The Experts below are selected from a list of 285 Experts worldwide ranked by ideXlab platform
Paul Symonds - One of the best experts on this subject based on the ideXlab platform.
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can the distress thermometer be improved by additional mood domains part ii what is the optimal combination of emotion Thermometers
Psycho-oncology, 2010Co-Authors: Alex J Mitchell, Elena A Bakerglenn, Bert Park, Lorraine Granger, Paul SymondsAbstract:Purpose: To examine the added value of an algorithmic combination of visual-analogue Thermometers compared with the Distress Thermometer (DT) when attempting to detect depression, anxiety or distress in early cancer. Methods: We report Classification and Regression Tree and logistic regression analyses of the new five-domain Emotion Thermometers tool. This is a combination of five visual-analogue scales in the form of four mood domains (distress, anxiety, depression, anger) as well as need for help. 130 patients attending for their first chemotherapy treatment were assessed. We calculated optimal accuracy for each domain alone and in combination against several criterion standards. Results: When attempting to diagnose depression the Depression Thermometer (DepT) used alone was the optimal approach, but when attempting to detect broadly defined distress or anxiety then a combination of Thermometers was most accurate. The DepT was significantly more accurate in detecting depression than the DT. For broadly defined distress a combination of depression, anger and help Thermometers was more accurate than the DT alone. For anxiety, while the anxiety thermometer (AnxT) improves upon the DT alone, a combination of the DepT and AnxT are optimal. In each case the optimal strategy allowed the detection of at least an additional 9% of individuals. However, combinations are more laborious to score. In settings where the simplest possible option is preferred the most accurate single thermometer might be preferable as a first stage assessment. Conclusion: The DT can be improved by specific combinations of simple Thermometers that incorporate depression, anxiety, anger and help. Copyright © 2009 John Wiley & Sons, Ltd.
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can the distress thermometer be improved by additional mood domains part i initial validation of the emotion Thermometers tool
Psycho-oncology, 2010Co-Authors: Alex J Mitchell, Elena A Bakerglenn, Lorraine Granger, Paul SymondsAbstract:Purpose: To examine the value of a new screening instrument in a visual-analogue format. Methods: We report the design and validation of a new five-dimensional tool called the Emotion Thermometers (ET). This is a combination of five visual-analogue scales in the form of four predictor domains (distress, anxiety, depression, anger) and one outcome domain (need for help). Between March and August 2007, 130 patients attending the chemotherapy suite for their first chemotherapy treatment were asked to complete several questionnaires with validation for distress, anxiety and depression. Results: Of 81 with low distress on the Distress Thermometer (DT), 51% recorded emotional difficulties on the new ET tool, suggesting added value beyond the DT alone. Of those with a broadly defined emotional complication, 93.3% could be identified using the Anxiety Thermometer (AnxT) alone, compared with 54.4% who would be recognized using the DT alone. Using a cut-off of 3v4 on all Thermometers against the total Hospital Anxiety and Depression Scale (HADS) score (cut-off 14v15), the optimal thermometer was the Anger Thermometer (sensitivity 61%, specificity 92%). Against HADS anxiety scale, the optimal thermometer was AnxT (sensitivity 92%, specificity 61%) and against the HADS depression scale, the optimal thermometer was the Depression Thermometer (DepT; sensitivity 60%, specificity 78%). Finally, against DSM-IV major depression, the optimal thermometer was the DepT (sensitivity 80%, specificity 79%). Further improvements may be possible by using a combination of Thermometers or by repeating the screen. Conclusion: The diagnostic accuracy of the DT can be improved by the inclusion of simple addition linear domains without substantially increasing the time needed to apply the test. Copyright © 2009 John Wiley & Sons, Ltd.
Alex J Mitchell - One of the best experts on this subject based on the ideXlab platform.
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accuracy of the emotion Thermometers et screening tool in patients undergoing surgery for upper gastrointestinal malignancies
Journal of Psychosocial Oncology, 2015Co-Authors: Jane R Schubart, Alex J Mitchell, Laura Dietrich, Niraj J GusaniAbstract:Distress is common in patients with gastrointestinal cancers. Most conventional scales are too long for routine clinic use. We tested the Emotion Thermometers (ET) tool, a brief visual-analogue scale. There are four emotional upset Thermometers: distress, anxiety, depression, and anger. Sixty-nine surgical patients were recruited from an academic hospital clinic in 2012; 64 had complete data for Beck depression inventory and ET. The sample size was modest due to the specialist nature of the sample. We examined sensitivity, specificity, and area under the receiver-operator-curve. A dimensional multi-domain approach to screening for emotional disorders is preferable to using the distress thermometer alone and can be achieved with little extra time burden to clinicians. The ET is a diagnostic tool that is primarily designed for screening to identify cancer patients who would benefit by enhanced psychosocial care.
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can the distress thermometer be improved by additional mood domains part ii what is the optimal combination of emotion Thermometers
Psycho-oncology, 2010Co-Authors: Alex J Mitchell, Elena A Bakerglenn, Bert Park, Lorraine Granger, Paul SymondsAbstract:Purpose: To examine the added value of an algorithmic combination of visual-analogue Thermometers compared with the Distress Thermometer (DT) when attempting to detect depression, anxiety or distress in early cancer. Methods: We report Classification and Regression Tree and logistic regression analyses of the new five-domain Emotion Thermometers tool. This is a combination of five visual-analogue scales in the form of four mood domains (distress, anxiety, depression, anger) as well as need for help. 130 patients attending for their first chemotherapy treatment were assessed. We calculated optimal accuracy for each domain alone and in combination against several criterion standards. Results: When attempting to diagnose depression the Depression Thermometer (DepT) used alone was the optimal approach, but when attempting to detect broadly defined distress or anxiety then a combination of Thermometers was most accurate. The DepT was significantly more accurate in detecting depression than the DT. For broadly defined distress a combination of depression, anger and help Thermometers was more accurate than the DT alone. For anxiety, while the anxiety thermometer (AnxT) improves upon the DT alone, a combination of the DepT and AnxT are optimal. In each case the optimal strategy allowed the detection of at least an additional 9% of individuals. However, combinations are more laborious to score. In settings where the simplest possible option is preferred the most accurate single thermometer might be preferable as a first stage assessment. Conclusion: The DT can be improved by specific combinations of simple Thermometers that incorporate depression, anxiety, anger and help. Copyright © 2009 John Wiley & Sons, Ltd.
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can the distress thermometer be improved by additional mood domains part i initial validation of the emotion Thermometers tool
Psycho-oncology, 2010Co-Authors: Alex J Mitchell, Elena A Bakerglenn, Lorraine Granger, Paul SymondsAbstract:Purpose: To examine the value of a new screening instrument in a visual-analogue format. Methods: We report the design and validation of a new five-dimensional tool called the Emotion Thermometers (ET). This is a combination of five visual-analogue scales in the form of four predictor domains (distress, anxiety, depression, anger) and one outcome domain (need for help). Between March and August 2007, 130 patients attending the chemotherapy suite for their first chemotherapy treatment were asked to complete several questionnaires with validation for distress, anxiety and depression. Results: Of 81 with low distress on the Distress Thermometer (DT), 51% recorded emotional difficulties on the new ET tool, suggesting added value beyond the DT alone. Of those with a broadly defined emotional complication, 93.3% could be identified using the Anxiety Thermometer (AnxT) alone, compared with 54.4% who would be recognized using the DT alone. Using a cut-off of 3v4 on all Thermometers against the total Hospital Anxiety and Depression Scale (HADS) score (cut-off 14v15), the optimal thermometer was the Anger Thermometer (sensitivity 61%, specificity 92%). Against HADS anxiety scale, the optimal thermometer was AnxT (sensitivity 92%, specificity 61%) and against the HADS depression scale, the optimal thermometer was the Depression Thermometer (DepT; sensitivity 60%, specificity 78%). Finally, against DSM-IV major depression, the optimal thermometer was the DepT (sensitivity 80%, specificity 79%). Further improvements may be possible by using a combination of Thermometers or by repeating the screen. Conclusion: The diagnostic accuracy of the DT can be improved by the inclusion of simple addition linear domains without substantially increasing the time needed to apply the test. Copyright © 2009 John Wiley & Sons, Ltd.
Seiichi Uchiyama - One of the best experts on this subject based on the ideXlab platform.
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intracellular temperature measurements with fluorescent polymeric Thermometers
Chemical Communications, 2017Co-Authors: Seiichi Uchiyama, Chie Gota, Toshikazu Tsuji, Noriko InadaAbstract:In 2003, we successfully created the first fluorescent polymeric thermometer by combining a thermo-responsive polymer and an environment-sensitive (polarity and hydrogen bonding-sensitive) fluorophore. Its high sensitivity to temperature variation and high hydrophilicity, even under conditions of high ionic strength, enabled intracellular temperature measurements. Along with the progress of our research projects, the development of new luminescent molecular Thermometers and the establishment of novel methods for measuring intracellular temperature have matured in this field. In this Feature Article, we summarize the background and history of intracellular temperature measurements using fluorescent polymeric Thermometers based on studies performed in our laboratory and the relationship between our methods and those of other eminent research groups. Future research directions regarding intracellular temperature measurements are also discussed.
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accurate fluorescent polymeric Thermometers containing an ionic component
Analyst, 2007Co-Authors: Chie Gota, Seiichi Uchiyama, Tomohiko OhwadaAbstract:Fluorescent polymeric Thermometers consisting of only N-alkylacrylamide and fluorescent components show rather low temperature resolution in their functional ranges (ca. 15–50 °C) because of the occurrence of intermolecular aggregation, which causes hysteresis in their fluorescence response to changes in temperature. By adding an ionic component to prevent such intermolecular aggregation, we obtained four fluorescent polymeric Thermometers that offer high temperature resolution (<0.2 °C). Each new fluorescent polymeric thermometer covered the temperature range, 9–33 °C, 30–51 °C, 49–66 °C or 4–38 °C.
Chie Gota - One of the best experts on this subject based on the ideXlab platform.
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intracellular temperature measurements with fluorescent polymeric Thermometers
Chemical Communications, 2017Co-Authors: Seiichi Uchiyama, Chie Gota, Toshikazu Tsuji, Noriko InadaAbstract:In 2003, we successfully created the first fluorescent polymeric thermometer by combining a thermo-responsive polymer and an environment-sensitive (polarity and hydrogen bonding-sensitive) fluorophore. Its high sensitivity to temperature variation and high hydrophilicity, even under conditions of high ionic strength, enabled intracellular temperature measurements. Along with the progress of our research projects, the development of new luminescent molecular Thermometers and the establishment of novel methods for measuring intracellular temperature have matured in this field. In this Feature Article, we summarize the background and history of intracellular temperature measurements using fluorescent polymeric Thermometers based on studies performed in our laboratory and the relationship between our methods and those of other eminent research groups. Future research directions regarding intracellular temperature measurements are also discussed.
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accurate fluorescent polymeric Thermometers containing an ionic component
Analyst, 2007Co-Authors: Chie Gota, Seiichi Uchiyama, Tomohiko OhwadaAbstract:Fluorescent polymeric Thermometers consisting of only N-alkylacrylamide and fluorescent components show rather low temperature resolution in their functional ranges (ca. 15–50 °C) because of the occurrence of intermolecular aggregation, which causes hysteresis in their fluorescence response to changes in temperature. By adding an ionic component to prevent such intermolecular aggregation, we obtained four fluorescent polymeric Thermometers that offer high temperature resolution (<0.2 °C). Each new fluorescent polymeric thermometer covered the temperature range, 9–33 °C, 30–51 °C, 49–66 °C or 4–38 °C.
Noriko Inada - One of the best experts on this subject based on the ideXlab platform.
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intracellular temperature measurements with fluorescent polymeric Thermometers
Chemical Communications, 2017Co-Authors: Seiichi Uchiyama, Chie Gota, Toshikazu Tsuji, Noriko InadaAbstract:In 2003, we successfully created the first fluorescent polymeric thermometer by combining a thermo-responsive polymer and an environment-sensitive (polarity and hydrogen bonding-sensitive) fluorophore. Its high sensitivity to temperature variation and high hydrophilicity, even under conditions of high ionic strength, enabled intracellular temperature measurements. Along with the progress of our research projects, the development of new luminescent molecular Thermometers and the establishment of novel methods for measuring intracellular temperature have matured in this field. In this Feature Article, we summarize the background and history of intracellular temperature measurements using fluorescent polymeric Thermometers based on studies performed in our laboratory and the relationship between our methods and those of other eminent research groups. Future research directions regarding intracellular temperature measurements are also discussed.
