The Experts below are selected from a list of 17817 Experts worldwide ranked by ideXlab platform
Joseph Firth - One of the best experts on this subject based on the ideXlab platform.
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The Lancet psychiatry commission a blueprint for protecting physical health in people with mental illness
The Lancet Psychiatry, 2019Co-Authors: Joseph Firth, Najma Siddiqi, Ai Koyanagi, Dan Siskind, Simon Rosenbaum, Cherrie Galletly, Stephanie AllanAbstract:People with mental illness have an increased risk of physical disease, as well as reduced access to adequate health care. Physical-health disparities are observed across all mental illnesses in all countries. The high rate of physical comorbidity, which often has poor clinical management, reduces life expectancy for people with mental illness, and increases The personal, social, and economic cost of mental illness across The lifespan. This Commission summarises advances in understanding on The topic of physical health in people with mental illness, and presents clear directions for health promotion, clinical care, and future research. It aims to: (1) establish highly pertinent aspects of physical health-related morbidity and mortality that have transdiagnostic applications; (2) highlight The common modifiable factors that drive disparities in physical health; (3) present actions and initiatives for health policy and clinical services to address These issues; and (4) identify promising areas for future research that could identify novel solutions.
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The Lancet psychiatry commission a blueprint for protecting physical health in people with mental illness
The Lancet Psychiatry, 2019Co-Authors: Joseph Firth, Najma Siddiqi, Ai Koyanagi, Dan Siskind, Simon Rosenbaum, Cherrie GalletlyAbstract:The poor physical health of people with mental illness is a multifaceted, transdiagnostic, and global problem. People with mental illness have an increased risk of physical disease, as well as reduced access to adequate health care. As a result, physical health disparities are observed across The entire spectrum of mental illnesses in low-income, middle-income, and high-income countries. The high rate of physical comorbidity, which often has poor clinical management, drastically reduces life expectancy for people with mental illness, and also increases The personal, social, and economic burden of mental illness across The lifespan. This Commission summarises advances in understanding on The topic of physical health in people with mental illness, and presents clear directions for health promotion, clinical care, and future research. The wide range and multifactorial nature of physical health disparities across The range of mental health diagnoses generate a vast number of potential considerations. Therefore, raTher than attempting to discuss all possible combinations of physical and mental comorbidities individually, The aims of this Commission are to: (1) establish highly pertinent aspects of physical health-related morbidity and mortality that have transdiagnostic applications; (2) highlight The common modifiable factors that drive disparities in physical health; (3) present actions and initiatives for health policy and clinical services to address These issues; and (4) identify promising areas for future research that could identify novel solutions. These aims are addressed across The five parts of The Commission: in Parts 1 and 2 we describe The scope, priorities, and key targets for physical health improvement across multiple mental illnesses; in Parts 3, 4, and 5, we highlight emerging strategies and present recommendations for improving physical health outcomes in people with mental illness.
Ai Koyanagi - One of the best experts on this subject based on the ideXlab platform.
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The Lancet psychiatry commission a blueprint for protecting physical health in people with mental illness
The Lancet Psychiatry, 2019Co-Authors: Joseph Firth, Najma Siddiqi, Ai Koyanagi, Dan Siskind, Simon Rosenbaum, Cherrie Galletly, Stephanie AllanAbstract:People with mental illness have an increased risk of physical disease, as well as reduced access to adequate health care. Physical-health disparities are observed across all mental illnesses in all countries. The high rate of physical comorbidity, which often has poor clinical management, reduces life expectancy for people with mental illness, and increases The personal, social, and economic cost of mental illness across The lifespan. This Commission summarises advances in understanding on The topic of physical health in people with mental illness, and presents clear directions for health promotion, clinical care, and future research. It aims to: (1) establish highly pertinent aspects of physical health-related morbidity and mortality that have transdiagnostic applications; (2) highlight The common modifiable factors that drive disparities in physical health; (3) present actions and initiatives for health policy and clinical services to address These issues; and (4) identify promising areas for future research that could identify novel solutions.
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The Lancet psychiatry commission a blueprint for protecting physical health in people with mental illness
The Lancet Psychiatry, 2019Co-Authors: Joseph Firth, Najma Siddiqi, Ai Koyanagi, Dan Siskind, Simon Rosenbaum, Cherrie GalletlyAbstract:The poor physical health of people with mental illness is a multifaceted, transdiagnostic, and global problem. People with mental illness have an increased risk of physical disease, as well as reduced access to adequate health care. As a result, physical health disparities are observed across The entire spectrum of mental illnesses in low-income, middle-income, and high-income countries. The high rate of physical comorbidity, which often has poor clinical management, drastically reduces life expectancy for people with mental illness, and also increases The personal, social, and economic burden of mental illness across The lifespan. This Commission summarises advances in understanding on The topic of physical health in people with mental illness, and presents clear directions for health promotion, clinical care, and future research. The wide range and multifactorial nature of physical health disparities across The range of mental health diagnoses generate a vast number of potential considerations. Therefore, raTher than attempting to discuss all possible combinations of physical and mental comorbidities individually, The aims of this Commission are to: (1) establish highly pertinent aspects of physical health-related morbidity and mortality that have transdiagnostic applications; (2) highlight The common modifiable factors that drive disparities in physical health; (3) present actions and initiatives for health policy and clinical services to address These issues; and (4) identify promising areas for future research that could identify novel solutions. These aims are addressed across The five parts of The Commission: in Parts 1 and 2 we describe The scope, priorities, and key targets for physical health improvement across multiple mental illnesses; in Parts 3, 4, and 5, we highlight emerging strategies and present recommendations for improving physical health outcomes in people with mental illness.
Barbora Szotakova - One of the best experts on this subject based on the ideXlab platform.
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The transport of albendazole and albendazole sulphoxide in The Lancet fluke dicrocoelium dendriticum
Veterinary Parasitology, 2011Co-Authors: Hana Bartikova, Veronika Forstovakřižova, Lenka Skalova, Ivan Petřik, Jiří Lamka, Barbora SzotakovaAbstract:Abstract Albendazole (ABZ) is one of The most important benzimidazole compounds possessing high activity against The Lancet fluke, Dicrocoelium dendriticum. ABZ sulphoxide (ABZ.SO) is The main molecule present in The bloodstream of an ABZ-treated host. The aim of this study was to characterise The pattern of ex vivo uptake of ABZ and ABZ.SO by Lancet flukes and The export of both anThelmintics from These parasites. Transport of These anThelmintics in both living and dead flukes was compared. The adult flukes were collected from mouflons (Ovis musimon) which had been infected naturally. Results showed that more lipophilic ABZ was imported to a higher extent than ABZ.SO, and that significantly higher concentrations of ABZ were detected within living flukes as compared to dead ones. The same pattern was revealed in The study of ABZ and ABZ.SO export from The flukes’ bodies. In addition to passive diffusion, active ABZ uptake and active efflux of ABZ and ABZ.SO in D. dendriticum could be assumed.
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in vitro oxidative metabolism of xenobiotics in The Lancet fluke dicrocoelium dendriticum and The effects of albendazole and albendazole sulphoxide ex vivo
Xenobiotica, 2010Co-Authors: Hana Bartikova, Lenka Skalova, Ivan Petřik, Jiří Lamka, Barbora SzotakovaAbstract:Dicrocoeliosis, a parasitic infection caused by Dicrocoelium dendriticum (Lancet fluke), is often treated by The anThelmintic drug albendazole (ABZ). In The Lancet fluke, ABZ metabolism via enzymatic sulphoxidation was found, but no information about ABZ oxidases has been available.The aim of our project was to find out which enzyme of The Lancet fluke is responsible for ABZ sulphoxidation, as well as to assay The activities of oxidation enzymes. We also studied wheTher ex vivo 24-h exposures of flukes to ABZ or its sulphoxide (ABZ.SO) would alter ABZ sulphoxidation rate and The activities of tested enzymes.In subcellular fractions from flukes, marked activities of peroxidase (Px), glutathione Px (GPx), catalase (CAT), superoxide dismutase, and thioredoxin glutathione reductase were found. Using specific inhibitors, The participation of flavine monooxygenases in ABZ-oxidation was found.The ex vivo exposition of flukes to ABZ or ABZ.SO did not change The rate of ABZ sulphoxidation in vitro, but The ex vivo...
Hana Bartikova - One of the best experts on this subject based on the ideXlab platform.
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The transport of albendazole and albendazole sulphoxide in The Lancet fluke dicrocoelium dendriticum
Veterinary Parasitology, 2011Co-Authors: Hana Bartikova, Veronika Forstovakřižova, Lenka Skalova, Ivan Petřik, Jiří Lamka, Barbora SzotakovaAbstract:Abstract Albendazole (ABZ) is one of The most important benzimidazole compounds possessing high activity against The Lancet fluke, Dicrocoelium dendriticum. ABZ sulphoxide (ABZ.SO) is The main molecule present in The bloodstream of an ABZ-treated host. The aim of this study was to characterise The pattern of ex vivo uptake of ABZ and ABZ.SO by Lancet flukes and The export of both anThelmintics from These parasites. Transport of These anThelmintics in both living and dead flukes was compared. The adult flukes were collected from mouflons (Ovis musimon) which had been infected naturally. Results showed that more lipophilic ABZ was imported to a higher extent than ABZ.SO, and that significantly higher concentrations of ABZ were detected within living flukes as compared to dead ones. The same pattern was revealed in The study of ABZ and ABZ.SO export from The flukes’ bodies. In addition to passive diffusion, active ABZ uptake and active efflux of ABZ and ABZ.SO in D. dendriticum could be assumed.
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in vitro oxidative metabolism of xenobiotics in The Lancet fluke dicrocoelium dendriticum and The effects of albendazole and albendazole sulphoxide ex vivo
Xenobiotica, 2010Co-Authors: Hana Bartikova, Lenka Skalova, Ivan Petřik, Jiří Lamka, Barbora SzotakovaAbstract:Dicrocoeliosis, a parasitic infection caused by Dicrocoelium dendriticum (Lancet fluke), is often treated by The anThelmintic drug albendazole (ABZ). In The Lancet fluke, ABZ metabolism via enzymatic sulphoxidation was found, but no information about ABZ oxidases has been available.The aim of our project was to find out which enzyme of The Lancet fluke is responsible for ABZ sulphoxidation, as well as to assay The activities of oxidation enzymes. We also studied wheTher ex vivo 24-h exposures of flukes to ABZ or its sulphoxide (ABZ.SO) would alter ABZ sulphoxidation rate and The activities of tested enzymes.In subcellular fractions from flukes, marked activities of peroxidase (Px), glutathione Px (GPx), catalase (CAT), superoxide dismutase, and thioredoxin glutathione reductase were found. Using specific inhibitors, The participation of flavine monooxygenases in ABZ-oxidation was found.The ex vivo exposition of flukes to ABZ or ABZ.SO did not change The rate of ABZ sulphoxidation in vitro, but The ex vivo...
Cherrie Galletly - One of the best experts on this subject based on the ideXlab platform.
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The Lancet psychiatry commission a blueprint for protecting physical health in people with mental illness
The Lancet Psychiatry, 2019Co-Authors: Joseph Firth, Najma Siddiqi, Ai Koyanagi, Dan Siskind, Simon Rosenbaum, Cherrie Galletly, Stephanie AllanAbstract:People with mental illness have an increased risk of physical disease, as well as reduced access to adequate health care. Physical-health disparities are observed across all mental illnesses in all countries. The high rate of physical comorbidity, which often has poor clinical management, reduces life expectancy for people with mental illness, and increases The personal, social, and economic cost of mental illness across The lifespan. This Commission summarises advances in understanding on The topic of physical health in people with mental illness, and presents clear directions for health promotion, clinical care, and future research. It aims to: (1) establish highly pertinent aspects of physical health-related morbidity and mortality that have transdiagnostic applications; (2) highlight The common modifiable factors that drive disparities in physical health; (3) present actions and initiatives for health policy and clinical services to address These issues; and (4) identify promising areas for future research that could identify novel solutions.
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The Lancet psychiatry commission a blueprint for protecting physical health in people with mental illness
The Lancet Psychiatry, 2019Co-Authors: Joseph Firth, Najma Siddiqi, Ai Koyanagi, Dan Siskind, Simon Rosenbaum, Cherrie GalletlyAbstract:The poor physical health of people with mental illness is a multifaceted, transdiagnostic, and global problem. People with mental illness have an increased risk of physical disease, as well as reduced access to adequate health care. As a result, physical health disparities are observed across The entire spectrum of mental illnesses in low-income, middle-income, and high-income countries. The high rate of physical comorbidity, which often has poor clinical management, drastically reduces life expectancy for people with mental illness, and also increases The personal, social, and economic burden of mental illness across The lifespan. This Commission summarises advances in understanding on The topic of physical health in people with mental illness, and presents clear directions for health promotion, clinical care, and future research. The wide range and multifactorial nature of physical health disparities across The range of mental health diagnoses generate a vast number of potential considerations. Therefore, raTher than attempting to discuss all possible combinations of physical and mental comorbidities individually, The aims of this Commission are to: (1) establish highly pertinent aspects of physical health-related morbidity and mortality that have transdiagnostic applications; (2) highlight The common modifiable factors that drive disparities in physical health; (3) present actions and initiatives for health policy and clinical services to address These issues; and (4) identify promising areas for future research that could identify novel solutions. These aims are addressed across The five parts of The Commission: in Parts 1 and 2 we describe The scope, priorities, and key targets for physical health improvement across multiple mental illnesses; in Parts 3, 4, and 5, we highlight emerging strategies and present recommendations for improving physical health outcomes in people with mental illness.
