Tetrachloroethylene

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Gábor Vasas - One of the best experts on this subject based on the ideXlab platform.

  • Laboratory and microcosm experiments testing the toxicity of chlorinated hydrocarbons on a cyanobacterium strain (Synechococcus PCC 6301) and on natural phytoplankton assemblages
    Hydrobiologia, 2013
    Co-Authors: István Bácsi, Tamás Török, Viktória B-béres, Péter Török, Béla Tóthmérész, Alex Sándor Nagy, Gábor Vasas
    Abstract:

    In the last few years, halogenated hydrocarbons have been detected in the soil, in the aquatic environment, in organisms, and even in drinking water. The toxic effects of three chlorinated aliphatic hydrocarbons (trichloroethylene, Tetrachloroethylene and tetrachloroethane) were studied in laboratory experiments (using the cyanobacterium Synecococcus elongatus PCC 6301 as test organism) and in field-like circumstances (natural phytoplankton assemblages enclosed in microcosms). The results of the laboratory experiments showed that all of the tested compounds significantly inhibited the growth of the cultures within the first 4 h. Enzymatic changes of the treated cultures suggested that oxidative stress occured—all of the three compounds caused an increase in the activity of peroxidases and superoxide dismutase, and also increased the levels of lipid peroxidation. Observed changes in microcosms were comparable with the results of the laboratory experiments: the number of individuals and chlorophyll contents decreased in the treated assemblages. The elevated levels of peroxidation on the second day in the assemblages treated with tetrachloroethane and tetrachloroetylene suggest that oxidative stress could occur in field conditions. One of the most important findings is the decrease in species number. Our results showed that cryptomonads, some green algae species and the cyanobacterium Limnothrix gradually disappeared from the treated beakers during the experiment.

M. V. Prabhakara Rao - One of the best experts on this subject based on the ideXlab platform.

Ann Aschengrau - One of the best experts on this subject based on the ideXlab platform.

  • modeled exposure to Tetrachloroethylene contaminated drinking water and the occurrence of birth defects a case control study from massachusetts and rhode island
    Environmental Health, 2018
    Co-Authors: Ann Aschengrau, Lisa G Gallagher, Michael Winter, Lindsey J Butler, Patricia M Fabian, Veronica M Vieira
    Abstract:

    Background Residents of Massachusetts and Rhode Island were exposed to Tetrachloroethylene-contaminated drinking water from 1968 through the early 1990s when it leached from the vinyl lining of asbestos cement water distribution pipes. While occupational exposure to solvents during pregnancy has consistently been linked to an increased risk of certain birth defects, mixed results have been observed for environmental sources of exposure, including contaminated drinking water. The present case-control study was undertaken to examine further the association between prenatal exposure to Tetrachloroethylene-contaminated drinking water and the risk of central nervous system defects, oral clefts and hypospadias.

  • Cancer Risk and Tetrachloroethylene-contaminated Drinking Water in Massachusetts
    Archives of environmental health, 1993
    Co-Authors: Ann Aschengrau, David Ozonoff, Christopher Paulu, Patricia F. Coogan, Richard M. Vezina, Timothy Heeren, Yuqing Zhang
    Abstract:

    A population-based case-control study was used to evaluate the relationship between cases of bladder cancer (n = 61), kidney cancer (n = 35), and leukemia (n = 34) and exposure to Tetrachloroethylene from public drinking water. Subjects were exposed to Tetrachloroethylene when it leached from the plastic lining of drinking water distribution pipes. Relative delivered dose of Tetrachloroethylene was estimated, using an algorithm that accounted for (1) residential history and duration, (2) whether lined pipe served the neighborhood, (3) distribution system flow characteristics, and (4) pipe age and dimensions. Whether or not latency was considered, an elevated relative risk of leukemia was observed among ever exposed subjects (adjusted OR = 1.96, 95% CI = 0.71-5.37, with latency; adjusted OR = 2.13, 95% CI = 0.88-5.19, without latency) that increased further among subjects whose exposure level was over the 90th percentile (adjusted OR = 5.84, 95% CI = 1.37-24.91, with latency; adjusted OR = 8.33, 95% CI = 1.53-45.29, without latency). When latency was ignored, there was also an increased relative risk of bladder cancer among subjects whose exposure level was over the 90th percentile (adjusted OR = 4.03, 95% CI = 0.65-25.10). Given that Tetrachloroethylene is a common environmental and workplace contaminant in the United States, its carcinogenic potential is a matter of public health concern.

Gilbert Pépin - One of the best experts on this subject based on the ideXlab platform.

Paul Marshall - One of the best experts on this subject based on the ideXlab platform.