Testicular Pain

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Steve Middleton - One of the best experts on this subject based on the ideXlab platform.

D. Kirk - One of the best experts on this subject based on the ideXlab platform.

  • Chronic Testicular Pain: an overview.
    European urology, 2004
    Co-Authors: P. Granitsiotis, D. Kirk
    Abstract:

    Chronic Testicular Pain (orchialgia, orchidynia or chronic scrotal Pain) is common and well recognized but its pathophysiology is poorly understood. Currently treatment is largely empirical. This article aims to present an overview of its prevalence, possible aetiology and the available treatment options. The contribution of psychological factors is unclear, although some of these patients undoubtedly are depressed. Post vasectomy chronic Testicular Pain may be due to functional obstruction of the vas, or to spermatic granuloma. The surgical technique used may be relevant and the application of intraoperative local anaesthetic may have a role in reducing the risk. The importance of the sympathetic nervous system and the role of a possible alteration of the adrenergic receptors of the vas deferens in patients with chronic Testicular Pain are discussed. For patients failing to respond to conservative treatment, microsurgical denervation of the spermatic cord, epididymectomy and vasovasostomy have all shown a degree of relief. Unfortunately a small number of patients fail to respond to both conservative and more invasive treatment methods and for them the only available therapeutic option is inguinal orchiectomy.

  • Chronic Testicular Pain following Vasectomy
    British journal of urology, 1992
    Co-Authors: A. Mcmahon, J. F. Buckley, A. Taylor, S. N. Lloyd, R. F. Deane, D. Kirk
    Abstract:

    The incidence of chronic Testicular Pain following vasectomy has not been previously assessed. We have carried out a survey by postal questionnaire and telephone interview of 172 patients 4 years after vasectomy to assess the incidence of chronic Testicular Pain. Significant early post-operative complications occurred in 6 patients (3.5%): 2 infection, 3 haematoma and 1 orchitis. Chronic Testicular discomfort was present in 56 patients (33%), considered by 26 (15%) to be troublesome but not by the other 30 (17%). Testicular discomfort related to sexual intercourse occurred in 9 cases (5%). Of the 9 patients who had sought further medical help only 2 had had further surgery (1 an epididymectomy and 1 excision of a hydrocele). Only 3 patients regretted having had the vasectomy because of chronic Pain. On ultrasound examination, epididymal cysts were a common finding on both asymptomatic and symptomatic patients following vasectomy. Prior to vasectomy, all patients should be counselled with regard to the risk of chronic Testicular Pain.

Jay Sandlow - One of the best experts on this subject based on the ideXlab platform.

  • varicocelectomy in the treatment of Testicular Pain a review
    Current Opinion in Urology, 2012
    Co-Authors: Anand Shridharani, Gina Lockwood, Jay Sandlow
    Abstract:

    PURPOSE OF REVIEW: Varicoceles are a common finding in adolescent boys and men. Most are asymptomatic, although up to 10% may cause Testicular Pain. This study will review the use of varicocelectomy in the treatment of Testicular Pain in men with clinical varicoceles, as well as provide prognostic indicators for successful outcome. RECENT FINDINGS: Recent studies that examined the impact of varix ligation on preoperative Testicular Pain were reviewed. Most studies are retrospective and uncontrolled; although objective outcome measures were used in the majority. Varicocele grade, duration of discomfort, and the quality of Pain tended to predict outcome but have not been universally supported. SUMMARY: On the basis of the majority of the recently published studies, varicocelectomy, in the properly chosen patients, results in significant improvement or resolution of Testicular Pain.

Brian Heckman - One of the best experts on this subject based on the ideXlab platform.

  • Testicular Pain following initiation of elexacaftor/tezacaftor/ivacaftor in males with cystic fibrosis
    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2020
    Co-Authors: Shannon M. Rotolo, Stephanie Duehlmeyer, Sarah M. Slack, Hollyann R. Jacobs, Brian Heckman
    Abstract:

    Elexacaftor/tezacaftor/ivacaftor (Trikafta) was approved by the Food and Drug Administration in October 2019 for treatment of cystic fibrosis (CF) in patients 12 years and older with at least one F508del mutation in the CFTR protein. There were no documented reports of Testicular Pain during clinical trials. In this case series, we discuss 7 males between 17 and 39 years of age who reported Testicular Pain or discomfort within the first two weeks of starting therapy. The precise mechanism of this side effect is unknown, but it may be related to restoration of CFTR function in the male reproductive tract. All patients experienced resolution of this side effect within a week after onset, regardless of the management, except for one. Further research is needed to determine short- and long-term impact of this drug on male fertility. Until more data is available, the authors recommend counseling patients on contraceptive options.

  • Testicular Pain following initiation of elexacaftor tezacaftor ivacaftor in males with cystic fibrosis
    Journal of Cystic Fibrosis, 2020
    Co-Authors: Shannon M. Rotolo, Stephanie Duehlmeyer, Sarah M. Slack, Hollyann R. Jacobs, Brian Heckman
    Abstract:

    Elexacaftor/tezacaftor/ivacaftor (Trikafta) was approved by the Food and Drug Administration in October 2019 for treatment of cystic fibrosis (CF) in patients 12 years and older with at least one F508del mutation in the CFTR protein. There were no documented reports of Testicular Pain during clinical trials. In this case series, we discuss 7 males between 17 and 39 years of age who reported Testicular Pain or discomfort within the first two weeks of starting therapy. The precise mechanism of this side effect is unknown, but it may be related to restoration of CFTR function in the male reproductive tract. All patients experienced resolution of this side effect within a week after onset, regardless of the management, except for one. Further research is needed to determine short- and long-term impact of this drug on male fertility. Until more data is available, the authors recommend counseling patients on contraceptive options.

James E. Leone - One of the best experts on this subject based on the ideXlab platform.

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