The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Gustav Hör - One of the best experts on this subject based on the ideXlab platform.
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Diagnosis of thrombosis with a murine anti-Thrombocyte Antibody (99mTc-BW 4): initial clinical results
Nuklearmedizin. Nuclear medicine, 1993Co-Authors: A Hertel, Richard P. Baum, T. Baew-christow, Gustav HörAbstract:The high incidence of deep venous thrombosis requires for successful therapy a timely and accurate diagnosis. We report early clinical results with a 99mTc-labelled anti-platelet Antibody (BW 4) for the diagnosis of thrombosis or for studying platelet kinetics. 10 patients were studied of whom 7 were imaged for the detection of thrombi. 3 deep venous thromboses were diagnosed. 3 patients were sent for diagnosing pathological platelet kinetics; 2 demonstrated a markedly changed platelet biodistribution (increased spleen uptake compared to thrombosis patients). The simple and safe handling of the labelling kit enables early studies (within 30 min). The short physical half-life of 99mTc allows a favourable target (thrombus) to non-target (blood-pool) ratio for diagnosis within 2-6 h after injection. Human anti-mouse antibodies were not found in the serum of 4 patients (blood drawn until 4 weeks after administration). There were no side effects.
A Hertel - One of the best experts on this subject based on the ideXlab platform.
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Diagnosis of thrombosis with a murine anti-Thrombocyte Antibody (99mTc-BW 4): initial clinical results
Nuklearmedizin. Nuclear medicine, 1993Co-Authors: A Hertel, Richard P. Baum, T. Baew-christow, Gustav HörAbstract:The high incidence of deep venous thrombosis requires for successful therapy a timely and accurate diagnosis. We report early clinical results with a 99mTc-labelled anti-platelet Antibody (BW 4) for the diagnosis of thrombosis or for studying platelet kinetics. 10 patients were studied of whom 7 were imaged for the detection of thrombi. 3 deep venous thromboses were diagnosed. 3 patients were sent for diagnosing pathological platelet kinetics; 2 demonstrated a markedly changed platelet biodistribution (increased spleen uptake compared to thrombosis patients). The simple and safe handling of the labelling kit enables early studies (within 30 min). The short physical half-life of 99mTc allows a favourable target (thrombus) to non-target (blood-pool) ratio for diagnosis within 2-6 h after injection. Human anti-mouse antibodies were not found in the serum of 4 patients (blood drawn until 4 weeks after administration). There were no side effects.
Richard P. Baum - One of the best experts on this subject based on the ideXlab platform.
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Diagnosis of thrombosis with a murine anti-Thrombocyte Antibody (99mTc-BW 4): initial clinical results
Nuklearmedizin. Nuclear medicine, 1993Co-Authors: A Hertel, Richard P. Baum, T. Baew-christow, Gustav HörAbstract:The high incidence of deep venous thrombosis requires for successful therapy a timely and accurate diagnosis. We report early clinical results with a 99mTc-labelled anti-platelet Antibody (BW 4) for the diagnosis of thrombosis or for studying platelet kinetics. 10 patients were studied of whom 7 were imaged for the detection of thrombi. 3 deep venous thromboses were diagnosed. 3 patients were sent for diagnosing pathological platelet kinetics; 2 demonstrated a markedly changed platelet biodistribution (increased spleen uptake compared to thrombosis patients). The simple and safe handling of the labelling kit enables early studies (within 30 min). The short physical half-life of 99mTc allows a favourable target (thrombus) to non-target (blood-pool) ratio for diagnosis within 2-6 h after injection. Human anti-mouse antibodies were not found in the serum of 4 patients (blood drawn until 4 weeks after administration). There were no side effects.
T. Baew-christow - One of the best experts on this subject based on the ideXlab platform.
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Diagnosis of thrombosis with a murine anti-Thrombocyte Antibody (99mTc-BW 4): initial clinical results
Nuklearmedizin. Nuclear medicine, 1993Co-Authors: A Hertel, Richard P. Baum, T. Baew-christow, Gustav HörAbstract:The high incidence of deep venous thrombosis requires for successful therapy a timely and accurate diagnosis. We report early clinical results with a 99mTc-labelled anti-platelet Antibody (BW 4) for the diagnosis of thrombosis or for studying platelet kinetics. 10 patients were studied of whom 7 were imaged for the detection of thrombi. 3 deep venous thromboses were diagnosed. 3 patients were sent for diagnosing pathological platelet kinetics; 2 demonstrated a markedly changed platelet biodistribution (increased spleen uptake compared to thrombosis patients). The simple and safe handling of the labelling kit enables early studies (within 30 min). The short physical half-life of 99mTc allows a favourable target (thrombus) to non-target (blood-pool) ratio for diagnosis within 2-6 h after injection. Human anti-mouse antibodies were not found in the serum of 4 patients (blood drawn until 4 weeks after administration). There were no side effects.
Setsuko Yoshioka - One of the best experts on this subject based on the ideXlab platform.
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A case of liposarcoma of the abdominal wall complicated by thrombocytpenia as a paraneoplastic syndrome
Gan to kagaku ryoho. Cancer & chemotherapy, 2012Co-Authors: Yasuhiro Toyoda, Wakio Endo, Fumiyoshi Kojima, Hiroki Matsunaga, Kaori Shimizu, Akiko Yoshioka, Yujiro Fujie, Hiroki Fukunaga, Shigeyuki Hojo, Setsuko YoshiokaAbstract:A 59-year-old woman was admitted to our hospital because of right chest pain. CT scan showed a mass on the right abdominal wall and bilateral pleural effusion. The histological diagnosis following core needle biopsy was undifferentiated sarcoma. The right pleural effusion gradually increased despite negative cytology. Although we planned chemotherapy for the clinically diagnosed pleural invasion, thrombocytopenia as a paraneoplastic syndrome appeared. The minimum Thrombocyte count was 4,000/mm3. While transfusion was not effective, per os dexamethasone at 2.0 mg/day kept the Thrombocyte count at around 6×10 4/mm3. Anti-Thrombocyte Antibody was negative. Tumor resection surgery with partial diaphragm resection and 11th and 12th rib resection, and abdominal wall plasty with mesh was performed. The final histological diagnosis was dedifferentiated liposarcoma. The Thrombocyte count returned to the normal range just after the operation. However, she died of pleural dissemination, peritoneal dissemination, and local recurrence 69 days after the operation.