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Gregg C Fonarow - One of the best experts on this subject based on the ideXlab platform.
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clinical presentation management and in hospital outcomes of patients admitted with acute decompensated heart failure with preserved Systolic Function a report from the acute decompensated heart failure national registry adhere database
Journal of the American College of Cardiology, 2006Co-Authors: Clyde W Yancy, Margarita Lopatin, Lynne W Stevenson, Teresa De Marco, Gregg C FonarowAbstract:Clinical Presentation, Management, and In-Hospital Outcomes of Patients Admitted With Acute Decompensated Heart Failure With Preserved Systolic Function: A Report From the Acute Decompensated Heart...
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clinical presentation management and in hospital outcomes of patients admitted with acute decompensated heart failure with preserved Systolic Function a report from the acute decompensated heart failure national registry adhere database
Journal of the American College of Cardiology, 2006Co-Authors: Clyde W Yancy, Margarita Lopatin, Lynne W Stevenson, Teresa De Marco, Gregg C FonarowAbstract:Clinical Presentation, Management, and In-Hospital Outcomes of Patients Admitted With Acute Decompensated Heart Failure With Preserved Systolic Function: A Report From the Acute Decompensated Heart Failure National Registry (ADHERE) Database Clyde W. Yancy, Margarita Lopatin, Lynne Warner Stevenson, Teresa De Marco, Gregg C. Fonarow, for the ADHERE Scientific Advisory Committee and Investigators Approximately 50% of patients hospitalized for heart failure have preserved Systolic Function. These patients are more likely to be older, women, and hypertensive. Their duration of hospitalization is similar to that of heart failure patients with Systolic dysFunction, but their in-hospital mortality risk is lower. This mortality risk is increased in the setting of renal insufficiency, and the two most important risk predictors are elevated blood urea nitrogen and Systolic blood pressure ≤125 mm Hg. Medical treatment strategies for patients with preserved Systolic Function are inconsistent and reflect the need for efficacious evidence-based treatment regimens. Objectives The aims of this analysis were to describe the clinical characteristics, management, and outcomes of patients hospitalized for acute decompensated heart failure (HF) with preserved Systolic Function (PSF). Background Clinically meaningful characteristics of these patients have not been fully studied in a large database. Methods Data from >100,000 hospitalizations from the Acute Decompensated Heart Failure National Registry (ADHERE) database were analyzed. Results Heart failure with PSF was present in 50.4% of patients with in-hospital assessment of left ventricular Function. When compared with patients with Systolic dysFunction, patients with PSF were more likely to be older, women, and hypertensive and less likely to have had a prior myocardial infarction or be receiving an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker. In-hospital mortality was lower in patients with PSF compared with patients with Systolic dysFunction (2.8% vs. 3.9%; adjusted odds ratio [OR]: 0.86; p = 0.005), but duration of intensive care unit stay and total hospital length of stay were similar. Serum creatinine >2 mg/dl was associated with increased in-hospital mortality in both Systolic Function groups (PSF: 4.8%; Systolic dysFunction: 8.4%; p 37 mg/dl (OR: 2.53; 95% confidence interval [CI]: 2.22 to 2.87) and Systolic blood pressure ≤125 mm Hg (OR: 2.58; 95% CI: 2.33 to 2.86). Conclusions Heart failure with PSF is common and is characterized by a unique patient profile. Event rates are worrisome and reflect a need for more effective management strategies.
Eva Gerdts - One of the best experts on this subject based on the ideXlab platform.
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low flow aortic stenosis in asymptomatic patients valvular arterial impedance and Systolic Function from the seas substudy
Jacc-cardiovascular Imaging, 2009Co-Authors: Dana Cramariuc, Giovanni Cioffi, Ashild E Rieck, Richard B Devereux, Eva M Staal, Simon Ray, Kristian Wachtell, Eva GerdtsAbstract:Low-Flow Aortic Stenosis in Asymptomatic Patients: Valvular–Arterial Impedance and Systolic Function From the SEAS SubstudyDana Cramariuc, Giovanni Cioffi, Ashild E. Rieck, Richard B. Devereux, Eva...
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low flow aortic stenosis in asymptomatic patients valvular arterial impedance and Systolic Function from the seas substudy
Jacc-cardiovascular Imaging, 2009Co-Authors: Dana Cramariuc, Giovanni Cioffi, Ashild E Rieck, Richard B Devereux, Eva M Staal, Kristian Wachtell, Eva GerdtsAbstract:Objectives This study sought to assess the impact of valvuloarterial impedance on left ventricular (LV) myocardial Systolic Function in asymptomatic aortic valve stenosis (AS). Background In atherosclerotic AS, LV global load consists of combined valvular and arterial resistance to LV ejection. Global load significantly impacts LV ejection fraction (EF) in symptomatic AS, but less is known about its effect on LV myocardial Function in asymptomatic AS. Methods Echocardiograms in 1,591 patients with asymptomatic AS (67 ± 10 years, 51% hypertensive) at baseline in the SEAS (Simvastatin Ezetimibe in Aortic Stenosis) study evaluating placebo-controlled combined simvastatin and ezetimibe treatment in AS were used to assess LV global load as valvuloarterial impedance and LV myocardial Function as stress-corrected midwall shortening. The study population was divided into tertiles of global load. Stress-corrected midwall shortening was considered low if 2.04 . Results Energy loss index decreased (0.85 cm 2 /m 2 vs. 0.77 and 0.75 cm 2 /m 2 ) and the prevalence of low stress-corrected midwall shortening increased (10% vs. 26% and 63%) with increasing LV global load (all p 2.04 and 77%, vs. 6.38 ± 2.04 mm Hg/ml·m 2.04 and 30%, respectively, p Conclusions LV global load impacts LV myocardial Function in asymptomatic AS independent of other main covariates of LV Systolic Function. LV myocardial Systolic dysFunction is common in asymptomatic AS in particular in patients with low-flow AS and increased valvuloarterial afterload, whereas EF is generally preserved. (An Investigational Drug on Clinical Outcomes in Patients With Aortic Stenosis [Narrowing of the Major Blood Vessel of the Heart]; NCT00092677 )
Clyde W Yancy - One of the best experts on this subject based on the ideXlab platform.
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clinical presentation management and in hospital outcomes of patients admitted with acute decompensated heart failure with preserved Systolic Function a report from the acute decompensated heart failure national registry adhere database
Journal of the American College of Cardiology, 2006Co-Authors: Clyde W Yancy, Margarita Lopatin, Lynne W Stevenson, Teresa De Marco, Gregg C FonarowAbstract:Clinical Presentation, Management, and In-Hospital Outcomes of Patients Admitted With Acute Decompensated Heart Failure With Preserved Systolic Function: A Report From the Acute Decompensated Heart...
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clinical presentation management and in hospital outcomes of patients admitted with acute decompensated heart failure with preserved Systolic Function a report from the acute decompensated heart failure national registry adhere database
Journal of the American College of Cardiology, 2006Co-Authors: Clyde W Yancy, Margarita Lopatin, Lynne W Stevenson, Teresa De Marco, Gregg C FonarowAbstract:Clinical Presentation, Management, and In-Hospital Outcomes of Patients Admitted With Acute Decompensated Heart Failure With Preserved Systolic Function: A Report From the Acute Decompensated Heart Failure National Registry (ADHERE) Database Clyde W. Yancy, Margarita Lopatin, Lynne Warner Stevenson, Teresa De Marco, Gregg C. Fonarow, for the ADHERE Scientific Advisory Committee and Investigators Approximately 50% of patients hospitalized for heart failure have preserved Systolic Function. These patients are more likely to be older, women, and hypertensive. Their duration of hospitalization is similar to that of heart failure patients with Systolic dysFunction, but their in-hospital mortality risk is lower. This mortality risk is increased in the setting of renal insufficiency, and the two most important risk predictors are elevated blood urea nitrogen and Systolic blood pressure ≤125 mm Hg. Medical treatment strategies for patients with preserved Systolic Function are inconsistent and reflect the need for efficacious evidence-based treatment regimens. Objectives The aims of this analysis were to describe the clinical characteristics, management, and outcomes of patients hospitalized for acute decompensated heart failure (HF) with preserved Systolic Function (PSF). Background Clinically meaningful characteristics of these patients have not been fully studied in a large database. Methods Data from >100,000 hospitalizations from the Acute Decompensated Heart Failure National Registry (ADHERE) database were analyzed. Results Heart failure with PSF was present in 50.4% of patients with in-hospital assessment of left ventricular Function. When compared with patients with Systolic dysFunction, patients with PSF were more likely to be older, women, and hypertensive and less likely to have had a prior myocardial infarction or be receiving an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker. In-hospital mortality was lower in patients with PSF compared with patients with Systolic dysFunction (2.8% vs. 3.9%; adjusted odds ratio [OR]: 0.86; p = 0.005), but duration of intensive care unit stay and total hospital length of stay were similar. Serum creatinine >2 mg/dl was associated with increased in-hospital mortality in both Systolic Function groups (PSF: 4.8%; Systolic dysFunction: 8.4%; p 37 mg/dl (OR: 2.53; 95% confidence interval [CI]: 2.22 to 2.87) and Systolic blood pressure ≤125 mm Hg (OR: 2.58; 95% CI: 2.33 to 2.86). Conclusions Heart failure with PSF is common and is characterized by a unique patient profile. Event rates are worrisome and reflect a need for more effective management strategies.
Teresa De Marco - One of the best experts on this subject based on the ideXlab platform.
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clinical presentation management and in hospital outcomes of patients admitted with acute decompensated heart failure with preserved Systolic Function a report from the acute decompensated heart failure national registry adhere database
Journal of the American College of Cardiology, 2006Co-Authors: Clyde W Yancy, Margarita Lopatin, Lynne W Stevenson, Teresa De Marco, Gregg C FonarowAbstract:Clinical Presentation, Management, and In-Hospital Outcomes of Patients Admitted With Acute Decompensated Heart Failure With Preserved Systolic Function: A Report From the Acute Decompensated Heart...
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clinical presentation management and in hospital outcomes of patients admitted with acute decompensated heart failure with preserved Systolic Function a report from the acute decompensated heart failure national registry adhere database
Journal of the American College of Cardiology, 2006Co-Authors: Clyde W Yancy, Margarita Lopatin, Lynne W Stevenson, Teresa De Marco, Gregg C FonarowAbstract:Clinical Presentation, Management, and In-Hospital Outcomes of Patients Admitted With Acute Decompensated Heart Failure With Preserved Systolic Function: A Report From the Acute Decompensated Heart Failure National Registry (ADHERE) Database Clyde W. Yancy, Margarita Lopatin, Lynne Warner Stevenson, Teresa De Marco, Gregg C. Fonarow, for the ADHERE Scientific Advisory Committee and Investigators Approximately 50% of patients hospitalized for heart failure have preserved Systolic Function. These patients are more likely to be older, women, and hypertensive. Their duration of hospitalization is similar to that of heart failure patients with Systolic dysFunction, but their in-hospital mortality risk is lower. This mortality risk is increased in the setting of renal insufficiency, and the two most important risk predictors are elevated blood urea nitrogen and Systolic blood pressure ≤125 mm Hg. Medical treatment strategies for patients with preserved Systolic Function are inconsistent and reflect the need for efficacious evidence-based treatment regimens. Objectives The aims of this analysis were to describe the clinical characteristics, management, and outcomes of patients hospitalized for acute decompensated heart failure (HF) with preserved Systolic Function (PSF). Background Clinically meaningful characteristics of these patients have not been fully studied in a large database. Methods Data from >100,000 hospitalizations from the Acute Decompensated Heart Failure National Registry (ADHERE) database were analyzed. Results Heart failure with PSF was present in 50.4% of patients with in-hospital assessment of left ventricular Function. When compared with patients with Systolic dysFunction, patients with PSF were more likely to be older, women, and hypertensive and less likely to have had a prior myocardial infarction or be receiving an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker. In-hospital mortality was lower in patients with PSF compared with patients with Systolic dysFunction (2.8% vs. 3.9%; adjusted odds ratio [OR]: 0.86; p = 0.005), but duration of intensive care unit stay and total hospital length of stay were similar. Serum creatinine >2 mg/dl was associated with increased in-hospital mortality in both Systolic Function groups (PSF: 4.8%; Systolic dysFunction: 8.4%; p 37 mg/dl (OR: 2.53; 95% confidence interval [CI]: 2.22 to 2.87) and Systolic blood pressure ≤125 mm Hg (OR: 2.58; 95% CI: 2.33 to 2.86). Conclusions Heart failure with PSF is common and is characterized by a unique patient profile. Event rates are worrisome and reflect a need for more effective management strategies.
Lynne W Stevenson - One of the best experts on this subject based on the ideXlab platform.
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clinical presentation management and in hospital outcomes of patients admitted with acute decompensated heart failure with preserved Systolic Function a report from the acute decompensated heart failure national registry adhere database
Journal of the American College of Cardiology, 2006Co-Authors: Clyde W Yancy, Margarita Lopatin, Lynne W Stevenson, Teresa De Marco, Gregg C FonarowAbstract:Clinical Presentation, Management, and In-Hospital Outcomes of Patients Admitted With Acute Decompensated Heart Failure With Preserved Systolic Function: A Report From the Acute Decompensated Heart...
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clinical presentation management and in hospital outcomes of patients admitted with acute decompensated heart failure with preserved Systolic Function a report from the acute decompensated heart failure national registry adhere database
Journal of the American College of Cardiology, 2006Co-Authors: Clyde W Yancy, Margarita Lopatin, Lynne W Stevenson, Teresa De Marco, Gregg C FonarowAbstract:Clinical Presentation, Management, and In-Hospital Outcomes of Patients Admitted With Acute Decompensated Heart Failure With Preserved Systolic Function: A Report From the Acute Decompensated Heart Failure National Registry (ADHERE) Database Clyde W. Yancy, Margarita Lopatin, Lynne Warner Stevenson, Teresa De Marco, Gregg C. Fonarow, for the ADHERE Scientific Advisory Committee and Investigators Approximately 50% of patients hospitalized for heart failure have preserved Systolic Function. These patients are more likely to be older, women, and hypertensive. Their duration of hospitalization is similar to that of heart failure patients with Systolic dysFunction, but their in-hospital mortality risk is lower. This mortality risk is increased in the setting of renal insufficiency, and the two most important risk predictors are elevated blood urea nitrogen and Systolic blood pressure ≤125 mm Hg. Medical treatment strategies for patients with preserved Systolic Function are inconsistent and reflect the need for efficacious evidence-based treatment regimens. Objectives The aims of this analysis were to describe the clinical characteristics, management, and outcomes of patients hospitalized for acute decompensated heart failure (HF) with preserved Systolic Function (PSF). Background Clinically meaningful characteristics of these patients have not been fully studied in a large database. Methods Data from >100,000 hospitalizations from the Acute Decompensated Heart Failure National Registry (ADHERE) database were analyzed. Results Heart failure with PSF was present in 50.4% of patients with in-hospital assessment of left ventricular Function. When compared with patients with Systolic dysFunction, patients with PSF were more likely to be older, women, and hypertensive and less likely to have had a prior myocardial infarction or be receiving an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker. In-hospital mortality was lower in patients with PSF compared with patients with Systolic dysFunction (2.8% vs. 3.9%; adjusted odds ratio [OR]: 0.86; p = 0.005), but duration of intensive care unit stay and total hospital length of stay were similar. Serum creatinine >2 mg/dl was associated with increased in-hospital mortality in both Systolic Function groups (PSF: 4.8%; Systolic dysFunction: 8.4%; p 37 mg/dl (OR: 2.53; 95% confidence interval [CI]: 2.22 to 2.87) and Systolic blood pressure ≤125 mm Hg (OR: 2.58; 95% CI: 2.33 to 2.86). Conclusions Heart failure with PSF is common and is characterized by a unique patient profile. Event rates are worrisome and reflect a need for more effective management strategies.
