The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform
Serkan Yildirim - One of the best experts on this subject based on the ideXlab platform.
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protective effect of silybum marianum and Taraxacum Officinale extracts against oxidative kidney injuries induced by carbon tetrachloride in rats
Renal Failure, 2017Co-Authors: Ali Karakuş, Y. Deger, Serkan YildirimAbstract:The protective effect of the extracts of the plants Silybum marianum and Taraxacum Officinale by carbon tetrachloride (CCl4) was researched. Sixty-six female Wistar albino rats were divided into si...
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Protective effect of Silybum marianum and Taraxacum Officinale extracts against oxidative kidney injuries induced by carbon tetrachloride in rats
Renal failure, 2016Co-Authors: Ali Karakuş, Y. Deger, Serkan YildirimAbstract:AbstractThe protective effect of the extracts of the plants Silybum marianum and Taraxacum Officinale by carbon tetrachloride (CCl4) was researched. Sixty-six female Wistar albino rats were divided into six groups: Control, Silybum marianum, Taraxacum Officinale, CCl4, Silybum marianum+ CCl4, Taraxacum Officinale+CCl4. The Silybum marianum and Taraxacum Officinale extracts were administered as 100 mg/kg/day by gavage. The CCl4 was administered as 1.5 mL/kg (i.p.). At the end of the trial period, in the serums obtained from the animals, in the CCl4 group it was found that the MDA level increased in the kidney tissue samples as well as in the ALP and GGT enzyme activities. It was also found that the GSH level and the GST enzyme activities decreased (p
Xuemei Zhang - One of the best experts on this subject based on the ideXlab platform.
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Taraxacum Officinale protects against lipopolysaccharide-induced acute lung injury in mice
Journal of ethnopharmacology, 2010Co-Authors: Liben Liu, Huanzhang Xiong, Jiaqi Ping, Xuemei ZhangAbstract:Abstract Aim of the study Taraxacum Officinale has been frequently used as a remedy for inflammatory diseases. In the present study, we investigated the in vivo protective effect of Taraxacum Officinale on acute lung injury (ALI) induced by lipopolysaccharide (LPS) in mice. Materials and methods Taraxacum Officinale at 2.5, 5 and 10 mg/kg was orally administered once per day for 5 days consecutively, followed by 500 μg/kg LPS was instilled intranasally. The lung wet/dry weight (W/D) ratio, protein concentration and the number of inflammatory cells in bronchoalveolar lavage fluid (BALF) were determined. Superoxidase dismutase (SOD) and myeloperoxidase (MPO) activities, and histological change in the lungs were examined. The levels of inflammatory cytokine tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the BALF were measured using ELISA. Results We found that Taraxacum Officinale decreased the lung W/D ratio, protein concentration and the number of neutrophils in the BALF at 24 h after LPS challenge. Taraxacum Officinale decreased LPS-induced MPO activity and increased SOD activity in the lungs. In addition, histopathological examination indicated that Taraxacum Officinale attenuated tissue injury of the lungs in LPS-induced ALI. Furthermore, Taraxacum Officinale also inhibited the production of inflammatory cytokines TNF-α and IL-6 in the BALF at 6 h after LPS challenge in a dose-dependent manner. Conclusions These results suggest that Taraxacum Officinale protects against LPS-induced ALI in mice.
Borzenko O. N. - One of the best experts on this subject based on the ideXlab platform.
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Change of triglyceride composition of Cucurbitaceae and Taraxacum Officinale seed oil during ripening
'Springer Science and Business Media LLC', 2020Co-Authors: Deineka V., Maslov A. N., Borzenko O. N.Abstract:yesThe change of triglyceride composition in seeds of certain plants of the Cucurbitaceae family and Taraxacum Officinale during ripening was studied by HPLC. A small decrease in the content of palmitic derivatives in Cucurbitaceae seed oil and a questionable change of the triglyceride composition of T. Officinale seed oil were found. Data for the triglyceride composition were compared with calculations performed assuming an equally probable statistical distribution of fatty-acid radicalsBelgorod State Universit
L. A. Deineka - One of the best experts on this subject based on the ideXlab platform.
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Change of Triglyceride Composition of Cucurbitaceae and Taraxacum Officinale Seed Oil During Ripening
Chemistry of Natural Compounds, 2003Co-Authors: V. I. Deineka, A. N. Maslov, O. N. Borzenko, A. A. Sirotin, L. A. DeinekaAbstract:The change of triglyceride composition in seeds of certain plants of the Cucurbitaceae family and Taraxacum Officinale during ripening was studied by HPLC. A small decrease in the content of palmitic derivatives in Cucurbitaceae seed oil and a questionable change of the triglyceride composition of T. Officinale seed oil were found. Data for the triglyceride composition were compared with calculations performed assuming an equally probable statistical distribution of fatty-acid radicals.
Linsha Dong - One of the best experts on this subject based on the ideXlab platform.
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Taraxacum Officinale Wigg. Attenuates Inflammatory Responses in Murine Microglia through the Nrf2/HO-1 and NF-κB Signaling Pathways.
The American journal of Chinese medicine, 2020Co-Authors: Linsha Dong, Zhuoma Dongzhi, Yonglong Jin, Youn-chul Kim, Dong-sung Lee, Shan Huang, Pharkphoom PanichayupakaranantAbstract:As a long-established medicinal and edible homologous plant, Taraxacum Officinale Wigg. is widely distributed in Asia, Europe, and other parts of the world. T. Officinale is reported to exert a var...
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neuroprotective effects of Taraxacum Officinale wigg extract on glutamate induced oxidative stress in ht22 cells via ho 1 nrf2 pathways
Nutrients, 2018Co-Authors: Shan Huang, Ning Meng, Zhiming Liu, Li Guo, Linsha DongAbstract:Oxidative stress-mediated neuron damage is considered an important contributor to the pathogenesis and development of neurodegenerative diseases. Taraxacum Officinale has been reported to possess antioxidant activities. However, whether it can protect neurons against oxidative damage and the underlying molecular mechanisms have not been fully determined. In the present study, we examined the neuroprotective effects of ethanol extracts of this plant (ETOW) on glutamate-induced oxidative stress in HT22 cells. Both cell viability and reactive oxygen species (ROS) assays showed that ETOW effectively attenuated glutamate-induced cytotoxicity and ROS generation. Furthermore, our results revealed that ETOW increased the expression of heme oxygenase-1 (HO-1) and promoted the nuclear translocation of nuclear factor erythroid 2-related factor-2 (Nrf2). The inhibitory effects of ETOW on glutamate-stimulated cell toxicity and ROS production were partially reversed by tin protoporphyrin (SnPP), an HO activity inhibitor. Taken together, these results demonstrate that ETOW can protect HT22 cells against glutamate-induced oxidative damage by inducing the Nrf2/HO-1 pathways. Our study supports the idea that Taraxacum Officinale Wigg. is a promising agent for preventing neurodegenerative diseases.
