The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform

B A Kudriashov - One of the best experts on this subject based on the ideXlab platform.

  • the antiheparin Thrombocyte Factor 4 and its interaction with heparin
    Izvestiia Akademii nauk SSSR. Seriia biologicheskaia, 1990
    Co-Authors: L A Liapina, V E Pastorova, B A Kudriashov
    Abstract:

    : A rat platelet Factor has a high antiheparin activity. It also decreases nonenzymatic fibrinolytic activity of normal rat plasma and antithrombin III-heparin complex. The platelet Factor 4 formed inactive complexes with heparin in molar ratios of 1:1 and 2:1. Intravenous injection of the platelet Factor 4 before injection of albino rats with tissue thromboplastin prevented the reaction of anticoagulation system inactivated the synthesis of endogenous thrombin. This effect is accompanied by high hypercoagulation and depression of nonenzymatic fibrinolysis in blood.

L A Liapina - One of the best experts on this subject based on the ideXlab platform.

  • the antiheparin Thrombocyte Factor 4 and its interaction with heparin
    Izvestiia Akademii nauk SSSR. Seriia biologicheskaia, 1990
    Co-Authors: L A Liapina, V E Pastorova, B A Kudriashov
    Abstract:

    : A rat platelet Factor has a high antiheparin activity. It also decreases nonenzymatic fibrinolytic activity of normal rat plasma and antithrombin III-heparin complex. The platelet Factor 4 formed inactive complexes with heparin in molar ratios of 1:1 and 2:1. Intravenous injection of the platelet Factor 4 before injection of albino rats with tissue thromboplastin prevented the reaction of anticoagulation system inactivated the synthesis of endogenous thrombin. This effect is accompanied by high hypercoagulation and depression of nonenzymatic fibrinolysis in blood.

V E Pastorova - One of the best experts on this subject based on the ideXlab platform.

  • the antiheparin Thrombocyte Factor 4 and its interaction with heparin
    Izvestiia Akademii nauk SSSR. Seriia biologicheskaia, 1990
    Co-Authors: L A Liapina, V E Pastorova, B A Kudriashov
    Abstract:

    : A rat platelet Factor has a high antiheparin activity. It also decreases nonenzymatic fibrinolytic activity of normal rat plasma and antithrombin III-heparin complex. The platelet Factor 4 formed inactive complexes with heparin in molar ratios of 1:1 and 2:1. Intravenous injection of the platelet Factor 4 before injection of albino rats with tissue thromboplastin prevented the reaction of anticoagulation system inactivated the synthesis of endogenous thrombin. This effect is accompanied by high hypercoagulation and depression of nonenzymatic fibrinolysis in blood.

Gandel' Vg - One of the best experts on this subject based on the ideXlab platform.

  • The effect of the new Russian concentrate of n-3 polyunsaturated fatty acids epaden on Thrombocyte functional activity in vitro
    Eksperimental'naia i klinicheskaia farmakologiia, 2020
    Co-Authors: Kalugin Sa, Petrukhina Gn, Makarov Va, Gandel' Vg
    Abstract:

    : Epaden, the new domestic concentrate of n-3 polyunsaturated fatty acids (PUFA), is capable of inhibiting in vitro the human Thrombocyte aggregation induced by ADP, collagen, and thrombin. It was established that the effect can hardly be related to the action of cyclooxygenase metabolites of eicosapentadienoic acid (entering into the epaden composition). The activity of epaden is probably explained by the effect of lipoxygenase metabolites of the n-3 polyunsaturated fatty acids or by the ligand properties of polyene acids entering into epaden. In addition, epaden is capable of reducing the release of Thrombocyte Factor 4 and tissue type plasminogen activator inhibitor from activated Thrombocytes.

Kalugin Sa - One of the best experts on this subject based on the ideXlab platform.

  • The effect of the new Russian concentrate of n-3 polyunsaturated fatty acids epaden on Thrombocyte functional activity in vitro
    Eksperimental'naia i klinicheskaia farmakologiia, 2020
    Co-Authors: Kalugin Sa, Petrukhina Gn, Makarov Va, Gandel' Vg
    Abstract:

    : Epaden, the new domestic concentrate of n-3 polyunsaturated fatty acids (PUFA), is capable of inhibiting in vitro the human Thrombocyte aggregation induced by ADP, collagen, and thrombin. It was established that the effect can hardly be related to the action of cyclooxygenase metabolites of eicosapentadienoic acid (entering into the epaden composition). The activity of epaden is probably explained by the effect of lipoxygenase metabolites of the n-3 polyunsaturated fatty acids or by the ligand properties of polyene acids entering into epaden. In addition, epaden is capable of reducing the release of Thrombocyte Factor 4 and tissue type plasminogen activator inhibitor from activated Thrombocytes.