The Experts below are selected from a list of 21 Experts worldwide ranked by ideXlab platform
Arthur D Broom - One of the best experts on this subject based on the ideXlab platform.
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An Unusual ‘‘Senseless’ ’ 2’,5’-Oligoribonucleotide with Potent Anti-HIV Activity y
2014Co-Authors: Tarek Aboul-fadl, Vijai K Agrawal, Robert W Buckheit, Arthur D Broom, Key WordsAbstract:A new 32-mer 2’,5’-oligoribonucleotide of 1-methyl-6-Thioinosinic Acid (10) has been synthesized. The design of this unique oligoribonucleotide is based on the reported HIV inhibitory activities of both 2’,5’-oligonucleotides and the 3’,5’-oligoribonucleotides containing the 1-methyl-6-mercaptopurine base. Tm and CD studies of 10 revealed that it has no organized secondary structure, presumably due to the rigidity of the molecule. The synthesized oligomer, 10, showed a potent inhibitory effect on HIV-1 RF and significantly inhibited HIV-1 reverse transcriptase
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An Unusual “Senseless” 2′,5′-Oligoribonucleotide With Potent Anti-Hiv Activity
Arthur D Broom, 2007Co-Authors: Tarek Aboul-fadl, Vijai K Agrawal, Robert W Buckheit, Arthur D BroomAbstract:A new 32-mer 2′,5′-oligoribonucleotide of 1-methyl-6-Thioinosinic Acid (10) has been synthesized. The design of this unique oligoribonucleotide is based on the reported HIV inhibitory activities of both 2′,5′-oligonucleotides and the 3′,5′-oligoribonucleotides containing the 1-methyl-6-mercaptopurine base. Tm and CD studies of 10 revealed that it has no organized secondary structure, presumably due to the rigidity of the molecule. The synthesized oligomer, 10, showed a potent inhibitory effect on HIV-1RF and significantly inhibited HIV-1 reverse transcriptas
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an unusual senseless 2 5 oligoribonucleotide with potent anti hiv activity
Nucleosides Nucleotides & Nucleic Acids, 2004Co-Authors: Tarek Aboulfadl, Vijai K Agrawal, Robert W Buckheit, Arthur D BroomAbstract:A new 32‐mer 2′,5′‐oligoribonucleotide of 1‐methyl‐6‐Thioinosinic Acid (10) has been synthesized. The design of this unique oligoribonucleotide is based on the reported HIV inhibitory activities of both 2′,5′‐oligonucleotides and the 3′,5′‐oligoribonucleotides containing the 1‐methyl‐6‐mercaptopurine base. Tm and CD studies of 10 revealed that it has no organized secondary structure, presumably due to the rigidity of the molecule. The synthesized oligomer, 10, showed a potent inhibitory effect on HIV‐1RF and significantly inhibited HIV‐1 reverse transcriptase. †In honor and celebration of the 70th birthday of Professor Leroy B. Townsend.
Robert W Buckheit - One of the best experts on this subject based on the ideXlab platform.
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An Unusual ‘‘Senseless’ ’ 2’,5’-Oligoribonucleotide with Potent Anti-HIV Activity y
2014Co-Authors: Tarek Aboul-fadl, Vijai K Agrawal, Robert W Buckheit, Arthur D Broom, Key WordsAbstract:A new 32-mer 2’,5’-oligoribonucleotide of 1-methyl-6-Thioinosinic Acid (10) has been synthesized. The design of this unique oligoribonucleotide is based on the reported HIV inhibitory activities of both 2’,5’-oligonucleotides and the 3’,5’-oligoribonucleotides containing the 1-methyl-6-mercaptopurine base. Tm and CD studies of 10 revealed that it has no organized secondary structure, presumably due to the rigidity of the molecule. The synthesized oligomer, 10, showed a potent inhibitory effect on HIV-1 RF and significantly inhibited HIV-1 reverse transcriptase
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An Unusual “Senseless” 2′,5′-Oligoribonucleotide With Potent Anti-Hiv Activity
Arthur D Broom, 2007Co-Authors: Tarek Aboul-fadl, Vijai K Agrawal, Robert W Buckheit, Arthur D BroomAbstract:A new 32-mer 2′,5′-oligoribonucleotide of 1-methyl-6-Thioinosinic Acid (10) has been synthesized. The design of this unique oligoribonucleotide is based on the reported HIV inhibitory activities of both 2′,5′-oligonucleotides and the 3′,5′-oligoribonucleotides containing the 1-methyl-6-mercaptopurine base. Tm and CD studies of 10 revealed that it has no organized secondary structure, presumably due to the rigidity of the molecule. The synthesized oligomer, 10, showed a potent inhibitory effect on HIV-1RF and significantly inhibited HIV-1 reverse transcriptas
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an unusual senseless 2 5 oligoribonucleotide with potent anti hiv activity
Nucleosides Nucleotides & Nucleic Acids, 2004Co-Authors: Tarek Aboulfadl, Vijai K Agrawal, Robert W Buckheit, Arthur D BroomAbstract:A new 32‐mer 2′,5′‐oligoribonucleotide of 1‐methyl‐6‐Thioinosinic Acid (10) has been synthesized. The design of this unique oligoribonucleotide is based on the reported HIV inhibitory activities of both 2′,5′‐oligonucleotides and the 3′,5′‐oligoribonucleotides containing the 1‐methyl‐6‐mercaptopurine base. Tm and CD studies of 10 revealed that it has no organized secondary structure, presumably due to the rigidity of the molecule. The synthesized oligomer, 10, showed a potent inhibitory effect on HIV‐1RF and significantly inhibited HIV‐1 reverse transcriptase. †In honor and celebration of the 70th birthday of Professor Leroy B. Townsend.
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An unusual "senseless" 2',5'-oligoribonucleotide with potent anti-HIV activity.
LNCN, 2004Co-Authors: Tarek Aboul-fadl, Vijai K Agrawal, Robert W BuckheitAbstract:A new 32-mer 2',5'-oligoribonucleotide of 1-methyl-6-Thioinosinic Acid (10) has been synthesized. The design of this unique oligoribonucleotide is based on the reported HIV inhibitory activities of both 2',5'-oligonucleotides and the 3',5'-oligoribonucleotides containing the 1-methyl-6-mercaptopurine base. Tm and CD studies of 10 revealed that it has no organized secondary structure, presumably due to the rigidity of the molecule. The synthesized oligomer, 10, showed a potent inhibitory effect on HIV-1RF and significantly inhibited HIV-1 reverse transcriptase
Helen J Singleton - One of the best experts on this subject based on the ideXlab platform.
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high performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6 mercaptopurine quantitation of red blood cell 6 thioguanine nucleotide 6 Thioinosinic Acid and 6 methylmercaptopurine metabolites in a single sample
Journal of Chromatography B: Biomedical Sciences and Applications, 1992Co-Authors: Lynne Lennard, Helen J SingletonAbstract:A reversed-phase high-performance liquid chromatographic assay was developed to quantify intracellular metabolites of the cytotoxic drug 6-mercaptopurine in the human red blood cell. The 6-thioguanine nucleotides, 6-Thioinosinic Acid and 6-methylmercaptopurine metabolites are measured in a single sample. A similar assay measures the parent thiopurine compounds. The limit of quantitation of the assay is 0.03, 0.03 and 0.12 nmol per 8 · 108 red blood cells for the 6-thioguanine nucleotides, 6-Thioinosinic Acid and the 6-methylmercaptopurine metabolites, respectively.
Tarek Aboul-fadl - One of the best experts on this subject based on the ideXlab platform.
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An Unusual ‘‘Senseless’ ’ 2’,5’-Oligoribonucleotide with Potent Anti-HIV Activity y
2014Co-Authors: Tarek Aboul-fadl, Vijai K Agrawal, Robert W Buckheit, Arthur D Broom, Key WordsAbstract:A new 32-mer 2’,5’-oligoribonucleotide of 1-methyl-6-Thioinosinic Acid (10) has been synthesized. The design of this unique oligoribonucleotide is based on the reported HIV inhibitory activities of both 2’,5’-oligonucleotides and the 3’,5’-oligoribonucleotides containing the 1-methyl-6-mercaptopurine base. Tm and CD studies of 10 revealed that it has no organized secondary structure, presumably due to the rigidity of the molecule. The synthesized oligomer, 10, showed a potent inhibitory effect on HIV-1 RF and significantly inhibited HIV-1 reverse transcriptase
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An Unusual “Senseless” 2′,5′-Oligoribonucleotide With Potent Anti-Hiv Activity
Arthur D Broom, 2007Co-Authors: Tarek Aboul-fadl, Vijai K Agrawal, Robert W Buckheit, Arthur D BroomAbstract:A new 32-mer 2′,5′-oligoribonucleotide of 1-methyl-6-Thioinosinic Acid (10) has been synthesized. The design of this unique oligoribonucleotide is based on the reported HIV inhibitory activities of both 2′,5′-oligonucleotides and the 3′,5′-oligoribonucleotides containing the 1-methyl-6-mercaptopurine base. Tm and CD studies of 10 revealed that it has no organized secondary structure, presumably due to the rigidity of the molecule. The synthesized oligomer, 10, showed a potent inhibitory effect on HIV-1RF and significantly inhibited HIV-1 reverse transcriptas
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An unusual "senseless" 2',5'-oligoribonucleotide with potent anti-HIV activity.
LNCN, 2004Co-Authors: Tarek Aboul-fadl, Vijai K Agrawal, Robert W BuckheitAbstract:A new 32-mer 2',5'-oligoribonucleotide of 1-methyl-6-Thioinosinic Acid (10) has been synthesized. The design of this unique oligoribonucleotide is based on the reported HIV inhibitory activities of both 2',5'-oligonucleotides and the 3',5'-oligoribonucleotides containing the 1-methyl-6-mercaptopurine base. Tm and CD studies of 10 revealed that it has no organized secondary structure, presumably due to the rigidity of the molecule. The synthesized oligomer, 10, showed a potent inhibitory effect on HIV-1RF and significantly inhibited HIV-1 reverse transcriptase
Vijai K Agrawal - One of the best experts on this subject based on the ideXlab platform.
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An Unusual ‘‘Senseless’ ’ 2’,5’-Oligoribonucleotide with Potent Anti-HIV Activity y
2014Co-Authors: Tarek Aboul-fadl, Vijai K Agrawal, Robert W Buckheit, Arthur D Broom, Key WordsAbstract:A new 32-mer 2’,5’-oligoribonucleotide of 1-methyl-6-Thioinosinic Acid (10) has been synthesized. The design of this unique oligoribonucleotide is based on the reported HIV inhibitory activities of both 2’,5’-oligonucleotides and the 3’,5’-oligoribonucleotides containing the 1-methyl-6-mercaptopurine base. Tm and CD studies of 10 revealed that it has no organized secondary structure, presumably due to the rigidity of the molecule. The synthesized oligomer, 10, showed a potent inhibitory effect on HIV-1 RF and significantly inhibited HIV-1 reverse transcriptase
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An Unusual “Senseless” 2′,5′-Oligoribonucleotide With Potent Anti-Hiv Activity
Arthur D Broom, 2007Co-Authors: Tarek Aboul-fadl, Vijai K Agrawal, Robert W Buckheit, Arthur D BroomAbstract:A new 32-mer 2′,5′-oligoribonucleotide of 1-methyl-6-Thioinosinic Acid (10) has been synthesized. The design of this unique oligoribonucleotide is based on the reported HIV inhibitory activities of both 2′,5′-oligonucleotides and the 3′,5′-oligoribonucleotides containing the 1-methyl-6-mercaptopurine base. Tm and CD studies of 10 revealed that it has no organized secondary structure, presumably due to the rigidity of the molecule. The synthesized oligomer, 10, showed a potent inhibitory effect on HIV-1RF and significantly inhibited HIV-1 reverse transcriptas
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an unusual senseless 2 5 oligoribonucleotide with potent anti hiv activity
Nucleosides Nucleotides & Nucleic Acids, 2004Co-Authors: Tarek Aboulfadl, Vijai K Agrawal, Robert W Buckheit, Arthur D BroomAbstract:A new 32‐mer 2′,5′‐oligoribonucleotide of 1‐methyl‐6‐Thioinosinic Acid (10) has been synthesized. The design of this unique oligoribonucleotide is based on the reported HIV inhibitory activities of both 2′,5′‐oligonucleotides and the 3′,5′‐oligoribonucleotides containing the 1‐methyl‐6‐mercaptopurine base. Tm and CD studies of 10 revealed that it has no organized secondary structure, presumably due to the rigidity of the molecule. The synthesized oligomer, 10, showed a potent inhibitory effect on HIV‐1RF and significantly inhibited HIV‐1 reverse transcriptase. †In honor and celebration of the 70th birthday of Professor Leroy B. Townsend.
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An unusual "senseless" 2',5'-oligoribonucleotide with potent anti-HIV activity.
LNCN, 2004Co-Authors: Tarek Aboul-fadl, Vijai K Agrawal, Robert W BuckheitAbstract:A new 32-mer 2',5'-oligoribonucleotide of 1-methyl-6-Thioinosinic Acid (10) has been synthesized. The design of this unique oligoribonucleotide is based on the reported HIV inhibitory activities of both 2',5'-oligonucleotides and the 3',5'-oligoribonucleotides containing the 1-methyl-6-mercaptopurine base. Tm and CD studies of 10 revealed that it has no organized secondary structure, presumably due to the rigidity of the molecule. The synthesized oligomer, 10, showed a potent inhibitory effect on HIV-1RF and significantly inhibited HIV-1 reverse transcriptase