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Christian L Boutwell - One of the best experts on this subject based on the ideXlab platform.
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innaTe immune reconsTiTuTion in humanized bone marrow liver Thymus hublT mice governs adapTive Cellular immune funcTion and responses To hiv 1 infecTion
Frontiers in Immunology, 2021Co-Authors: Wilfredo F Garciabeltran, Daniel T Claiborne, Colby R Maldini, Meredith Phelps, Vladimir Vrbanac, Marshall Karpel, Katharine Krupp, Karen A Power, Christian L BoutwellAbstract:Humanized bone marrow-liver-Thymus (HuBLT) mice have faciliTaTed The sTudy of human immune funcTion and human-resTricTed paThogens, including human immunodeficiency virus Type 1 (HIV-1). These mice noT only supporT robusT HIV-1 infecTion, buT also uniquely harbor long-Term in vivo developmenT of HLA-resTricTed human T Cells and recapiTulaTe many aspecTs of acuTe and chronic HIV-1 paThogenesis. However, HuBLT mice challenged wiTh HIV-1 exhibiT variable T-Cell responses across individual mice, hindering The abiliTy To confidenTly deTecT HIV-1–specific responses or vaccine-associaTed effecTs. To undersTand The source of This variabiliTy, we comprehensively analyzed T-Cell developmenT, diversiTy, and priming in HuBLT mice. We found ThaT while T-Cell diversiTy, Thymic developmenT, and differenTiaTion appeared inTacT in HuBLT mice, There was a defecT in T-Cell funcTion, polarizaTion, and priming ThaT correlaTed wiTh poor reconsTiTuTion of innaTe immune Cells, parTicularly monocyTes. While virTually all HuBLT mice were well-reconsTiTuTed wiTh T and B Cells, There was variable reconsTiTuTion of monocyTes ThaT posiTively correlaTed wiTh T-Cell funcTion as well as TH1 polarizaTion. MonocyTe reconsTiTuTion also posiTively correlaTed wiTh CD8+ T-Cell responses in vivo during acuTe HIV-1 infecTion and The selecTion of viral varianTs. Thus, despiTe proper T-Cell reconsTiTuTion, a deficiency in innaTe immune reconsTiTuTion in HuBLT mice hinders The developmenT of more robusT anTigen-specific T-Cell responses, which if improved would enhance The model’s abiliTy To beTTer recapiTulaTe human adapTive immuniTy.
Marshall Karpel - One of the best experts on this subject based on the ideXlab platform.
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innaTe immune reconsTiTuTion in humanized bone marrow liver Thymus hublT mice governs adapTive Cellular immune funcTion and responses To hiv 1 infecTion
Frontiers in Immunology, 2021Co-Authors: Wilfredo F Garciabeltran, Daniel T Claiborne, Colby R Maldini, Meredith Phelps, Vladimir Vrbanac, Marshall Karpel, Katharine Krupp, Karen A Power, Christian L BoutwellAbstract:Humanized bone marrow-liver-Thymus (HuBLT) mice have faciliTaTed The sTudy of human immune funcTion and human-resTricTed paThogens, including human immunodeficiency virus Type 1 (HIV-1). These mice noT only supporT robusT HIV-1 infecTion, buT also uniquely harbor long-Term in vivo developmenT of HLA-resTricTed human T Cells and recapiTulaTe many aspecTs of acuTe and chronic HIV-1 paThogenesis. However, HuBLT mice challenged wiTh HIV-1 exhibiT variable T-Cell responses across individual mice, hindering The abiliTy To confidenTly deTecT HIV-1–specific responses or vaccine-associaTed effecTs. To undersTand The source of This variabiliTy, we comprehensively analyzed T-Cell developmenT, diversiTy, and priming in HuBLT mice. We found ThaT while T-Cell diversiTy, Thymic developmenT, and differenTiaTion appeared inTacT in HuBLT mice, There was a defecT in T-Cell funcTion, polarizaTion, and priming ThaT correlaTed wiTh poor reconsTiTuTion of innaTe immune Cells, parTicularly monocyTes. While virTually all HuBLT mice were well-reconsTiTuTed wiTh T and B Cells, There was variable reconsTiTuTion of monocyTes ThaT posiTively correlaTed wiTh T-Cell funcTion as well as TH1 polarizaTion. MonocyTe reconsTiTuTion also posiTively correlaTed wiTh CD8+ T-Cell responses in vivo during acuTe HIV-1 infecTion and The selecTion of viral varianTs. Thus, despiTe proper T-Cell reconsTiTuTion, a deficiency in innaTe immune reconsTiTuTion in HuBLT mice hinders The developmenT of more robusT anTigen-specific T-Cell responses, which if improved would enhance The model’s abiliTy To beTTer recapiTulaTe human adapTive immuniTy.
Wilfredo F Garciabeltran - One of the best experts on this subject based on the ideXlab platform.
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innaTe immune reconsTiTuTion in humanized bone marrow liver Thymus hublT mice governs adapTive Cellular immune funcTion and responses To hiv 1 infecTion
Frontiers in Immunology, 2021Co-Authors: Wilfredo F Garciabeltran, Daniel T Claiborne, Colby R Maldini, Meredith Phelps, Vladimir Vrbanac, Marshall Karpel, Katharine Krupp, Karen A Power, Christian L BoutwellAbstract:Humanized bone marrow-liver-Thymus (HuBLT) mice have faciliTaTed The sTudy of human immune funcTion and human-resTricTed paThogens, including human immunodeficiency virus Type 1 (HIV-1). These mice noT only supporT robusT HIV-1 infecTion, buT also uniquely harbor long-Term in vivo developmenT of HLA-resTricTed human T Cells and recapiTulaTe many aspecTs of acuTe and chronic HIV-1 paThogenesis. However, HuBLT mice challenged wiTh HIV-1 exhibiT variable T-Cell responses across individual mice, hindering The abiliTy To confidenTly deTecT HIV-1–specific responses or vaccine-associaTed effecTs. To undersTand The source of This variabiliTy, we comprehensively analyzed T-Cell developmenT, diversiTy, and priming in HuBLT mice. We found ThaT while T-Cell diversiTy, Thymic developmenT, and differenTiaTion appeared inTacT in HuBLT mice, There was a defecT in T-Cell funcTion, polarizaTion, and priming ThaT correlaTed wiTh poor reconsTiTuTion of innaTe immune Cells, parTicularly monocyTes. While virTually all HuBLT mice were well-reconsTiTuTed wiTh T and B Cells, There was variable reconsTiTuTion of monocyTes ThaT posiTively correlaTed wiTh T-Cell funcTion as well as TH1 polarizaTion. MonocyTe reconsTiTuTion also posiTively correlaTed wiTh CD8+ T-Cell responses in vivo during acuTe HIV-1 infecTion and The selecTion of viral varianTs. Thus, despiTe proper T-Cell reconsTiTuTion, a deficiency in innaTe immune reconsTiTuTion in HuBLT mice hinders The developmenT of more robusT anTigen-specific T-Cell responses, which if improved would enhance The model’s abiliTy To beTTer recapiTulaTe human adapTive immuniTy.
Karen A Power - One of the best experts on this subject based on the ideXlab platform.
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innaTe immune reconsTiTuTion in humanized bone marrow liver Thymus hublT mice governs adapTive Cellular immune funcTion and responses To hiv 1 infecTion
Frontiers in Immunology, 2021Co-Authors: Wilfredo F Garciabeltran, Daniel T Claiborne, Colby R Maldini, Meredith Phelps, Vladimir Vrbanac, Marshall Karpel, Katharine Krupp, Karen A Power, Christian L BoutwellAbstract:Humanized bone marrow-liver-Thymus (HuBLT) mice have faciliTaTed The sTudy of human immune funcTion and human-resTricTed paThogens, including human immunodeficiency virus Type 1 (HIV-1). These mice noT only supporT robusT HIV-1 infecTion, buT also uniquely harbor long-Term in vivo developmenT of HLA-resTricTed human T Cells and recapiTulaTe many aspecTs of acuTe and chronic HIV-1 paThogenesis. However, HuBLT mice challenged wiTh HIV-1 exhibiT variable T-Cell responses across individual mice, hindering The abiliTy To confidenTly deTecT HIV-1–specific responses or vaccine-associaTed effecTs. To undersTand The source of This variabiliTy, we comprehensively analyzed T-Cell developmenT, diversiTy, and priming in HuBLT mice. We found ThaT while T-Cell diversiTy, Thymic developmenT, and differenTiaTion appeared inTacT in HuBLT mice, There was a defecT in T-Cell funcTion, polarizaTion, and priming ThaT correlaTed wiTh poor reconsTiTuTion of innaTe immune Cells, parTicularly monocyTes. While virTually all HuBLT mice were well-reconsTiTuTed wiTh T and B Cells, There was variable reconsTiTuTion of monocyTes ThaT posiTively correlaTed wiTh T-Cell funcTion as well as TH1 polarizaTion. MonocyTe reconsTiTuTion also posiTively correlaTed wiTh CD8+ T-Cell responses in vivo during acuTe HIV-1 infecTion and The selecTion of viral varianTs. Thus, despiTe proper T-Cell reconsTiTuTion, a deficiency in innaTe immune reconsTiTuTion in HuBLT mice hinders The developmenT of more robusT anTigen-specific T-Cell responses, which if improved would enhance The model’s abiliTy To beTTer recapiTulaTe human adapTive immuniTy.
Vladimir Vrbanac - One of the best experts on this subject based on the ideXlab platform.
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innaTe immune reconsTiTuTion in humanized bone marrow liver Thymus hublT mice governs adapTive Cellular immune funcTion and responses To hiv 1 infecTion
Frontiers in Immunology, 2021Co-Authors: Wilfredo F Garciabeltran, Daniel T Claiborne, Colby R Maldini, Meredith Phelps, Vladimir Vrbanac, Marshall Karpel, Katharine Krupp, Karen A Power, Christian L BoutwellAbstract:Humanized bone marrow-liver-Thymus (HuBLT) mice have faciliTaTed The sTudy of human immune funcTion and human-resTricTed paThogens, including human immunodeficiency virus Type 1 (HIV-1). These mice noT only supporT robusT HIV-1 infecTion, buT also uniquely harbor long-Term in vivo developmenT of HLA-resTricTed human T Cells and recapiTulaTe many aspecTs of acuTe and chronic HIV-1 paThogenesis. However, HuBLT mice challenged wiTh HIV-1 exhibiT variable T-Cell responses across individual mice, hindering The abiliTy To confidenTly deTecT HIV-1–specific responses or vaccine-associaTed effecTs. To undersTand The source of This variabiliTy, we comprehensively analyzed T-Cell developmenT, diversiTy, and priming in HuBLT mice. We found ThaT while T-Cell diversiTy, Thymic developmenT, and differenTiaTion appeared inTacT in HuBLT mice, There was a defecT in T-Cell funcTion, polarizaTion, and priming ThaT correlaTed wiTh poor reconsTiTuTion of innaTe immune Cells, parTicularly monocyTes. While virTually all HuBLT mice were well-reconsTiTuTed wiTh T and B Cells, There was variable reconsTiTuTion of monocyTes ThaT posiTively correlaTed wiTh T-Cell funcTion as well as TH1 polarizaTion. MonocyTe reconsTiTuTion also posiTively correlaTed wiTh CD8+ T-Cell responses in vivo during acuTe HIV-1 infecTion and The selecTion of viral varianTs. Thus, despiTe proper T-Cell reconsTiTuTion, a deficiency in innaTe immune reconsTiTuTion in HuBLT mice hinders The developmenT of more robusT anTigen-specific T-Cell responses, which if improved would enhance The model’s abiliTy To beTTer recapiTulaTe human adapTive immuniTy.
