T Cell Leukemia

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  • Human T-Cell Leukemia Virus Type 1 Tax and Cellular TransformaTion
    International Journal of Hematology, 2007
    Co-Authors: Jean-marie Peloponese, Takao Kinjo, Kuan-teh Jeang
    Abstract:

    InfecTion of T-Cells by human T-Cell Leukemia virus Type 1 (HTLV-1) causes a lymphoproliferaTive malignancy known as adulT T-Cell Leukemia (ATL). ATL is characTerized by abnormal lymphocyTes, called flower Cells , which have cleaved and convoluTed nuclei. Tax, encoded by The HTLV-1 pX region, is a criTical nonsTrucTural proTein ThaT plays a cenTral role in leuke-mogenesis; however, The mechanisms of HTLV-1 oncogenesis have noT been clarified fully. In This review, we summarize currenT Thinking on how Tax may affecT ATL leukemogenesis.

  • role for akT proTein kinase b and acTivaTor proTein 1 in Cellular proliferaTion induced by The human T Cell Leukemia virus Type 1 Tax oncoproTein
    Journal of Biological Chemistry, 2006
    Co-Authors: Jean-marie Peloponese, Kuan-teh Jeang
    Abstract:

    Human T-Cell Leukemia virus Type 1 is an oncogenic reTrovirus eTiologically causal of adulT T-Cell Leukemia. The virus encodes a Tax oncoproTein, which funcTions in TranscripTional regulaTion, Cell cycle conTrol, and TransformaTion. Because adulT T-Cell Leukemia is a highly virulenT cancer ThaT is resisTanT To numerous chemoTherapeuTic TreaTmenTs, To undersTand beTTer This disease iT is imporTanT To comprehend how human T-Cell Leukemia virus Type 1 promoTes Cellular growTh and survival. MosT of The exisTing daTa poinT To Tax acTivaTion of NF-kappaB as imporTanT for Cellular proliferaTion and TransformaTion. We show here ThaT Tax, in The absence of NF-kappaB signaling, can acTivaTe acTivaTor proTein-1 To promoTe Cellular proliferaTion and survival. Tax is shown To acTivaTe acTivaTor proTein-1 Through The phosphaTidylinosiTol 3-kinase/AkT paThway.

  • Role for AkT/ProTein Kinase B and AcTivaTor ProTein-1 in Cellular ProliferaTion Induced by The Human T-Cell Leukemia Virus Type 1 Tax OncoproTein
    Journal of Biological Chemistry, 2006
    Co-Authors: Jean-marie Peloponese, Kuan-teh Jeang
    Abstract:

    Human T-Cell Leukemia virus Type 1 is an oncogenic reTrovirus eTiologically causal of adulT T-Cell Leukemia. The virus encodes a Tax oncoproTein, which funcTions in TranscripTional regulaTion, Cell cycle conTrol, and TransformaTion. Because adulT T-Cell Leukemia is a highly virulenT cancer ThaT is resisTanT To numerous chemoTherapeuTic TreaTmenTs, To undersTand beTTer This disease iT is imporTanT To comprehend how human T-Cell Leukemia virus Type 1 promoTes Cellular growTh and survival. MosT of The exisTing daTa poinT To Tax acTivaTion of NF-kappaB as imporTanT for Cellular proliferaTion and TransformaTion. We show here ThaT Tax, in The absence of NF-kappaB signaling, can acTivaTe acTivaTor proTein-1 To promoTe Cellular proliferaTion and survival. Tax is shown To acTivaTe acTivaTor proTein-1 Through The phosphaTidylinosiTol 3-kinase/AkT paThway.

  • ModulaTion of nuclear facTor-ϰB by human T Cell Leukemia virus Type 1 Tax proTein
    Immunologic Research, 2006
    Co-Authors: Jean-marie Peloponese, Man Lung Yeung, Kuan-teh Jeang
    Abstract:

    AcTivaTion of The nuclear facTor kappa B (NF-ϰB) TranscripTion facTor family by differenT sTimuli, such as inflammaTory cyTokines, sTress inducers, or paThogens, resulTs in innaTe and adapTive immuniTy. While The main funcTion of NF-ϰB is To promoTe The hosT's immune response, The NF-ϰB paThway is frequenTly dysregulaTed by invading viral paThogens. Human T Cell Leukemia virus Type 1 (HTLV-1) is The causaTive agenT of a faTal malignancy known as adulT T Cell Leukemia (ATL) and an inflammaTory disease named Tropical spasTic paraparesis/HTLV-1 associaTed myelopaThy (TSP/HAM). HTLV-1 encodes an oncoproTein, Tax, which plays a significanT role in The iniTiaTion of Cellular TransformaTion and The eliciTaTion of The hosT's inflammaTory responses. Here, we review currenT Thinking on how Tax may affecT boTh diseases Through acTivaTion of NF-ϰB signaling.

  • UbiquiTinaTion of Human T-Cell Leukemia Virus Type 1 Tax ModulaTes ITs AcTiviTy
    Journal of Virology, 2004
    Co-Authors: Jean-marie Peloponese, Hidekatsu Iha, Venkat Yedavalli, Akiko Miyazato, Kerstin Haller, Monsef Benkirane, Kuan-teh Jeang
    Abstract:

    Human T-Cell Leukemia virus Type 1 (HTLV-1) encodes a 40-kDa Tax phosphoproTein. Tax is a TranscripTional acTivaTor which modulaTes expression of The viral long Terminal repeaT and TranscripTion of many Cellular genes. Because Tax is a criTical HTLV-1 facTor which mediaTes viral TransformaTion of T Cells during The genesis of adulT T-Cell Leukemia, iT is imporTanT To undersTand The processes which can acTivaTe or inacTivaTe Tax funcTion. Here, we reporT ThaT ubiquiTinaTion of Tax is a posTTranscripTional mechanism which regulaTes Tax funcTion. We show ThaT ubiquiTinaTion does noT TargeT Tax for degradaTion by The proTeasome. RaTher, ubiquiTin addiTion modifies Tax in a proTeasome-independenT manner from an acTive To a less-acTive TranscripTional form.

Peter D Aplan - One of the best experts on this subject based on the ideXlab platform.

Jean-marie Peloponese - One of the best experts on this subject based on the ideXlab platform.

  • Human T-Cell Leukemia Virus Type 1 Tax and Cellular TransformaTion
    International Journal of Hematology, 2007
    Co-Authors: Jean-marie Peloponese, Takao Kinjo, Kuan-teh Jeang
    Abstract:

    InfecTion of T-Cells by human T-Cell Leukemia virus Type 1 (HTLV-1) causes a lymphoproliferaTive malignancy known as adulT T-Cell Leukemia (ATL). ATL is characTerized by abnormal lymphocyTes, called flower Cells , which have cleaved and convoluTed nuclei. Tax, encoded by The HTLV-1 pX region, is a criTical nonsTrucTural proTein ThaT plays a cenTral role in leuke-mogenesis; however, The mechanisms of HTLV-1 oncogenesis have noT been clarified fully. In This review, we summarize currenT Thinking on how Tax may affecT ATL leukemogenesis.

  • role for akT proTein kinase b and acTivaTor proTein 1 in Cellular proliferaTion induced by The human T Cell Leukemia virus Type 1 Tax oncoproTein
    Journal of Biological Chemistry, 2006
    Co-Authors: Jean-marie Peloponese, Kuan-teh Jeang
    Abstract:

    Human T-Cell Leukemia virus Type 1 is an oncogenic reTrovirus eTiologically causal of adulT T-Cell Leukemia. The virus encodes a Tax oncoproTein, which funcTions in TranscripTional regulaTion, Cell cycle conTrol, and TransformaTion. Because adulT T-Cell Leukemia is a highly virulenT cancer ThaT is resisTanT To numerous chemoTherapeuTic TreaTmenTs, To undersTand beTTer This disease iT is imporTanT To comprehend how human T-Cell Leukemia virus Type 1 promoTes Cellular growTh and survival. MosT of The exisTing daTa poinT To Tax acTivaTion of NF-kappaB as imporTanT for Cellular proliferaTion and TransformaTion. We show here ThaT Tax, in The absence of NF-kappaB signaling, can acTivaTe acTivaTor proTein-1 To promoTe Cellular proliferaTion and survival. Tax is shown To acTivaTe acTivaTor proTein-1 Through The phosphaTidylinosiTol 3-kinase/AkT paThway.

  • Role for AkT/ProTein Kinase B and AcTivaTor ProTein-1 in Cellular ProliferaTion Induced by The Human T-Cell Leukemia Virus Type 1 Tax OncoproTein
    Journal of Biological Chemistry, 2006
    Co-Authors: Jean-marie Peloponese, Kuan-teh Jeang
    Abstract:

    Human T-Cell Leukemia virus Type 1 is an oncogenic reTrovirus eTiologically causal of adulT T-Cell Leukemia. The virus encodes a Tax oncoproTein, which funcTions in TranscripTional regulaTion, Cell cycle conTrol, and TransformaTion. Because adulT T-Cell Leukemia is a highly virulenT cancer ThaT is resisTanT To numerous chemoTherapeuTic TreaTmenTs, To undersTand beTTer This disease iT is imporTanT To comprehend how human T-Cell Leukemia virus Type 1 promoTes Cellular growTh and survival. MosT of The exisTing daTa poinT To Tax acTivaTion of NF-kappaB as imporTanT for Cellular proliferaTion and TransformaTion. We show here ThaT Tax, in The absence of NF-kappaB signaling, can acTivaTe acTivaTor proTein-1 To promoTe Cellular proliferaTion and survival. Tax is shown To acTivaTe acTivaTor proTein-1 Through The phosphaTidylinosiTol 3-kinase/AkT paThway.

  • ModulaTion of nuclear facTor-ϰB by human T Cell Leukemia virus Type 1 Tax proTein
    Immunologic Research, 2006
    Co-Authors: Jean-marie Peloponese, Man Lung Yeung, Kuan-teh Jeang
    Abstract:

    AcTivaTion of The nuclear facTor kappa B (NF-ϰB) TranscripTion facTor family by differenT sTimuli, such as inflammaTory cyTokines, sTress inducers, or paThogens, resulTs in innaTe and adapTive immuniTy. While The main funcTion of NF-ϰB is To promoTe The hosT's immune response, The NF-ϰB paThway is frequenTly dysregulaTed by invading viral paThogens. Human T Cell Leukemia virus Type 1 (HTLV-1) is The causaTive agenT of a faTal malignancy known as adulT T Cell Leukemia (ATL) and an inflammaTory disease named Tropical spasTic paraparesis/HTLV-1 associaTed myelopaThy (TSP/HAM). HTLV-1 encodes an oncoproTein, Tax, which plays a significanT role in The iniTiaTion of Cellular TransformaTion and The eliciTaTion of The hosT's inflammaTory responses. Here, we review currenT Thinking on how Tax may affecT boTh diseases Through acTivaTion of NF-ϰB signaling.

  • UbiquiTinaTion of Human T-Cell Leukemia Virus Type 1 Tax ModulaTes ITs AcTiviTy
    Journal of Virology, 2004
    Co-Authors: Jean-marie Peloponese, Hidekatsu Iha, Venkat Yedavalli, Akiko Miyazato, Kerstin Haller, Monsef Benkirane, Kuan-teh Jeang
    Abstract:

    Human T-Cell Leukemia virus Type 1 (HTLV-1) encodes a 40-kDa Tax phosphoproTein. Tax is a TranscripTional acTivaTor which modulaTes expression of The viral long Terminal repeaT and TranscripTion of many Cellular genes. Because Tax is a criTical HTLV-1 facTor which mediaTes viral TransformaTion of T Cells during The genesis of adulT T-Cell Leukemia, iT is imporTanT To undersTand The processes which can acTivaTe or inacTivaTe Tax funcTion. Here, we reporT ThaT ubiquiTinaTion of Tax is a posTTranscripTional mechanism which regulaTes Tax funcTion. We show ThaT ubiquiTinaTion does noT TargeT Tax for degradaTion by The proTeasome. RaTher, ubiquiTin addiTion modifies Tax in a proTeasome-independenT manner from an acTive To a less-acTive TranscripTional form.

David S. Chervinsky - One of the best experts on this subject based on the ideXlab platform.

D H Lam - One of the best experts on this subject based on the ideXlab platform.

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