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John Strong - One of the best experts on this subject based on the ideXlab platform.
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reproducibility of the measurement of bulk Tapped Density of pharmaceutical powders between pharmaceutical laboratories
Journal of Pharmaceutical Sciences, 2019Co-Authors: Ilgaz Akseli, Jon Hilden, Jeffrey M. Katz, Ron C. Kelly, Timothy T. Kramer, Chen Mao, Frederick Oseiyeboah, John StrongAbstract:The bulk properties of a powder are dependent on the preparation, treatment, and storage of the sample, that is, how it was handled. The particles can be packed to have a range of bulk densities and, moreover, the slightest disturbance of the powder bed may result in a changed bulk Density. Thus, the bulk Density of a powder is often difficult to measure with good reproducibility and, in reporting the results, it is essential to specify how the determination was made. In this article, we measured the bulk Density, Tapped Density, and calculated the Hausner ratio of commonly used excipients with similar Tapped Density testers and followed the United States Pharmacopeia 30-National Formulary 25-S1 testing procedure. Based on the analysis, within lot and lot-to-lot variability and the relative errors for bulk Density, Tapped Density, and Hausner ratio were found to be acceptable. Lot-to-lot differences were generally not measurable using this test as they were found to be within the variability of the test. The results also indicated that there was no statistically significant bias between sites for Tapped Density and Hausner ratio, but there was a marginally significant bias in the bulk Density data set.
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Reproducibility of the Measurement of Bulk/Tapped Density of Pharmaceutical Powders Between Pharmaceutical Laboratories.
Journal of Pharmaceutical Sciences, 2018Co-Authors: Ilgaz Akseli, Jon Hilden, Jeffrey M. Katz, Ron C. Kelly, Timothy T. Kramer, Frederick Osei-yeboah, John StrongAbstract:Abstract The bulk properties of a powder are dependent on the preparation, treatment, and storage of the sample, that is, how it was handled. The particles can be packed to have a range of bulk densities and, moreover, the slightest disturbance of the powder bed may result in a changed bulk Density. Thus, the bulk Density of a powder is often difficult to measure with good reproducibility and, in reporting the results, it is essential to specify how the determination was made. In this article, we measured the bulk Density, Tapped Density, and calculated the Hausner ratio of commonly used excipients with similar Tapped Density testers and followed the United States Pharmacopeia 30-National Formulary 25-S1 testing procedure. Based on the analysis, within lot and lot-to-lot variability and the relative errors for bulk Density, Tapped Density, and Hausner ratio were found to be acceptable. Lot-to-lot differences were generally not measurable using this test as they were found to be within the variability of the test. The results also indicated that there was no statistically significant bias between sites for Tapped Density and Hausner ratio, but there was a marginally significant bias in the bulk Density data set.
Hossein Kiani - One of the best experts on this subject based on the ideXlab platform.
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New Studies on the Galactomannan Extracted from Trigonella foenum-graecum (Fenugreek) Seed: Effect of Subsequent Use of Ultrasound and Microwave on the Physicochemical and Rheological Properties
Food and Bioprocess Technology, 2020Co-Authors: Rasoul Niknam, Mohammad Mousavi, Hossein KianiAbstract:The effect of subsequent use of ultrasound and microwave on the physicochemical and rheological properties of galactomannan extracted from fenugreek seed (locally called as Shanbalileh) was investigated. Maximum yield of 18.54% was gained at optimized conditions: ultrasound power of 150 W, microwave power of 500 W, seed to water ratio of 1:30, and extraction time of 150 min. Chemical composition of the galactomannan was 7.03% (wb) moisture, 5.35% (db) ash, 0.85% (db) protein, 0.59% (db) lipid, and 85.89% (db) carbohydrate, respectively. FT-IR analysis admitted representative peaks of polysaccharide at 3400, 2920, 1620, 1400, and 1050/cm. Thermal analysis results revealed a melting range of 60–135 °C and degradation temperature of 280.54 °C. XRD pattern illustrated a large degree of crystallinity in the galactomannan structure. The results of SEM imaging indicated that the obtained galactomannan had a smooth surface. The steady shear flow experiments showed that the shear stress–shear rate, apparent viscosity–shear rate, and shear stress–time well fitted in Herschel–Bulkley, Carraeu, and Figuni–Shoemaker models. The samples with 0.5 and 1% w/v concentration demonstrated viscous-like and sample with 1.5% w/v indicated gel-like behavior upon strain and frequency sweep tests. Other parameters including bulk and Tapped Density, powder cohesiveness, powder compressibility index, DPPH-free radical scavenging activity, powder solubility, water holding capacity (WHC), and oil holding capacity (OHC) were also evaluated.
Peter C Seville - One of the best experts on this subject based on the ideXlab platform.
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chitosan based spray dried respirable powders for sustained delivery of terbutaline sulfate
European Journal of Pharmaceutics and Biopharmaceutics, 2008Co-Authors: Tristan P Learoyd, Jane L Burrows, Eddie French, Peter C SevilleAbstract:In this study, we describe the preparation of highly dispersible dry powders for pulmonary drug delivery that display sustained drug release characteristics. Powders were prepared by spray-drying 30% v/v aqueous ethanol formulations containing terbutaline sulfate as a model drug, chitosan as a drug release modifier and leucine as an aerosolisation enhancer. The influence of chitosan molecular weight on the drug release profile was investigated by using low, medium and high molecular weight chitosan or combinations thereof. Following spray-drying, resultant powders were characterised using scanning electron microscopy, laser diffraction, Tapped Density analysis, differential scanning calorimetry and thermogravitational analysis. The in vitro aerosolisation performance and drug release profile were investigated using Multi-Stage Liquid Impinger analysis and modified USP II dissolution apparatus, respectively. The powders generated were of a suitable aerodynamic size for inhalation, had low moisture content and were amorphous in nature. The powders were highly dispersible, with emitted doses of over 90% and fine particle fractions of up to 82% of the total loaded dose, and mass median aerodynamic diameters of less than 2.5microm. A sustained drug release profile was observed during dissolution testing; increasing the molecular weight of the chitosan in the formulation increased the duration of drug release. (c)2007 Elsevier B.V. All rights reserved.
M Z Islam - One of the best experts on this subject based on the ideXlab platform.
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effects of micro wet milling and vacuum spray drying on the physicochemical and antioxidant properties of orange citrus unshiu juice with pulp powder
Food and Bioproducts Processing, 2017Co-Authors: M Z Islam, Yutaka Kitamura, Mito Kokawa, K Monalisa, Fuhsuan Tsai, Shinichi MiyamuraAbstract:Abstract The aim of this study was to produce concentrated orange juice (OJ) powders by the application of two new techniques, namely micro-wet milling (MWM) and vacuum spray drying (VSD) process. MWM produced OJ with smaller particle sizes (55.0 ± 1.05 μm) than conventional methods and increased the nutritional and antioxidant properties of the concentrated juice over the commercial OJ. VSD process was conducted at low temperature (40–60 °C) using superheated steam (200 °C) as a heating medium and maltodextrin (13DE) as a carrier. The effects of VSD on physicochemical and antioxidant properties of MWM OJ powders produced with four different weight ratios of juice solids to maltodextrin solids; 60:40, 50:50, 40:60 and 30:70 were investigated. The obtained powders were analyzed for moisture content, water activity, bulk Density, Tapped Density, particle Density, porosity, and particle size and distributions and microstructure of the particles. The quality in respect to the physical properties of OJ powders was improved except color parameter with increases of maltodextrin solids. The VSD powders retained a higher amount of ascorbic acid, total phenolic content (TPC) and total flavonoid content (TFC) than spray drying. MWM orange powder with overall good quality in terms of color, yield, ascorbic acid, TFC, TPC and DPPH activity was successfully produced by VSD.
Ilgaz Akseli - One of the best experts on this subject based on the ideXlab platform.
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reproducibility of the measurement of bulk Tapped Density of pharmaceutical powders between pharmaceutical laboratories
Journal of Pharmaceutical Sciences, 2019Co-Authors: Ilgaz Akseli, Jon Hilden, Jeffrey M. Katz, Ron C. Kelly, Timothy T. Kramer, Chen Mao, Frederick Oseiyeboah, John StrongAbstract:The bulk properties of a powder are dependent on the preparation, treatment, and storage of the sample, that is, how it was handled. The particles can be packed to have a range of bulk densities and, moreover, the slightest disturbance of the powder bed may result in a changed bulk Density. Thus, the bulk Density of a powder is often difficult to measure with good reproducibility and, in reporting the results, it is essential to specify how the determination was made. In this article, we measured the bulk Density, Tapped Density, and calculated the Hausner ratio of commonly used excipients with similar Tapped Density testers and followed the United States Pharmacopeia 30-National Formulary 25-S1 testing procedure. Based on the analysis, within lot and lot-to-lot variability and the relative errors for bulk Density, Tapped Density, and Hausner ratio were found to be acceptable. Lot-to-lot differences were generally not measurable using this test as they were found to be within the variability of the test. The results also indicated that there was no statistically significant bias between sites for Tapped Density and Hausner ratio, but there was a marginally significant bias in the bulk Density data set.
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Reproducibility of the Measurement of Bulk/Tapped Density of Pharmaceutical Powders Between Pharmaceutical Laboratories.
Journal of Pharmaceutical Sciences, 2018Co-Authors: Ilgaz Akseli, Jon Hilden, Jeffrey M. Katz, Ron C. Kelly, Timothy T. Kramer, Frederick Osei-yeboah, John StrongAbstract:Abstract The bulk properties of a powder are dependent on the preparation, treatment, and storage of the sample, that is, how it was handled. The particles can be packed to have a range of bulk densities and, moreover, the slightest disturbance of the powder bed may result in a changed bulk Density. Thus, the bulk Density of a powder is often difficult to measure with good reproducibility and, in reporting the results, it is essential to specify how the determination was made. In this article, we measured the bulk Density, Tapped Density, and calculated the Hausner ratio of commonly used excipients with similar Tapped Density testers and followed the United States Pharmacopeia 30-National Formulary 25-S1 testing procedure. Based on the analysis, within lot and lot-to-lot variability and the relative errors for bulk Density, Tapped Density, and Hausner ratio were found to be acceptable. Lot-to-lot differences were generally not measurable using this test as they were found to be within the variability of the test. The results also indicated that there was no statistically significant bias between sites for Tapped Density and Hausner ratio, but there was a marginally significant bias in the bulk Density data set.
