 h−1 for simultaneous measurement of nitrite and nitrate. With automated dilution, the calibration curve for nitrate was linear up to a concentration of 400 μmol L−1 (R2 > 0.999). The relative standard deviation of 24-h measurement (n = 288) of nitrite is 0.92% and that of nitrate is 1.4%. Both the reference solutions and samples of different salinities (range of 0–35) were measured (n = 85). According to the statistical t-test (P = 0.95), the results were insignificantly different from the results obtained using the reference method. After several cruise tests, the analyzer showed excellent spatial resolution for underway analysis of nitrite and nitrate in estuarine and coastal waters.
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high frequency underway analysis of ammonium in coastal waters using an integrated Syringe Pump based environmental water analyzer isea
Talanta, 2019Co-Authors: Yao Deng, Kunning Lin, Nengwang Chen, Jixin Chen, Huilin Shu, Yiong Jiang, Dongxing YuanAbstract:Abstract Accurate methods and related robust analytical instruments for sensitive shipboard determination of ammonium in coastal waters are highly desirable for both oceanographers and environmental scientists. In this study, a multipurpose integrated Syringe-Pump-based environmental-water analyzer (iSEA) was combined with an on-line filtration system for underway analysis of ammonium in coastal areas. The chemistry is based on a modified indophenol method using o-phenylphenol. The effects of reagent concentrations and sample temperatures were evaluated. The detection limit was 0.15 μM with a 3-cm Z-flow cell, and the linearity was as high as 200 μM. The relative standard deviations at different concentrations (2, 10, and 20 μM) were 2.2%, 0.33%, 0.32% (n = 11). For n = 288 and without any stoppage during repeated analysis for 24 h, the relative standard deviation was 0.85%. The sample throughput was 12 h−1. The effects of salinity and five organic nitrogen compounds were evaluated and showed no interference using the proposed protocol for ammonium analysis. Between results obtained by reference and the present methods, there were no significant differences in the measurements of reference materials and different aqueous samples (n = 51). The analyzers worked well in the transect of 420 km during 7 cruises. A total of 716 analyses were performed automatically on board, demonstrating the capability of iSEA in automated real-time mapping of ammonium distribution in a shipboard laboratory.
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automated Syringe Pump based flow batch analysis for spectrophotometric determination of trace hexavalent chromium in water samples
Microchemical Journal, 2019Co-Authors: Xiangyu Zhu, Yao Deng, Dongxing YuanAbstract:Abstract In this work, we established an automated spectrophotometric method for determining hexavalent chromium in water samples using an integrated Syringe Pump-based environmental water analyzer (iSEA) based on the classic 1,5‑diphenylcarbazide chemistry. The device was computer-controlled with programs written by LabVIEW. The effects of reagent concentration, sample salinity and foreign ion interferences were investigated. Standard solutions (GBW(E)081584-1) were used to test the accuracy of the method. When equipped with a 5 cm Z-shaped flow cell, the detection limit was 0.024 μM with sample throughput of >30 h−1. In order to meet the requirements for trace Cr(VI) determination, the system was modified with a 2.5 m liquid waveguide capillary cell (internal diameter of 0.55 mm). The sample consumption was
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development of an integrated Syringe Pump based environmental water analyzer isea and application of it for fully automated real time determination of ammonium in fresh water
Analytical Chemistry, 2018Co-Authors: Zhaoying Chen, Yiyong Jiang, Kunning Lin, Nengwang Chen, Jixin Chen, Bangqin Huang, Dongxing YuanAbstract:The development of a multipurpose integrated Syringe-Pump-based environmental-water analyzer ( iSEA) and its application for spectrophotometric determination of ammonium is presented. The iSEA consists of a mini-Syringe Pump equipped with a selection valve and laboratory-programmed software written by LabVIEW. The chemistry is based on a modified indophenol method using o-phenylphenol. The effect of reagent concentrations and sample temperatures was evaluated. This fully automated analyzer had a detection limit of 0.12 μM with sample throughput of 12 h-1. Relative standard deviations at different concentrations (0-20 μM) were 0.23-3.36% ( n = 3-11) and 1.0% ( n = 144, in 24 h of continuous measurement, ∼5 μM). Calibration curves were linear ( R2 = 0.9998) over the range of 0-20 and 0-70 μM for the detection at 700 and 600 nm, respectively. The iSEA was applied in continuous real-time monitoring of ammonium variations in a river for 24 h and 14 days. A total of 1802 samples were measured, and only 0.4% was outlier data (≥3 sigma residuals). Measurements of reference materials and different aqueous samples ( n = 26) showed no significant difference between results obtained by reference and present methods. The system is compact (18 cm × 22 cm × 24 cm), portable (4.8 kg), and robust (high-resolution real-time monitoring in harsh environments) and consumes a small amount of chemicals (20-30 μL/run) and sample/standards (2.9 mL/run).
M Weiss - One of the best experts on this subject based on the ideXlab platform.
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Pressurized bag Pump and Syringe Pump arterial flushing systems: an unrecognized hazard in neonates?
Intensive care medicine, 2002Co-Authors: Anita Cornelius, Joachim E Fischer, Oskar Baenziger, Bernhard Frey, Andreas C. Gerber, M WeissAbstract:Abstract Objective. Hand-held flushing of radial arterial lines at 0.5 ml/s in neonates can result in retrograde embolization of flush solution into the central arterial circulation. We studied flush flow velocities during intermittent arterial line purging using a flow regulating device with an infusion bag Pump and a Syringe Pump system. Measurements and interventions. In this in vitro experiment we simulated flushing of a 24- and a 22-G cannula against a mean arterial pressure of 45 mmHg. Fluid flow velocities were gravimetrically measured during flushing from an infusion bag system pressurized to 100, 200, and 300 mmHg and from a Syringe Pump flush system after initialization of boluses of 0.5, 1.0, 1.5, 2.0, and 2.5 ml. The flow regulating device was opened for 1, 2, and 5 s. Results. Both flush systems tested allowed delivery of flush flow velocities exceeding 0.5 ml/s (e.g., 22-G cannula; bag system, pressure 300 mmHg up to 0.64±0.08 ml/s; Syringe Pump, 2 ml bolus up to 0.74±0.05 ml/s). In Syringe Pump systems the main determinant of flow velocity was bolus size, in bag Pump systems flushing time and bag pressure. Conclusions. Based on data about critical flow velocities through an radial arterial cannula in neonates, both tested flushing systems carry the risk of exceeding the critical value of 0.5 ml/s. They are likely to cause retrograde embolization of flushing solution into the central arterial circulation with the associated risk of clot and air embolization. In vivo studies should identify margins of safety to minimize the risk of retrograde flushing into the central arterial circulation.
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infusion Pump performance with vertical displacement effect of Syringe Pump and assembly type
Intensive Care Medicine, 2001Co-Authors: Thomas Neff, Joachim E Fischer, Gabriele Schulz, Oskar Baenziger, M WeissAbstract:Objective: To evaluate the effect of different infusion Pump models on continuity of drug delivery during vertical displacement of Syringe Pumps. Design: Zero-drug delivery time (ZDDT), retrograde aspiration volume, and infusion bolus were recorded using the same Syringe in three different models of Syringe Pump after lowering and elevating the Pump. Compliance of each infusion assembly was measured using the occlusion release technique at 38 mmHg. Results: Lowering the Pump by 50 cm at an infusion rate of 1 ml/h resulted in ZDDT values ranging from 2.78±0.29 to 5.99±1.09 min. Elevating the Syringe Pump to its original position caused infusion boluses between 44.1±3.2 and 77.1±5.1 µl. The results demonstrated that there are large differences between Syringe Pump models (F=66.8, df=2/33, p<0.0001) and between Pumps of the same model (F=21.3, df=1/34, p<0.0001). A similar pattern was found in retrograde aspiration volume and infusion bolus. Conclusion: All tested Pumps led to clinically relevant flow irregularities during vertical displacement of the Syringe Pump. Thus, vertical displacement of any Syringe Pump connected to an infusion line delivering highly potent drugs at low infusion rates should be avoided. The variability across Syringe Pumps indicates that Syringe Pump design remains an area of potential further improvement for reducing the risk of adverse patient events.
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infusion Pump performance with vertical displacement effect of Syringe Pump and assembly type
Intensive Care Medicine, 2001Co-Authors: Thomas Neff, Joachim E Fischer, Gabriele Schulz, Oskar Baenziger, M WeissAbstract:Objective: To evaluate the effect of different infusion Pump models on continuity of drug delivery during vertical displacement of Syringe Pumps. Design: Zero-drug delivery time (ZDDT), retrograde aspiration volume, and infusion bolus were recorded using the same Syringe in three different models of Syringe Pump after lowering and elevating the Pump. Compliance of each infusion assembly was measured using the occlusion release technique at 38 mmHg. Results: Lowering the Pump by 50 cm at an infusion rate of 1 ml/h resulted in ZDDT values ranging from 2.78±0.29 to 5.99±1.09 min. Elevating the Syringe Pump to its original position caused infusion boluses between 44.1±3.2 and 77.1±5.1 µl. The results demonstrated that there are large differences between Syringe Pump models (F=66.8, df=2/33, p<0.0001) and between Pumps of the same model (F=21.3, df=1/34, p<0.0001). A similar pattern was found in retrograde aspiration volume and infusion bolus. Conclusion: All tested Pumps led to clinically relevant flow irregularities during vertical displacement of the Syringe Pump. Thus, vertical displacement of any Syringe Pump connected to an infusion line delivering highly potent drugs at low infusion rates should be avoided. The variability across Syringe Pumps indicates that Syringe Pump design remains an area of potential further improvement for reducing the risk of adverse patient events.
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Infusion Pump performance with vertical displacement: effect of Syringe Pump and assembly type
Intensive care medicine, 2000Co-Authors: Thomas Neff, Joachim E Fischer, Gabriele Schulz, Oskar Baenziger, M WeissAbstract:Objective: To evaluate the effect of different infusion Pump models on continuity of drug delivery during vertical displacement of Syringe Pumps. Design: Zero-drug delivery time (ZDDT), retrograde aspiration volume, and infusion bolus were recorded using the same Syringe in three different models of Syringe Pump after lowering and elevating the Pump. Compliance of each infusion assembly was measured using the occlusion release technique at 38 mmHg. Results: Lowering the Pump by 50 cm at an infusion rate of 1 ml/h resulted in ZDDT values ranging from 2.78±0.29 to 5.99±1.09 min. Elevating the Syringe Pump to its original position caused infusion boluses between 44.1±3.2 and 77.1±5.1 µl. The results demonstrated that there are large differences between Syringe Pump models (F=66.8, df=2/33, p
Thomas Neff - One of the best experts on this subject based on the ideXlab platform.
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infusion Pump performance with vertical displacement effect of Syringe Pump and assembly type
Intensive Care Medicine, 2001Co-Authors: Thomas Neff, Joachim E Fischer, Gabriele Schulz, Oskar Baenziger, M WeissAbstract:Objective: To evaluate the effect of different infusion Pump models on continuity of drug delivery during vertical displacement of Syringe Pumps. Design: Zero-drug delivery time (ZDDT), retrograde aspiration volume, and infusion bolus were recorded using the same Syringe in three different models of Syringe Pump after lowering and elevating the Pump. Compliance of each infusion assembly was measured using the occlusion release technique at 38 mmHg. Results: Lowering the Pump by 50 cm at an infusion rate of 1 ml/h resulted in ZDDT values ranging from 2.78±0.29 to 5.99±1.09 min. Elevating the Syringe Pump to its original position caused infusion boluses between 44.1±3.2 and 77.1±5.1 µl. The results demonstrated that there are large differences between Syringe Pump models (F=66.8, df=2/33, p<0.0001) and between Pumps of the same model (F=21.3, df=1/34, p<0.0001). A similar pattern was found in retrograde aspiration volume and infusion bolus. Conclusion: All tested Pumps led to clinically relevant flow irregularities during vertical displacement of the Syringe Pump. Thus, vertical displacement of any Syringe Pump connected to an infusion line delivering highly potent drugs at low infusion rates should be avoided. The variability across Syringe Pumps indicates that Syringe Pump design remains an area of potential further improvement for reducing the risk of adverse patient events.
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infusion Pump performance with vertical displacement effect of Syringe Pump and assembly type
Intensive Care Medicine, 2001Co-Authors: Thomas Neff, Joachim E Fischer, Gabriele Schulz, Oskar Baenziger, M WeissAbstract:Objective: To evaluate the effect of different infusion Pump models on continuity of drug delivery during vertical displacement of Syringe Pumps. Design: Zero-drug delivery time (ZDDT), retrograde aspiration volume, and infusion bolus were recorded using the same Syringe in three different models of Syringe Pump after lowering and elevating the Pump. Compliance of each infusion assembly was measured using the occlusion release technique at 38 mmHg. Results: Lowering the Pump by 50 cm at an infusion rate of 1 ml/h resulted in ZDDT values ranging from 2.78±0.29 to 5.99±1.09 min. Elevating the Syringe Pump to its original position caused infusion boluses between 44.1±3.2 and 77.1±5.1 µl. The results demonstrated that there are large differences between Syringe Pump models (F=66.8, df=2/33, p<0.0001) and between Pumps of the same model (F=21.3, df=1/34, p<0.0001). A similar pattern was found in retrograde aspiration volume and infusion bolus. Conclusion: All tested Pumps led to clinically relevant flow irregularities during vertical displacement of the Syringe Pump. Thus, vertical displacement of any Syringe Pump connected to an infusion line delivering highly potent drugs at low infusion rates should be avoided. The variability across Syringe Pumps indicates that Syringe Pump design remains an area of potential further improvement for reducing the risk of adverse patient events.
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Infusion Pump performance with vertical displacement: effect of Syringe Pump and assembly type
Intensive care medicine, 2000Co-Authors: Thomas Neff, Joachim E Fischer, Gabriele Schulz, Oskar Baenziger, M WeissAbstract:Objective: To evaluate the effect of different infusion Pump models on continuity of drug delivery during vertical displacement of Syringe Pumps. Design: Zero-drug delivery time (ZDDT), retrograde aspiration volume, and infusion bolus were recorded using the same Syringe in three different models of Syringe Pump after lowering and elevating the Pump. Compliance of each infusion assembly was measured using the occlusion release technique at 38 mmHg. Results: Lowering the Pump by 50 cm at an infusion rate of 1 ml/h resulted in ZDDT values ranging from 2.78±0.29 to 5.99±1.09 min. Elevating the Syringe Pump to its original position caused infusion boluses between 44.1±3.2 and 77.1±5.1 µl. The results demonstrated that there are large differences between Syringe Pump models (F=66.8, df=2/33, p
Oskar Baenziger - One of the best experts on this subject based on the ideXlab platform.
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Pressurized bag Pump and Syringe Pump arterial flushing systems: an unrecognized hazard in neonates?
Intensive care medicine, 2002Co-Authors: Anita Cornelius, Joachim E Fischer, Oskar Baenziger, Bernhard Frey, Andreas C. Gerber, M WeissAbstract:Abstract Objective. Hand-held flushing of radial arterial lines at 0.5 ml/s in neonates can result in retrograde embolization of flush solution into the central arterial circulation. We studied flush flow velocities during intermittent arterial line purging using a flow regulating device with an infusion bag Pump and a Syringe Pump system. Measurements and interventions. In this in vitro experiment we simulated flushing of a 24- and a 22-G cannula against a mean arterial pressure of 45 mmHg. Fluid flow velocities were gravimetrically measured during flushing from an infusion bag system pressurized to 100, 200, and 300 mmHg and from a Syringe Pump flush system after initialization of boluses of 0.5, 1.0, 1.5, 2.0, and 2.5 ml. The flow regulating device was opened for 1, 2, and 5 s. Results. Both flush systems tested allowed delivery of flush flow velocities exceeding 0.5 ml/s (e.g., 22-G cannula; bag system, pressure 300 mmHg up to 0.64±0.08 ml/s; Syringe Pump, 2 ml bolus up to 0.74±0.05 ml/s). In Syringe Pump systems the main determinant of flow velocity was bolus size, in bag Pump systems flushing time and bag pressure. Conclusions. Based on data about critical flow velocities through an radial arterial cannula in neonates, both tested flushing systems carry the risk of exceeding the critical value of 0.5 ml/s. They are likely to cause retrograde embolization of flushing solution into the central arterial circulation with the associated risk of clot and air embolization. In vivo studies should identify margins of safety to minimize the risk of retrograde flushing into the central arterial circulation.
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infusion Pump performance with vertical displacement effect of Syringe Pump and assembly type
Intensive Care Medicine, 2001Co-Authors: Thomas Neff, Joachim E Fischer, Gabriele Schulz, Oskar Baenziger, M WeissAbstract:Objective: To evaluate the effect of different infusion Pump models on continuity of drug delivery during vertical displacement of Syringe Pumps. Design: Zero-drug delivery time (ZDDT), retrograde aspiration volume, and infusion bolus were recorded using the same Syringe in three different models of Syringe Pump after lowering and elevating the Pump. Compliance of each infusion assembly was measured using the occlusion release technique at 38 mmHg. Results: Lowering the Pump by 50 cm at an infusion rate of 1 ml/h resulted in ZDDT values ranging from 2.78±0.29 to 5.99±1.09 min. Elevating the Syringe Pump to its original position caused infusion boluses between 44.1±3.2 and 77.1±5.1 µl. The results demonstrated that there are large differences between Syringe Pump models (F=66.8, df=2/33, p<0.0001) and between Pumps of the same model (F=21.3, df=1/34, p<0.0001). A similar pattern was found in retrograde aspiration volume and infusion bolus. Conclusion: All tested Pumps led to clinically relevant flow irregularities during vertical displacement of the Syringe Pump. Thus, vertical displacement of any Syringe Pump connected to an infusion line delivering highly potent drugs at low infusion rates should be avoided. The variability across Syringe Pumps indicates that Syringe Pump design remains an area of potential further improvement for reducing the risk of adverse patient events.
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infusion Pump performance with vertical displacement effect of Syringe Pump and assembly type
Intensive Care Medicine, 2001Co-Authors: Thomas Neff, Joachim E Fischer, Gabriele Schulz, Oskar Baenziger, M WeissAbstract:Objective: To evaluate the effect of different infusion Pump models on continuity of drug delivery during vertical displacement of Syringe Pumps. Design: Zero-drug delivery time (ZDDT), retrograde aspiration volume, and infusion bolus were recorded using the same Syringe in three different models of Syringe Pump after lowering and elevating the Pump. Compliance of each infusion assembly was measured using the occlusion release technique at 38 mmHg. Results: Lowering the Pump by 50 cm at an infusion rate of 1 ml/h resulted in ZDDT values ranging from 2.78±0.29 to 5.99±1.09 min. Elevating the Syringe Pump to its original position caused infusion boluses between 44.1±3.2 and 77.1±5.1 µl. The results demonstrated that there are large differences between Syringe Pump models (F=66.8, df=2/33, p<0.0001) and between Pumps of the same model (F=21.3, df=1/34, p<0.0001). A similar pattern was found in retrograde aspiration volume and infusion bolus. Conclusion: All tested Pumps led to clinically relevant flow irregularities during vertical displacement of the Syringe Pump. Thus, vertical displacement of any Syringe Pump connected to an infusion line delivering highly potent drugs at low infusion rates should be avoided. The variability across Syringe Pumps indicates that Syringe Pump design remains an area of potential further improvement for reducing the risk of adverse patient events.
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Infusion Pump performance with vertical displacement: effect of Syringe Pump and assembly type
Intensive care medicine, 2000Co-Authors: Thomas Neff, Joachim E Fischer, Gabriele Schulz, Oskar Baenziger, M WeissAbstract:Objective: To evaluate the effect of different infusion Pump models on continuity of drug delivery during vertical displacement of Syringe Pumps. Design: Zero-drug delivery time (ZDDT), retrograde aspiration volume, and infusion bolus were recorded using the same Syringe in three different models of Syringe Pump after lowering and elevating the Pump. Compliance of each infusion assembly was measured using the occlusion release technique at 38 mmHg. Results: Lowering the Pump by 50 cm at an infusion rate of 1 ml/h resulted in ZDDT values ranging from 2.78±0.29 to 5.99±1.09 min. Elevating the Syringe Pump to its original position caused infusion boluses between 44.1±3.2 and 77.1±5.1 µl. The results demonstrated that there are large differences between Syringe Pump models (F=66.8, df=2/33, p
Joachim E Fischer - One of the best experts on this subject based on the ideXlab platform.
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Pressurized bag Pump and Syringe Pump arterial flushing systems: an unrecognized hazard in neonates?
Intensive care medicine, 2002Co-Authors: Anita Cornelius, Joachim E Fischer, Oskar Baenziger, Bernhard Frey, Andreas C. Gerber, M WeissAbstract:Abstract Objective. Hand-held flushing of radial arterial lines at 0.5 ml/s in neonates can result in retrograde embolization of flush solution into the central arterial circulation. We studied flush flow velocities during intermittent arterial line purging using a flow regulating device with an infusion bag Pump and a Syringe Pump system. Measurements and interventions. In this in vitro experiment we simulated flushing of a 24- and a 22-G cannula against a mean arterial pressure of 45 mmHg. Fluid flow velocities were gravimetrically measured during flushing from an infusion bag system pressurized to 100, 200, and 300 mmHg and from a Syringe Pump flush system after initialization of boluses of 0.5, 1.0, 1.5, 2.0, and 2.5 ml. The flow regulating device was opened for 1, 2, and 5 s. Results. Both flush systems tested allowed delivery of flush flow velocities exceeding 0.5 ml/s (e.g., 22-G cannula; bag system, pressure 300 mmHg up to 0.64±0.08 ml/s; Syringe Pump, 2 ml bolus up to 0.74±0.05 ml/s). In Syringe Pump systems the main determinant of flow velocity was bolus size, in bag Pump systems flushing time and bag pressure. Conclusions. Based on data about critical flow velocities through an radial arterial cannula in neonates, both tested flushing systems carry the risk of exceeding the critical value of 0.5 ml/s. They are likely to cause retrograde embolization of flushing solution into the central arterial circulation with the associated risk of clot and air embolization. In vivo studies should identify margins of safety to minimize the risk of retrograde flushing into the central arterial circulation.
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infusion Pump performance with vertical displacement effect of Syringe Pump and assembly type
Intensive Care Medicine, 2001Co-Authors: Thomas Neff, Joachim E Fischer, Gabriele Schulz, Oskar Baenziger, M WeissAbstract:Objective: To evaluate the effect of different infusion Pump models on continuity of drug delivery during vertical displacement of Syringe Pumps. Design: Zero-drug delivery time (ZDDT), retrograde aspiration volume, and infusion bolus were recorded using the same Syringe in three different models of Syringe Pump after lowering and elevating the Pump. Compliance of each infusion assembly was measured using the occlusion release technique at 38 mmHg. Results: Lowering the Pump by 50 cm at an infusion rate of 1 ml/h resulted in ZDDT values ranging from 2.78±0.29 to 5.99±1.09 min. Elevating the Syringe Pump to its original position caused infusion boluses between 44.1±3.2 and 77.1±5.1 µl. The results demonstrated that there are large differences between Syringe Pump models (F=66.8, df=2/33, p<0.0001) and between Pumps of the same model (F=21.3, df=1/34, p<0.0001). A similar pattern was found in retrograde aspiration volume and infusion bolus. Conclusion: All tested Pumps led to clinically relevant flow irregularities during vertical displacement of the Syringe Pump. Thus, vertical displacement of any Syringe Pump connected to an infusion line delivering highly potent drugs at low infusion rates should be avoided. The variability across Syringe Pumps indicates that Syringe Pump design remains an area of potential further improvement for reducing the risk of adverse patient events.
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infusion Pump performance with vertical displacement effect of Syringe Pump and assembly type
Intensive Care Medicine, 2001Co-Authors: Thomas Neff, Joachim E Fischer, Gabriele Schulz, Oskar Baenziger, M WeissAbstract:Objective: To evaluate the effect of different infusion Pump models on continuity of drug delivery during vertical displacement of Syringe Pumps. Design: Zero-drug delivery time (ZDDT), retrograde aspiration volume, and infusion bolus were recorded using the same Syringe in three different models of Syringe Pump after lowering and elevating the Pump. Compliance of each infusion assembly was measured using the occlusion release technique at 38 mmHg. Results: Lowering the Pump by 50 cm at an infusion rate of 1 ml/h resulted in ZDDT values ranging from 2.78±0.29 to 5.99±1.09 min. Elevating the Syringe Pump to its original position caused infusion boluses between 44.1±3.2 and 77.1±5.1 µl. The results demonstrated that there are large differences between Syringe Pump models (F=66.8, df=2/33, p<0.0001) and between Pumps of the same model (F=21.3, df=1/34, p<0.0001). A similar pattern was found in retrograde aspiration volume and infusion bolus. Conclusion: All tested Pumps led to clinically relevant flow irregularities during vertical displacement of the Syringe Pump. Thus, vertical displacement of any Syringe Pump connected to an infusion line delivering highly potent drugs at low infusion rates should be avoided. The variability across Syringe Pumps indicates that Syringe Pump design remains an area of potential further improvement for reducing the risk of adverse patient events.
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Infusion Pump performance with vertical displacement: effect of Syringe Pump and assembly type
Intensive care medicine, 2000Co-Authors: Thomas Neff, Joachim E Fischer, Gabriele Schulz, Oskar Baenziger, M WeissAbstract:Objective: To evaluate the effect of different infusion Pump models on continuity of drug delivery during vertical displacement of Syringe Pumps. Design: Zero-drug delivery time (ZDDT), retrograde aspiration volume, and infusion bolus were recorded using the same Syringe in three different models of Syringe Pump after lowering and elevating the Pump. Compliance of each infusion assembly was measured using the occlusion release technique at 38 mmHg. Results: Lowering the Pump by 50 cm at an infusion rate of 1 ml/h resulted in ZDDT values ranging from 2.78±0.29 to 5.99±1.09 min. Elevating the Syringe Pump to its original position caused infusion boluses between 44.1±3.2 and 77.1±5.1 µl. The results demonstrated that there are large differences between Syringe Pump models (F=66.8, df=2/33, p
