The Experts below are selected from a list of 25839 Experts worldwide ranked by ideXlab platform
Li-de Zhang - One of the best experts on this subject based on the ideXlab platform.
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Facile fabrication of magnetic metal–organic framework nanocomposites for potential Targeted Drug Delivery
Journal of Materials Chemistry, 2011Co-Authors: Fei Ke, Yu-hua Shen, An-jian Xie, Ling-guang Qiu, Jun-fa Zhu, Xing-you Tian, Yu-peng Yuan, Li-de ZhangAbstract:In this paper, we describe a facile, efficient, and environmentally friendly fabrication of a novel type of magnetic porous metalorganic-framework (MOF)-based nanocomposites that can be potentially used for Targeted Drug Delivery. The magnetic MOF nanocomposites were fabricated by incorporation of Fe3O4 nanorods with nanocrystals of Cu3(BTC)2 (HKUST-1), a three dimensional (3D) MOF with a 3D channel system. The as-synthesized materials exhibited both magnetic characteristics and high porosity, making them excellent candidates for Targeted Drug Delivery systems. An anti-cancer Drug acting as a selective cyclooxygenase-2 (COX-2) inhibitor for pancreatic cancer treatment, Nimesulide, was laden into pores of the nanocomposites. These MOF-based magnetic nanocomposites could adsorb up to 0.2 g of Nimesulide per gram of composite, and it took as long as 11 days to complete the Drug release in physiological saline at 37 C.
Kinam Park - One of the best experts on this subject based on the ideXlab platform.
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Analysis on the current status of Targeted Drug Delivery to tumors
Journal of Controlled Release, 2012Co-Authors: Il Keun Kwon, Bumsoo Han, Sang Cheon Lee, Kinam ParkAbstract:Targeted Drug Delivery to tumor sites is one of the ultimate goals in Drug Delivery. Recent progress in nanoparticle engineering has certainly improved Drug targeting, but the results are not as good as expected. This is largely due to the fact that nanoparticles, regardless of how advanced they are, find the target as a result of blood circulation, like the conventional Drug Delivery systems do. Currently, the nanoparticle-based Drug Delivery to the target tumor tissues is based on wrong assumptions that most of the nanoparticles, either PEGylated or not, reach the target by the enhanced permeation and retention (EPR) effect. Studies have shown that so-called targeting moieties, i.e., antibodies or ligands, on the nanoparticle surface do not really improve Delivery to target tumors. Targeted Drug Delivery to tumor sites is associated with highly complex biological, mechanical, chemical and transport phenomena, of which characteristics vary spatiotemporally. Yet, most of the efforts have been focused on design and surface manipulation of the Drug carrying nanoparticles with relatively little attention to other aspects. This article examines the current misunderstandings and the main difficulties in Targeted Drug Delivery.
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Targeted Drug Delivery to tumors: Myths, reality and possibility
Journal of Controlled Release, 2011Co-Authors: You Han Bae, Kinam ParkAbstract:The ultimate goal of Drug Delivery research is to help patients by developing clinically useful formulations. During the last several decades controlled Drug Delivery technology has advanced significantly, leading to the development of various clinical formulations improving patient compliance and convenience [1]. Current technologies allow Delivery of Drugs at desired release kinetics for extended periods of time ranging from days to years. Oral and transdermal Drug Delivery systems routinely deliver Drugs for 24 h, substantially improving Drug efficacy and minimizing side effects. Implantable systems can locally deliver Drugs for months, even years. While significant advances have been made, there are still areas where substantial improvements need to be made to reach the next level of clinical relevance. One such area is Targeted Drug Delivery to solid tumors. The clinically significant impact of Targeted Drug Delivery lies in the ability to specifically target a Drug or Drug carrier to minimize Drug-originated systemic toxic effects. Successful translation (from bench to bedside) of potential cancer and gene therapies, particularly small interfering RNA (siRNA) Delivery, will largely depend on Targeted Drug Delivery strategies. Overcoming the many challenges of identifying a successful Targeted Drug Delivery strategy requires an understanding of events involving transport of Drug or Drug carrier to a target site after intravenous (i.v.) administration as well as issues relevant for specific target diseases and the body’s response toward a Drug Delivery system. The current lack of clear recognition of problems facing the Drug Delivery field can be anticipated to result in only marginal advances in Targeted Drug Delivery technologies in the coming years. The current unmet needs and challenges in this area were summarized by Professor Alexander T. Florence who is one of the few who raised awareness on the exaggerated claims of the nanoparticle-based Drug targeting [2,3]. They need to be better appreciated and understood for achieving greater success in Drug targeting to tumors. Thus, it would be profitable to address a variety of issues and factors that could affect the development of improved Targeted Drug Delivery systems. Many terms have been used to describe nano-sized Drug Delivery systems, and here the term “nanoparticle” is used to represent a spectrum of systems, including nanocarrier, nanovehicle, nanosystem, nanostructure, and other terms used in the literature.
Sanjay K Jain - One of the best experts on this subject based on the ideXlab platform.
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polysaccharides for colon Targeted Drug Delivery
Drug Delivery, 2004Co-Authors: Manish K Chourasia, Sanjay K JainAbstract:Colon Targeted Drug Delivery has the potential to deliver bioactive agents for the treatment of a variety of colonic diseases and to deliver proteins and peptides to the colon for their systemic absorption. Various strategies, currently available to target the release of Drugs to colon, include formation of proDrug, coating of pH-sensitive polymers, use of colon-specific biodegradable polymers, timed released systems, osmotic systems, and pressure controlled Drug Delivery systems. Among the different approaches to achieve Targeted Drug release to the colon, the use of polymers especially biodegradable by colonic bacteria holds great promise. Polysaccharidases are bacterial enzymes that are available in sufficient quantity to be exploited in colon targeting of Drugs. Based on this approach, various polysaccharides have been investigated for colon-specific Drug release. These polysaccharides include pectin, guar gum, amylose, inulin, dextran, chitosan, and chondroitin sulphate. This family of natural polyme...
Fei Ke - One of the best experts on this subject based on the ideXlab platform.
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Facile fabrication of magnetic metal–organic framework nanocomposites for potential Targeted Drug Delivery
Journal of Materials Chemistry, 2011Co-Authors: Fei Ke, Yu-hua Shen, An-jian Xie, Ling-guang Qiu, Jun-fa Zhu, Xing-you Tian, Yu-peng Yuan, Li-de ZhangAbstract:In this paper, we describe a facile, efficient, and environmentally friendly fabrication of a novel type of magnetic porous metalorganic-framework (MOF)-based nanocomposites that can be potentially used for Targeted Drug Delivery. The magnetic MOF nanocomposites were fabricated by incorporation of Fe3O4 nanorods with nanocrystals of Cu3(BTC)2 (HKUST-1), a three dimensional (3D) MOF with a 3D channel system. The as-synthesized materials exhibited both magnetic characteristics and high porosity, making them excellent candidates for Targeted Drug Delivery systems. An anti-cancer Drug acting as a selective cyclooxygenase-2 (COX-2) inhibitor for pancreatic cancer treatment, Nimesulide, was laden into pores of the nanocomposites. These MOF-based magnetic nanocomposites could adsorb up to 0.2 g of Nimesulide per gram of composite, and it took as long as 11 days to complete the Drug release in physiological saline at 37 C.
Shi Da - One of the best experts on this subject based on the ideXlab platform.
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Preparation and clinical use of oral colon Targeted Drug Delivery systems
Practical Pharmacy and Clinical Remedies, 2014Co-Authors: Shi DaAbstract:Objective According to the special advantages in the treatment of intestinal or some systemic diseases,oral colon Targeted Drug Delivery system has received much attention. How ever,the complexity of the digestive tract may have adverse effects on Drugs and the reproducibility in colon Targeted Drug Delivery. The physiological factors,preparation techniques,as w ell as the use of oral colon Targeted Drug medication are summarized in the review.
