The Experts below are selected from a list of 52698 Experts worldwide ranked by ideXlab platform
Gaurav S Sukhatme - One of the best experts on this subject based on the ideXlab platform.
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adaptive spatio Temporal Organization in groups of robots
Intelligent Robots and Systems, 2002Co-Authors: Torbjorn S Dahl, Maja J Mataric, Gaurav S SukhatmeAbstract:This paper presents experiments, in simulation, with a group of robots that improve their performance on a straightforward transportation task by using reinforcement learning to associate input states with a set of abstract behaviors. We show that the improvement in performance is a result of the group adapting its spatio-Temporal Organization to the given environment. Spatio-Temporal adaptation is a general form of adaptation in that it can improve performance over a range of different tasks and environments. Hence it increases the general applicability and autonomy of robotic systems. Lastly, we present two communication strategies that improve this ability to adapt by generally improving learning rates for cooperative robots in highly dynamic domains.
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IROS - Adaptive spatio-Temporal Organization in groups of robots
IEEE RSJ International Conference on Intelligent Robots and System, 1Co-Authors: Torbjorn S Dahl, Maja J. Matarić, Gaurav S SukhatmeAbstract:This paper presents experiments, in simulation, with a group of robots that improve their performance on a straightforward transportation task by using reinforcement learning to associate input states with a set of abstract behaviors. We show that the improvement in performance is a result of the group adapting its spatio-Temporal Organization to the given environment. Spatio-Temporal adaptation is a general form of adaptation in that it can improve performance over a range of different tasks and environments. Hence it increases the general applicability and autonomy of robotic systems. Lastly, we present two communication strategies that improve this ability to adapt by generally improving learning rates for cooperative robots in highly dynamic domains.
David Z. Rudner - One of the best experts on this subject based on the ideXlab platform.
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Spatio-Temporal Organization of Replication in Bacteria and Eukaryotes (Nucleoids and Nuclei)
Cold Spring Harbor perspectives in biology, 2012Co-Authors: Dean A. Jackson, Xindan Wang, David Z. RudnerAbstract:Herewediscussthespatio-TemporalOrganizationofreplicationineubacteriaandeukaryotes. Althoughtherearesignificantdifferencesinhowreplicationisorganizedincellsthatcontain nuclei from those that do not, you will see that Organization of replication in all organisms is principally dictated by the structured arrangement of the chromosome. We will begin with how replication is organized in eubacteria with particular emphasis on three well studied model organisms. We will then discuss spatial and Temporal Organization of replication in eukaryotes highlighting the similarities and differences between these two domains of life.
Andrew Seeber - One of the best experts on this subject based on the ideXlab platform.
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Monitoring the spatio-Temporal Organization and dynamics of the genome.
Nucleic acids research, 2020Co-Authors: Haitham A. Shaban, Andrew SeeberAbstract:The spatio-Temporal Organization of chromatin in the eukaryotic cell nucleus is of vital importance for transcription, DNA replication and genome maintenance. Each of these activities is tightly regulated in both time and space. While we have a good understanding of chromatin Organization in space, for example in fixed snapshots as a result of techniques like FISH and Hi-C, little is known about chromatin dynamics in living cells. The rapid development of flexible genomic loci imaging approaches can address fundamental questions on chromatin dynamics in a range of model organisms. Moreover, it is now possible to visualize not only single genomic loci but the whole genome simultaneously. These advances have opened many doors leading to insight into several nuclear processes including transcription and DNA repair. In this review, we discuss new chromatin imaging methods and how they have been applied to study transcription.
G. V. Shivashankar - One of the best experts on this subject based on the ideXlab platform.
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Spatio-Temporal Organization of Transcription Compartments Within Living Cells
Biophysical Journal, 2012Co-Authors: Shovamayee Maharana, G. V. ShivashankarAbstract:Recent studies have shown that transcriptional activity in the nucleus is organized in compartmentalized foci, where genes either loop out or are co-clustered to form active chromatin hubs. In addition, our studies are beginning to reveal that gene-active chromosomes share physical proximity within the 3D architecture of the cell nucleus. However the spatio-Temporal Organization of TFs and its functional implications are unclear. Using high-resolution live-cell fluorescence imaging and spectroscopy, we analyze the dynamic Organization of Transcription Compartments (TCs). For this we labeled TCs using fluorescent UTPs which co-localize with active RNA Pol-II antibody in a transcription dependent manner. Interestingly time-lapse imaging of these compartments exhibited a dynamic behavior with runs, pauses and steps. This dynamic Organization of TCs was dependent on ATP, lamin B1, histone acetylation levels, cytoplasmic to nuclear anchorage and transcriptional activity. Importantly during runs, TCs are mobile within the inter-chromosome territories. The spatio-Temporal Organization of TCs that we observe may provide possible mechanisms to alter gene expression programs upon integration of physico-chemical signals to the nucleus.
Ronald Berezney - One of the best experts on this subject based on the ideXlab platform.
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the spatio Temporal Organization of dna replication sites is identical in primary immortalized and transformed mammalian cells
Journal of Cell Science, 2002Co-Authors: Daniela S Dimitrova, Ronald BerezneyAbstract:We investigated the Organization of DNA replication sites in primary (young or presenescent), immortalized and transformed mammalian cells. Four different methods were used to visualize replication sites: in vivo pulse-labeling with 5-bromo-2'-deoxyuridine (BrdU), followed by either acid depurination, or incubation in nuclease cocktail to expose single-stranded BrdU-substituted DNA regions for immunolabeling; biotin-dUTP labeling of nascent DNA by run-on replication within intact nuclei and staining with fluorescent streptavidin; and, finally, immunolabeling of the replication fork proteins PCNA and RPA. All methods produced identical results, demonstrating no fundamental differences in the spatio-Temporal Organization of replication patterns between primary, immortal or transformed mammalian cells. In addition, we did not detect a spatial coincidence between the early firing replicons and nuclear lamin proteins, the retinoblastoma protein or the nucleolus in primary human and rodent cells. The retinoblastoma protein does not colocalize in vivo with members of the Mcm family of proteins (Mcm2, 3 and 7) at any point of the cell cycle and neither in the chromatin-bound nor in the soluble nucleoplasmic fraction. These results argue against a direct role for the retinoblastoma or nuclear lamin proteins in mammalian DNA synthesis under normal physiological conditions.
