The Experts below are selected from a list of 4266 Experts worldwide ranked by ideXlab platform
Uttam Singh - One of the best experts on this subject based on the ideXlab platform.
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Physicochemical and Preliminary Phytochemical Studies on the Fruit of Terminalia chebula Retz
Asian Journal of Research in Chemistry, 2010Co-Authors: A K Meena, M. M. Rao, Kiran L. Sharma, Ajay Yadav, Uttam SinghAbstract:The present communication attempts to evaluate the physicochemical and preliminary phytochemical studies on the fruit of Terminalia chebula Retz. Combretaceae family. Haritaki is semi-deciduous tree grows up to 24 meter in height. Terminalia chebula is found throughout India chiefly in deciduous forests, on dry slopes up to 900m especially in Tamil Nadu, widely distributed through the greater parts of India, from Ravi eastwards to West Bengal and Assam, Bihar, Orissa, Madhya Pradesh, Deccan, West coast and Western Ghats. The plant is also reported in Sri Lanka, Nepal and Burma. Terminalia chebula is traditionally used in the formulation for anti-diabetic, antimicrobial, laxative, antiinflammatory, laxative, anti-fungal, cardiotonic, diuretic, hyperlipidemic activity. As there is no detailed standardisation work reported on fruit, the physicochemical parameters, preliminary phytochemical constants, toxic heavy metals, pesticide residue, and aflatoxin analysis are carried out. The study revealed specific identities for the particular crude drug which will be useful in identification and control to adulterations of the raw drug.
Pradeep Singh - One of the best experts on this subject based on the ideXlab platform.
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Effect of Terminalia chebula extract and chlorhexidine on salivary pH and periodontal health: 2 weeks randomized control trial.
Phytotherapy research : PTR, 2013Co-Authors: Devanand Gupta, Rajendra Kumar Gupta, Dara John Bhaskar, Bushra Karim, Vishal Gupta, Himanshu Punia, Manu Batra, Ankita Jain, Amit Agarwal, Pradeep SinghAbstract:A double blind, randomized, controlled study with three parallel treatment groups was done to evaluate the efficacy of a Terminalia chebula 10% mouth rinse compared with chlorhexidine 0.12% mouth rinse, applied two times daily for 2 weeks, in the treatment of dental plaque and gingivitis. Seventy-eight patients were included in the study. The efficacy variables were periodontal indices on days 0, 7 and 14 after commencement of therapy. Twenty six patients received chlorhexidine mouth rinse, twenty six Terminalia chebula mouth rinse and twenty six received saline solution. The clinical parameters were significantly reduced by both chlorhexidine and Terminalia chebula mouth rinse although no significant difference was seen between the two groups (P > 0.05). This study demonstrated that Terminalia chebula mouth rinse is effective in reducing microbial plaque, gingival inflammation and neutralizing salivary pH. Copyright © 2013 John Wiley & Sons, Ltd.
A K Meena - One of the best experts on this subject based on the ideXlab platform.
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Physicochemical and Preliminary Phytochemical Studies on the Fruit of Terminalia chebula Retz
Asian Journal of Research in Chemistry, 2010Co-Authors: A K Meena, M. M. Rao, Kiran L. Sharma, Ajay Yadav, Uttam SinghAbstract:The present communication attempts to evaluate the physicochemical and preliminary phytochemical studies on the fruit of Terminalia chebula Retz. Combretaceae family. Haritaki is semi-deciduous tree grows up to 24 meter in height. Terminalia chebula is found throughout India chiefly in deciduous forests, on dry slopes up to 900m especially in Tamil Nadu, widely distributed through the greater parts of India, from Ravi eastwards to West Bengal and Assam, Bihar, Orissa, Madhya Pradesh, Deccan, West coast and Western Ghats. The plant is also reported in Sri Lanka, Nepal and Burma. Terminalia chebula is traditionally used in the formulation for anti-diabetic, antimicrobial, laxative, antiinflammatory, laxative, anti-fungal, cardiotonic, diuretic, hyperlipidemic activity. As there is no detailed standardisation work reported on fruit, the physicochemical parameters, preliminary phytochemical constants, toxic heavy metals, pesticide residue, and aflatoxin analysis are carried out. The study revealed specific identities for the particular crude drug which will be useful in identification and control to adulterations of the raw drug.
Devanand Gupta - One of the best experts on this subject based on the ideXlab platform.
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comparative evaluation of Terminalia chebula extract mouthwash and chlorhexidine mouthwash on plaque and gingival inflammation 4 week randomised control trial
Oral Health & Preventive Dentistry, 2015Co-Authors: Devanand Gupta, Rajendra Kumar Gupta, Dara John BhaskarAbstract:PURPOSE The present study was conducted to assess the effectiveness of Terminalia chebula on plaque and gingival inflammation and compare it with the gold standard chlorhexidine (CHX 0.2%) and distilled water as control (placebo). MATERIALS AND METHODS A double-blind randomised control trial was conducted among undergraduate students who volunteered. They were randomly allocated into three study groups: 1) Terminalia chebula mouthwash (n = 30); 2) chlorhexidine (active control) (n = 30); 3) distilled water (placebo) (n = 30). Assessment was carried out according to plaque score and gingival score. Statistical analysis was carried out to compare the effect of both mouthwashes. ANOVA and post-hoc LSD tests were performed using SPSS version 17 with p ≤ 0.05 considered statistically significant. RESULTS Our result showed that Terminalia chebula mouthrinse is as effective as chlorhexidine in reducing dental plaque and gingival inflammation. The results demonstrated a significant reduction of gingival bleeding and plaque indices in both groups over a period of 15 and 30 days as compared to the placebo. CONCLUSION The results of the present study indicate that Terminalia chebula may prove to be an effective mouthwash. Terminalia chebula extract mouthrinse can be used as an alternative to chlorhexidine mouthrinse as it has similar properties without the side-effects of the latter.
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Effect of Terminalia chebula extract and chlorhexidine on salivary pH and periodontal health: 2 weeks randomized control trial.
Phytotherapy research : PTR, 2013Co-Authors: Devanand Gupta, Rajendra Kumar Gupta, Dara John Bhaskar, Bushra Karim, Vishal Gupta, Himanshu Punia, Manu Batra, Ankita Jain, Amit Agarwal, Pradeep SinghAbstract:A double blind, randomized, controlled study with three parallel treatment groups was done to evaluate the efficacy of a Terminalia chebula 10% mouth rinse compared with chlorhexidine 0.12% mouth rinse, applied two times daily for 2 weeks, in the treatment of dental plaque and gingivitis. Seventy-eight patients were included in the study. The efficacy variables were periodontal indices on days 0, 7 and 14 after commencement of therapy. Twenty six patients received chlorhexidine mouth rinse, twenty six Terminalia chebula mouth rinse and twenty six received saline solution. The clinical parameters were significantly reduced by both chlorhexidine and Terminalia chebula mouth rinse although no significant difference was seen between the two groups (P > 0.05). This study demonstrated that Terminalia chebula mouth rinse is effective in reducing microbial plaque, gingival inflammation and neutralizing salivary pH. Copyright © 2013 John Wiley & Sons, Ltd.
Rabi Ranjan Chattopadhyay - One of the best experts on this subject based on the ideXlab platform.
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the development of Terminalia chebula retz combretaceae in clinical research
Asian pacific Journal of Tropical Biomedicine, 2013Co-Authors: Anwesa Bag, S K Bhattacharyya, Rabi Ranjan ChattopadhyayAbstract:Medicinal plants are part and parcel of human society to combat diseases from the dawn of civilization. Terminalia chebula Retz. (Fam. Combretaceae), is called the ‘King of Medicine’ in Tibet and is always listed at the top of the list of ‘Ayurvedic Materia Medica’ because of its extraordinary power of healing. The whole plant possesses high medicinal value and traditionally used for the treatment of various ailments for human beings. Some of the folklore people used this plant in the treatment of asthma, sore throat, vomiting, hiccough, diarrhea, dysentery, bleeding piles, ulcers, gout, heart and bladder diseases. The plant has been demonstrated to possess multiple pharmacological and medicinal activities, such as antioxidant, antimicrobial, antidiabetic, hepatoprotective, anti-inflammatory, antimutagenic, antiproliferative, radioprotective, cardioprotective, antiarthritic, anticaries, gastrointestinal motility and wound healing activity. But no systematic updated information on the therapeutic effectiveness of Terminalia chebula, a popular herbal remedy in India and South-East Asia has so far been reported. This review highlights an updated information particularly on the phytochemistry and various pharmacological and medicinal properties of Terminalia chebula Retz. and some of its isolated compounds, along with their safety evaluation. This may provide incentive for proper evaluation of the plant as medicinal agent against the human diseases and also to bridge the lacunae in the existing literature and future scope which may offer immense opportunity for researchers engaged in validation of the traditional claims and development of safe and effective botanical medicine.
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Therapeutic potential of Terminalia chebula Retz. (Combretaceae): The Ayurvedic wonder
2013Co-Authors: Anwesa Bag, Rabi Ranjan ChattopadhyayAbstract:Medicinal plants are part and parcel of human society to combat diseases from the dawn of civilization. Terminalia chebula Retz. (Fam. Combretaceae), is called the 'King of Medicine' in Tibet and is always listed at the top of the list of 'Ayurvedic Materia Medica' because of its extraordinary power of healing. The whole plant possesses high medicinal value and traditionally used for the treatment of various ailments for human beings. Some of the folklore people used this plant in the treatment of asthma, sore throat, vomiting, hiccough, diarrhea, dysentery, bleeding piles, ulcers, gout, heart and bladder diseases. The plant has been demonstrated to possess multiple pharmacological and medicinal activities, such as antioxidant, antimicrobial, antidiabetic, hepatoprotective, anti-inflammatory, antimutagenic, antiproliferative, radioprotective, cardioprotective, antiarthritic, anticaries, gastrointestinal motility and wound healing activity. But no systematic updated information on the therapeutic effectiveness of Terminalia chebula, a popular herbal remedy in India and South-East Asia has so far been reported. This review highlights an updated information particularly on the phytochemistry and various pharmacological and medicinal properties of Terminalia chebula Retz. and some of its isolated compounds, along with their safety evaluation. This may provide incentive for proper evaluation of the plant as medicinal agent against the human diseases and also to bridge the lacunae in the existing literature and future scope which may offer immense opportunity for researchers engaged in validation of the traditional claims and development of safe and effective botanical medicine.