The Experts below are selected from a list of 30 Experts worldwide ranked by ideXlab platform
Chul Soo Shin - One of the best experts on this subject based on the ideXlab platform.
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in vivo anti obesity effects of monascus pigment Threonine Derivative with enhanced hydrophilicity
Journal of Functional Foods, 2020Co-Authors: Deokyeong Choe, Chul Soo Shin, Heeyoung Jang, Hyun Ho Jung, Tony V Johnston, Daehwan KimAbstract:Abstract The hydrophobicity and anti-obesity characteristics of the Threonine (Thr) Derivative of Monascus pigment were determined and compared with 2-(p-tolyl)-ethylamine (TEA) and tryptophan (Trp) Derivatives of the same. Treatment by all three Derivatives decreased body weight gain, epididymal fat weight, and abdominal fat in mice. The lowest body weight gain and epididymal fat weight were observed with the Monascus-Thr Derivative treatment, which is more hydrophilic than other the other treatments tested. Further in vivo tests with the Thr Derivative at different concentrations demonstrated that body weight, epididymal fat weight, and serum lipid level are reduced in a concentration-dependent manner. Significant reduction was exhibited at 0.10 mg/g-mouse/day of the Thr Derivative, and less reduction was observed at 0.05 or 0.01 mg/g-mouse/day. In comparison with mice fed a normal diet, there was no statistical weight change in the liver, kidney, or spleen, indicating the Thr Derivative was not toxic to mice.
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effect of the monascus pigment Threonine Derivative on regulation of the cholesterol level in mice
Food Chemistry, 2008Co-Authors: Jungae Jeun, Heeyong Jung, Jong Hoon Kim, Yong Ook Kim, Sung Hun Youn, Chul Soo ShinAbstract:Abstract Different amino acid Derivatives were synthesized during cultivation of a Monascus species. Derivatives exhibiting an inhibitory activity against HMG-CoA reductase were screened by in vitro tests. The Threonine Derivative had a high inhibitory activity of 38% while four other Derivatives showed a greater than 23% activity. The orange monascus pigment showed a high activity of 36%. In vivo tests using female C57BL/6 mice were performed with the Threonine Derivative and orange pigment. Changes in the cholesterol and lipid levels in mice due to addition of the pigments were investigated. The total cholesterol (TC) level of mouse serum was reduced by 8–9% with the Threonine Derivative and by 16% with orange pigment. Supplementation with the Threonine Derivative and orange pigment decreased the LDL cholesterol level by 18–26% and increased the HDL cholesterol level by 1–9%. The atherogenic index (AI) value was reduced by 23–27% with pigment supplementation. The anti-atherosclerosis effect of monascus pigments can be induced by control of the lipid content in the serum rather than in the liver of mice.
Daehwan Kim - One of the best experts on this subject based on the ideXlab platform.
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in vivo anti obesity effects of monascus pigment Threonine Derivative with enhanced hydrophilicity
Journal of Functional Foods, 2020Co-Authors: Deokyeong Choe, Chul Soo Shin, Heeyoung Jang, Hyun Ho Jung, Tony V Johnston, Daehwan KimAbstract:Abstract The hydrophobicity and anti-obesity characteristics of the Threonine (Thr) Derivative of Monascus pigment were determined and compared with 2-(p-tolyl)-ethylamine (TEA) and tryptophan (Trp) Derivatives of the same. Treatment by all three Derivatives decreased body weight gain, epididymal fat weight, and abdominal fat in mice. The lowest body weight gain and epididymal fat weight were observed with the Monascus-Thr Derivative treatment, which is more hydrophilic than other the other treatments tested. Further in vivo tests with the Thr Derivative at different concentrations demonstrated that body weight, epididymal fat weight, and serum lipid level are reduced in a concentration-dependent manner. Significant reduction was exhibited at 0.10 mg/g-mouse/day of the Thr Derivative, and less reduction was observed at 0.05 or 0.01 mg/g-mouse/day. In comparison with mice fed a normal diet, there was no statistical weight change in the liver, kidney, or spleen, indicating the Thr Derivative was not toxic to mice.
Jungae Jeun - One of the best experts on this subject based on the ideXlab platform.
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effect of the monascus pigment Threonine Derivative on regulation of the cholesterol level in mice
Food Chemistry, 2008Co-Authors: Jungae Jeun, Heeyong Jung, Jong Hoon Kim, Yong Ook Kim, Sung Hun Youn, Chul Soo ShinAbstract:Abstract Different amino acid Derivatives were synthesized during cultivation of a Monascus species. Derivatives exhibiting an inhibitory activity against HMG-CoA reductase were screened by in vitro tests. The Threonine Derivative had a high inhibitory activity of 38% while four other Derivatives showed a greater than 23% activity. The orange monascus pigment showed a high activity of 36%. In vivo tests using female C57BL/6 mice were performed with the Threonine Derivative and orange pigment. Changes in the cholesterol and lipid levels in mice due to addition of the pigments were investigated. The total cholesterol (TC) level of mouse serum was reduced by 8–9% with the Threonine Derivative and by 16% with orange pigment. Supplementation with the Threonine Derivative and orange pigment decreased the LDL cholesterol level by 18–26% and increased the HDL cholesterol level by 1–9%. The atherogenic index (AI) value was reduced by 23–27% with pigment supplementation. The anti-atherosclerosis effect of monascus pigments can be induced by control of the lipid content in the serum rather than in the liver of mice.
Deokyeong Choe - One of the best experts on this subject based on the ideXlab platform.
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in vivo anti obesity effects of monascus pigment Threonine Derivative with enhanced hydrophilicity
Journal of Functional Foods, 2020Co-Authors: Deokyeong Choe, Chul Soo Shin, Heeyoung Jang, Hyun Ho Jung, Tony V Johnston, Daehwan KimAbstract:Abstract The hydrophobicity and anti-obesity characteristics of the Threonine (Thr) Derivative of Monascus pigment were determined and compared with 2-(p-tolyl)-ethylamine (TEA) and tryptophan (Trp) Derivatives of the same. Treatment by all three Derivatives decreased body weight gain, epididymal fat weight, and abdominal fat in mice. The lowest body weight gain and epididymal fat weight were observed with the Monascus-Thr Derivative treatment, which is more hydrophilic than other the other treatments tested. Further in vivo tests with the Thr Derivative at different concentrations demonstrated that body weight, epididymal fat weight, and serum lipid level are reduced in a concentration-dependent manner. Significant reduction was exhibited at 0.10 mg/g-mouse/day of the Thr Derivative, and less reduction was observed at 0.05 or 0.01 mg/g-mouse/day. In comparison with mice fed a normal diet, there was no statistical weight change in the liver, kidney, or spleen, indicating the Thr Derivative was not toxic to mice.
Heeyong Jung - One of the best experts on this subject based on the ideXlab platform.
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effect of the monascus pigment Threonine Derivative on regulation of the cholesterol level in mice
Food Chemistry, 2008Co-Authors: Jungae Jeun, Heeyong Jung, Jong Hoon Kim, Yong Ook Kim, Sung Hun Youn, Chul Soo ShinAbstract:Abstract Different amino acid Derivatives were synthesized during cultivation of a Monascus species. Derivatives exhibiting an inhibitory activity against HMG-CoA reductase were screened by in vitro tests. The Threonine Derivative had a high inhibitory activity of 38% while four other Derivatives showed a greater than 23% activity. The orange monascus pigment showed a high activity of 36%. In vivo tests using female C57BL/6 mice were performed with the Threonine Derivative and orange pigment. Changes in the cholesterol and lipid levels in mice due to addition of the pigments were investigated. The total cholesterol (TC) level of mouse serum was reduced by 8–9% with the Threonine Derivative and by 16% with orange pigment. Supplementation with the Threonine Derivative and orange pigment decreased the LDL cholesterol level by 18–26% and increased the HDL cholesterol level by 1–9%. The atherogenic index (AI) value was reduced by 23–27% with pigment supplementation. The anti-atherosclerosis effect of monascus pigments can be induced by control of the lipid content in the serum rather than in the liver of mice.