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Okada S - One of the best experts on this subject based on the ideXlab platform.
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Thiamine Hydrochloride Solution Reference Standard (Control 991) of National Institute of Health Sciences
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2000Co-Authors: Iwata M, Maekawa K, Saito H, Tanimoto T, Koide T, Okada SAbstract:The raw material of Thiamine Hydrochloride solution was examined for preparation of the "Thiamine Hydrochloride Solution Reference Standard (Control 991)". The analytical data obtained were: assay by HPLC, 101.0%; spectrophotometric assay, 100.4%. Based on the above results, the raw material was authorized as the Thiamine Hydrochloride Solution Reference Standard (Control 991) of the National Institute of Health Sciences.
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Thiamine Hydrochloride Solution Reference Standard (Control 971) of National Institute of Health Sciences
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 1998Co-Authors: Kitajima A, Iwata M, Maekawa K, Saito H, Tanimoto T, Okada SAbstract:The raw material of Thiamine Hydrochloride solution was examined for the preparation of the "Thiamine Hydrochloride Solution Reference Standard (Control 971)". Analytical data obtained were as follows: assay by HPLC, 100.8%; spectrophotometric assay, 99.8%. Based on the above results, the raw material was authorized to be the Thiamine Hydrochloride Solution Reference Standard of the National Institute of Health Sciences.
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The Thiamine Hydrochloride Reference Standard (Control 931) of the National Institute of Health Sciences
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences, 1994Co-Authors: Kitajima A, Yoshii K, Komatsu H, Ishimitsu S, Okada SAbstract:Raw Thiamine Hydrochloride material was tested for preparation of the "Thiamine Hydrochloride Reference Standard (Control 931)". Analytical data obtained were as follows: melting point, 242.7 degrees C (decomposition); infrared spectrum, the same as that of the JP Thiamine Hydrochloride Reference Standard; thin-layer chromatography, one impurity was detected; high-performance liquid chromatography (HPLC), a trace amount of one impurity was detected; assay results, 100.4% by UV spectrophotometry and 100.0% by HPLC, respectively. Based on the above findings, the raw material was authorized as the JP Thiamine Hydrochloride Reference Standard (Control 931).
Charansingh H. Gill - One of the best experts on this subject based on the ideXlab platform.
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Microwave-Assisted One-Pot Synthesis of Octahydroquinazolinone Derivatives Catalyzed by Thiamine Hydrochloride Under Solvent-free Condition
Journal of the Korean Chemical Society, 2011Co-Authors: Pravin V. Badadhe, Asha V. Chate, Dattatraya G. Hingane, Pravin S. Mahajan, Namdev M. Chavhan, Charansingh H. GillAbstract:Thiamine Hydrochloride (VB1) has been used as an acid catalyst in organic synthesis. One pot three component Biginelli condensation of dimedone, urea/thiourea and substituted aromatic aldehydes catalyzed by 10 mol % of Thiamine Hydrochloride (VB1) in solvent free condition under microwave irradiation in good to excellent yields has been investigated. Utilization of microwave irradiation, simple reaction conditions, short reaction time, ease of product isolation, and purification makes this manipulation very interesting from an economic and environmental perspective.
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Thiamine Hydrochloride vb1 an efficient catalyst for one pot synthesis of α aminophosphonates under ultrasonic irradiation
Chinese Chemical Letters, 2011Co-Authors: Priyanka G. Mandhane, Ratnadeep S. Joshi, Deepak R. Nagargoje, Charansingh H. GillAbstract:Abstract An efficient synthesis of novel α-aminophosphonates by the reaction of aldehydes and amines with triethyl phosphite in the presence of the easily available, inexpensive, and nontoxic catalyst Thiamine Hydrochloride (VB1). This method affords the α-aminophosphonates under the influence of ultrasound irradiation in aqueous medium, in short reaction times (4–6 min), high yields (85–95%), with improved purity. The process is green, mild, inexpensive and excellent yields are the main compensation of this procedure.
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Thiamine Hydrochloride（VB1）：An efficient catalyst for one-pot synthesis of α-aminophosphonates under ultrasonic irradiation
Chinese Chemical Letters, 2011Co-Authors: Priyanka G. Mandhane, Ratnadeep S. Joshi, Deepak R. Nagargoje, Charansingh H. GillAbstract:Abstract An efficient synthesis of novel α-aminophosphonates by the reaction of aldehydes and amines with triethyl phosphite in the presence of the easily available, inexpensive, and nontoxic catalyst Thiamine Hydrochloride (VB1). This method affords the α-aminophosphonates under the influence of ultrasound irradiation in aqueous medium, in short reaction times (4–6 min), high yields (85–95%), with improved purity. The process is green, mild, inexpensive and excellent yields are the main compensation of this procedure.
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an efficient synthesis of 3 4 dihydropyrimidin 2 1h ones catalyzed by Thiamine Hydrochloride in water under ultrasound irradiation
Tetrahedron Letters, 2010Co-Authors: Priyanka G. Mandhane, Ratnadeep S. Joshi, Deepak R. Nagargoje, Charansingh H. GillAbstract:An environmentally benign aqueous Biginelli protocol for the synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones using Thiamine Hydrochloride as a catalyst has been achieved. These ultrasound-assisted reactions proceed efficiently in water in the absence of organic solvent. Utilization of ultrasound irradiation, simple reaction conditions, isolation, and purification makes this manipulation very interesting from an economic and environmental perspective.
Roman Szostak - One of the best experts on this subject based on the ideXlab platform.
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quantitative analysis of Thiamine Hydrochloride in tablets comparison of infrared attenuated total reflection diffuse reflectance infrared and raman spectroscopy
Vibrational Spectroscopy, 2012Co-Authors: Sylwester Mazurek, Roman SzostakAbstract:Abstract The application of FTIR ATR (Fourier transform infrared attenuated total reflection), DRIFT (diffuse reflectance infrared Fourier transform) and FT Raman spectroscopy for the quantification of Thiamine Hydrochloride, or vitamin B1, in tablets was compared. PLS (partial least squares) calibration models were built and validated using the spectra of 40 samples containing vitamin B1 and excipients. To evaluate the predictive ability of these models, the relative standard errors of prediction (RSEP) were calculated. In the case of vitamin B1 determination from the Raman data, RSEP error values of 1.5 % and 2.1 % were obtained for the calibration and validation data sets, respectively. When DRIFT spectra were applied, the respective RSEP errors were found to be 2.1 % and 2.2 %. For ATR models, these errors amounted to 3.1 % and 3.2 %, respectively. Commercial tablets containing 25 mg of Thiamine Hydrochloride were quantified using the developed models. Derived concentrations correlated strongly with the results of the reference analysis and yielded recoveries of 99.2–100.8 %. Each of the three applied spectroscopic techniques can be employed as fast and reliable alternatives to the standard pharmacopeial methods of vitamin B1 quantification in tablets. DRIFT spectroscopy has the highest potential to become a routine technique for the quantification of solid mixtures within the pharmaceutical industry.
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Quantitative analysis of Thiamine Hydrochloride in tablets—Comparison of infrared attenuated total reflection, diffuse reflectance infrared and Raman spectroscopy
Vibrational Spectroscopy, 2012Co-Authors: Sylwester Mazurek, Roman SzostakAbstract:Abstract The application of FTIR ATR (Fourier transform infrared attenuated total reflection), DRIFT (diffuse reflectance infrared Fourier transform) and FT Raman spectroscopy for the quantification of Thiamine Hydrochloride, or vitamin B1, in tablets was compared. PLS (partial least squares) calibration models were built and validated using the spectra of 40 samples containing vitamin B1 and excipients. To evaluate the predictive ability of these models, the relative standard errors of prediction (RSEP) were calculated. In the case of vitamin B1 determination from the Raman data, RSEP error values of 1.5 % and 2.1 % were obtained for the calibration and validation data sets, respectively. When DRIFT spectra were applied, the respective RSEP errors were found to be 2.1 % and 2.2 %. For ATR models, these errors amounted to 3.1 % and 3.2 %, respectively. Commercial tablets containing 25 mg of Thiamine Hydrochloride were quantified using the developed models. Derived concentrations correlated strongly with the results of the reference analysis and yielded recoveries of 99.2–100.8 %. Each of the three applied spectroscopic techniques can be employed as fast and reliable alternatives to the standard pharmacopeial methods of vitamin B1 quantification in tablets. DRIFT spectroscopy has the highest potential to become a routine technique for the quantification of solid mixtures within the pharmaceutical industry.
Min Lei - One of the best experts on this subject based on the ideXlab platform.
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Thiamine Hydrochloride vb1 catalyzed one pot synthesis of e n benzylidene 2 phenyl 1h benzo d imidazo 1 2 a imidazol 3 amine derivatives
ChemInform, 2013Co-Authors: Fanglei Chen, Min LeiAbstract:A Thiamine Hydrochloride catalyzed three-component one-pot synthesis of the title compounds is described.
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Thiamine Hydrochloride (VB1)‐Catalyzed One‐Pot Synthesis of (E)‐N‐Benzylidene‐2‐phenyl‐1H‐benzo[d]imidazo[1,2‐a]imidazol‐3‐amine Derivatives.
ChemInform, 2013Co-Authors: Fanglei Chen, Min LeiAbstract:A Thiamine Hydrochloride catalyzed three-component one-pot synthesis of the title compounds is described.
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one pot synthesis of 1h benzimidazole derivatives using Thiamine Hydrochloride as a reusable organocatalyst
ChemInform, 2012Co-Authors: Min LeiAbstract:Thiamine Hydrochloride is shown to be an efficient catalyst for the synthesis of benzimidazole derivatives of type (III) or (V) from o-phenylendiamine and aromatic aldehydes.
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One‐Pot Synthesis of 1H‐Benzimidazole Derivatives Using Thiamine Hydrochloride as a Reusable Organocatalyst.
ChemInform, 2012Co-Authors: Min LeiAbstract:Thiamine Hydrochloride is shown to be an efficient catalyst for the synthesis of benzimidazole derivatives of type (III) or (V) from o-phenylendiamine and aromatic aldehydes.
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One-Pot Synthesis of 1H-Benzimidazole Derivatives Using Thiamine Hydrochloride as a Reusable Organocatalyst
Synthetic Communications, 2012Co-Authors: Min LeiAbstract:Abstract A simple and efficient one-pot synthesis of 1H-benzimidazole derivatives using Thiamine Hydrochloride (VB1) as the organocatalyst from o-phenylenediamine and aldehyde in dimethylformamide is described. Compared to classical reaction conditions, this new method consistently has the advantages of excellent yields, metal-ion-free procedure, and good recovery and reusablity of catalyst.
Sylwester Mazurek - One of the best experts on this subject based on the ideXlab platform.
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quantitative analysis of Thiamine Hydrochloride in tablets comparison of infrared attenuated total reflection diffuse reflectance infrared and raman spectroscopy
Vibrational Spectroscopy, 2012Co-Authors: Sylwester Mazurek, Roman SzostakAbstract:Abstract The application of FTIR ATR (Fourier transform infrared attenuated total reflection), DRIFT (diffuse reflectance infrared Fourier transform) and FT Raman spectroscopy for the quantification of Thiamine Hydrochloride, or vitamin B1, in tablets was compared. PLS (partial least squares) calibration models were built and validated using the spectra of 40 samples containing vitamin B1 and excipients. To evaluate the predictive ability of these models, the relative standard errors of prediction (RSEP) were calculated. In the case of vitamin B1 determination from the Raman data, RSEP error values of 1.5 % and 2.1 % were obtained for the calibration and validation data sets, respectively. When DRIFT spectra were applied, the respective RSEP errors were found to be 2.1 % and 2.2 %. For ATR models, these errors amounted to 3.1 % and 3.2 %, respectively. Commercial tablets containing 25 mg of Thiamine Hydrochloride were quantified using the developed models. Derived concentrations correlated strongly with the results of the reference analysis and yielded recoveries of 99.2–100.8 %. Each of the three applied spectroscopic techniques can be employed as fast and reliable alternatives to the standard pharmacopeial methods of vitamin B1 quantification in tablets. DRIFT spectroscopy has the highest potential to become a routine technique for the quantification of solid mixtures within the pharmaceutical industry.
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Quantitative analysis of Thiamine Hydrochloride in tablets—Comparison of infrared attenuated total reflection, diffuse reflectance infrared and Raman spectroscopy
Vibrational Spectroscopy, 2012Co-Authors: Sylwester Mazurek, Roman SzostakAbstract:Abstract The application of FTIR ATR (Fourier transform infrared attenuated total reflection), DRIFT (diffuse reflectance infrared Fourier transform) and FT Raman spectroscopy for the quantification of Thiamine Hydrochloride, or vitamin B1, in tablets was compared. PLS (partial least squares) calibration models were built and validated using the spectra of 40 samples containing vitamin B1 and excipients. To evaluate the predictive ability of these models, the relative standard errors of prediction (RSEP) were calculated. In the case of vitamin B1 determination from the Raman data, RSEP error values of 1.5 % and 2.1 % were obtained for the calibration and validation data sets, respectively. When DRIFT spectra were applied, the respective RSEP errors were found to be 2.1 % and 2.2 %. For ATR models, these errors amounted to 3.1 % and 3.2 %, respectively. Commercial tablets containing 25 mg of Thiamine Hydrochloride were quantified using the developed models. Derived concentrations correlated strongly with the results of the reference analysis and yielded recoveries of 99.2–100.8 %. Each of the three applied spectroscopic techniques can be employed as fast and reliable alternatives to the standard pharmacopeial methods of vitamin B1 quantification in tablets. DRIFT spectroscopy has the highest potential to become a routine technique for the quantification of solid mixtures within the pharmaceutical industry.