Tailored Mechanical Property

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Jiang Chang - One of the best experts on this subject based on the ideXlab platform.

  • An Anisotropically and Heterogeneously Aligned Patterned Electrospun Scaffold with Tailored Mechanical Property and Improved Bioactivity for Vascular Tissue Engineering
    ACS Applied Materials & Interfaces, 2015
    Co-Authors: He Xu, Haiyan Li, Qinfei Ke, Jiang Chang
    Abstract:

    The development of vascular scaffolds with controlled Mechanical properties and stimulatory effects on biological activities of endothelial cells still remains a significant challenge to vascular tissue engineering. In this work, we reported an innovative approach to prepare a new type of vascular scaffolds with anisotropically and heterogeneously aligned patterns using electrospinning technique with unique wire spring templates, and further investigated the structural effects of the patterned electrospun scaffolds on Mechanical properties and angiogenic differentiation of human umbilical vein endothelial cells (HUVECs). Results showed that anisotropically aligned patterned nanofibrous structure was obtained by depositing nanofibers on template in a structurally different manner, one part of nanofibers densely deposited on the embossments of wire spring and formed cylindrical-like structures in the transverse direction, while others loosely suspended and aligned along the longitudinal direction, forming a...

  • An anisotropically and heterogeneously aligned patterned electrospun scaffold with Tailored Mechanical Property and improved bioactivity for vascular tissue engineering.
    ACS applied materials & interfaces, 2015
    Co-Authors: Jiang Chang
    Abstract:

    The development of vascular scaffolds with controlled Mechanical properties and stimulatory effects on biological activities of endothelial cells still remains a significant challenge to vascular tissue engineering. In this work, we reported an innovative approach to prepare a new type of vascular scaffolds with anisotropically and heterogeneously aligned patterns using electrospinning technique with unique wire spring templates, and further investigated the structural effects of the patterned electrospun scaffolds on Mechanical properties and angiogenic differentiation of human umbilical vein endothelial cells (HUVECs). Results showed that anisotropically aligned patterned nanofibrous structure was obtained by depositing nanofibers on template in a structurally different manner, one part of nanofibers densely deposited on the embossments of wire spring and formed cylindrical-like structures in the transverse direction, while others loosely suspended and aligned along the longitudinal direction, forming a three-dimensional porous microstructure. We further found that such structures could efficiently control the Mechanical properties of electrospun vascular scaffolds in both longitudinal and transverse directions by altering the interval distances between the embossments of patterned scaffolds. When HUVECs were cultured on scaffolds with different microstructures, the patterned scaffolds distinctively promoted adhesion of HUVECs at early stage and proliferation during the culture period. Most importantly, cells experienced a large shape change associated with cell cytoskeleton and nuclei remodeling, leading to a stimulatory effect on angiogenesis differentiation of HUVECs by the patterned microstructures of electrospun scaffolds, and the scaffolds with larger distances of intervals showed a higher stimulatory effect. These results suggest that electrospun scaffolds with the anisotropically and heterogeneously aligned patterns, which could efficiently control the Mechanical properties and bioactivities of the scaffolds, might have great potential in vascular tissue engineering application.

He Xu - One of the best experts on this subject based on the ideXlab platform.

  • An Anisotropically and Heterogeneously Aligned Patterned Electrospun Scaffold with Tailored Mechanical Property and Improved Bioactivity for Vascular Tissue Engineering
    ACS Applied Materials & Interfaces, 2015
    Co-Authors: He Xu, Haiyan Li, Qinfei Ke, Jiang Chang
    Abstract:

    The development of vascular scaffolds with controlled Mechanical properties and stimulatory effects on biological activities of endothelial cells still remains a significant challenge to vascular tissue engineering. In this work, we reported an innovative approach to prepare a new type of vascular scaffolds with anisotropically and heterogeneously aligned patterns using electrospinning technique with unique wire spring templates, and further investigated the structural effects of the patterned electrospun scaffolds on Mechanical properties and angiogenic differentiation of human umbilical vein endothelial cells (HUVECs). Results showed that anisotropically aligned patterned nanofibrous structure was obtained by depositing nanofibers on template in a structurally different manner, one part of nanofibers densely deposited on the embossments of wire spring and formed cylindrical-like structures in the transverse direction, while others loosely suspended and aligned along the longitudinal direction, forming a...

Haiyan Li - One of the best experts on this subject based on the ideXlab platform.

  • An Anisotropically and Heterogeneously Aligned Patterned Electrospun Scaffold with Tailored Mechanical Property and Improved Bioactivity for Vascular Tissue Engineering
    ACS Applied Materials & Interfaces, 2015
    Co-Authors: He Xu, Haiyan Li, Qinfei Ke, Jiang Chang
    Abstract:

    The development of vascular scaffolds with controlled Mechanical properties and stimulatory effects on biological activities of endothelial cells still remains a significant challenge to vascular tissue engineering. In this work, we reported an innovative approach to prepare a new type of vascular scaffolds with anisotropically and heterogeneously aligned patterns using electrospinning technique with unique wire spring templates, and further investigated the structural effects of the patterned electrospun scaffolds on Mechanical properties and angiogenic differentiation of human umbilical vein endothelial cells (HUVECs). Results showed that anisotropically aligned patterned nanofibrous structure was obtained by depositing nanofibers on template in a structurally different manner, one part of nanofibers densely deposited on the embossments of wire spring and formed cylindrical-like structures in the transverse direction, while others loosely suspended and aligned along the longitudinal direction, forming a...

Qinfei Ke - One of the best experts on this subject based on the ideXlab platform.

  • An Anisotropically and Heterogeneously Aligned Patterned Electrospun Scaffold with Tailored Mechanical Property and Improved Bioactivity for Vascular Tissue Engineering
    ACS Applied Materials & Interfaces, 2015
    Co-Authors: He Xu, Haiyan Li, Qinfei Ke, Jiang Chang
    Abstract:

    The development of vascular scaffolds with controlled Mechanical properties and stimulatory effects on biological activities of endothelial cells still remains a significant challenge to vascular tissue engineering. In this work, we reported an innovative approach to prepare a new type of vascular scaffolds with anisotropically and heterogeneously aligned patterns using electrospinning technique with unique wire spring templates, and further investigated the structural effects of the patterned electrospun scaffolds on Mechanical properties and angiogenic differentiation of human umbilical vein endothelial cells (HUVECs). Results showed that anisotropically aligned patterned nanofibrous structure was obtained by depositing nanofibers on template in a structurally different manner, one part of nanofibers densely deposited on the embossments of wire spring and formed cylindrical-like structures in the transverse direction, while others loosely suspended and aligned along the longitudinal direction, forming a...