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Li-xin Wang - One of the best experts on this subject based on the ideXlab platform.
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direct enantioselective amination of α ketoester catalyzed by Tertiary Amine thiourea a new approach to chiral α hydroxy β amino acid
Tetrahedron Letters, 2015Co-Authors: Qilin Wang, Yongyuan Gui, Li-xin WangAbstract:Abstract A highly enantioselective amination of α-ketoesters catalyzed by chiral Tertiary Amine thioureas was reported to afford α-hydroxy-β-amino acids with two continuous stereocenters in high yields (up to 90%) and enantioselectivities (up to 93% ee).
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Asymmetric Michael addition of α-substituted isocyanoacetates with maleimides catalyzed by chiral Tertiary Amine thiourea.
Journal of Organic Chemistry, 2012Co-Authors: Liang-liang Wang, Lin Peng, Fang Tian, Guang-yun He, Xiao-ying Xu, Li-xin WangAbstract:A highly diastereoselective and enantioselective Michael addition of α-substituted isocyanoacetates with maleimides catalyzed by bifunctional Tertiary Amine thioureas has been developed. Various chiral succinimide derivatives bearing adjacent quaternary and Tertiary stereocenters were prepared in excellent yields (up to 98%), diastereoselectivities (up to 99:1), and enantioselectivities (up to 98% ee). The synthetic utility of chiral succinimide derivatives is also demonstrated in the preparation of h5-HT1d receptor agonist motifs.
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asymmetric hydroxyamination of oxindoles catalyzed by chiral bifunctional Tertiary Amine thiourea construction of 3 amino 2 oxindoles with quaternary stereocenters
Organic and Biomolecular Chemistry, 2012Co-Authors: Lina Jia, Liang-liang Wang, Lin Peng, Fang Tian, Jun Huang, Jianfei Bai, Li-xin WangAbstract:Chiral bifunctional Tertiary Amine thiourea was applied to catalyze the asymmetric hydroxyamination of 3-subsituted oxindoles with nitrosobenzene to construct 3-amino-2-oxindoles with quaternary stereocenters in good yields (up to 91%) and enantioselectivities (up to 90% ee).
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metal free asymmetric 1 3 dipolar cycloaddition of n arylmaleimides to azomethine ylides catalyzed by chiral Tertiary Amine thiourea
European Journal of Organic Chemistry, 2011Co-Authors: Jianfei Bai, Liang-liang Wang, Lin Peng, Yunlong Guo, Junnan Ming, Feiying Wang, Li-xin WangAbstract:The first metal-free asymmetric 1,3-dipolar cycloaddition of N-arylmaleimides to azomethine ylides catalyzed by chiral Tertiary Amine thiourea to form multiply substituted pyrrolidines in excellent yields (up to 89 %) and enantioselectivities (up to 96 % ee) is presented. This procedure allows a rapid diversity-oriented synthesis of chiral pyrrolidine derivatives with high optical purity.
Rui Wang - One of the best experts on this subject based on the ideXlab platform.
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highly enantioselective friedel crafts alkylation reaction catalyzed by rosin derived Tertiary Amine thiourea synthesis of modified chromanes with anticancer potency
Chemical Communications, 2012Co-Authors: Xianxing Jiang, Yanhong Xing, Long Wang, Shoulei Wang, Zongyao Chen, Rui WangAbstract:We present herein for the first time the synthesis and preliminary biological evaluation of various modified chromanesvia a rosin-derived Tertiary Amine–thiourea-catalyzed highly enantioselective Friedel–Crafts alkylation reaction.
James N Scutt - One of the best experts on this subject based on the ideXlab platform.
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Tertiary Amine promoted aziridination preparation of nh aziridines from aliphatic α β unsaturated ketones
Synlett, 2015Co-Authors: Alan Armstrong, Robert D C Pullin, James N ScuttAbstract:trans-NH-Aziridines were prepared from aliphatic α,β-unsaturated ketones using a Tertiary Amine promoted reaction via in situ generated N,N-ylides. Through use of modified conditions the reaction proved to be applicable for the diastereoselective aziridination of a range of enolisable aliphatic α,β-unsaturated ketones of varying substitution patterns.
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Tertiary Amine promoted enone aziridination investigations into factors influencing enantioselective induction
Tetrahedron-asymmetry, 2014Co-Authors: Alan Armstrong, Robert D C Pullin, Chloe R Jenner, Klement Foo, Andrew J P White, James N ScuttAbstract:Abstract trans-N- Unsubstituted aziridines were synthesised (up to 77% ee) via a chiral Tertiary Amine-promoted nucleophilic aziridination of α,β-unsaturated ketones utilising in situ generated N – N ylides (aminimines). A wide range of chiral Tertiary Amines were synthesised and evaluated, allowing structure–activity relationships to be drawn. The most efficient promoter for asymmetric aziridination, quinine, was assessed with several enones to ascertain the effect of substrate structure on product ee, while the intermediate hydrazinium salt was characterised by X-ray crystallography.
Jian Zhou - One of the best experts on this subject based on the ideXlab platform.
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sequential au i chiral Tertiary Amine catalysis a tandem c h functionalization of anisoles or a thiophene asymmetric michael addition sequence to quaternary oxindoles
Chemical Communications, 2016Co-Authors: Yulei Zhao, Jian ZhouAbstract:We report an unprecedented sequential Au(I)/bifunctional Tertiary Amine catalysis, which enables a tandem C–H functionalization of weak nucleophiles (anisoles or thiophenes) and asymmetric Michael addition for the highly enantioselective synthesis of quaternary oxindoles from diazooxindoles and nitroenynes.
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catalytic asymmetric strecker reaction bifunctional chiral Tertiary Amine hydrogen bond donor catalysis joins the field
Synthesis, 2015Co-Authors: Yunlin Liu, Jian ZhouAbstract:Bifunctional chiral Tertiary Amine/hydrogen-bond donor catalysis has recently emerged as a powerful strategy for developing catalytic asymmetric Strecker reactions for the synthesis of various types of optically active α-amino nitriles, useful as versatile building blocks for the synthesis of value-added products such as α-amino acids, 1,2-diAmines, or heterocycles. This short review discusses the advantages of this strategy, summarizes recent advances, and describes the synthetic opportunities that remain open. 1 Introduction 2 Tertiary Amine/Hydrogen-Bond Donor Catalysis of Asymmetric Strecker Reactions 3 Summary and Outlook
Yinglei Wang - One of the best experts on this subject based on the ideXlab platform.
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a peg bridged Tertiary Amine functionalized ionic liquid exhibiting thermoregulated reversible biphasic behavior with cyclohexane isopropanol synthesis and application in knoevenagel condensation
ChemInform, 2013Co-Authors: Yinglei WangAbstract:A novel Tertiary Amine functionalized polyethylene glycol bridged dicationic ionic liquid is synthesized and used as facile and recyclable catalyst and co-solvent in Knoevenagel condensation reactions of aromatic aldehydes with active methylene compounds.
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a peg bridged Tertiary Amine functionalized ionic liquid exhibiting thermoregulated reversible biphasic behavior with cyclohexane isopropanol synthesis and application in knoevenagel condensation
New Journal of Chemistry, 2013Co-Authors: Yinglei WangAbstract:A novel poly(ethylene glycol) bridged Tertiary Amine functionalized ionic liquid PEG800-DPIL(Cl) was synthesized. It can form a temperature driven reversible biphasic system with cyclohexane/isopropanol mixed solvent. This biphasic system was applied in Knoevenagel condensation up to 99%. PEG800-DPIL(Cl) could be simply recovered and recycled for several runs.