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Stefan Müller-hülsbeck - One of the best experts on this subject based on the ideXlab platform.

  • Influence of thrombus age on the mechanical Thrombectomy efficacy of the amplatz Thrombectomy Device in vitro.
    CardioVascular and Interventional Radiology, 2003
    Co-Authors: Jan Grimm, Thomas Jahnke, Martin Heller, Claus Muhle, Stefan Müller-hülsbeck
    Abstract:

    Purpose: To determine the efficacy of Thrombectomy for the Amplatz Thrombectomy Device (ATD) according to the age of the thrombus. Methods: Thrombectomy was performed with the 7 Fr or 8 Fr ATD. Five-day-old or 8-day-old thrombi were made from porcine blood by clotting within silicone tubes to be used in a flow model. Emboli sizes, weight, remaining thrombus and activation time were evaluated. Results: The age of the thrombus had no influence on the activation time necessary for complete thrombolysis. A significant difference was found in the overall amount of embolization only with the 7 Fr Device although a similar trend was shown with the 8 Fr Device. The amount of embolized thrombotic material was higher for both Devices if older thrombi (i.e., 8 days old) were processed. The overall impression was that the 8 Fr Device showed slightly better results (less remaining thrombus and embolization). Conclusion: A tendency toward higher amounts of embolization was observed if older thrombi were used in the model. Therefore the interventional radiologist should be aware of the potentially higher risk of peripheral embolization when performing mechanical Thrombectomy (with the ATD) in older thrombotic occlusions, especially since the higher rate of embolization was mainly due to an increased proportion of larger embolic particles (1 mm), which are clinically more significant.

  • Influence of Thrombus Age on the Mechanical Thrombectomy Efficacy of the Amplatz Thrombectomy Device In Vitro
    CardioVascular and Interventional Radiology, 2003
    Co-Authors: Jan Grimm, Thomas Jahnke, Martin Heller, Claus Muhle, Stefan Müller-hülsbeck
    Abstract:

    Purpose: To determine the efficacy of Thrombectomy for the Amplatz Thrombectomy Device (ATD) according to the age of the thrombus. Methods: Thrombectomy was performed with the 7 Fr or 8 Fr ATD. Five-day-old or 8-day-old thrombi were made from porcine blood by clotting within silicone tubes to be used in a flow model. Emboli sizes, weight, remaining thrombus and activation time were evaluated. Results: The age of the thrombus had no influence on the activation time necessary for complete thrombolysis. A significant difference was found in the overall amount of embolization only with the 7 Fr Device although a similar trend was shown with the 8 Fr Device. The amount of embolized thrombotic material was higher for both Devices if older thrombi (i.e., 8 days old) were processed. The overall impression was that the 8 Fr Device showed slightly better results (less remaining thrombus and embolization). Conclusion: A tendency toward higher amounts of embolization was observed if older thrombi were used in the model. Therefore the interventional radiologist should be aware of the potentially higher risk of peripheral embolization when performing mechanical Thrombectomy (with the ATD) in older thrombotic occlusions, especially since the higher rate of embolization was mainly due to an increased proportion of larger embolic particles (1 mm), which are clinically more significant.

  • Influence of thrombus age on the mechanical Thrombectomy efficacy of the amplatz Thrombectomy Device in vitro.
    Cardiovascular and interventional radiology, 2003
    Co-Authors: Jan Grimm, Thomas Jahnke, Martin Heller, Claus Muhle, Stefan Müller-hülsbeck
    Abstract:

    Purpose: To determine the efficacy of Thrombectomy for the Amplatz Thrombectomy Device (ATD) according to the age of the thrombus. Methods: Thrombectomy was performed with the 7 Fr or 8 Fr ATD. Five-day-old or 8-day-old thrombi were made from porcine blood by clotting within silicone tubes to be used in a flow model. Emboli sizes, weight, remaining thrombus and activation time were evaluated. Results: The age of the thrombus had no influence on the activation time necessary for complete thrombolysis. A significant difference was found in the overall amount of embolization only with the 7 Fr Device although a similar trend was shown with the 8 Fr Device. The amount of embolized thrombotic material was higher for both Devices if older thrombi (i.e., 8 days old) were processed. The overall impression was that the 8 Fr Device showed slightly better results (less remaining thrombus and embolization). Conclusion: A tendency toward higher amounts of embolization was observed if older thrombi were used in the model. Therefore the interventional radiologist should be aware of the potentially higher risk of peripheral embolization when performing mechanical Thrombectomy (with the ATD) in older thrombotic occlusions, especially since the higher rate of embolization was mainly due to an increased proportion of larger embolic particles (1 mm), which are clinically more significant.

  • Mechanical Thrombectomy of major and massive pulmonary embolism with use of the Amplatz Thrombectomy Device.
    Investigative Radiology, 2001
    Co-Authors: Stefan Müller-hülsbeck, Joachim Brossmann, Burkhardt Bewig, Jan Grimm, Thomas Jahnke, Michael Reuter, Martin Heller
    Abstract:

    Muller-Hulsbeck S, Brossmann J, Jahnke T, et al. Mechanical Thrombectomy of major and massive pulmonary embolism with use of the Amplatz Thrombectomy Device. Invest Radiol 2001;36:317–322.rationale and objectives. To evaluate the feasibility of mechanical Thrombectomy with the Amplatz Thrombectomy d

  • Comparison of the mechanical Thrombectomy efficacy of the Amplatz Thrombectomy Device and the Cragg thrombolytic brush in vitro.
    Investigative Radiology, 2001
    Co-Authors: Jan Grimm, Stefan Müller-hülsbeck, Martin Heller
    Abstract:

    RATIONALE AND OBJECTIVES: To determine the efficacy of Thrombectomy (without thrombolytic agents) for the Amplatz Thrombectomy Device (ATD) and the Cragg thrombolytic brush catheter (CBC) in vitro. METHODS: Thrombectomy was performed with the ATD or CBC (6F) in a flow model. Embolus sizes, weight, remaining thrombus, and activation time were evaluated. RESULTS: No significant difference in the activation time was found. The CBC produced significantly less embolism (3.3% vs. 0.03% in the 5-mm and 89% vs. 0.5% in the 7-mm model), but also much more thrombus remained in the system than with the ATD (1% vs. 41% in the 5-mm and 0.1% vs. 62% in the 7-mm model). CONCLUSIONS: The ATD can remove almost all thrombus (99%), whereas the CBC removes only up to 60%, producing fewer emboli than the ATD. This might be due to the lower rotational speed of the CBC compared with the ATD, which is 20 times greater. The soft nylon brush offers less resistance and shear force toward the thrombus than the stainless-steel impeller of the ATD. Because of the large amount of remaining thrombus, the CBC should not be used without lytic agents.

Martin Heller - One of the best experts on this subject based on the ideXlab platform.

  • Influence of thrombus age on the mechanical Thrombectomy efficacy of the amplatz Thrombectomy Device in vitro.
    CardioVascular and Interventional Radiology, 2003
    Co-Authors: Jan Grimm, Thomas Jahnke, Martin Heller, Claus Muhle, Stefan Müller-hülsbeck
    Abstract:

    Purpose: To determine the efficacy of Thrombectomy for the Amplatz Thrombectomy Device (ATD) according to the age of the thrombus. Methods: Thrombectomy was performed with the 7 Fr or 8 Fr ATD. Five-day-old or 8-day-old thrombi were made from porcine blood by clotting within silicone tubes to be used in a flow model. Emboli sizes, weight, remaining thrombus and activation time were evaluated. Results: The age of the thrombus had no influence on the activation time necessary for complete thrombolysis. A significant difference was found in the overall amount of embolization only with the 7 Fr Device although a similar trend was shown with the 8 Fr Device. The amount of embolized thrombotic material was higher for both Devices if older thrombi (i.e., 8 days old) were processed. The overall impression was that the 8 Fr Device showed slightly better results (less remaining thrombus and embolization). Conclusion: A tendency toward higher amounts of embolization was observed if older thrombi were used in the model. Therefore the interventional radiologist should be aware of the potentially higher risk of peripheral embolization when performing mechanical Thrombectomy (with the ATD) in older thrombotic occlusions, especially since the higher rate of embolization was mainly due to an increased proportion of larger embolic particles (1 mm), which are clinically more significant.

  • Influence of Thrombus Age on the Mechanical Thrombectomy Efficacy of the Amplatz Thrombectomy Device In Vitro
    CardioVascular and Interventional Radiology, 2003
    Co-Authors: Jan Grimm, Thomas Jahnke, Martin Heller, Claus Muhle, Stefan Müller-hülsbeck
    Abstract:

    Purpose: To determine the efficacy of Thrombectomy for the Amplatz Thrombectomy Device (ATD) according to the age of the thrombus. Methods: Thrombectomy was performed with the 7 Fr or 8 Fr ATD. Five-day-old or 8-day-old thrombi were made from porcine blood by clotting within silicone tubes to be used in a flow model. Emboli sizes, weight, remaining thrombus and activation time were evaluated. Results: The age of the thrombus had no influence on the activation time necessary for complete thrombolysis. A significant difference was found in the overall amount of embolization only with the 7 Fr Device although a similar trend was shown with the 8 Fr Device. The amount of embolized thrombotic material was higher for both Devices if older thrombi (i.e., 8 days old) were processed. The overall impression was that the 8 Fr Device showed slightly better results (less remaining thrombus and embolization). Conclusion: A tendency toward higher amounts of embolization was observed if older thrombi were used in the model. Therefore the interventional radiologist should be aware of the potentially higher risk of peripheral embolization when performing mechanical Thrombectomy (with the ATD) in older thrombotic occlusions, especially since the higher rate of embolization was mainly due to an increased proportion of larger embolic particles (1 mm), which are clinically more significant.

  • Influence of thrombus age on the mechanical Thrombectomy efficacy of the amplatz Thrombectomy Device in vitro.
    Cardiovascular and interventional radiology, 2003
    Co-Authors: Jan Grimm, Thomas Jahnke, Martin Heller, Claus Muhle, Stefan Müller-hülsbeck
    Abstract:

    Purpose: To determine the efficacy of Thrombectomy for the Amplatz Thrombectomy Device (ATD) according to the age of the thrombus. Methods: Thrombectomy was performed with the 7 Fr or 8 Fr ATD. Five-day-old or 8-day-old thrombi were made from porcine blood by clotting within silicone tubes to be used in a flow model. Emboli sizes, weight, remaining thrombus and activation time were evaluated. Results: The age of the thrombus had no influence on the activation time necessary for complete thrombolysis. A significant difference was found in the overall amount of embolization only with the 7 Fr Device although a similar trend was shown with the 8 Fr Device. The amount of embolized thrombotic material was higher for both Devices if older thrombi (i.e., 8 days old) were processed. The overall impression was that the 8 Fr Device showed slightly better results (less remaining thrombus and embolization). Conclusion: A tendency toward higher amounts of embolization was observed if older thrombi were used in the model. Therefore the interventional radiologist should be aware of the potentially higher risk of peripheral embolization when performing mechanical Thrombectomy (with the ATD) in older thrombotic occlusions, especially since the higher rate of embolization was mainly due to an increased proportion of larger embolic particles (1 mm), which are clinically more significant.

  • Mechanical Thrombectomy of major and massive pulmonary embolism with use of the Amplatz Thrombectomy Device.
    Investigative Radiology, 2001
    Co-Authors: Stefan Müller-hülsbeck, Joachim Brossmann, Burkhardt Bewig, Jan Grimm, Thomas Jahnke, Michael Reuter, Martin Heller
    Abstract:

    Muller-Hulsbeck S, Brossmann J, Jahnke T, et al. Mechanical Thrombectomy of major and massive pulmonary embolism with use of the Amplatz Thrombectomy Device. Invest Radiol 2001;36:317–322.rationale and objectives. To evaluate the feasibility of mechanical Thrombectomy with the Amplatz Thrombectomy d

  • Comparison of the mechanical Thrombectomy efficacy of the Amplatz Thrombectomy Device and the Cragg thrombolytic brush in vitro.
    Investigative Radiology, 2001
    Co-Authors: Jan Grimm, Stefan Müller-hülsbeck, Martin Heller
    Abstract:

    RATIONALE AND OBJECTIVES: To determine the efficacy of Thrombectomy (without thrombolytic agents) for the Amplatz Thrombectomy Device (ATD) and the Cragg thrombolytic brush catheter (CBC) in vitro. METHODS: Thrombectomy was performed with the ATD or CBC (6F) in a flow model. Embolus sizes, weight, remaining thrombus, and activation time were evaluated. RESULTS: No significant difference in the activation time was found. The CBC produced significantly less embolism (3.3% vs. 0.03% in the 5-mm and 89% vs. 0.5% in the 7-mm model), but also much more thrombus remained in the system than with the ATD (1% vs. 41% in the 5-mm and 0.1% vs. 62% in the 7-mm model). CONCLUSIONS: The ATD can remove almost all thrombus (99%), whereas the CBC removes only up to 60%, producing fewer emboli than the ATD. This might be due to the lower rotational speed of the CBC compared with the ATD, which is 20 times greater. The soft nylon brush offers less resistance and shear force toward the thrombus than the stainless-steel impeller of the ATD. Because of the large amount of remaining thrombus, the CBC should not be used without lytic agents.

Jan Grimm - One of the best experts on this subject based on the ideXlab platform.

  • Influence of thrombus age on the mechanical Thrombectomy efficacy of the amplatz Thrombectomy Device in vitro.
    CardioVascular and Interventional Radiology, 2003
    Co-Authors: Jan Grimm, Thomas Jahnke, Martin Heller, Claus Muhle, Stefan Müller-hülsbeck
    Abstract:

    Purpose: To determine the efficacy of Thrombectomy for the Amplatz Thrombectomy Device (ATD) according to the age of the thrombus. Methods: Thrombectomy was performed with the 7 Fr or 8 Fr ATD. Five-day-old or 8-day-old thrombi were made from porcine blood by clotting within silicone tubes to be used in a flow model. Emboli sizes, weight, remaining thrombus and activation time were evaluated. Results: The age of the thrombus had no influence on the activation time necessary for complete thrombolysis. A significant difference was found in the overall amount of embolization only with the 7 Fr Device although a similar trend was shown with the 8 Fr Device. The amount of embolized thrombotic material was higher for both Devices if older thrombi (i.e., 8 days old) were processed. The overall impression was that the 8 Fr Device showed slightly better results (less remaining thrombus and embolization). Conclusion: A tendency toward higher amounts of embolization was observed if older thrombi were used in the model. Therefore the interventional radiologist should be aware of the potentially higher risk of peripheral embolization when performing mechanical Thrombectomy (with the ATD) in older thrombotic occlusions, especially since the higher rate of embolization was mainly due to an increased proportion of larger embolic particles (1 mm), which are clinically more significant.

  • Influence of Thrombus Age on the Mechanical Thrombectomy Efficacy of the Amplatz Thrombectomy Device In Vitro
    CardioVascular and Interventional Radiology, 2003
    Co-Authors: Jan Grimm, Thomas Jahnke, Martin Heller, Claus Muhle, Stefan Müller-hülsbeck
    Abstract:

    Purpose: To determine the efficacy of Thrombectomy for the Amplatz Thrombectomy Device (ATD) according to the age of the thrombus. Methods: Thrombectomy was performed with the 7 Fr or 8 Fr ATD. Five-day-old or 8-day-old thrombi were made from porcine blood by clotting within silicone tubes to be used in a flow model. Emboli sizes, weight, remaining thrombus and activation time were evaluated. Results: The age of the thrombus had no influence on the activation time necessary for complete thrombolysis. A significant difference was found in the overall amount of embolization only with the 7 Fr Device although a similar trend was shown with the 8 Fr Device. The amount of embolized thrombotic material was higher for both Devices if older thrombi (i.e., 8 days old) were processed. The overall impression was that the 8 Fr Device showed slightly better results (less remaining thrombus and embolization). Conclusion: A tendency toward higher amounts of embolization was observed if older thrombi were used in the model. Therefore the interventional radiologist should be aware of the potentially higher risk of peripheral embolization when performing mechanical Thrombectomy (with the ATD) in older thrombotic occlusions, especially since the higher rate of embolization was mainly due to an increased proportion of larger embolic particles (1 mm), which are clinically more significant.

  • Influence of thrombus age on the mechanical Thrombectomy efficacy of the amplatz Thrombectomy Device in vitro.
    Cardiovascular and interventional radiology, 2003
    Co-Authors: Jan Grimm, Thomas Jahnke, Martin Heller, Claus Muhle, Stefan Müller-hülsbeck
    Abstract:

    Purpose: To determine the efficacy of Thrombectomy for the Amplatz Thrombectomy Device (ATD) according to the age of the thrombus. Methods: Thrombectomy was performed with the 7 Fr or 8 Fr ATD. Five-day-old or 8-day-old thrombi were made from porcine blood by clotting within silicone tubes to be used in a flow model. Emboli sizes, weight, remaining thrombus and activation time were evaluated. Results: The age of the thrombus had no influence on the activation time necessary for complete thrombolysis. A significant difference was found in the overall amount of embolization only with the 7 Fr Device although a similar trend was shown with the 8 Fr Device. The amount of embolized thrombotic material was higher for both Devices if older thrombi (i.e., 8 days old) were processed. The overall impression was that the 8 Fr Device showed slightly better results (less remaining thrombus and embolization). Conclusion: A tendency toward higher amounts of embolization was observed if older thrombi were used in the model. Therefore the interventional radiologist should be aware of the potentially higher risk of peripheral embolization when performing mechanical Thrombectomy (with the ATD) in older thrombotic occlusions, especially since the higher rate of embolization was mainly due to an increased proportion of larger embolic particles (1 mm), which are clinically more significant.

  • Mechanical Thrombectomy of major and massive pulmonary embolism with use of the Amplatz Thrombectomy Device.
    Investigative Radiology, 2001
    Co-Authors: Stefan Müller-hülsbeck, Joachim Brossmann, Burkhardt Bewig, Jan Grimm, Thomas Jahnke, Michael Reuter, Martin Heller
    Abstract:

    Muller-Hulsbeck S, Brossmann J, Jahnke T, et al. Mechanical Thrombectomy of major and massive pulmonary embolism with use of the Amplatz Thrombectomy Device. Invest Radiol 2001;36:317–322.rationale and objectives. To evaluate the feasibility of mechanical Thrombectomy with the Amplatz Thrombectomy d

  • Comparison of the mechanical Thrombectomy efficacy of the Amplatz Thrombectomy Device and the Cragg thrombolytic brush in vitro.
    Investigative Radiology, 2001
    Co-Authors: Jan Grimm, Stefan Müller-hülsbeck, Martin Heller
    Abstract:

    RATIONALE AND OBJECTIVES: To determine the efficacy of Thrombectomy (without thrombolytic agents) for the Amplatz Thrombectomy Device (ATD) and the Cragg thrombolytic brush catheter (CBC) in vitro. METHODS: Thrombectomy was performed with the ATD or CBC (6F) in a flow model. Embolus sizes, weight, remaining thrombus, and activation time were evaluated. RESULTS: No significant difference in the activation time was found. The CBC produced significantly less embolism (3.3% vs. 0.03% in the 5-mm and 89% vs. 0.5% in the 7-mm model), but also much more thrombus remained in the system than with the ATD (1% vs. 41% in the 5-mm and 0.1% vs. 62% in the 7-mm model). CONCLUSIONS: The ATD can remove almost all thrombus (99%), whereas the CBC removes only up to 60%, producing fewer emboli than the ATD. This might be due to the lower rotational speed of the CBC compared with the ATD, which is 20 times greater. The soft nylon brush offers less resistance and shear force toward the thrombus than the stainless-steel impeller of the ATD. Because of the large amount of remaining thrombus, the CBC should not be used without lytic agents.

Kurt Amplatz - One of the best experts on this subject based on the ideXlab platform.

  • Injury potential to venous valves from the Amplatz Thrombectomy Device.
    Journal of vascular and interventional radiology : JVIR, 1999
    Co-Authors: Melhem J. Sharafuddin, Myra Urness, Young-min Han, Roland Gunther, Kurt Amplatz
    Abstract:

    Purpose To evaluate the acute effects of the Amplatz Thrombectomy Device (ATD) on peripheral venous valves in a canine model. Materials and Methods ATD Thrombectomy was performed in 17 veins, and control experiments with use of an 8-F sheath-dilator were performed in four veins. PreThrombectomy ascending venography was performed, followed by Device passage across the vein segment. Post-Thrombectomy ascending venography was then performed, followed by heparinization and euthanasia. The treated veins were carefully explanted and stored in formaldehyde for histopathologic examination. Severity of valve injury was graded on a scale of 0 to 4. Results In ATD-treated veins: 10 veins sustained no injury [grade 0] (diameter, 6.7mm±1.7; antegrade/retrograde approach, 5/5), five veins sustained mild injury [grade 1-2] (diameter, 5.2mm±0.8; antegrade/retrograde, 3/2), while the remaining two veins sustained moderate-to-severe injury [grade 3-4] (diameter, 5 and 6 mm; antegrade/retrograde, 1/1). In sheath-dilator treated veins: no injury [grade 0] in any of the four treated veins (mean diameter, 5.5mm±0.6; all retrograde). In ATD-treated veins, valve injury (of any grade) was significantly more frequent in veins 6mm or less in diameter than in veins at least 7 mm in diameter (seven of 12 vs zero of five; P Conclusion Veins 7mm or greater in diameter were associated with no significant valve injury during ATD Thrombectomy. However, long-term and short-term effects on valvular function will need to be assessed.

  • ACUTE AND DELAYED OUTCOMES OF MECHANICAL Thrombectomy WITH USE OF THE STEERABLE AMPLATZ Thrombectomy Device IN A MODEL OF SUBACUTE INFERIOR VENA CAVA THROMBOSIS
    Journal of Vascular and Interventional Radiology, 1997
    Co-Authors: Xiaoping Gu, Myra Urness, Jose J. Cervera-ceballos, Gregory D. Ruth, Melhem J. Sharafuddin, Jack L. Titus, Kurt Amplatz
    Abstract:

    Purpose To study the efficacy and delayed outcome of mechanical Thrombectomy with the Amplatz Thrombectomy Device (ATD) in an experimental model of subacute inferior vena cava (IVC) thrombosis. Materials and Methods Mechanical Thrombectomy was performed in 23 dogs with subacute infrarenal IVC thrombosis (6–15 days old). Heparin was administered during Thrombectomy in all procedures (activated clotting time > 300 sec). Thirteen animals were killed immediately after Thrombectomy, and the remaining 10 were allowed to survive for up to 1 month with no anticoagulation therapy. Results Venographic patency of the IVC was restored in all animals, although residual mural thrombus remained in nine dogs ( μ m) in four. Conclusion Mechanical Thrombectomy with use of the ATD can effectively clear subacute IVC thrombus. However, rethrombosis is common and may be due to the high prevalence of phlebitis and residual thrombus. Anticoagulation may need to be continued after successful Thrombectomy to prevent progression of residual thrombus and allow mural phlebitic changes to subside.

  • Hemolytic Effect of the Amplatz Thrombectomy Device
    Journal of vascular and interventional radiology : JVIR, 1994
    Co-Authors: Gwen K. Nazarian, Carol C. Coleman, Zhong Qian, Gail J. Rengel, Wilfrido R. Castaneda-zuniga, David W. Hunter, Kurt Amplatz
    Abstract:

    Purpose The hemolytic effect of the Amplatz Thrombectomy Device (ATD) was evaluated in nine dogs and in nine patients. Materials and Methods The Device was activated for 1–2 minutes in the abdominal aorta, inferior vena cava, or femoral artery of nine dogs. The Device was activated for 1–4 minutes in the nine patients in occluded lower extremity bypass grafts ( n = 5), native superficial femoral artery ( n = 1), a pulmonary artery embolus ( n = 1), a portocaval shunt ( n = 1), and an iliac vein stent ( n = 1). Patients were examined for laboratory evidence of hemolysis following mechanical Thrombectomy. Results In all dogs haptoglobin level decreased, free hemoglobin level in the plasma increased, and hemoglobinuria was present. There was no change in renal function. The level of haptoglobin decreased and the level of plasma free hemoglobin increased in eight patients, with hemoglobinuria detected in one. More hemolysis was observed in the animals than in the patients. Conclusion The ATD has a definite transient hemolytic effect. Until further studied, it should not be used in children and should be used with caution in patients who are anemic, hypoxemic, or have potentially reversible renal insufficiency. Activation time should be monitored closely because hemolysis probably increases with increasing activation time.

  • Mechanical Thrombectomy: results of early experience.
    Radiology, 1993
    Co-Authors: Carol C. Coleman, Charles Krenzel, Charles A. Dietz, Gwen K. Nazarian, Kurt Amplatz
    Abstract:

    PURPOSE: To evaluate the clinical application of a mechanical Thrombectomy Device in occluded lower extremity arteries and bypass grafts. MATERIALS AND METHODS: A mechanical Thrombectomy Device was used in five patients with acutely occluded lower extremity bypass grafts (n = 2) or superficial femoral arteries (n = 3). RESULTS: The thrombus was completely removed in three cases (two bypass grafts and one native superficial femoral artery). In two of the patients with occlusions in the native superficial femoral artery, the thrombus was partially removed. In these two patients, the aspirate demonstrated a more fibrous thrombus that was not easily fragmented. In one of these two patients, the coagulum was thought to be embolic from the heart. CONCLUSION: The Thrombectomy Device works well in recent thromboses, particularly in polytetrafluoroethylene grafts in which organization does not occur. Its efficacy in chronically occluded vessels is not certain.

Choon Sik Yoon - One of the best experts on this subject based on the ideXlab platform.

  • Mechanical Thrombectomy of Acute Iliofemoral Deep Vein Thrombosis with Use of an Arrow-Trerotola Percutaneous Thrombectomy Device
    Journal of Vascular and Interventional Radiology, 2006
    Co-Authors: Choon Sik Yoon
    Abstract:

    PURPOSE To evaluate the immediate and 1-year clinical outcomes of mechanical Thrombectomy with use of the Arrow-Trerotola percutaneous Thrombectomy Device (PTD) with or without low-dose urokinase in the treatment of acute iliofemoral deep vein thrombosis (DVT) MATERIALS AND METHODS Mechanical Thrombectomy with the PTD was performed in 25 patients with acute iliofemoral DVT. Thrombolytic therapy with low-dose urokinase was used in all patients without contraindications ( n = 20). Other therapies used in combination included inferior vena cava filter insertion ( n = 5), sheath aspiration Thrombectomy ( n = 25), and angioplasty and stent placement ( n = 20) RESULTS Initial technical and clinical success was achieved in all cases. In the 20 patients who had no contraindications to the use of urokinase, the dosage of urokinase did not exceed 1 million IU (range, 360,000–1,000,000 IU; mean, 640,000 IU). The mean time of urokinase infusion was 16 hours (range, 12–20). In five patients who had a contraindication to the use of urokinase, mechanical Thrombectomy with the PTD was successful without the use of urokinase. There were no major complications. Primary patency of the stent-implanted common iliac vein segment was achieved at 1 year in 17 of 20 patients (85%). The overall 1-year clinical success rate was 92% (23 of 25 patients). Valvular insufficiency occurred in two patients (8%) CONCLUSION The PTD is an effective mechanical Thrombectomy Device in the treatment of acute iliofemoral DVT with or without adjunctive urokinase thrombolysis

  • Mechanical Thrombectomy of Acute Iliofemoral Deep Vein Thrombosis with Use of an Arrow-Trerotola Percutaneous Thrombectomy Device
    Journal of Vascular and Interventional Radiology, 2006
    Co-Authors: Choon Sik Yoon
    Abstract:

    PURPOSE To evaluate the immediate and 1-year clinical outcomes of mechanical Thrombectomy with use of the Arrow-Trerotola percutaneous Thrombectomy Device (PTD) with or without low-dose urokinase in the treatment of acute iliofemoral deep vein thrombosis (DVT) MATERIALS AND METHODS Mechanical Thrombectomy with the PTD was performed in 25 patients with acute iliofemoral DVT. Thrombolytic therapy with low-dose urokinase was used in all patients without contraindications ( n = 20). Other therapies used in combination included inferior vena cava filter insertion ( n = 5), sheath aspiration Thrombectomy ( n = 25), and angioplasty and stent placement ( n = 20) RESULTS Initial technical and clinical success was achieved in all cases. In the 20 patients who had no contraindications to the use of urokinase, the dosage of urokinase did not exceed 1 million IU (range, 360,000–1,000,000 IU; mean, 640,000 IU). The mean time of urokinase infusion was 16 hours (range, 12–20). In five patients who had a contraindication to the use of urokinase, mechanical Thrombectomy with the PTD was successful without the use of urokinase. There were no major complications. Primary patency of the stent-implanted common iliac vein segment was achieved at 1 year in 17 of 20 patients (85%). The overall 1-year clinical success rate was 92% (23 of 25 patients). Valvular insufficiency occurred in two patients (8%) CONCLUSION The PTD is an effective mechanical Thrombectomy Device in the treatment of acute iliofemoral DVT with or without adjunctive urokinase thrombolysis