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Huei-wen Yang - One of the best experts on this subject based on the ideXlab platform.
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Organosoluble optically transparent poly(ether imide)s based on a Tert‐Butylhydroquinone bis(ether anhydride)
Macromolecular Chemistry and Physics, 2000Co-Authors: Chin-ping Yang, Sheng-huei Hsiao, Huei-wen YangAbstract:Full Paper: A novel bis(ether anhydride) monomer, 1,4-bis(3,4-dicarboxyphenoxy)-2-Tert-butylbenzene dianhydride, was synthesized from the nitro displacement of 4-nitrophthalodinitrile by the phenoxide ion of Tert-Butylhydroquinone, followed by alkaline hydrolysis of the intermediate bis(ether dinitrile) and dehydration of the resulting bis(ether diacid). A series of colorless and organosoluble poly(ether imide)s (PEIs) bearing pendent Tert-butyl groups were prepared from the bis(ether anhydride) with various aromatic diamines via a conventional two-stage process that included ring-opening polyaddition to form the poly(amic acid)s followed by chemical or thermal cyclodehydration to the PEIs. The inherent viscosities of these PEIs are in the range of 0.70-1.44 dL/g. Most PEIs show excellent solubilities in amide polar solvents, m-cresol and chlorohydrocarbons. The glass transition temperatures (T g ) of these PEIs were recorded between 217-278°C, and the decomposition temperatures at 10% weight loss are all above 460°C in air or nitrogen atmosphere. Solvent-cast films have high tensile moduli and strengths. The PEIs obtained from long chain diamines exhibit high extension to break.
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organosoluble optically transparent poly ether imide s based on a Tert Butylhydroquinone bis ether anhydride
Macromolecular Chemistry and Physics, 2000Co-Authors: Chin-ping Yang, Sheng-huei Hsiao, Huei-wen YangAbstract:Full Paper: A novel bis(ether anhydride) monomer, 1,4-bis(3,4-dicarboxyphenoxy)-2-Tert-butylbenzene dianhydride, was synthesized from the nitro displacement of 4-nitrophthalodinitrile by the phenoxide ion of Tert-Butylhydroquinone, followed by alkaline hydrolysis of the intermediate bis(ether dinitrile) and dehydration of the resulting bis(ether diacid). A series of colorless and organosoluble poly(ether imide)s (PEIs) bearing pendent Tert-butyl groups were prepared from the bis(ether anhydride) with various aromatic diamines via a conventional two-stage process that included ring-opening polyaddition to form the poly(amic acid)s followed by chemical or thermal cyclodehydration to the PEIs. The inherent viscosities of these PEIs are in the range of 0.70-1.44 dL/g. Most PEIs show excellent solubilities in amide polar solvents, m-cresol and chlorohydrocarbons. The glass transition temperatures (T g ) of these PEIs were recorded between 217-278°C, and the decomposition temperatures at 10% weight loss are all above 460°C in air or nitrogen atmosphere. Solvent-cast films have high tensile moduli and strengths. The PEIs obtained from long chain diamines exhibit high extension to break.
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Synthesis and characterization of aromatic polyamides based on a bis(ether‐carboxylic acid) or a dietheramine derived from Tert‐Butylhydroquinone
Macromolecular Chemistry and Physics, 1999Co-Authors: Chin-ping Yang, Sheng-huei Hsiao, Huei-wen YangAbstract:1,4-Bis(4-carboxyphenoxy)-2-Tert-butylbenzene (2a) and 1,4-bis(4-aminophenoxy)-2-Tert-butylbenzene (2b) were synthesized in two steps starting from the nucleophilic aromatic substitution reaction of p-fluorobenzonitrile and p-chloronitrobenzene, respectively, with Tert-Butylhydroquinone in the presence of potassium carbonate in N,N-dimethylformamide (DMF). Aromatic polyamides were synthesized by direct polycondensation from diacid 2a with various diamines or from diamine 2b with various diacids, by means of triphenyl phosphite and pyridine in N-methyl-2-pyrrolidone solution containing calcium chloride. Inherent viscosities of the polyamides ranged from 0.64 to 1.04 dL/g. Almost all the polyamides are readily soluble in various organic solvents and afford transparent and tough films by solvent casting. The polyamides display T g values of 209-267°C and 10% weight loss values above 460°C in nitrogen and 439°C in air. A comparative study of some polyamides with an isomeric repeating unit is also presented.
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synthesis and characterization of aromatic polyamides based on a bis ether carboxylic acid or a dietheramine derived from Tert Butylhydroquinone
Macromolecular Chemistry and Physics, 1999Co-Authors: Chin-ping Yang, Sheng-huei Hsiao, Huei-wen YangAbstract:1,4-Bis(4-carboxyphenoxy)-2-Tert-butylbenzene (2a) and 1,4-bis(4-aminophenoxy)-2-Tert-butylbenzene (2b) were synthesized in two steps starting from the nucleophilic aromatic substitution reaction of p-fluorobenzonitrile and p-chloronitrobenzene, respectively, with Tert-Butylhydroquinone in the presence of potassium carbonate in N,N-dimethylformamide (DMF). Aromatic polyamides were synthesized by direct polycondensation from diacid 2a with various diamines or from diamine 2b with various diacids, by means of triphenyl phosphite and pyridine in N-methyl-2-pyrrolidone solution containing calcium chloride. Inherent viscosities of the polyamides ranged from 0.64 to 1.04 dL/g. Almost all the polyamides are readily soluble in various organic solvents and afford transparent and tough films by solvent casting. The polyamides display T g values of 209-267°C and 10% weight loss values above 460°C in nitrogen and 439°C in air. A comparative study of some polyamides with an isomeric repeating unit is also presented.
Chin-ping Yang - One of the best experts on this subject based on the ideXlab platform.
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Organosoluble optically transparent poly(ether imide)s based on a Tert‐Butylhydroquinone bis(ether anhydride)
Macromolecular Chemistry and Physics, 2000Co-Authors: Chin-ping Yang, Sheng-huei Hsiao, Huei-wen YangAbstract:Full Paper: A novel bis(ether anhydride) monomer, 1,4-bis(3,4-dicarboxyphenoxy)-2-Tert-butylbenzene dianhydride, was synthesized from the nitro displacement of 4-nitrophthalodinitrile by the phenoxide ion of Tert-Butylhydroquinone, followed by alkaline hydrolysis of the intermediate bis(ether dinitrile) and dehydration of the resulting bis(ether diacid). A series of colorless and organosoluble poly(ether imide)s (PEIs) bearing pendent Tert-butyl groups were prepared from the bis(ether anhydride) with various aromatic diamines via a conventional two-stage process that included ring-opening polyaddition to form the poly(amic acid)s followed by chemical or thermal cyclodehydration to the PEIs. The inherent viscosities of these PEIs are in the range of 0.70-1.44 dL/g. Most PEIs show excellent solubilities in amide polar solvents, m-cresol and chlorohydrocarbons. The glass transition temperatures (T g ) of these PEIs were recorded between 217-278°C, and the decomposition temperatures at 10% weight loss are all above 460°C in air or nitrogen atmosphere. Solvent-cast films have high tensile moduli and strengths. The PEIs obtained from long chain diamines exhibit high extension to break.
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organosoluble optically transparent poly ether imide s based on a Tert Butylhydroquinone bis ether anhydride
Macromolecular Chemistry and Physics, 2000Co-Authors: Chin-ping Yang, Sheng-huei Hsiao, Huei-wen YangAbstract:Full Paper: A novel bis(ether anhydride) monomer, 1,4-bis(3,4-dicarboxyphenoxy)-2-Tert-butylbenzene dianhydride, was synthesized from the nitro displacement of 4-nitrophthalodinitrile by the phenoxide ion of Tert-Butylhydroquinone, followed by alkaline hydrolysis of the intermediate bis(ether dinitrile) and dehydration of the resulting bis(ether diacid). A series of colorless and organosoluble poly(ether imide)s (PEIs) bearing pendent Tert-butyl groups were prepared from the bis(ether anhydride) with various aromatic diamines via a conventional two-stage process that included ring-opening polyaddition to form the poly(amic acid)s followed by chemical or thermal cyclodehydration to the PEIs. The inherent viscosities of these PEIs are in the range of 0.70-1.44 dL/g. Most PEIs show excellent solubilities in amide polar solvents, m-cresol and chlorohydrocarbons. The glass transition temperatures (T g ) of these PEIs were recorded between 217-278°C, and the decomposition temperatures at 10% weight loss are all above 460°C in air or nitrogen atmosphere. Solvent-cast films have high tensile moduli and strengths. The PEIs obtained from long chain diamines exhibit high extension to break.
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Synthesis and characterization of aromatic polyamides based on a bis(ether‐carboxylic acid) or a dietheramine derived from Tert‐Butylhydroquinone
Macromolecular Chemistry and Physics, 1999Co-Authors: Chin-ping Yang, Sheng-huei Hsiao, Huei-wen YangAbstract:1,4-Bis(4-carboxyphenoxy)-2-Tert-butylbenzene (2a) and 1,4-bis(4-aminophenoxy)-2-Tert-butylbenzene (2b) were synthesized in two steps starting from the nucleophilic aromatic substitution reaction of p-fluorobenzonitrile and p-chloronitrobenzene, respectively, with Tert-Butylhydroquinone in the presence of potassium carbonate in N,N-dimethylformamide (DMF). Aromatic polyamides were synthesized by direct polycondensation from diacid 2a with various diamines or from diamine 2b with various diacids, by means of triphenyl phosphite and pyridine in N-methyl-2-pyrrolidone solution containing calcium chloride. Inherent viscosities of the polyamides ranged from 0.64 to 1.04 dL/g. Almost all the polyamides are readily soluble in various organic solvents and afford transparent and tough films by solvent casting. The polyamides display T g values of 209-267°C and 10% weight loss values above 460°C in nitrogen and 439°C in air. A comparative study of some polyamides with an isomeric repeating unit is also presented.
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synthesis and characterization of aromatic polyamides based on a bis ether carboxylic acid or a dietheramine derived from Tert Butylhydroquinone
Macromolecular Chemistry and Physics, 1999Co-Authors: Chin-ping Yang, Sheng-huei Hsiao, Huei-wen YangAbstract:1,4-Bis(4-carboxyphenoxy)-2-Tert-butylbenzene (2a) and 1,4-bis(4-aminophenoxy)-2-Tert-butylbenzene (2b) were synthesized in two steps starting from the nucleophilic aromatic substitution reaction of p-fluorobenzonitrile and p-chloronitrobenzene, respectively, with Tert-Butylhydroquinone in the presence of potassium carbonate in N,N-dimethylformamide (DMF). Aromatic polyamides were synthesized by direct polycondensation from diacid 2a with various diamines or from diamine 2b with various diacids, by means of triphenyl phosphite and pyridine in N-methyl-2-pyrrolidone solution containing calcium chloride. Inherent viscosities of the polyamides ranged from 0.64 to 1.04 dL/g. Almost all the polyamides are readily soluble in various organic solvents and afford transparent and tough films by solvent casting. The polyamides display T g values of 209-267°C and 10% weight loss values above 460°C in nitrogen and 439°C in air. A comparative study of some polyamides with an isomeric repeating unit is also presented.
J. Ezzati Nazhad Dolatabadi - One of the best experts on this subject based on the ideXlab platform.
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Cytotoxicity and DNA damage properties of Tert-Butylhydroquinone (TBHQ) food additive
Food chemistry, 2014Co-Authors: Morteza Eskandani, Hamed Hamishehkar, J. Ezzati Nazhad DolatabadiAbstract:Tert-Butylhydroquinone (TBHQ) was tested for potential cytotoxicity and genotoxicity upon A549 lung cancer cells and Human Umbilical Vein Endothelial Cells (HUVEC). Cytotoxicity was evaluated by MTT assay and flow cytometry analysis, while genotoxicity was assessed in vitro by alkaline comet, DNA fragmentation and DAPI staining assays. TBHQ dose- and time-dependently decreased the growth of A549 and HUVEC cells. Flow cytometry analyses determined early and late apoptosis in the treated cells. Also, single strand DNA breaking has been observed through comet assay technique. In addition, morphology of DAPI stained cells and DNA fragmentation assay using gel electrophoresis showed clear fragmentation in the chromatin and DNA rings within the nucleus of cell's treated TBHQ.
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DNA binding studies of 2-Tert-Butylhydroquinone (TBHQ) food additive
Food Chemistry, 2009Co-Authors: Soheila Kashanian, J. Ezzati Nazhad DolatabadiAbstract:Abstract The interaction of native calf thymus DNA with 2- Tert -Butylhydroquinone (TBHQ) in 10 mM Tris–HCl aqueous solutions at neutral pH 7.4, has been investigated by spectrophotometric, spectrofluorometric, voltammetric and viscosimetric techniques. It is found that TBHQ molecules could intercalate between base pairs of DNA as are evidenced by: hyperchromism in UV absorption band of DNA, sharp increase in specific viscosity of DNA and decrease in the fluorescence of TBHQ solutions in the presence of increasing amounts of DNA. Also peak current decrease, positive shift in the cyclic voltammetry (CV) and differential pulse voltammetry (DPV) are other evidences to indicate that, TBHQ is able to be intercalated in the DNA base pairs.
Sheng-huei Hsiao - One of the best experts on this subject based on the ideXlab platform.
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Organosoluble optically transparent poly(ether imide)s based on a Tert‐Butylhydroquinone bis(ether anhydride)
Macromolecular Chemistry and Physics, 2000Co-Authors: Chin-ping Yang, Sheng-huei Hsiao, Huei-wen YangAbstract:Full Paper: A novel bis(ether anhydride) monomer, 1,4-bis(3,4-dicarboxyphenoxy)-2-Tert-butylbenzene dianhydride, was synthesized from the nitro displacement of 4-nitrophthalodinitrile by the phenoxide ion of Tert-Butylhydroquinone, followed by alkaline hydrolysis of the intermediate bis(ether dinitrile) and dehydration of the resulting bis(ether diacid). A series of colorless and organosoluble poly(ether imide)s (PEIs) bearing pendent Tert-butyl groups were prepared from the bis(ether anhydride) with various aromatic diamines via a conventional two-stage process that included ring-opening polyaddition to form the poly(amic acid)s followed by chemical or thermal cyclodehydration to the PEIs. The inherent viscosities of these PEIs are in the range of 0.70-1.44 dL/g. Most PEIs show excellent solubilities in amide polar solvents, m-cresol and chlorohydrocarbons. The glass transition temperatures (T g ) of these PEIs were recorded between 217-278°C, and the decomposition temperatures at 10% weight loss are all above 460°C in air or nitrogen atmosphere. Solvent-cast films have high tensile moduli and strengths. The PEIs obtained from long chain diamines exhibit high extension to break.
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organosoluble optically transparent poly ether imide s based on a Tert Butylhydroquinone bis ether anhydride
Macromolecular Chemistry and Physics, 2000Co-Authors: Chin-ping Yang, Sheng-huei Hsiao, Huei-wen YangAbstract:Full Paper: A novel bis(ether anhydride) monomer, 1,4-bis(3,4-dicarboxyphenoxy)-2-Tert-butylbenzene dianhydride, was synthesized from the nitro displacement of 4-nitrophthalodinitrile by the phenoxide ion of Tert-Butylhydroquinone, followed by alkaline hydrolysis of the intermediate bis(ether dinitrile) and dehydration of the resulting bis(ether diacid). A series of colorless and organosoluble poly(ether imide)s (PEIs) bearing pendent Tert-butyl groups were prepared from the bis(ether anhydride) with various aromatic diamines via a conventional two-stage process that included ring-opening polyaddition to form the poly(amic acid)s followed by chemical or thermal cyclodehydration to the PEIs. The inherent viscosities of these PEIs are in the range of 0.70-1.44 dL/g. Most PEIs show excellent solubilities in amide polar solvents, m-cresol and chlorohydrocarbons. The glass transition temperatures (T g ) of these PEIs were recorded between 217-278°C, and the decomposition temperatures at 10% weight loss are all above 460°C in air or nitrogen atmosphere. Solvent-cast films have high tensile moduli and strengths. The PEIs obtained from long chain diamines exhibit high extension to break.
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Synthesis and characterization of aromatic polyamides based on a bis(ether‐carboxylic acid) or a dietheramine derived from Tert‐Butylhydroquinone
Macromolecular Chemistry and Physics, 1999Co-Authors: Chin-ping Yang, Sheng-huei Hsiao, Huei-wen YangAbstract:1,4-Bis(4-carboxyphenoxy)-2-Tert-butylbenzene (2a) and 1,4-bis(4-aminophenoxy)-2-Tert-butylbenzene (2b) were synthesized in two steps starting from the nucleophilic aromatic substitution reaction of p-fluorobenzonitrile and p-chloronitrobenzene, respectively, with Tert-Butylhydroquinone in the presence of potassium carbonate in N,N-dimethylformamide (DMF). Aromatic polyamides were synthesized by direct polycondensation from diacid 2a with various diamines or from diamine 2b with various diacids, by means of triphenyl phosphite and pyridine in N-methyl-2-pyrrolidone solution containing calcium chloride. Inherent viscosities of the polyamides ranged from 0.64 to 1.04 dL/g. Almost all the polyamides are readily soluble in various organic solvents and afford transparent and tough films by solvent casting. The polyamides display T g values of 209-267°C and 10% weight loss values above 460°C in nitrogen and 439°C in air. A comparative study of some polyamides with an isomeric repeating unit is also presented.
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synthesis and characterization of aromatic polyamides based on a bis ether carboxylic acid or a dietheramine derived from Tert Butylhydroquinone
Macromolecular Chemistry and Physics, 1999Co-Authors: Chin-ping Yang, Sheng-huei Hsiao, Huei-wen YangAbstract:1,4-Bis(4-carboxyphenoxy)-2-Tert-butylbenzene (2a) and 1,4-bis(4-aminophenoxy)-2-Tert-butylbenzene (2b) were synthesized in two steps starting from the nucleophilic aromatic substitution reaction of p-fluorobenzonitrile and p-chloronitrobenzene, respectively, with Tert-Butylhydroquinone in the presence of potassium carbonate in N,N-dimethylformamide (DMF). Aromatic polyamides were synthesized by direct polycondensation from diacid 2a with various diamines or from diamine 2b with various diacids, by means of triphenyl phosphite and pyridine in N-methyl-2-pyrrolidone solution containing calcium chloride. Inherent viscosities of the polyamides ranged from 0.64 to 1.04 dL/g. Almost all the polyamides are readily soluble in various organic solvents and afford transparent and tough films by solvent casting. The polyamides display T g values of 209-267°C and 10% weight loss values above 460°C in nitrogen and 439°C in air. A comparative study of some polyamides with an isomeric repeating unit is also presented.
Weibang Liang - One of the best experts on this subject based on the ideXlab platform.
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Tert Butylhydroquinone protects the spinal cord against inflammatory response produced by spinal cord injury
Annals of Clinical and Laboratory Science, 2014Co-Authors: Wei Jin, Handong Wang, Jian Jiang, Xiaoshan Hou, Xing Ming, Jing Wang, Baoyu Yuan, Tiansheng Zhu, Weibang LiangAbstract:Antioxidant transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) has been shown in our previous studies to play an important role in protection against spinal cord injury (SCI) induced inflammatory response. The objective of this study was to test whether Tert-Butylhydroquinone (tBHQ), a novel Nrf2 activator, can protect the spinal cord against SCI-induced inflammatory damage. Adult male Sprague-Dawley rats were subjected to laminectomy at T8-T9 and compression with a vascular clip. Three groups were analyzed: a sham group, a SCI group, and a SCI+rhEPO group (n=16 per group). We mea- sured Nrf2 and nuclear factor kappa B (NF-κB) binding activities by an electrophoretic mobility shift assay (EMSA). We also measured the concentrations of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) by an enzyme-linked immunosorbent assay (ELISA); we also measured hindlimb locomotion function by the Basso, Beattie, and Bresnahan (BBB) rating, spinal cord edema by wet/dry weight method, and apoptosis by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) analysis. The results showed that the induction of the Nrf2 activity by tBHQ markedly decreased NF-κB activation and inflammatory cytokines production in the injured spinal cord. Administra- tion of tBHQ also significantly attenuated SCI induced hindlimb locomotion deficits, spinal cord edema, and apoptosis. To conclude, pre-treatment with tBHQ could attenuate the spinal cord inflammatory re - sponse after SCI.
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Protective effect of Tert-Butylhydroquinone on cerebral inflammatory response following traumatic brain injury in mice.
Injury, 2011Co-Authors: Wei Jin, Handong Wang, Jian Jiang, Jie Kong, Weibang LiangAbstract:Abstract Aim Antioxidant transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) has been shown in our previous studies to play a crucial role in protection against TBI induced inflammatory response in the brain. The objective of this study was to test whether Tert -Butylhydroquinone (tBHQ), a novel Nrf2 activator, can protect mice brain against TBI-induced inflammatory damage. Methods Adult male ICR mice were randomly divided into three groups: (1) sham + vehicle group; (2) TBI + vehicle group; and (3) TBI + tBHQ group ( n = 12 per group). Closed head injury was adopted using Hall's weight-dropping method. We measured Nrf2 and nuclear factor kappa B (NF-κB) binding activities by electrophoretic mobility shift assay (EMSA), concentrations of tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) by enzyme-linked immunosorbent assay (ELISA), brain oedema by wet/dry weight method, and cortical apoptosis by terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling (TUNEL) analysis. Results Induction of the Nrf2 activity by tBHQ markedly decreased NF-κB activation and inflammatory cytokine production in the injured brain. Administration of tBHQ also significantly attenuated TBI-induced brain oedema and cortical apoptosis. Conclusion Pre-treatment with tBHQ could attenuate the cerebral inflammatory response after TBI.
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Effects of Tert-Butylhydroquinone on intestinal inflammatory response and apoptosis following traumatic brain injury in mice.
Mediators of inflammation, 2010Co-Authors: Wei Jin, Yuxiang Dai, Handong Wang, Jian Jiang, Weibang LiangAbstract:Traumatic brain injury (TBI) can induce intestinal inflammatory response and mucosal injury. Antioxidant transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) has been shown in our previous studies to prevent oxidative stress and inflammatory response in gut after TBI. The objective of this study was to test whether Tert-Butylhydroquinone (tBHQ), an Nrf2 inducer, can protect against TBI-induced intestinal inflammatory response and mucosal injury in mice. Adult male ICR mice were randomly divided into three groups: (1) sham