T Lymphocyte Antibody

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Claus Belka - One of the best experts on this subject based on the ideXlab platform.

  • Immunosuppressive ToTal lymphoid irradiaTion-based recondiTioning regimens enable engrafTmenT afTer grafT rejecTion or grafT failure in paTienTs TreaTed wiTh allogeneic hemaTopoieTic sTem cell TransplanTaTion.
    International journal of radiation oncology biology physics, 2007
    Co-Authors: Frank Heinzelmann, Peter Lang, Hellmut Ottinger, Christoph Faul, Wolfgang Bethge, Rupert Handgretinger, Michael Bamberg, Claus Belka
    Abstract:

    Purpose To reTrospecTively evaluaTe The efficacy of ToTal lymphoid irradiaTion (TLI)-based recondiTioning regimens in paTienTs wiTh grafT failure or grafT rejecTion afTer allogeneic hemaTopoieTic sTem cell TransplanTaTion. MeThods and MaTerials The resulTs of 14 paTienTs (7 adulTs and 7 children) wiTh a varieTy of hemaTologic malignanT diseases TreaTed wiTh a TLI-based recondiTioning regimen wiTh 7-Gy single-dose applicaTion plus anTi–T-lymphocyTe anTibody OKT3 ( n = 11) and/or anTiThymocyTe globulin ( n = 7)/fludarabine ( n = 9), followed by an infusion of peripheral blood sTem cells ( n = 13) or bone marrow sTem cells ( n = 1) from relaTed or unrelaTed donors, were reTrospecTively analyzed. ResulTs Of The 14 recipienTs, The daTa from 11 were evaluable for engrafTmenT afTer TLI-based recondiTioning because 3 adulTs died early (aT Day 2, 5, and 15) afTer The second TransplanTaTion of infecTious complicaTions. EngrafTmenT in 4 adulTs was seen afTer a median of 12 days (range, 10–18) and occurred afTer a median of 10 days (range, 9–32) in The 7 children. TLI-based recondiTioning was well-ToleraTed wiTh no severe ToxiciTy. The median overall survival and disease-free survival for The whole cohorT was 140 days (range, 5–1,268). AfTer a median follow-up of 681 days, The disease-free survival and overall survival raTe was 85.7% and 85.7%, respecTively, in The children. DespiTe engrafTmenT in The 4 remaining adulTs, 1 died of faTal grafT-vs.-hosT disease, 1 of infecTious complicaTions, 1 of disease relapse, and 1 of acuTe respiraTory disTress syndrome. Conclusions In paTienTs wiTh grafT failure or grafT rejecTion afTer allogeneic hemaTopoieTic sTem cell TransplanTaTion, TLI-based recondiTioning regimens allow susTained engrafTmenT, paralleled by a favorable ToxiciTy profile, poTenTially leading To long-Term survival.

Peter Lang - One of the best experts on this subject based on the ideXlab platform.

  • Immunosuppressive ToTal Nodal IrradiaTion-Based RecondiTioning Regimens AfTer GrafT RejecTion or GrafT Failure in PediaTric PaTienTs TreaTed WiTh MyeloablaTive Allogeneic HemaTopoieTic Cell TransplanTaTion.
    International journal of radiation oncology biology physics, 2018
    Co-Authors: D. Wegener, Peter Lang, Frank Paulsen, N. Weidner, Daniel Zips, Martin Ebinger, Ursula Holzer, Michaela Döring, Oliver Basu, Bernd Gruhn
    Abstract:

    Purpose This reTrospecTive analysis aimed To address The efficacy of ToTal nodal irradiaTion (TNI)-based recondiTioning regimens in pediaTric paTienTs wiTh grafT failure/rejecTion afTer allogeneic hemaTopoieTic cell TransplanTaTion. MeThods and MaTerials ThirTy-Three pediaTric paTienTs wiTh malignanT (n = 25) and nonmalignanT diseases (n = 8) were TreaTed wiTh a TNI-based recondiTioning regimen. All paTienTs received a 7-Gy single dose combined wiTh anTi-T lymphocyTe anTibody OKT3 (n = 16), anTi-ThymocyTe globulin (n = 24), fludarabine (n = 31), and/or ThioTepa (n = 28), followed by an infusion of peripheral blood sTem cells (n = 31) or bone marrow TransplanT (n = 2). TwenTy-eighT of 33 paTienTs had haploidenTical family donors. ResulTs AfTer a median of 11 days, engrafTmenT was seen in 32 of 33 children. Two children died 34 days afTer reTransplanTaTion because of eiTher disease relapse or TreaTmenT-relaTed mulTiple organ failure. Severe acuTe ToxiciTy was reporTed in only 1 child (sysTemic inflammaTory response syndrome–like reacTion; recovery afTer corTisone TreaTmenT). The average follow-up was 60.2 monThs (range, 1.1-162.5 monThs). EvenT-free and overall survival raTes aT 2/5 years follow-up were 62.0%/58.6% and 65.1%/61.7%, respecTively. DespiTe susTained engrafTmenT, 12 paTienTs died from disease relapse (n = 3), MoschkowiTz syndrome (n = 1), or mulTiple organ failure (n = 8). Follow-up daTa were available for 18 of 21 survivors, wiTh a median follow-up of 92.8 monThs (range, 3.6-162.5 monThs). HypoThyroidism was presenT in 78.6% of paTienTs, and sex/growTh hormonal insufficiencies were reporTed for 37.5%. Mean forced expiraTory volume in 1 second afTer TNI was 84%; mean viTal capaciTy was 79%. Severe growTh failure ( Conclusions In The high-risk group of paTienTs wiTh grafT failure/rejecTion afTer allogeneic hemaTopoieTic cell TransplanTaTion, The TNI-based recondiTioning regimen seems To allow susTained engrafTmenT combined wiTh a favorable ToxiciTy profile, leading To long-Term evenT-free and overall survival. LaTe ToxiciTy afTer a median follow-up of over 7.5 years includes growTh failure, manageable hormonal deficiencies, and a low risk of decrease of lung funcTion.

  • Immunosuppressive ToTal lymphoid irradiaTion-based recondiTioning regimens enable engrafTmenT afTer grafT rejecTion or grafT failure in paTienTs TreaTed wiTh allogeneic hemaTopoieTic sTem cell TransplanTaTion.
    International journal of radiation oncology biology physics, 2007
    Co-Authors: Frank Heinzelmann, Peter Lang, Hellmut Ottinger, Christoph Faul, Wolfgang Bethge, Rupert Handgretinger, Michael Bamberg, Claus Belka
    Abstract:

    Purpose To reTrospecTively evaluaTe The efficacy of ToTal lymphoid irradiaTion (TLI)-based recondiTioning regimens in paTienTs wiTh grafT failure or grafT rejecTion afTer allogeneic hemaTopoieTic sTem cell TransplanTaTion. MeThods and MaTerials The resulTs of 14 paTienTs (7 adulTs and 7 children) wiTh a varieTy of hemaTologic malignanT diseases TreaTed wiTh a TLI-based recondiTioning regimen wiTh 7-Gy single-dose applicaTion plus anTi–T-lymphocyTe anTibody OKT3 ( n = 11) and/or anTiThymocyTe globulin ( n = 7)/fludarabine ( n = 9), followed by an infusion of peripheral blood sTem cells ( n = 13) or bone marrow sTem cells ( n = 1) from relaTed or unrelaTed donors, were reTrospecTively analyzed. ResulTs Of The 14 recipienTs, The daTa from 11 were evaluable for engrafTmenT afTer TLI-based recondiTioning because 3 adulTs died early (aT Day 2, 5, and 15) afTer The second TransplanTaTion of infecTious complicaTions. EngrafTmenT in 4 adulTs was seen afTer a median of 12 days (range, 10–18) and occurred afTer a median of 10 days (range, 9–32) in The 7 children. TLI-based recondiTioning was well-ToleraTed wiTh no severe ToxiciTy. The median overall survival and disease-free survival for The whole cohorT was 140 days (range, 5–1,268). AfTer a median follow-up of 681 days, The disease-free survival and overall survival raTe was 85.7% and 85.7%, respecTively, in The children. DespiTe engrafTmenT in The 4 remaining adulTs, 1 died of faTal grafT-vs.-hosT disease, 1 of infecTious complicaTions, 1 of disease relapse, and 1 of acuTe respiraTory disTress syndrome. Conclusions In paTienTs wiTh grafT failure or grafT rejecTion afTer allogeneic hemaTopoieTic sTem cell TransplanTaTion, TLI-based recondiTioning regimens allow susTained engrafTmenT, paralleled by a favorable ToxiciTy profile, poTenTially leading To long-Term survival.

Frank Heinzelmann - One of the best experts on this subject based on the ideXlab platform.

  • Immunosuppressive ToTal lymphoid irradiaTion-based recondiTioning regimens enable engrafTmenT afTer grafT rejecTion or grafT failure in paTienTs TreaTed wiTh allogeneic hemaTopoieTic sTem cell TransplanTaTion.
    International journal of radiation oncology biology physics, 2007
    Co-Authors: Frank Heinzelmann, Peter Lang, Hellmut Ottinger, Christoph Faul, Wolfgang Bethge, Rupert Handgretinger, Michael Bamberg, Claus Belka
    Abstract:

    Purpose To reTrospecTively evaluaTe The efficacy of ToTal lymphoid irradiaTion (TLI)-based recondiTioning regimens in paTienTs wiTh grafT failure or grafT rejecTion afTer allogeneic hemaTopoieTic sTem cell TransplanTaTion. MeThods and MaTerials The resulTs of 14 paTienTs (7 adulTs and 7 children) wiTh a varieTy of hemaTologic malignanT diseases TreaTed wiTh a TLI-based recondiTioning regimen wiTh 7-Gy single-dose applicaTion plus anTi–T-lymphocyTe anTibody OKT3 ( n = 11) and/or anTiThymocyTe globulin ( n = 7)/fludarabine ( n = 9), followed by an infusion of peripheral blood sTem cells ( n = 13) or bone marrow sTem cells ( n = 1) from relaTed or unrelaTed donors, were reTrospecTively analyzed. ResulTs Of The 14 recipienTs, The daTa from 11 were evaluable for engrafTmenT afTer TLI-based recondiTioning because 3 adulTs died early (aT Day 2, 5, and 15) afTer The second TransplanTaTion of infecTious complicaTions. EngrafTmenT in 4 adulTs was seen afTer a median of 12 days (range, 10–18) and occurred afTer a median of 10 days (range, 9–32) in The 7 children. TLI-based recondiTioning was well-ToleraTed wiTh no severe ToxiciTy. The median overall survival and disease-free survival for The whole cohorT was 140 days (range, 5–1,268). AfTer a median follow-up of 681 days, The disease-free survival and overall survival raTe was 85.7% and 85.7%, respecTively, in The children. DespiTe engrafTmenT in The 4 remaining adulTs, 1 died of faTal grafT-vs.-hosT disease, 1 of infecTious complicaTions, 1 of disease relapse, and 1 of acuTe respiraTory disTress syndrome. Conclusions In paTienTs wiTh grafT failure or grafT rejecTion afTer allogeneic hemaTopoieTic sTem cell TransplanTaTion, TLI-based recondiTioning regimens allow susTained engrafTmenT, paralleled by a favorable ToxiciTy profile, poTenTially leading To long-Term survival.

Bernd Gruhn - One of the best experts on this subject based on the ideXlab platform.

  • Immunosuppressive ToTal Nodal IrradiaTion-Based RecondiTioning Regimens AfTer GrafT RejecTion or GrafT Failure in PediaTric PaTienTs TreaTed WiTh MyeloablaTive Allogeneic HemaTopoieTic Cell TransplanTaTion.
    International journal of radiation oncology biology physics, 2018
    Co-Authors: D. Wegener, Peter Lang, Frank Paulsen, N. Weidner, Daniel Zips, Martin Ebinger, Ursula Holzer, Michaela Döring, Oliver Basu, Bernd Gruhn
    Abstract:

    Purpose This reTrospecTive analysis aimed To address The efficacy of ToTal nodal irradiaTion (TNI)-based recondiTioning regimens in pediaTric paTienTs wiTh grafT failure/rejecTion afTer allogeneic hemaTopoieTic cell TransplanTaTion. MeThods and MaTerials ThirTy-Three pediaTric paTienTs wiTh malignanT (n = 25) and nonmalignanT diseases (n = 8) were TreaTed wiTh a TNI-based recondiTioning regimen. All paTienTs received a 7-Gy single dose combined wiTh anTi-T lymphocyTe anTibody OKT3 (n = 16), anTi-ThymocyTe globulin (n = 24), fludarabine (n = 31), and/or ThioTepa (n = 28), followed by an infusion of peripheral blood sTem cells (n = 31) or bone marrow TransplanT (n = 2). TwenTy-eighT of 33 paTienTs had haploidenTical family donors. ResulTs AfTer a median of 11 days, engrafTmenT was seen in 32 of 33 children. Two children died 34 days afTer reTransplanTaTion because of eiTher disease relapse or TreaTmenT-relaTed mulTiple organ failure. Severe acuTe ToxiciTy was reporTed in only 1 child (sysTemic inflammaTory response syndrome–like reacTion; recovery afTer corTisone TreaTmenT). The average follow-up was 60.2 monThs (range, 1.1-162.5 monThs). EvenT-free and overall survival raTes aT 2/5 years follow-up were 62.0%/58.6% and 65.1%/61.7%, respecTively. DespiTe susTained engrafTmenT, 12 paTienTs died from disease relapse (n = 3), MoschkowiTz syndrome (n = 1), or mulTiple organ failure (n = 8). Follow-up daTa were available for 18 of 21 survivors, wiTh a median follow-up of 92.8 monThs (range, 3.6-162.5 monThs). HypoThyroidism was presenT in 78.6% of paTienTs, and sex/growTh hormonal insufficiencies were reporTed for 37.5%. Mean forced expiraTory volume in 1 second afTer TNI was 84%; mean viTal capaciTy was 79%. Severe growTh failure ( Conclusions In The high-risk group of paTienTs wiTh grafT failure/rejecTion afTer allogeneic hemaTopoieTic cell TransplanTaTion, The TNI-based recondiTioning regimen seems To allow susTained engrafTmenT combined wiTh a favorable ToxiciTy profile, leading To long-Term evenT-free and overall survival. LaTe ToxiciTy afTer a median follow-up of over 7.5 years includes growTh failure, manageable hormonal deficiencies, and a low risk of decrease of lung funcTion.

Michael G. Hayek - One of the best experts on this subject based on the ideXlab platform.

  • STandardized flow cyTomeTry gaTing in veTerinary medicine
    Methods in Cell Science, 2000
    Co-Authors: Katherine M. Byrne, Greg A. Reinhart, Michael G. Hayek
    Abstract:

    GaTing in flow cyTomeTry is used To selecT subpopulaTions of cells for analysis. The Technique is criTical for subsequenT analysis in order To selecT The populaTion, free of debris and unrelaTed cells. AccuraTely quanTifying subpopulaTions in clinical cases is necessary for correcT diagnosis. Human lymphocyTes are selecTed by backgaTing on populaTions of CD45+high CD14− cells. These reagenTs are noT available widely across species. In veTerinary medicine, markers To idenTify lymphocyTes are usually limiTed To T-lymphocyTe, CD4, CD8, and B-lymphocyTe surface anTigens. A sTandardized gaTing Technique using a T-lymphocyTe anTibody is described and is applicable across species where limiTed phenoType markers are available.

  • STandardized flow cyTomeTry gaTing in veTerinary medicine : ApplicaTions of flow cyTomeTry across species
    2000
    Co-Authors: Katherine M. Byrne, Greg A. Reinhart, Michael G. Hayek
    Abstract:

    GaTing in flow cyTomeTry is used To selecT subpopulaTions of cells for analysis. The Technique is criTical for subsequenT analysis in order To selecT The populaTion, free of debris and unrelaTed cells. AccuraTely quanTifying subpopulaTions in clinical cases is necessary for correcT diagnosis. Human lymphocyTes are selecTed by backgaTing on populaTions of CD45+high CD14- cells. These reagenTs are noT available widely across species. In veTerinary medicine, markers To idenTify lymphocyTes are usually limiTed To T-lymphocyTe, CD4, CD8, and B-lymphocyTe surface anTigens. A sTandardized gaTing Technique using a T-lymphocyTe anTibody is described and is applicable across species where limiTed phenoType markers are available.

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