The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform
Xiangzhi Song - One of the best experts on this subject based on the ideXlab platform.
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a naphthalimide indole fused chromophore based fluorescent probe for instantaneous detection of Thiophenol with a red emission and a large stokes shift
Sensors and Actuators B-chemical, 2018Co-Authors: Shuang Zhou, Yifan Rong, Han Wang, Xingjiang Liu, Liuhe Wei, Xiangzhi SongAbstract:Abstract This work presented a naphthalimide-indole fused chromophore-based fluorescent probe for the detection of Thiophenol using 2,4-dinitrobenzene moiety as a sensing unit. This probe was able to work in aqueous media and instantaneously respond to Thiophenol (within 5 min). In detecting Thiophenol, this probe displayed a red emission (λmax = 590 nm), a 140 nm Stokes shift and a low detect limit (3.6 × 10−8 M). Furthermore, the potential ability for practical applications of this probe has been successfully demonstrated in monitoring Thiophenol in living cells and in real water samples.
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an aqueous methylated chromenoquinoline based fluorescent probe for instantaneous sensing of Thiophenol with a red emission and a large stokes shift
Sensors and Actuators B-chemical, 2018Co-Authors: Yani Geng, Liu Yang, Xingjiang Liu, Huihui Tian, Xiangzhi SongAbstract:Abstract A sensitive and selective fluorescent probe, MCQ-O-DNB, for the detection of Thiophenol in aqueous media has been developed based on a methylated chromenoquinoline chromophore. This probe can instantaneously respond to Thiophenol and reach to a balance within 2 min. In the detection process, this probe exhibited a large Stokes shift (108 nm) and a low detection limit (8.1 nM, based on S/N = 3). Importantly, practical application experiments demonstrated that this probe was able to detect Thiophenol in real water samples and living cells.
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a triple emission fluorescent probe for discriminatory detection of cysteine homocysteine glutathione hydrogen sulfide and Thiophenol in living cells
ACS Sensors, 2018Co-Authors: Lei Yang, Yani Geng, Yun Zhang, Xiaojie Ren, Xiangzhi SongAbstract:Thiols, such as cysteine (Cys), homocysteine (Hcy), glutathione (GSH), hydrogen sulfide (H2S), and Thiophenol are metabolically correlated with each other via redox reactions. As a result of the similarity of chemical properties between Cys, Hcy, GSH, H2S, and Thiophenol, it is very challenging to develop an effective methodology to differentiate them. In this work, a triple-emission fluorescent probe, NCQ, was reported for the simultaneous detection of Cys/Hcy, GSH/H2S, and Thiophenol with high sensitivity and selectivity. The solution of NCQ displayed distinct fluorescent signals toward Cys/Hcy, GSH/H2S, and Thiophenol: blue and green for Cys/Hcy, blue for GSH/H2S, blue and red for Thiophenol. Through the blue–green–red emission color combination, Cys/Hcy, GSH/H2S, and Thiophenol could be discriminatively detected in solution and in living cells.
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detection of Thiophenol in buffer in serum on filter paper strip and in living cells using a red emitting amino phenothiazine boranil based fluorescent probe with a large stokes shift
Tetrahedron, 2017Co-Authors: Wenqiang Chen, Xiuxiu Yue, Yuanqiang Hao, Linlin Zhu, Jiarong Sheng, Jinyan Gai, Qi Xiao, Shan Huang, Xiangzhi SongAbstract:Abstract A novel red-emitting dye, PB-NH2, was synthesized by incorporation of an electron rich phenothiazine moiety to classical boranil dye. PB-NH2 displayed excellent photophysical properties, such as long emission wavelength, large Stokes shift, strong emission both in solution and in solid state. Based on this attractive platform, Probe 1, was constructed for selective detection of Thiophenol. Notably, Probe 1 was ultrasensitive in response to Thiophenol, and the corresponding detection limits for Thiophenol in theoretical and in experimental were determined to be 1.4 and 10 nM, respectively. Significantly, Probe 1 showed great potential for practical applications, and the applications in real water samples, in serum, on filter paper strips and in living cells were successfully demonstrated.
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a phenothiazine coumarin based red emitting fluorescent probe for nanomolar detection of Thiophenol with a large stokes shift
Sensors and Actuators B-chemical, 2017Co-Authors: Wenqiang Chen, Xiuxiu Yue, Yuanqiang Hao, Liangliang Zhang, Linlin Zhu, Jiarong Sheng, Xiangzhi SongAbstract:Abstract By introducing phenothiazine framework as an electron donating component, we have developed a unique deep-red functional fluorescent dye 5b , bearing excellent photophysical properties. Using dye 5b as a platform, we further constructed a novel red emitting fluorescent probe ( 1 ) for Thiophenol on the basis of a unique Thiophenol-mediated substitution-cyclization-hydrolysis reaction cascade. Probe 1 exhibits highly selective and sensitive response to Thiophenol over aliphatic thiols, with a detection limit of 2.9 nM (S/N = 3). Moreover, this probe features a remarkable large Stokes shift (141 nm) in PB buffer (pH = 7.4, containing 1 mM CTAB). Importantly, it was successfully applied for detection of Thiophenol both in real water samples and in living HeLa cells, indicating that this probe has great potential for practical applications.
Debankan Ghosh - One of the best experts on this subject based on the ideXlab platform.
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Thiophenol mediated radical cyclization: an expedient approach to 2H-pyrrolo[3,2-d]pyrimidines (9-deazaxanthine analogs)
Tetrahedron Letters, 2010Co-Authors: Krishna C. Majumdar, Shovan Mondal, Debankan GhoshAbstract:A new efficient route for the synthesis of substituted 2H-pyrrolopyrimidines (9-deazaxanthine analogs) via Thiophenol mediated radical cyclization has been achieved. The stereochemistry of the newly synthesised compounds has been settled from NOE data.
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An easy access to pyrimidine-fused azocine derivatives by Thiophenol-mediated radical cyclization via 8-endo-trig mode
Tetrahedron Letters, 2010Co-Authors: Krishna C. Majumdar, Shovan Mondal, Debankan GhoshAbstract:Abstract An efficient route for the synthesis of eight-membered nitrogen heterocycles has been developed via a Thiophenol-mediated intramolecular 8-endo-trig radical cyclization. The radical precursors were prepared using BF3·Et2O-catalyzed aza-Claisen rearrangement followed by the reaction with propargyl bromide. The alkenyl radicals are generated from Thiophenol initiated by the benzoyl peroxide instead of commonly used AIBN for easy and facile isolation of the pure products.
Krishna C. Majumdar - One of the best experts on this subject based on the ideXlab platform.
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Thiophenol mediated radical cyclization: an expedient approach to 2H-pyrrolo[3,2-d]pyrimidines (9-deazaxanthine analogs)
Tetrahedron Letters, 2010Co-Authors: Krishna C. Majumdar, Shovan Mondal, Debankan GhoshAbstract:A new efficient route for the synthesis of substituted 2H-pyrrolopyrimidines (9-deazaxanthine analogs) via Thiophenol mediated radical cyclization has been achieved. The stereochemistry of the newly synthesised compounds has been settled from NOE data.
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An easy access to pyrimidine-fused azocine derivatives by Thiophenol-mediated radical cyclization via 8-endo-trig mode
Tetrahedron Letters, 2010Co-Authors: Krishna C. Majumdar, Shovan Mondal, Debankan GhoshAbstract:Abstract An efficient route for the synthesis of eight-membered nitrogen heterocycles has been developed via a Thiophenol-mediated intramolecular 8-endo-trig radical cyclization. The radical precursors were prepared using BF3·Et2O-catalyzed aza-Claisen rearrangement followed by the reaction with propargyl bromide. The alkenyl radicals are generated from Thiophenol initiated by the benzoyl peroxide instead of commonly used AIBN for easy and facile isolation of the pure products.
Haijun Yang - One of the best experts on this subject based on the ideXlab platform.
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Thiophenol catalyzed visible light photoredox decarboxylative couplings of n acetoxy phthalimides
Organic Letters, 2016Co-Authors: Yunhe Jin, Haijun YangAbstract:We have developed visible-light photoredox decarboxylative couplings of N-(acetoxy)phthalimides without an added photocatalyst in which simple and commercially available Thiophenols are used as the effective organocatalysts, and 4-(trifluoromethyl)Thiophenol shows optimal catalytic activity. Three representative decarboxylative examples were chosen including one amination and two C–C bond couplings to confirm efficacy of the visible-light photoredox reactions, and the results exhibited that they performed very well at room temperature. The interesting discovery should provide a novel and environmentally friendly strategy for visible-light photoredox transformation of organic molecules.
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Thiophenol-Catalyzed Visible-Light Photoredox Decarboxylative Couplings of N‑(Acetoxy)phthalimides
2016Co-Authors: Yunhe Jin, Haijun YangAbstract:We have developed visible-light photoredox decarboxylative couplings of N-(acetoxy)phthalimides without an added photocatalyst in which simple and commercially available Thiophenols are used as the effective organocatalysts, and 4-(trifluoromethyl)Thiophenol shows optimal catalytic activity. Three representative decarboxylative examples were chosen including one amination and two C–C bond couplings to confirm efficacy of the visible-light photoredox reactions, and the results exhibited that they performed very well at room temperature. The interesting discovery should provide a novel and environmentally friendly strategy for visible-light photoredox transformation of organic molecules
Pinaki Talukdar - One of the best experts on this subject based on the ideXlab platform.
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structural imposition on the off on response of naphthalimide based probes for selective Thiophenol sensing
RSC Advances, 2014Co-Authors: Dnyaneshwar Kand, Tanmoy Saha, Prashant S Mandal, Pinaki TalukdarAbstract:N-Phenyl-1,8-naphthalimide based fluorescent probes are reported with various positions of dinitrobenzenesulfonyl (DNs) quencher on the phenyl ring. The probe with –DNs at the ortho-position was predicted to show better response compared to those with the quencher at the meta and para positions. The probe showed selective and very fast response (response time, tR = 1 min) toward Thiophenol with 20-fold off–on fluorescence sensitivity. Thiophenol sensing applications by the probe were demonstrated via water sample analysis and live cell imaging studies.
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iminocoumarin based fluorophores indispensable scaffolds for rapid selective and sensitive detection of Thiophenol
Dyes and Pigments, 2014Co-Authors: Dnyaneshwar Kand, Prashant S Mandal, Avdhoot Datar, Pinaki TalukdarAbstract:Abstract Off - on fluorescence probes for the detection of Thiophenol were designed based on the reaction mechanism to ensure rapid sensing process. 2,4-Dinitrophenylsulfonyl based probes with iminocoumarin fluorophores were validated by theoretical calculations for their off -fluorescence states. Reaction of these probes with Thiophenol released strong fluorescent iminocoumarin species with good response times. These results, upon comparing with reported probes, confirmed that higher p K aH values of the imino nitrogen of iminocoumarins are important for rapid sensing process. Reactivity of these probes was limited to only Thiophenol and no reaction was observed with aliphatic thiols. The benzothiazole substituted probe displayed up to 260-fold fluorescence enhancement upon reaction with Thiophenol. Sensing of the analyte by the probe was characterized by change in color from red to yellow and with appearance of the green fluorescence. A detection limit up to 6.9 × 10 −9 M was also determined for this probe.
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bodipy based colorimetric fluorescent probe for selective Thiophenol detection theoretical and experimental studies
Analyst, 2012Co-Authors: Dnyaneshwar Kand, Pratyush Kumar Mishra, Tanmoy Saha, Mayurika Lahiri, Pinaki TalukdarAbstract:A BODIPY-based selective Thiophenol probe capable of discriminating aliphatic thiols is reported. The fluorescence off–on effect upon reaction with thiol is elucidated with theoretical calculations. The sensing of Thiophenol is associated with a color change from red to yellow and 63-fold enhancement in green fluorescence. Application of the probe for selective Thiophenol detection is demonstrated by live cell imaging.
