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Claudia Wiegand - One of the best experts on this subject based on the ideXlab platform.

  • Molecular effects and bioaccumulation of levonorgestrel in the non-Target Organism Dreissena polymorpha
    Environmental Pollution, 2011
    Co-Authors: Valeska Contardo-jara, Claudia Lorenz, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, Claudia Wiegand
    Abstract:

    Bioaccumulation and effects of the contraceptive hormone levonorgestrel were examined in the nonTarget Organism Dreissena polymorpha. Molecular biomarkers of biotransformation, elimination, antioxidant defence and protein damage were analyzed after exposure to increasing concentrations of levonorgestrel in a flow-through system. The lowest concentration (0.312 mg L-1) was 100-fold bioconcentrated within four days. A decrease of the bioconcentration factor was observed within one week for the highest test concentrations (3.12 and 6.24 mg L-1) suggesting enhanced excretory processes. The immediate mRNA up-regulation of pi class glutathione S-transferase proved that phase II biotransformation processes were induced. Disturbance of fundamental cell functions was assumed since the aryl hydrocarbon receptor has been permanently down-regulated. mRNA up-regulation of P-glycoprotein, superoxide dismutase and metallothioneine suggested enhanced elimination processes and ongoing oxidative stress. mRNA up-regulation of heat shock protein 70 in mussels exposed to the two highest concentrations clearly indicated impacts on protein damage.

  • The β-receptor blocker metoprolol alters detoxification processes in the non-Target Organism Dreissena polymorpha.
    Environmental pollution (Barking Essex : 1987), 2010
    Co-Authors: Valeska Contardo-jara, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, Claudia Wiegand
    Abstract:

    Abstract Due to increasing amounts of pharmaceutically active compounds (PhACs) in the aquatic environment, their largely unknown effects to non-Target Organisms need to be assessed. This study examined physiological changes in the freshwater mussel Dreissena polymorpha exposed to increasing concentrations (0.534, 5.34, 53.4 and 534 μg L −1 ) of the β-blocker metoprolol in a flow-through system for seven days. The two lower concentrations represent the environmentally relevant range. Surprisingly, metallothionein mRNA was immediately up-regulated in all treatments. For the two higher concentrations mRNA up-regulation in gills was found for P-glycoprotein after one day, and after four days for pi class glutathione S-transferase, demonstrating elimination and biotransformation processes, respectively. Additionally, catalase and superoxide dismutase were up-regulated in the digestive gland indicating oxidative stress. In all treated mussels a significant up-regulation of heat shock protein mRNA was observed in gills after four days, which suggests protein damage and the requirement for repair processes. Metoprolol was 20-fold bioaccumulated for environmentally relevant concentrations.

  • The beta-receptor blocker metoprolol alters detoxification processes in the non-Target Organism Dreissena polymorpha
    Environmental Pollution, 2010
    Co-Authors: Valeska Contardo-jara, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, Claudia Wiegand
    Abstract:

    Due to increasing amounts of pharmaceutically active compounds (PhACs) in the aquatic environment, their largely unknown effects to non-Target Organisms need to be assessed. This study examined physiological changes in the freshwater mussel Dreissena polymorpha exposed to increasing concentrations (0.534, 5.34, 53.4 and 534 mg L1) of the b-blocker metoprolol in a flow-through system for seven days. The two lower concentrations represent the environmentally relevant range. Surprisingly, metallothionein mRNA was immediately up-regulated in all treatments. For the two higher concentrations mRNA up-regulation in gills was found for P-glycoprotein after one day, and after four days for pi class glutathione S-transferase, demonstrating elimination and biotransformation processes, respectively. Additionally, catalase and superoxide dismutase were up-regulated in the digestive gland indicating oxidative stress. In all treated mussels a significant up-regulation of heat shock protein mRNA was observed in gills after four days, which suggests protein damage and the requirement for repair processes. Metoprolol was 20-fold bioaccumulated for environmentally relevant concentrations.

Valeska Contardo-jara - One of the best experts on this subject based on the ideXlab platform.

  • Molecular effects and bioaccumulation of levonorgestrel in the non-Target Organism Dreissena polymorpha
    Environmental Pollution, 2011
    Co-Authors: Valeska Contardo-jara, Claudia Lorenz, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, Claudia Wiegand
    Abstract:

    Bioaccumulation and effects of the contraceptive hormone levonorgestrel were examined in the nonTarget Organism Dreissena polymorpha. Molecular biomarkers of biotransformation, elimination, antioxidant defence and protein damage were analyzed after exposure to increasing concentrations of levonorgestrel in a flow-through system. The lowest concentration (0.312 mg L-1) was 100-fold bioconcentrated within four days. A decrease of the bioconcentration factor was observed within one week for the highest test concentrations (3.12 and 6.24 mg L-1) suggesting enhanced excretory processes. The immediate mRNA up-regulation of pi class glutathione S-transferase proved that phase II biotransformation processes were induced. Disturbance of fundamental cell functions was assumed since the aryl hydrocarbon receptor has been permanently down-regulated. mRNA up-regulation of P-glycoprotein, superoxide dismutase and metallothioneine suggested enhanced elimination processes and ongoing oxidative stress. mRNA up-regulation of heat shock protein 70 in mussels exposed to the two highest concentrations clearly indicated impacts on protein damage.

  • The β-receptor blocker metoprolol alters detoxification processes in the non-Target Organism Dreissena polymorpha.
    Environmental pollution (Barking Essex : 1987), 2010
    Co-Authors: Valeska Contardo-jara, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, Claudia Wiegand
    Abstract:

    Abstract Due to increasing amounts of pharmaceutically active compounds (PhACs) in the aquatic environment, their largely unknown effects to non-Target Organisms need to be assessed. This study examined physiological changes in the freshwater mussel Dreissena polymorpha exposed to increasing concentrations (0.534, 5.34, 53.4 and 534 μg L −1 ) of the β-blocker metoprolol in a flow-through system for seven days. The two lower concentrations represent the environmentally relevant range. Surprisingly, metallothionein mRNA was immediately up-regulated in all treatments. For the two higher concentrations mRNA up-regulation in gills was found for P-glycoprotein after one day, and after four days for pi class glutathione S-transferase, demonstrating elimination and biotransformation processes, respectively. Additionally, catalase and superoxide dismutase were up-regulated in the digestive gland indicating oxidative stress. In all treated mussels a significant up-regulation of heat shock protein mRNA was observed in gills after four days, which suggests protein damage and the requirement for repair processes. Metoprolol was 20-fold bioaccumulated for environmentally relevant concentrations.

  • The beta-receptor blocker metoprolol alters detoxification processes in the non-Target Organism Dreissena polymorpha
    Environmental Pollution, 2010
    Co-Authors: Valeska Contardo-jara, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, Claudia Wiegand
    Abstract:

    Due to increasing amounts of pharmaceutically active compounds (PhACs) in the aquatic environment, their largely unknown effects to non-Target Organisms need to be assessed. This study examined physiological changes in the freshwater mussel Dreissena polymorpha exposed to increasing concentrations (0.534, 5.34, 53.4 and 534 mg L1) of the b-blocker metoprolol in a flow-through system for seven days. The two lower concentrations represent the environmentally relevant range. Surprisingly, metallothionein mRNA was immediately up-regulated in all treatments. For the two higher concentrations mRNA up-regulation in gills was found for P-glycoprotein after one day, and after four days for pi class glutathione S-transferase, demonstrating elimination and biotransformation processes, respectively. Additionally, catalase and superoxide dismutase were up-regulated in the digestive gland indicating oxidative stress. In all treated mussels a significant up-regulation of heat shock protein mRNA was observed in gills after four days, which suggests protein damage and the requirement for repair processes. Metoprolol was 20-fold bioaccumulated for environmentally relevant concentrations.

Gunnar Nutzmann - One of the best experts on this subject based on the ideXlab platform.

  • Molecular effects and bioaccumulation of levonorgestrel in the non-Target Organism Dreissena polymorpha
    Environmental Pollution, 2011
    Co-Authors: Valeska Contardo-jara, Claudia Lorenz, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, Claudia Wiegand
    Abstract:

    Bioaccumulation and effects of the contraceptive hormone levonorgestrel were examined in the nonTarget Organism Dreissena polymorpha. Molecular biomarkers of biotransformation, elimination, antioxidant defence and protein damage were analyzed after exposure to increasing concentrations of levonorgestrel in a flow-through system. The lowest concentration (0.312 mg L-1) was 100-fold bioconcentrated within four days. A decrease of the bioconcentration factor was observed within one week for the highest test concentrations (3.12 and 6.24 mg L-1) suggesting enhanced excretory processes. The immediate mRNA up-regulation of pi class glutathione S-transferase proved that phase II biotransformation processes were induced. Disturbance of fundamental cell functions was assumed since the aryl hydrocarbon receptor has been permanently down-regulated. mRNA up-regulation of P-glycoprotein, superoxide dismutase and metallothioneine suggested enhanced elimination processes and ongoing oxidative stress. mRNA up-regulation of heat shock protein 70 in mussels exposed to the two highest concentrations clearly indicated impacts on protein damage.

  • The β-receptor blocker metoprolol alters detoxification processes in the non-Target Organism Dreissena polymorpha.
    Environmental pollution (Barking Essex : 1987), 2010
    Co-Authors: Valeska Contardo-jara, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, Claudia Wiegand
    Abstract:

    Abstract Due to increasing amounts of pharmaceutically active compounds (PhACs) in the aquatic environment, their largely unknown effects to non-Target Organisms need to be assessed. This study examined physiological changes in the freshwater mussel Dreissena polymorpha exposed to increasing concentrations (0.534, 5.34, 53.4 and 534 μg L −1 ) of the β-blocker metoprolol in a flow-through system for seven days. The two lower concentrations represent the environmentally relevant range. Surprisingly, metallothionein mRNA was immediately up-regulated in all treatments. For the two higher concentrations mRNA up-regulation in gills was found for P-glycoprotein after one day, and after four days for pi class glutathione S-transferase, demonstrating elimination and biotransformation processes, respectively. Additionally, catalase and superoxide dismutase were up-regulated in the digestive gland indicating oxidative stress. In all treated mussels a significant up-regulation of heat shock protein mRNA was observed in gills after four days, which suggests protein damage and the requirement for repair processes. Metoprolol was 20-fold bioaccumulated for environmentally relevant concentrations.

  • The beta-receptor blocker metoprolol alters detoxification processes in the non-Target Organism Dreissena polymorpha
    Environmental Pollution, 2010
    Co-Authors: Valeska Contardo-jara, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, Claudia Wiegand
    Abstract:

    Due to increasing amounts of pharmaceutically active compounds (PhACs) in the aquatic environment, their largely unknown effects to non-Target Organisms need to be assessed. This study examined physiological changes in the freshwater mussel Dreissena polymorpha exposed to increasing concentrations (0.534, 5.34, 53.4 and 534 mg L1) of the b-blocker metoprolol in a flow-through system for seven days. The two lower concentrations represent the environmentally relevant range. Surprisingly, metallothionein mRNA was immediately up-regulated in all treatments. For the two higher concentrations mRNA up-regulation in gills was found for P-glycoprotein after one day, and after four days for pi class glutathione S-transferase, demonstrating elimination and biotransformation processes, respectively. Additionally, catalase and superoxide dismutase were up-regulated in the digestive gland indicating oxidative stress. In all treated mussels a significant up-regulation of heat shock protein mRNA was observed in gills after four days, which suggests protein damage and the requirement for repair processes. Metoprolol was 20-fold bioaccumulated for environmentally relevant concentrations.

Werner Kloas - One of the best experts on this subject based on the ideXlab platform.

  • Molecular effects and bioaccumulation of levonorgestrel in the non-Target Organism Dreissena polymorpha
    Environmental Pollution, 2011
    Co-Authors: Valeska Contardo-jara, Claudia Lorenz, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, Claudia Wiegand
    Abstract:

    Bioaccumulation and effects of the contraceptive hormone levonorgestrel were examined in the nonTarget Organism Dreissena polymorpha. Molecular biomarkers of biotransformation, elimination, antioxidant defence and protein damage were analyzed after exposure to increasing concentrations of levonorgestrel in a flow-through system. The lowest concentration (0.312 mg L-1) was 100-fold bioconcentrated within four days. A decrease of the bioconcentration factor was observed within one week for the highest test concentrations (3.12 and 6.24 mg L-1) suggesting enhanced excretory processes. The immediate mRNA up-regulation of pi class glutathione S-transferase proved that phase II biotransformation processes were induced. Disturbance of fundamental cell functions was assumed since the aryl hydrocarbon receptor has been permanently down-regulated. mRNA up-regulation of P-glycoprotein, superoxide dismutase and metallothioneine suggested enhanced elimination processes and ongoing oxidative stress. mRNA up-regulation of heat shock protein 70 in mussels exposed to the two highest concentrations clearly indicated impacts on protein damage.

  • The β-receptor blocker metoprolol alters detoxification processes in the non-Target Organism Dreissena polymorpha.
    Environmental pollution (Barking Essex : 1987), 2010
    Co-Authors: Valeska Contardo-jara, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, Claudia Wiegand
    Abstract:

    Abstract Due to increasing amounts of pharmaceutically active compounds (PhACs) in the aquatic environment, their largely unknown effects to non-Target Organisms need to be assessed. This study examined physiological changes in the freshwater mussel Dreissena polymorpha exposed to increasing concentrations (0.534, 5.34, 53.4 and 534 μg L −1 ) of the β-blocker metoprolol in a flow-through system for seven days. The two lower concentrations represent the environmentally relevant range. Surprisingly, metallothionein mRNA was immediately up-regulated in all treatments. For the two higher concentrations mRNA up-regulation in gills was found for P-glycoprotein after one day, and after four days for pi class glutathione S-transferase, demonstrating elimination and biotransformation processes, respectively. Additionally, catalase and superoxide dismutase were up-regulated in the digestive gland indicating oxidative stress. In all treated mussels a significant up-regulation of heat shock protein mRNA was observed in gills after four days, which suggests protein damage and the requirement for repair processes. Metoprolol was 20-fold bioaccumulated for environmentally relevant concentrations.

  • The beta-receptor blocker metoprolol alters detoxification processes in the non-Target Organism Dreissena polymorpha
    Environmental Pollution, 2010
    Co-Authors: Valeska Contardo-jara, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, Claudia Wiegand
    Abstract:

    Due to increasing amounts of pharmaceutically active compounds (PhACs) in the aquatic environment, their largely unknown effects to non-Target Organisms need to be assessed. This study examined physiological changes in the freshwater mussel Dreissena polymorpha exposed to increasing concentrations (0.534, 5.34, 53.4 and 534 mg L1) of the b-blocker metoprolol in a flow-through system for seven days. The two lower concentrations represent the environmentally relevant range. Surprisingly, metallothionein mRNA was immediately up-regulated in all treatments. For the two higher concentrations mRNA up-regulation in gills was found for P-glycoprotein after one day, and after four days for pi class glutathione S-transferase, demonstrating elimination and biotransformation processes, respectively. Additionally, catalase and superoxide dismutase were up-regulated in the digestive gland indicating oxidative stress. In all treated mussels a significant up-regulation of heat shock protein mRNA was observed in gills after four days, which suggests protein damage and the requirement for repair processes. Metoprolol was 20-fold bioaccumulated for environmentally relevant concentrations.

Stephan Pflugmacher - One of the best experts on this subject based on the ideXlab platform.

  • Molecular effects and bioaccumulation of levonorgestrel in the non-Target Organism Dreissena polymorpha
    Environmental Pollution, 2011
    Co-Authors: Valeska Contardo-jara, Claudia Lorenz, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, Claudia Wiegand
    Abstract:

    Bioaccumulation and effects of the contraceptive hormone levonorgestrel were examined in the nonTarget Organism Dreissena polymorpha. Molecular biomarkers of biotransformation, elimination, antioxidant defence and protein damage were analyzed after exposure to increasing concentrations of levonorgestrel in a flow-through system. The lowest concentration (0.312 mg L-1) was 100-fold bioconcentrated within four days. A decrease of the bioconcentration factor was observed within one week for the highest test concentrations (3.12 and 6.24 mg L-1) suggesting enhanced excretory processes. The immediate mRNA up-regulation of pi class glutathione S-transferase proved that phase II biotransformation processes were induced. Disturbance of fundamental cell functions was assumed since the aryl hydrocarbon receptor has been permanently down-regulated. mRNA up-regulation of P-glycoprotein, superoxide dismutase and metallothioneine suggested enhanced elimination processes and ongoing oxidative stress. mRNA up-regulation of heat shock protein 70 in mussels exposed to the two highest concentrations clearly indicated impacts on protein damage.

  • The β-receptor blocker metoprolol alters detoxification processes in the non-Target Organism Dreissena polymorpha.
    Environmental pollution (Barking Essex : 1987), 2010
    Co-Authors: Valeska Contardo-jara, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, Claudia Wiegand
    Abstract:

    Abstract Due to increasing amounts of pharmaceutically active compounds (PhACs) in the aquatic environment, their largely unknown effects to non-Target Organisms need to be assessed. This study examined physiological changes in the freshwater mussel Dreissena polymorpha exposed to increasing concentrations (0.534, 5.34, 53.4 and 534 μg L −1 ) of the β-blocker metoprolol in a flow-through system for seven days. The two lower concentrations represent the environmentally relevant range. Surprisingly, metallothionein mRNA was immediately up-regulated in all treatments. For the two higher concentrations mRNA up-regulation in gills was found for P-glycoprotein after one day, and after four days for pi class glutathione S-transferase, demonstrating elimination and biotransformation processes, respectively. Additionally, catalase and superoxide dismutase were up-regulated in the digestive gland indicating oxidative stress. In all treated mussels a significant up-regulation of heat shock protein mRNA was observed in gills after four days, which suggests protein damage and the requirement for repair processes. Metoprolol was 20-fold bioaccumulated for environmentally relevant concentrations.

  • The beta-receptor blocker metoprolol alters detoxification processes in the non-Target Organism Dreissena polymorpha
    Environmental Pollution, 2010
    Co-Authors: Valeska Contardo-jara, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, Claudia Wiegand
    Abstract:

    Due to increasing amounts of pharmaceutically active compounds (PhACs) in the aquatic environment, their largely unknown effects to non-Target Organisms need to be assessed. This study examined physiological changes in the freshwater mussel Dreissena polymorpha exposed to increasing concentrations (0.534, 5.34, 53.4 and 534 mg L1) of the b-blocker metoprolol in a flow-through system for seven days. The two lower concentrations represent the environmentally relevant range. Surprisingly, metallothionein mRNA was immediately up-regulated in all treatments. For the two higher concentrations mRNA up-regulation in gills was found for P-glycoprotein after one day, and after four days for pi class glutathione S-transferase, demonstrating elimination and biotransformation processes, respectively. Additionally, catalase and superoxide dismutase were up-regulated in the digestive gland indicating oxidative stress. In all treated mussels a significant up-regulation of heat shock protein mRNA was observed in gills after four days, which suggests protein damage and the requirement for repair processes. Metoprolol was 20-fold bioaccumulated for environmentally relevant concentrations.