The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Hang Xiao - One of the best experts on this subject based on the ideXlab platform.
-
Encapsulation of Polymethoxyflavones in Citrus Oil Emulsion-Based Delivery Systems.
Journal of agricultural and food chemistry, 2017Co-Authors: Ying Yang, Zhao Chengying, Jingjing Chen, Tian Guifang, Hang Xiao, Jinkai ZhengAbstract:The purpose of this work was to elucidate the effects of citrus oil type on polymethoxyflavone (PMF) solubility and on the physicochemical properties of PMF-loaded emulsion-based delivery systems. Citrus oils were extracted from mandarin, orange, sweet orange, and bergamot. The major constituents were determined by GC/MS: sweet orange oil (97.4% d-limonene); mandarin oil (72.4% d-limonene); orange oil (67.2% d-limonene); and bergamot oil (34.6% linalyl acetate and 25.3% d-limonene). PMF-loaded emulsions were fabricated using 10% oil phase (containing 0.1% w/v nobiletin or Tangeretin) and 90% aqueous phase (containing 1% w/v Tween 80) using high-pressure homogenization. Delivery systems prepared using mandarin oil had the largest mean droplet diameters (386 or 400 nm), followed by orange oil (338 or 390 nm), bergamot oil (129 or 133 nm), and sweet orange oil (122 or 126 nm) for nobiletin- or Tangeretin-loaded emulsions, respectively. The optical clarity of the emulsions increased with decreasing droplet si...
-
improving nutraceutical bioavailability using mixed colloidal delivery systems lipid nanoparticles increase Tangeretin bioaccessibility and absorption from Tangeretin loaded zein nanoparticles
RSC Advances, 2015Co-Authors: Jingjing Chen, Jinkai Zheng, David Julian Mcclements, Eric A Decker, Hang XiaoAbstract:The objective of this study was to evaluate the influence of dietary lipids on the gastrointestinal fate of Tangeretin-loaded zein nanoparticles. The zein delivery systems were mixed with different amounts of oil-in-water emulsions to represent varying levels of digestible fat in the diet, and then passed through a simulated gastrointestinal tract model. Tangeretin bioaccessibility increased with increasing fat content due to enhanced solubilization within the mixed micelles formed by lipid digestion products (fatty acids and monoacylglycerols) in the intestinal fluids. Indeed, the Tangeretin concentration in the micelle phase was about twelve times higher in the presence of fat droplets than in their absence. The intestinal epithelium absorption study indicated that Tangeretin permeability across the model epithelium cells also increased with increasing fat content. This study suggests that utilizing mixed colloidal systems consisting of both lipid nanoparticles and protein nanoparticles may promote the bioavailability of hydrophobic bioactive agents.
-
Tangeretin loaded protein nanoparticles fabricated from zein β lactoglobulin preparation characterization and functional performance
Food Chemistry, 2014Co-Authors: Jingjing Chen, Jinkai Zheng, David Julian Mcclements, Hang XiaoAbstract:Abstract The aim of this study was to design a colloidal delivery system to encapsulate poor water-soluble bioactive flavonoid Tangeretin so that it could be utilized in various food products as functional ingredient. Tangeretin-loaded protein nanoparticles were produced by mixing an organic phase containing zein and Tangeretin with an aqueous phase containing β-lactoglobulin and then converted into powder by freeze-drying. This powder formed a colloidal suspension when dispersed in water that is relatively stable to particle aggregation and sedimentation. The influence of temperature, ionic strength, and pH on the stability of the protein nanoparticles was tested. Extensive particle aggregation occurred at high ionic strength (>100 mM) and intermediate pH (4.5–5.5) due to reduced electrostatic repulsion. Extensive aggregation also occurred at temperatures exceeding 60 °C, which was presumably due to increased hydrophobic attraction. Overall, this study shows that protein-based nanoparticles can be used to encapsulate bioactive Tangeretin so that it can be readily dispersed in compatible food products.
-
characterization and bioaccessibility of Tangeretin loaded zein colloidal system
The FASEB Journal, 2013Co-Authors: Jingjing Chen, Jinkai Zheng, David Julian Mcclements, Hang XiaoAbstract:Tangeretin, a citrus flavonoid has been shown to possess many beneficial bioactivities. However, bioaccessibility of Tangeretin is relatively low due to its high hydrophobicity, which limits its ab...
David Julian Mcclements - One of the best experts on this subject based on the ideXlab platform.
-
biopolymer additives enhance Tangeretin bioavailability in emulsion based delivery systems an in vitro and in vivo study
Journal of Agricultural and Food Chemistry, 2021Co-Authors: Fei Liu, Junxiao Pang, David Julian Mcclements, Zhiqin ZhouAbstract:The oral bioavailability of Tangeretin, a poly(methoxyflavone) found in citrus fruits, is typically very low because of its extremely limited solubility. In this research, Tangeretin was encapsulated within whey protein-stabilized emulsions containing ingredients that may alter their behavior under gastrointestinal conditions and enhance the bioavailability of Tangeretin after oral administration: cinnamaldehyde (CA), gum arabic (GA), or hydroxypropyl methylcellulose (HPMC). The presence of these ingredients altered the size, aggregation state, and encapsulation efficiency of Tangeretin in the emulsions. In vitro studies demonstrated that the bioaccessibility of the encapsulated Tangeretin was much higher than that of a crude Tangeretin oil suspension. Particularly, the addition of HPMC increased the bioaccessibility of Tangeretin from around 36 to 90%. In vivo pharmacokinetics results using rats indicated that Tangeretin concentration in the plasma increased from 4- to 20-fold after encapsulation, especially in the presence of HPMC. HPMC also prolonged the release of Tangeretin to 22 h. Tangeretin preferentially accumulated within the liver and kidney of the animals. Overall, the knowledge confirmed that structured emulsion-based delivery systems could be used to improve the oral bioavailability of hydrophobic functional ingredients.
-
improving nutraceutical bioavailability using mixed colloidal delivery systems lipid nanoparticles increase Tangeretin bioaccessibility and absorption from Tangeretin loaded zein nanoparticles
RSC Advances, 2015Co-Authors: Jingjing Chen, Jinkai Zheng, David Julian Mcclements, Eric A Decker, Hang XiaoAbstract:The objective of this study was to evaluate the influence of dietary lipids on the gastrointestinal fate of Tangeretin-loaded zein nanoparticles. The zein delivery systems were mixed with different amounts of oil-in-water emulsions to represent varying levels of digestible fat in the diet, and then passed through a simulated gastrointestinal tract model. Tangeretin bioaccessibility increased with increasing fat content due to enhanced solubilization within the mixed micelles formed by lipid digestion products (fatty acids and monoacylglycerols) in the intestinal fluids. Indeed, the Tangeretin concentration in the micelle phase was about twelve times higher in the presence of fat droplets than in their absence. The intestinal epithelium absorption study indicated that Tangeretin permeability across the model epithelium cells also increased with increasing fat content. This study suggests that utilizing mixed colloidal systems consisting of both lipid nanoparticles and protein nanoparticles may promote the bioavailability of hydrophobic bioactive agents.
-
Tangeretin loaded protein nanoparticles fabricated from zein β lactoglobulin preparation characterization and functional performance
Food Chemistry, 2014Co-Authors: Jingjing Chen, Jinkai Zheng, David Julian Mcclements, Hang XiaoAbstract:Abstract The aim of this study was to design a colloidal delivery system to encapsulate poor water-soluble bioactive flavonoid Tangeretin so that it could be utilized in various food products as functional ingredient. Tangeretin-loaded protein nanoparticles were produced by mixing an organic phase containing zein and Tangeretin with an aqueous phase containing β-lactoglobulin and then converted into powder by freeze-drying. This powder formed a colloidal suspension when dispersed in water that is relatively stable to particle aggregation and sedimentation. The influence of temperature, ionic strength, and pH on the stability of the protein nanoparticles was tested. Extensive particle aggregation occurred at high ionic strength (>100 mM) and intermediate pH (4.5–5.5) due to reduced electrostatic repulsion. Extensive aggregation also occurred at temperatures exceeding 60 °C, which was presumably due to increased hydrophobic attraction. Overall, this study shows that protein-based nanoparticles can be used to encapsulate bioactive Tangeretin so that it can be readily dispersed in compatible food products.
-
characterization and bioaccessibility of Tangeretin loaded zein colloidal system
The FASEB Journal, 2013Co-Authors: Jingjing Chen, Jinkai Zheng, David Julian Mcclements, Hang XiaoAbstract:Tangeretin, a citrus flavonoid has been shown to possess many beneficial bioactivities. However, bioaccessibility of Tangeretin is relatively low due to its high hydrophobicity, which limits its ab...
Jingjing Chen - One of the best experts on this subject based on the ideXlab platform.
-
Encapsulation of Polymethoxyflavones in Citrus Oil Emulsion-Based Delivery Systems.
Journal of agricultural and food chemistry, 2017Co-Authors: Ying Yang, Zhao Chengying, Jingjing Chen, Tian Guifang, Hang Xiao, Jinkai ZhengAbstract:The purpose of this work was to elucidate the effects of citrus oil type on polymethoxyflavone (PMF) solubility and on the physicochemical properties of PMF-loaded emulsion-based delivery systems. Citrus oils were extracted from mandarin, orange, sweet orange, and bergamot. The major constituents were determined by GC/MS: sweet orange oil (97.4% d-limonene); mandarin oil (72.4% d-limonene); orange oil (67.2% d-limonene); and bergamot oil (34.6% linalyl acetate and 25.3% d-limonene). PMF-loaded emulsions were fabricated using 10% oil phase (containing 0.1% w/v nobiletin or Tangeretin) and 90% aqueous phase (containing 1% w/v Tween 80) using high-pressure homogenization. Delivery systems prepared using mandarin oil had the largest mean droplet diameters (386 or 400 nm), followed by orange oil (338 or 390 nm), bergamot oil (129 or 133 nm), and sweet orange oil (122 or 126 nm) for nobiletin- or Tangeretin-loaded emulsions, respectively. The optical clarity of the emulsions increased with decreasing droplet si...
-
improving nutraceutical bioavailability using mixed colloidal delivery systems lipid nanoparticles increase Tangeretin bioaccessibility and absorption from Tangeretin loaded zein nanoparticles
RSC Advances, 2015Co-Authors: Jingjing Chen, Jinkai Zheng, David Julian Mcclements, Eric A Decker, Hang XiaoAbstract:The objective of this study was to evaluate the influence of dietary lipids on the gastrointestinal fate of Tangeretin-loaded zein nanoparticles. The zein delivery systems were mixed with different amounts of oil-in-water emulsions to represent varying levels of digestible fat in the diet, and then passed through a simulated gastrointestinal tract model. Tangeretin bioaccessibility increased with increasing fat content due to enhanced solubilization within the mixed micelles formed by lipid digestion products (fatty acids and monoacylglycerols) in the intestinal fluids. Indeed, the Tangeretin concentration in the micelle phase was about twelve times higher in the presence of fat droplets than in their absence. The intestinal epithelium absorption study indicated that Tangeretin permeability across the model epithelium cells also increased with increasing fat content. This study suggests that utilizing mixed colloidal systems consisting of both lipid nanoparticles and protein nanoparticles may promote the bioavailability of hydrophobic bioactive agents.
-
Tangeretin loaded protein nanoparticles fabricated from zein β lactoglobulin preparation characterization and functional performance
Food Chemistry, 2014Co-Authors: Jingjing Chen, Jinkai Zheng, David Julian Mcclements, Hang XiaoAbstract:Abstract The aim of this study was to design a colloidal delivery system to encapsulate poor water-soluble bioactive flavonoid Tangeretin so that it could be utilized in various food products as functional ingredient. Tangeretin-loaded protein nanoparticles were produced by mixing an organic phase containing zein and Tangeretin with an aqueous phase containing β-lactoglobulin and then converted into powder by freeze-drying. This powder formed a colloidal suspension when dispersed in water that is relatively stable to particle aggregation and sedimentation. The influence of temperature, ionic strength, and pH on the stability of the protein nanoparticles was tested. Extensive particle aggregation occurred at high ionic strength (>100 mM) and intermediate pH (4.5–5.5) due to reduced electrostatic repulsion. Extensive aggregation also occurred at temperatures exceeding 60 °C, which was presumably due to increased hydrophobic attraction. Overall, this study shows that protein-based nanoparticles can be used to encapsulate bioactive Tangeretin so that it can be readily dispersed in compatible food products.
-
characterization and bioaccessibility of Tangeretin loaded zein colloidal system
The FASEB Journal, 2013Co-Authors: Jingjing Chen, Jinkai Zheng, David Julian Mcclements, Hang XiaoAbstract:Tangeretin, a citrus flavonoid has been shown to possess many beneficial bioactivities. However, bioaccessibility of Tangeretin is relatively low due to its high hydrophobicity, which limits its ab...
Jinkai Zheng - One of the best experts on this subject based on the ideXlab platform.
-
Encapsulation of Polymethoxyflavones in Citrus Oil Emulsion-Based Delivery Systems.
Journal of agricultural and food chemistry, 2017Co-Authors: Ying Yang, Zhao Chengying, Jingjing Chen, Tian Guifang, Hang Xiao, Jinkai ZhengAbstract:The purpose of this work was to elucidate the effects of citrus oil type on polymethoxyflavone (PMF) solubility and on the physicochemical properties of PMF-loaded emulsion-based delivery systems. Citrus oils were extracted from mandarin, orange, sweet orange, and bergamot. The major constituents were determined by GC/MS: sweet orange oil (97.4% d-limonene); mandarin oil (72.4% d-limonene); orange oil (67.2% d-limonene); and bergamot oil (34.6% linalyl acetate and 25.3% d-limonene). PMF-loaded emulsions were fabricated using 10% oil phase (containing 0.1% w/v nobiletin or Tangeretin) and 90% aqueous phase (containing 1% w/v Tween 80) using high-pressure homogenization. Delivery systems prepared using mandarin oil had the largest mean droplet diameters (386 or 400 nm), followed by orange oil (338 or 390 nm), bergamot oil (129 or 133 nm), and sweet orange oil (122 or 126 nm) for nobiletin- or Tangeretin-loaded emulsions, respectively. The optical clarity of the emulsions increased with decreasing droplet si...
-
improving nutraceutical bioavailability using mixed colloidal delivery systems lipid nanoparticles increase Tangeretin bioaccessibility and absorption from Tangeretin loaded zein nanoparticles
RSC Advances, 2015Co-Authors: Jingjing Chen, Jinkai Zheng, David Julian Mcclements, Eric A Decker, Hang XiaoAbstract:The objective of this study was to evaluate the influence of dietary lipids on the gastrointestinal fate of Tangeretin-loaded zein nanoparticles. The zein delivery systems were mixed with different amounts of oil-in-water emulsions to represent varying levels of digestible fat in the diet, and then passed through a simulated gastrointestinal tract model. Tangeretin bioaccessibility increased with increasing fat content due to enhanced solubilization within the mixed micelles formed by lipid digestion products (fatty acids and monoacylglycerols) in the intestinal fluids. Indeed, the Tangeretin concentration in the micelle phase was about twelve times higher in the presence of fat droplets than in their absence. The intestinal epithelium absorption study indicated that Tangeretin permeability across the model epithelium cells also increased with increasing fat content. This study suggests that utilizing mixed colloidal systems consisting of both lipid nanoparticles and protein nanoparticles may promote the bioavailability of hydrophobic bioactive agents.
-
Tangeretin loaded protein nanoparticles fabricated from zein β lactoglobulin preparation characterization and functional performance
Food Chemistry, 2014Co-Authors: Jingjing Chen, Jinkai Zheng, David Julian Mcclements, Hang XiaoAbstract:Abstract The aim of this study was to design a colloidal delivery system to encapsulate poor water-soluble bioactive flavonoid Tangeretin so that it could be utilized in various food products as functional ingredient. Tangeretin-loaded protein nanoparticles were produced by mixing an organic phase containing zein and Tangeretin with an aqueous phase containing β-lactoglobulin and then converted into powder by freeze-drying. This powder formed a colloidal suspension when dispersed in water that is relatively stable to particle aggregation and sedimentation. The influence of temperature, ionic strength, and pH on the stability of the protein nanoparticles was tested. Extensive particle aggregation occurred at high ionic strength (>100 mM) and intermediate pH (4.5–5.5) due to reduced electrostatic repulsion. Extensive aggregation also occurred at temperatures exceeding 60 °C, which was presumably due to increased hydrophobic attraction. Overall, this study shows that protein-based nanoparticles can be used to encapsulate bioactive Tangeretin so that it can be readily dispersed in compatible food products.
-
characterization and bioaccessibility of Tangeretin loaded zein colloidal system
The FASEB Journal, 2013Co-Authors: Jingjing Chen, Jinkai Zheng, David Julian Mcclements, Hang XiaoAbstract:Tangeretin, a citrus flavonoid has been shown to possess many beneficial bioactivities. However, bioaccessibility of Tangeretin is relatively low due to its high hydrophobicity, which limits its ab...
Elshaimaa A Arafa - One of the best experts on this subject based on the ideXlab platform.
-
Tangeretin attenuates cisplatin induced renal injury in rats impact on the inflammatory cascade and oxidative perturbations
Chemico-Biological Interactions, 2016Co-Authors: Hany H Arab, Elshaimaa A Arafa, Bassant M Barakat, Wafaa R MohamedAbstract:Abstract Background Despite the efficacy of cisplatin as a chemotherapeutic agent against various cancers, its clinical utility is limited by serious adverse reactions including nephrotoxicity. Aim The current study aims to investigate the protective potential of Tangeretin, a citrus flavone with marked antioxidant actions, against cisplatin-induced renal injury in rats. Methods Tangeretin was administered at 50 and 100 mg/kg p.o. for 1 week starting one day before cisplatin (7.5 mg/kg i.p.) injection. Likewise, silymarin was administered at 100 mg/kg orally. Renal function tests, histopathology, oxidative stress and inflammatory events were investigated. Results Tangeretin mitigated the increased levels of serum creatinine, blood urea nitrogen and histopathologic alterations evoked by cisplatin. It alleviated renal oxidative stress due to cisplatin by lowering lipid peroxides, nitric oxide and Nrf2 levels with concomitant enhancement of GSH and GPx. Tangeretin also suppressed the upregulated inflammatory response seen with cisplatin treatment by downregulation of activated NF-κB p65 protein expression together with its downstream effectors e.g., iNOS and TNF-α, with restoration of the anti-inflammatory interleukin IL-10. Additionally, it down-regulated the expression of caspase-3, an apoptotic marker, thus favoring renal cell survival. Importantly, Tangeretin enhanced the cytotoxic actions of cisplatin in Hep3B and HCT-116 human cancer cell lines. Conclusion Together, these findings accentuate the dual benefit of Tangeretin: mitigation of renal injury-induced by cisplatin and enhancement of its cytotoxic effects.
-
Tangeretin alleviates cisplatin induced acute hepatic injury in rats targeting mapks and apoptosis
PLOS ONE, 2016Co-Authors: Elshaimaa A Arafa, Hany A Omar, Wafaa R Mohamed, Hany H ArabAbstract:Despite its broad applications, cisplatin affords considerable nephro- and hepatotoxicity through triggering inflammatory and oxidative stress cascades. The aim of the current investigation was to study the possible protective effects of Tangeretin on cisplatin-induced hepatotoxicity. The impact of Tangeretin on cisplatin-evoked hepatic dysfunction and histopathologic changes along with oxidative stress, inflammatory and apoptotic biomarkers were investigated compared to silymarin. Tangeretin pre-treatment significantly improved liver function tests (ALT and AST), inhibited cisplatin-induced lipid profile aberrations (total cholesterol and triglycerides) and diminished histopathologic structural damage in liver tissues. Tangeretin also attenuated cisplatin-induced hepatic inflammatory events as indicated by suppression of tumor necrosis factor-α (TNF-α) and enhancement of interleukin-10 (IL-10). Meanwhile, it lowered malondialdehyde (MDA), nitric oxide (NO) and nuclear factor erythroid 2-related factor 2 (NRF-2) levels with restoration of glutathione (GSH), and glutathione peroxidase (GPx). Regarding mitogen-activated protein kinase (MAPK) pathway, Tangeretin attenuated cisplatin-induced increase in phospho-p38, phospho-c-Jun N-terminal kinase (p-JNK) and phospho-extracellular signal-regulated kinase (p-ERK1/2) in liver tissues. In addition, Tangeretin downregulated Bax expression with augmentation of Bcl-2 promoting liver cell survival. Our results highlight the protective effects of Tangeretin against cisplatin-induced acute hepatic injury via the concerted modulation of inflammation, oxidative stress, MAPKs and apoptotic pathways.
-
Tangeretin sensitizes cisplatin resistant human ovarian cancer cells through downregulation of phosphoinositide 3 kinase akt signaling pathway
Cancer Research, 2009Co-Authors: Elshaimaa A Arafa, Qianzheng Zhu, Bassant M Barakat, Gulzar Wani, Qun Zhao, Mohamed A Elmahdy, Altaf A WaniAbstract:Combination of innocuous dietary components with anticancer drugs is an emerging new strategy for cancer chemotherapy to increase antitumor responses. Tangeretin is a citrus flavonoid known to inhibit cancer cell proliferation. Here, we show an enhanced response of A2780/CP70 and 2008/C13 cisplatin-resistant human ovarian cancer cells to various combination treatments of cisplatin and Tangeretin. Pretreatment of cells with Tangeretin before cisplatin treatment synergistically inhibited cancer cell proliferation. This combination was effective in activating apoptosis via caspase cascade as well as arresting cell cycle at G(2)-M phase. Moreover, phospho-Akt and its downstream substrates, e.g., NF-kappaB, phospho-GSK-3beta, and phospho-BAD, were downregulated upon Tangeretin-cisplatin treatment. The Tangeretin-cisplatin-induced apoptosis in A2780/CP70 cells was increased by phosphoinositide-3 kinase (PI3K) inhibition and siRNA-mediated Akt silencing, but reduced by overexpression of constitutively activated Akt and GSK-3beta inhibition. The overall results indicated that Tangeretin exposure preconditions cisplatin-resistant human ovarian cancer cells for a conventional response to low-dose cisplatin-induced cell death occurring through downregulation of PI3K/Akt signaling pathway. Thus, effectiveness of Tangeretin combinations, as a promising modality in the treatment of resistant cancers, warrants systematic clinical studies.
