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Nazrul Haq - One of the best experts on this subject based on the ideXlab platform.
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solubility and Thermodynamic Function of apremilast in different transcutol water cosolvent mixtures measurement correlation and molecular interactions
Journal of Industrial and Engineering Chemistry, 2017Co-Authors: Faiyaz Shakeel, Nazrul Haq, Fars K Alanazi, Ibrahim A AlsarraAbstract:Abstract The solubility of apremilast (APM) in different “Transcutol® + water” cosolvent mixtures was determined and correlated at “T = 298.2 K–318.2 K” and ‘p = 0.1 MPa’. The experimental solubilities of APM were determined and correlated with “Apelblat, van’t Hoff, Yalkowsky and Jouyban–Acree equations”. The maximum solubilities of APM in mole fraction were obtained in neat Transcutol (2.53 × 10−2 at T = 318.2 K). Based on activity coefficients, strong molecular interactions were obtained between APM and neat Transcutol in comparison with APM and neat water. “Apparent Thermodynamic analysis” showed an “endothermic and entropy-driven dissolution” of APM.
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solubility and Thermodynamic Function of vitamin d3 in different mono solvents
Journal of Molecular Liquids, 2017Co-Authors: Fahad Almarri, Nazrul Haq, Fars K Alanazi, Ibrahim A Alsarra, Kazi Mohsin, Fadilah Sfouq Aleanizy, Faiyaz ShakeelAbstract:Abstract In this study, the solubility of a fat soluble vitamin (vitamin D3) was measured in eleven different mono solvents including “water, ethanol, 2-propanol (IPA), 1-butanol, 2-butanol, 2-(2-ethoxyethoxy) ethanol [Transcutol ® ], ethylene glycol (EG), propylene glycol (PG), polyethylene glycol-400 (PEG-400), ethyl acetate (EA) and dimethyl sulfoxide (DMSO)” at temperatures “ T = 273.2 K to 298.2 K” and “atmospheric pressure p = 0.1 MPa”. Experimental solubility data of vitamin D3 in mole fraction were correlated well with “Van't Hoff and Apelblat models” with mean percent deviations of T = 298.2 K” were obtained highest in Transcutol® (4.03 × 10 − 1 ) followed by IPA (2.45 × 10 − 1 ), EA (1.95 × 10 − 1 ), 2-butanol (1.87 × 10 − 1 ), ethanol (1.77 × 10 − 1 ), 1-butanol (1.69 × 10 − 1 ), PEG-400 (2.91 × 10 − 2 ), DMSO (7.23 × 10 − 3 ), PG (3.37 × 10 − 3 ), EG (5.24 × 10 − 4 ) and water (1.03 × 10 − 6 ). Thermodynamic treatment of solubility data of vitamin D3 by “Apparent Thermodynamic analysis” indicated an “endothermic and entropy-driven dissolution” of vitamin D3 in all mono solvents investigated. Based on the results of this study, vitamin D3 has been considered as practically insoluble in water, sparingly soluble in DMSO, PG and PEG-400, poorly soluble in EG and very soluble in ethanol, IPA, EA, 1-butanol, 2-butanol and Transcutol®.
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solubility and Thermodynamic Function of a bioactive compound bergenin in various pharmaceutically acceptable neat solvents at different temperatures
The Journal of Chemical Thermodynamics, 2016Co-Authors: Faiyaz Shakeel, Mohamed F Alajmi, Nazrul Haq, Nasir A Siddiqui, Perwez Alam, Adnan J AlrehailyAbstract:Bergenin is neither a highly lipophilic nor a highly hydrophilic bioactive compound due to which its dissolution and permeation are poor which results in poor oral bioavailability. The solubility data of bergenin are scarce in literature. Therefore, in this study, the solubility of bergenin was determined in eleven different pharmaceutically acceptable neat solvents namely water, ethanol, isopropanol (IPA), ethylene glycol (EG), propylene glycol (PG), 1-butanol, 2-butanol, ethyl acetate (EA), dimethyl sulfoxide (DMSO), polyethylene glycol-400 (PEG-400) and Transcutol at five different temperatures (T = 298.15 K–318.15 K) and atmospheric pressure (p = 0.1 MPa). Experimental solubility expressed in mole fraction of bergenin was correlated with semi-empirical models. Root mean square deviations were recorded <1% for the Apelblat model and <2% for the van’t Hoff model. The mole fraction solubility of bergenin was recorded highest in PEG-400 (4.15 × 10−2 at T = 318.15 K) followed by DMSO (2.30 × 10−2 at T = 318.15 K), Transcutol (2.28 × 10−2 at T = 318.15 K), PG (1.19 × 10−2 at T = 318.15 K), EG (1.17 × 10−2 at T = 318.15 K), ethanol (7.77 × 10−3 at T = 318.15 K), IPA (1.69 × 10−3 at T = 318.15 K), EA (6.71 × 10−4 at T = 318.15 K), 2-butanol (5.14 × 10−4 at T = 318.15 K), 1-butanol (4.92 × 10−4 at T = 318.15 K) and water (1.87 × 10−4 at T = 318.15 K). The results of apparent Thermodynamic analysis in terms of standard enthalpy indicated that the dissolution of bergenin is endothermic in all pharmaceutically acceptable neat solvents. The solubility results of this study could be useful in purification, recrystallization and formulation development of bergenin.
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solubility and Thermodynamic Function of bergenin in different dmso water mixtures at different temperatures
Journal of Molecular Liquids, 2016Co-Authors: Faiyaz Shakeel, Nazrul Haq, Nasir A Siddiqui, Ramzi A Mothana, Mai M Aloqail, Adnan J AlrehailyAbstract:Abstract The cosolvency action of dimethyl sulfoxide (DMSO) in solubility enhancement and Thermodynamic Function of drugs had rarely been investigated in literature. Hence, in the current research work, the cosolvency action of DMSO was evaluated for the solubilization of bergenin. The mole fraction solubilities of bergenin in different binary solvent mixtures of DMSO and water were measured at five different temperatures i.e. T = (298.15 to 318.15) K and atmospheric pressure (p = 0.1 MPa). The resulting experimental data of bergenin were correlated well with three semiempirical mathematical models (Apelblat, van't Hoff and Yalkowsky models). The mole fraction solubility of bergenin was found to be increased with increase in the temperature and mass fraction of DMSO in binary solvent mixtures. The highest and lowest mole fraction solubility of bergenin was recorded in neat DMSO (2.29 × 10− 2 at T = 318.15 K) and neat water (7.50 × 10− 5 at T = 298.15 K), respectively. Thermodynamic treatment of solubility data of bergenin supported that its dissolution was an endothermic and entropy-driven in all (DMSO + water) binary solvent mixtures investigated.
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solubility and Thermodynamic Function of lornoxicam in peg 400 water mixtures at different temperatures
Journal of Molecular Liquids, 2016Co-Authors: Faiyaz Shakeel, Nazrul Haq, Fars K Alanazi, Ibrahim A AlsarraAbstract:Abstract The present study was undertaken to determine the solubility and Thermodynamic Function of a poorly soluble drug lornoxicam (LNX) in various [polyethylene glycol-400 (PEG-400) + water] mixtures at five different temperatures from T = (298.15 to 323.15) K and atmospheric pressure. The measured solubilities of LNX were correlated with three different mathematical models which showed good correlation of experimental solubilities of LNX with calculated ones. The mole fraction solubility of LNX was found to be highest in pure PEG-400 (1.71 × 10− 2 at T = 323.15 K) and lowest in pure water (2.90 × 10− 6 at T = 298.15 K) at all five different temperatures investigated. Thermodynamic Function of LNX in different (PEG-400 + water) mixtures was recorded as an endothermic, spontaneous and entropy driven. These results indicated that PEG-400 could be utilized as a good solvent for solubilization and stabilization of LNX in an aqueous media.
Faiyaz Shakeel - One of the best experts on this subject based on the ideXlab platform.
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solubility and Thermodynamic Function of apremilast in different transcutol water cosolvent mixtures measurement correlation and molecular interactions
Journal of Industrial and Engineering Chemistry, 2017Co-Authors: Faiyaz Shakeel, Nazrul Haq, Fars K Alanazi, Ibrahim A AlsarraAbstract:Abstract The solubility of apremilast (APM) in different “Transcutol® + water” cosolvent mixtures was determined and correlated at “T = 298.2 K–318.2 K” and ‘p = 0.1 MPa’. The experimental solubilities of APM were determined and correlated with “Apelblat, van’t Hoff, Yalkowsky and Jouyban–Acree equations”. The maximum solubilities of APM in mole fraction were obtained in neat Transcutol (2.53 × 10−2 at T = 318.2 K). Based on activity coefficients, strong molecular interactions were obtained between APM and neat Transcutol in comparison with APM and neat water. “Apparent Thermodynamic analysis” showed an “endothermic and entropy-driven dissolution” of APM.
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solubility and Thermodynamic Function of vitamin d3 in different mono solvents
Journal of Molecular Liquids, 2017Co-Authors: Fahad Almarri, Nazrul Haq, Fars K Alanazi, Ibrahim A Alsarra, Kazi Mohsin, Fadilah Sfouq Aleanizy, Faiyaz ShakeelAbstract:Abstract In this study, the solubility of a fat soluble vitamin (vitamin D3) was measured in eleven different mono solvents including “water, ethanol, 2-propanol (IPA), 1-butanol, 2-butanol, 2-(2-ethoxyethoxy) ethanol [Transcutol ® ], ethylene glycol (EG), propylene glycol (PG), polyethylene glycol-400 (PEG-400), ethyl acetate (EA) and dimethyl sulfoxide (DMSO)” at temperatures “ T = 273.2 K to 298.2 K” and “atmospheric pressure p = 0.1 MPa”. Experimental solubility data of vitamin D3 in mole fraction were correlated well with “Van't Hoff and Apelblat models” with mean percent deviations of T = 298.2 K” were obtained highest in Transcutol® (4.03 × 10 − 1 ) followed by IPA (2.45 × 10 − 1 ), EA (1.95 × 10 − 1 ), 2-butanol (1.87 × 10 − 1 ), ethanol (1.77 × 10 − 1 ), 1-butanol (1.69 × 10 − 1 ), PEG-400 (2.91 × 10 − 2 ), DMSO (7.23 × 10 − 3 ), PG (3.37 × 10 − 3 ), EG (5.24 × 10 − 4 ) and water (1.03 × 10 − 6 ). Thermodynamic treatment of solubility data of vitamin D3 by “Apparent Thermodynamic analysis” indicated an “endothermic and entropy-driven dissolution” of vitamin D3 in all mono solvents investigated. Based on the results of this study, vitamin D3 has been considered as practically insoluble in water, sparingly soluble in DMSO, PG and PEG-400, poorly soluble in EG and very soluble in ethanol, IPA, EA, 1-butanol, 2-butanol and Transcutol®.
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solubility and Thermodynamic Function of a bioactive compound bergenin in various pharmaceutically acceptable neat solvents at different temperatures
The Journal of Chemical Thermodynamics, 2016Co-Authors: Faiyaz Shakeel, Mohamed F Alajmi, Nazrul Haq, Nasir A Siddiqui, Perwez Alam, Adnan J AlrehailyAbstract:Bergenin is neither a highly lipophilic nor a highly hydrophilic bioactive compound due to which its dissolution and permeation are poor which results in poor oral bioavailability. The solubility data of bergenin are scarce in literature. Therefore, in this study, the solubility of bergenin was determined in eleven different pharmaceutically acceptable neat solvents namely water, ethanol, isopropanol (IPA), ethylene glycol (EG), propylene glycol (PG), 1-butanol, 2-butanol, ethyl acetate (EA), dimethyl sulfoxide (DMSO), polyethylene glycol-400 (PEG-400) and Transcutol at five different temperatures (T = 298.15 K–318.15 K) and atmospheric pressure (p = 0.1 MPa). Experimental solubility expressed in mole fraction of bergenin was correlated with semi-empirical models. Root mean square deviations were recorded <1% for the Apelblat model and <2% for the van’t Hoff model. The mole fraction solubility of bergenin was recorded highest in PEG-400 (4.15 × 10−2 at T = 318.15 K) followed by DMSO (2.30 × 10−2 at T = 318.15 K), Transcutol (2.28 × 10−2 at T = 318.15 K), PG (1.19 × 10−2 at T = 318.15 K), EG (1.17 × 10−2 at T = 318.15 K), ethanol (7.77 × 10−3 at T = 318.15 K), IPA (1.69 × 10−3 at T = 318.15 K), EA (6.71 × 10−4 at T = 318.15 K), 2-butanol (5.14 × 10−4 at T = 318.15 K), 1-butanol (4.92 × 10−4 at T = 318.15 K) and water (1.87 × 10−4 at T = 318.15 K). The results of apparent Thermodynamic analysis in terms of standard enthalpy indicated that the dissolution of bergenin is endothermic in all pharmaceutically acceptable neat solvents. The solubility results of this study could be useful in purification, recrystallization and formulation development of bergenin.
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solubility and Thermodynamic Function of bergenin in different dmso water mixtures at different temperatures
Journal of Molecular Liquids, 2016Co-Authors: Faiyaz Shakeel, Nazrul Haq, Nasir A Siddiqui, Ramzi A Mothana, Mai M Aloqail, Adnan J AlrehailyAbstract:Abstract The cosolvency action of dimethyl sulfoxide (DMSO) in solubility enhancement and Thermodynamic Function of drugs had rarely been investigated in literature. Hence, in the current research work, the cosolvency action of DMSO was evaluated for the solubilization of bergenin. The mole fraction solubilities of bergenin in different binary solvent mixtures of DMSO and water were measured at five different temperatures i.e. T = (298.15 to 318.15) K and atmospheric pressure (p = 0.1 MPa). The resulting experimental data of bergenin were correlated well with three semiempirical mathematical models (Apelblat, van't Hoff and Yalkowsky models). The mole fraction solubility of bergenin was found to be increased with increase in the temperature and mass fraction of DMSO in binary solvent mixtures. The highest and lowest mole fraction solubility of bergenin was recorded in neat DMSO (2.29 × 10− 2 at T = 318.15 K) and neat water (7.50 × 10− 5 at T = 298.15 K), respectively. Thermodynamic treatment of solubility data of bergenin supported that its dissolution was an endothermic and entropy-driven in all (DMSO + water) binary solvent mixtures investigated.
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solubility and Thermodynamic Function of lornoxicam in peg 400 water mixtures at different temperatures
Journal of Molecular Liquids, 2016Co-Authors: Faiyaz Shakeel, Nazrul Haq, Fars K Alanazi, Ibrahim A AlsarraAbstract:Abstract The present study was undertaken to determine the solubility and Thermodynamic Function of a poorly soluble drug lornoxicam (LNX) in various [polyethylene glycol-400 (PEG-400) + water] mixtures at five different temperatures from T = (298.15 to 323.15) K and atmospheric pressure. The measured solubilities of LNX were correlated with three different mathematical models which showed good correlation of experimental solubilities of LNX with calculated ones. The mole fraction solubility of LNX was found to be highest in pure PEG-400 (1.71 × 10− 2 at T = 323.15 K) and lowest in pure water (2.90 × 10− 6 at T = 298.15 K) at all five different temperatures investigated. Thermodynamic Function of LNX in different (PEG-400 + water) mixtures was recorded as an endothermic, spontaneous and entropy driven. These results indicated that PEG-400 could be utilized as a good solvent for solubilization and stabilization of LNX in an aqueous media.
William E Acree - One of the best experts on this subject based on the ideXlab platform.
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comments on solubility and Thermodynamic Function of a new anticancer drug ibrutinib in 2 2 ethoxyethoxy ethanol water mixtures at different temperatures
The Journal of Chemical Thermodynamics, 2016Co-Authors: Fleming Martinez, Abolghasem Jouyban, William E AcreeAbstract:Abstract The aim of this communication is to expand the results of the numerical analyses performed by Shakeel et al. on their experimental solubility of anti-cancer drug ibrutinib in {2-(2-ethoxyethoxy)ethanol + water} mixtures at different temperatures, in terms of modelling the solubility according to the Jouyban–Acree model and also the evaluation of the preferential solvation of ibrutinib by both solvents in the saturated mixtures based on the inverse Kirkwood–Buff integrals.
Mounir M Salembekhit - One of the best experts on this subject based on the ideXlab platform.
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solubility and Thermodynamic Function of a new anticancer drug ibrutinib in 2 2 ethoxyethoxy ethanol water mixtures at different temperatures
The Journal of Chemical Thermodynamics, 2015Co-Authors: Faiyaz Shakeel, Mounir M Salembekhit, Muzaffar Iqbal, Nazrul HaqAbstract:Abstract Ibrutinib is a recently approved anticancer drug recommended for the treatment of mantle cell lymphoma and chronic lymphocytic leukemia. It has been reported as practically insoluble in water and hence it is available in the market at higher doses. Poor solubility of ibrutinib limits its development to oral solid dosage forms only. In this work, the solubilities of ibrutinib were measured in various 2-(2-ethoxyethoxy)ethanol (Carbitol) + water mixtures at T = (298.15 to 323.15) and p = 0.1 MPa. The solubility of ibrutinib was measured using an isothermal method. The Thermodynamics Function of ibrutinib was also studied. The measured solubilities of ibrutinib were correlated and fitted with Van’t Hoff, the modified Apelblat and Yalkowsky models. The results of curve fitting of all three models showed good correlation of experimental solubilities of ibrutinib with calculated ones. The mole fraction solubility of ibrutinib was observed highest in pure 2-(2-ethoxyethoxy)ethanol (2.67 · 10−2 at T = 298.15 K) and lowest in pure water (1.43 · 10−7 at T = 298.15 K) at T = (298.15 to 323.15) K. Thermodynamics data of ibrutinib showed an endothermic, spontaneous and an entropy-driven dissolution behavior of ibrutinib in all 2-(2-ethoxyethoxy)ethanol + water mixtures. Based on these results, ibrutinib has been considered as practically insoluble in water and freely soluble in 2-(2-ethoxyethoxy)ethanol. Therefore, 2-(2-ethoxyethoxy)ethanol could be used as a physiologically compatible cosolvent for solubilization and stabilization of ibrutinib in an aqueous media. The solubility data of this work could be extremely useful in preformulation studies and formulation development of ibrutinib.
Fleming Martinez - One of the best experts on this subject based on the ideXlab platform.
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comments on solubility and Thermodynamic Function of a new anticancer drug ibrutinib in 2 2 ethoxyethoxy ethanol water mixtures at different temperatures
The Journal of Chemical Thermodynamics, 2016Co-Authors: Fleming Martinez, Abolghasem Jouyban, William E AcreeAbstract:Abstract The aim of this communication is to expand the results of the numerical analyses performed by Shakeel et al. on their experimental solubility of anti-cancer drug ibrutinib in {2-(2-ethoxyethoxy)ethanol + water} mixtures at different temperatures, in terms of modelling the solubility according to the Jouyban–Acree model and also the evaluation of the preferential solvation of ibrutinib by both solvents in the saturated mixtures based on the inverse Kirkwood–Buff integrals.
