The Experts below are selected from a list of 75 Experts worldwide ranked by ideXlab platform

Mehmet Faruk Oktay - One of the best experts on this subject based on the ideXlab platform.

  • Investigation of the effects of Thrombocyte-Rich Plasma, systemic ozone and hyperbaric oxygen treatment on intraoral wound healing in rats: experimental study
    European Archives of Oto-Rhino-Laryngology, 2020
    Co-Authors: Kemal Uslu, Hasan Deniz Tansuker, Alper Tabaru, Selim Engin Egeren, Kemal Kutay Kulahci, Pınar Bulut, Funda Emre, Mehmet Faruk Oktay
    Abstract:

    Objective In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-Rich Plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats. Materials and methods In this study, thirty-six Wistar Hannover rats with weight of 250–350 g, fed with standard feeds, were anesthetized to create intraoral wound on the hard palate. Rats were divided into four groups as the following: control group, PRP, HBO and Ozone groups. 0.1 ml of PRP was injected on the wound edges of each rat in the PRP group on days 1, 3 and 7. Each rat in the ozone group was systemically injected with 2.3–3.0 ml ozone gas on the 1st, 3rd and 7th days. The wounds of the rats in the control group were not performed anything. The rats in the HBO group were placed in the HBO pressure chamber and were treated with one session (2 h for each session) of 100% oxygen each day for 7 days. Rats in all groups were killed on the 15th day and the hard palates were excised for histopathological examination. Inflammation severity, neovascularization, fibroblast proliferation, collagen density and epithelization were evaluated. Results The rate of intense wound closure (epithelialization intensity) was significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group ( p  

  • Investigation of the effects of Thrombocyte-Rich Plasma, systemic ozone and hyperbaric oxygen treatment on intraoral wound healing in rats: experimental study.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated wi, 2020
    Co-Authors: Kemal Uslu, Hasan Deniz Tansuker, Alper Tabaru, Selim Engin Egeren, Kemal Kutay Kulahci, Pınar Bulut, Funda Emre, Mehmet Faruk Oktay
    Abstract:

    In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-Rich Plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats. In this study, thirty-six Wistar Hannover rats with weight of 250–350 g, fed with standard feeds, were anesthetized to create intraoral wound on the hard palate. Rats were divided into four groups as the following: control group, PRP, HBO and Ozone groups. 0.1 ml of PRP was injected on the wound edges of each rat in the PRP group on days 1, 3 and 7. Each rat in the ozone group was systemically injected with 2.3–3.0 ml ozone gas on the 1st, 3rd and 7th days. The wounds of the rats in the control group were not performed anything. The rats in the HBO group were placed in the HBO pressure chamber and were treated with one session (2 h for each session) of 100% oxygen each day for 7 days. Rats in all groups were killed on the 15th day and the hard palates were excised for histopathological examination. Inflammation severity, neovascularization, fibroblast proliferation, collagen density and epithelization were evaluated. The rate of intense wound closure (epithelialization intensity) was significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group (p 

  • investigation of the effects of Thrombocyte Rich Plasma systemic ozone and hyperbaric oxygen treatment on intraoral wound healing in rats experimental study
    European Archives of Oto-rhino-laryngology, 2020
    Co-Authors: Kemal Uslu, Hasan Deniz Tansuker, Alper Tabaru, Selim Engin Egeren, Kemal Kutay Kulahci, Pınar Bulut, Funda Emre, Mehmet Faruk Oktay
    Abstract:

    In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-Rich Plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats. In this study, thirty-six Wistar Hannover rats with weight of 250–350 g, fed with standard feeds, were anesthetized to create intraoral wound on the hard palate. Rats were divided into four groups as the following: control group, PRP, HBO and Ozone groups. 0.1 ml of PRP was injected on the wound edges of each rat in the PRP group on days 1, 3 and 7. Each rat in the ozone group was systemically injected with 2.3–3.0 ml ozone gas on the 1st, 3rd and 7th days. The wounds of the rats in the control group were not performed anything. The rats in the HBO group were placed in the HBO pressure chamber and were treated with one session (2 h for each session) of 100% oxygen each day for 7 days. Rats in all groups were killed on the 15th day and the hard palates were excised for histopathological examination. Inflammation severity, neovascularization, fibroblast proliferation, collagen density and epithelization were evaluated. The rate of intense wound closure (epithelialization intensity) was significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group (p < 0.05). Fibroblast proliferation level was higher in PRP group (p < 0.05), followed by ozone, HBO and control groups, respectively. Histologically, inflammation was significantly higher in the control group than the treatment groups (p < 0.05). For the treatment groups; it was lowest in the PRP group, followed by the ozone and HBO groups, respectively. The rates of angiogenesis and collagenization were significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group (p < 0.05). In this study, no significance difference was found between the groups in terms of blood glucose levels (p = 0.21). In this study, all three treatment modalities were found to be effective in wound healing, and PRP was found to be more effective than the others.

Kemal Uslu - One of the best experts on this subject based on the ideXlab platform.

  • Investigation of the effects of Thrombocyte-Rich Plasma, systemic ozone and hyperbaric oxygen treatment on intraoral wound healing in rats: experimental study
    European Archives of Oto-Rhino-Laryngology, 2020
    Co-Authors: Kemal Uslu, Hasan Deniz Tansuker, Alper Tabaru, Selim Engin Egeren, Kemal Kutay Kulahci, Pınar Bulut, Funda Emre, Mehmet Faruk Oktay
    Abstract:

    Objective In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-Rich Plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats. Materials and methods In this study, thirty-six Wistar Hannover rats with weight of 250–350 g, fed with standard feeds, were anesthetized to create intraoral wound on the hard palate. Rats were divided into four groups as the following: control group, PRP, HBO and Ozone groups. 0.1 ml of PRP was injected on the wound edges of each rat in the PRP group on days 1, 3 and 7. Each rat in the ozone group was systemically injected with 2.3–3.0 ml ozone gas on the 1st, 3rd and 7th days. The wounds of the rats in the control group were not performed anything. The rats in the HBO group were placed in the HBO pressure chamber and were treated with one session (2 h for each session) of 100% oxygen each day for 7 days. Rats in all groups were killed on the 15th day and the hard palates were excised for histopathological examination. Inflammation severity, neovascularization, fibroblast proliferation, collagen density and epithelization were evaluated. Results The rate of intense wound closure (epithelialization intensity) was significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group ( p  

  • Investigation of the effects of Thrombocyte-Rich Plasma, systemic ozone and hyperbaric oxygen treatment on intraoral wound healing in rats: experimental study.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated wi, 2020
    Co-Authors: Kemal Uslu, Hasan Deniz Tansuker, Alper Tabaru, Selim Engin Egeren, Kemal Kutay Kulahci, Pınar Bulut, Funda Emre, Mehmet Faruk Oktay
    Abstract:

    In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-Rich Plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats. In this study, thirty-six Wistar Hannover rats with weight of 250–350 g, fed with standard feeds, were anesthetized to create intraoral wound on the hard palate. Rats were divided into four groups as the following: control group, PRP, HBO and Ozone groups. 0.1 ml of PRP was injected on the wound edges of each rat in the PRP group on days 1, 3 and 7. Each rat in the ozone group was systemically injected with 2.3–3.0 ml ozone gas on the 1st, 3rd and 7th days. The wounds of the rats in the control group were not performed anything. The rats in the HBO group were placed in the HBO pressure chamber and were treated with one session (2 h for each session) of 100% oxygen each day for 7 days. Rats in all groups were killed on the 15th day and the hard palates were excised for histopathological examination. Inflammation severity, neovascularization, fibroblast proliferation, collagen density and epithelization were evaluated. The rate of intense wound closure (epithelialization intensity) was significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group (p 

  • investigation of the effects of Thrombocyte Rich Plasma systemic ozone and hyperbaric oxygen treatment on intraoral wound healing in rats experimental study
    European Archives of Oto-rhino-laryngology, 2020
    Co-Authors: Kemal Uslu, Hasan Deniz Tansuker, Alper Tabaru, Selim Engin Egeren, Kemal Kutay Kulahci, Pınar Bulut, Funda Emre, Mehmet Faruk Oktay
    Abstract:

    In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-Rich Plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats. In this study, thirty-six Wistar Hannover rats with weight of 250–350 g, fed with standard feeds, were anesthetized to create intraoral wound on the hard palate. Rats were divided into four groups as the following: control group, PRP, HBO and Ozone groups. 0.1 ml of PRP was injected on the wound edges of each rat in the PRP group on days 1, 3 and 7. Each rat in the ozone group was systemically injected with 2.3–3.0 ml ozone gas on the 1st, 3rd and 7th days. The wounds of the rats in the control group were not performed anything. The rats in the HBO group were placed in the HBO pressure chamber and were treated with one session (2 h for each session) of 100% oxygen each day for 7 days. Rats in all groups were killed on the 15th day and the hard palates were excised for histopathological examination. Inflammation severity, neovascularization, fibroblast proliferation, collagen density and epithelization were evaluated. The rate of intense wound closure (epithelialization intensity) was significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group (p < 0.05). Fibroblast proliferation level was higher in PRP group (p < 0.05), followed by ozone, HBO and control groups, respectively. Histologically, inflammation was significantly higher in the control group than the treatment groups (p < 0.05). For the treatment groups; it was lowest in the PRP group, followed by the ozone and HBO groups, respectively. The rates of angiogenesis and collagenization were significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group (p < 0.05). In this study, no significance difference was found between the groups in terms of blood glucose levels (p = 0.21). In this study, all three treatment modalities were found to be effective in wound healing, and PRP was found to be more effective than the others.

Selim Engin Egeren - One of the best experts on this subject based on the ideXlab platform.

  • Investigation of the effects of Thrombocyte-Rich Plasma, systemic ozone and hyperbaric oxygen treatment on intraoral wound healing in rats: experimental study
    European Archives of Oto-Rhino-Laryngology, 2020
    Co-Authors: Kemal Uslu, Hasan Deniz Tansuker, Alper Tabaru, Selim Engin Egeren, Kemal Kutay Kulahci, Pınar Bulut, Funda Emre, Mehmet Faruk Oktay
    Abstract:

    Objective In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-Rich Plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats. Materials and methods In this study, thirty-six Wistar Hannover rats with weight of 250–350 g, fed with standard feeds, were anesthetized to create intraoral wound on the hard palate. Rats were divided into four groups as the following: control group, PRP, HBO and Ozone groups. 0.1 ml of PRP was injected on the wound edges of each rat in the PRP group on days 1, 3 and 7. Each rat in the ozone group was systemically injected with 2.3–3.0 ml ozone gas on the 1st, 3rd and 7th days. The wounds of the rats in the control group were not performed anything. The rats in the HBO group were placed in the HBO pressure chamber and were treated with one session (2 h for each session) of 100% oxygen each day for 7 days. Rats in all groups were killed on the 15th day and the hard palates were excised for histopathological examination. Inflammation severity, neovascularization, fibroblast proliferation, collagen density and epithelization were evaluated. Results The rate of intense wound closure (epithelialization intensity) was significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group ( p  

  • Investigation of the effects of Thrombocyte-Rich Plasma, systemic ozone and hyperbaric oxygen treatment on intraoral wound healing in rats: experimental study.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated wi, 2020
    Co-Authors: Kemal Uslu, Hasan Deniz Tansuker, Alper Tabaru, Selim Engin Egeren, Kemal Kutay Kulahci, Pınar Bulut, Funda Emre, Mehmet Faruk Oktay
    Abstract:

    In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-Rich Plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats. In this study, thirty-six Wistar Hannover rats with weight of 250–350 g, fed with standard feeds, were anesthetized to create intraoral wound on the hard palate. Rats were divided into four groups as the following: control group, PRP, HBO and Ozone groups. 0.1 ml of PRP was injected on the wound edges of each rat in the PRP group on days 1, 3 and 7. Each rat in the ozone group was systemically injected with 2.3–3.0 ml ozone gas on the 1st, 3rd and 7th days. The wounds of the rats in the control group were not performed anything. The rats in the HBO group were placed in the HBO pressure chamber and were treated with one session (2 h for each session) of 100% oxygen each day for 7 days. Rats in all groups were killed on the 15th day and the hard palates were excised for histopathological examination. Inflammation severity, neovascularization, fibroblast proliferation, collagen density and epithelization were evaluated. The rate of intense wound closure (epithelialization intensity) was significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group (p 

  • investigation of the effects of Thrombocyte Rich Plasma systemic ozone and hyperbaric oxygen treatment on intraoral wound healing in rats experimental study
    European Archives of Oto-rhino-laryngology, 2020
    Co-Authors: Kemal Uslu, Hasan Deniz Tansuker, Alper Tabaru, Selim Engin Egeren, Kemal Kutay Kulahci, Pınar Bulut, Funda Emre, Mehmet Faruk Oktay
    Abstract:

    In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-Rich Plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats. In this study, thirty-six Wistar Hannover rats with weight of 250–350 g, fed with standard feeds, were anesthetized to create intraoral wound on the hard palate. Rats were divided into four groups as the following: control group, PRP, HBO and Ozone groups. 0.1 ml of PRP was injected on the wound edges of each rat in the PRP group on days 1, 3 and 7. Each rat in the ozone group was systemically injected with 2.3–3.0 ml ozone gas on the 1st, 3rd and 7th days. The wounds of the rats in the control group were not performed anything. The rats in the HBO group were placed in the HBO pressure chamber and were treated with one session (2 h for each session) of 100% oxygen each day for 7 days. Rats in all groups were killed on the 15th day and the hard palates were excised for histopathological examination. Inflammation severity, neovascularization, fibroblast proliferation, collagen density and epithelization were evaluated. The rate of intense wound closure (epithelialization intensity) was significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group (p < 0.05). Fibroblast proliferation level was higher in PRP group (p < 0.05), followed by ozone, HBO and control groups, respectively. Histologically, inflammation was significantly higher in the control group than the treatment groups (p < 0.05). For the treatment groups; it was lowest in the PRP group, followed by the ozone and HBO groups, respectively. The rates of angiogenesis and collagenization were significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group (p < 0.05). In this study, no significance difference was found between the groups in terms of blood glucose levels (p = 0.21). In this study, all three treatment modalities were found to be effective in wound healing, and PRP was found to be more effective than the others.

Funda Emre - One of the best experts on this subject based on the ideXlab platform.

  • Investigation of the effects of Thrombocyte-Rich Plasma, systemic ozone and hyperbaric oxygen treatment on intraoral wound healing in rats: experimental study
    European Archives of Oto-Rhino-Laryngology, 2020
    Co-Authors: Kemal Uslu, Hasan Deniz Tansuker, Alper Tabaru, Selim Engin Egeren, Kemal Kutay Kulahci, Pınar Bulut, Funda Emre, Mehmet Faruk Oktay
    Abstract:

    Objective In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-Rich Plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats. Materials and methods In this study, thirty-six Wistar Hannover rats with weight of 250–350 g, fed with standard feeds, were anesthetized to create intraoral wound on the hard palate. Rats were divided into four groups as the following: control group, PRP, HBO and Ozone groups. 0.1 ml of PRP was injected on the wound edges of each rat in the PRP group on days 1, 3 and 7. Each rat in the ozone group was systemically injected with 2.3–3.0 ml ozone gas on the 1st, 3rd and 7th days. The wounds of the rats in the control group were not performed anything. The rats in the HBO group were placed in the HBO pressure chamber and were treated with one session (2 h for each session) of 100% oxygen each day for 7 days. Rats in all groups were killed on the 15th day and the hard palates were excised for histopathological examination. Inflammation severity, neovascularization, fibroblast proliferation, collagen density and epithelization were evaluated. Results The rate of intense wound closure (epithelialization intensity) was significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group ( p  

  • Investigation of the effects of Thrombocyte-Rich Plasma, systemic ozone and hyperbaric oxygen treatment on intraoral wound healing in rats: experimental study.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated wi, 2020
    Co-Authors: Kemal Uslu, Hasan Deniz Tansuker, Alper Tabaru, Selim Engin Egeren, Kemal Kutay Kulahci, Pınar Bulut, Funda Emre, Mehmet Faruk Oktay
    Abstract:

    In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-Rich Plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats. In this study, thirty-six Wistar Hannover rats with weight of 250–350 g, fed with standard feeds, were anesthetized to create intraoral wound on the hard palate. Rats were divided into four groups as the following: control group, PRP, HBO and Ozone groups. 0.1 ml of PRP was injected on the wound edges of each rat in the PRP group on days 1, 3 and 7. Each rat in the ozone group was systemically injected with 2.3–3.0 ml ozone gas on the 1st, 3rd and 7th days. The wounds of the rats in the control group were not performed anything. The rats in the HBO group were placed in the HBO pressure chamber and were treated with one session (2 h for each session) of 100% oxygen each day for 7 days. Rats in all groups were killed on the 15th day and the hard palates were excised for histopathological examination. Inflammation severity, neovascularization, fibroblast proliferation, collagen density and epithelization were evaluated. The rate of intense wound closure (epithelialization intensity) was significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group (p 

  • investigation of the effects of Thrombocyte Rich Plasma systemic ozone and hyperbaric oxygen treatment on intraoral wound healing in rats experimental study
    European Archives of Oto-rhino-laryngology, 2020
    Co-Authors: Kemal Uslu, Hasan Deniz Tansuker, Alper Tabaru, Selim Engin Egeren, Kemal Kutay Kulahci, Pınar Bulut, Funda Emre, Mehmet Faruk Oktay
    Abstract:

    In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-Rich Plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats. In this study, thirty-six Wistar Hannover rats with weight of 250–350 g, fed with standard feeds, were anesthetized to create intraoral wound on the hard palate. Rats were divided into four groups as the following: control group, PRP, HBO and Ozone groups. 0.1 ml of PRP was injected on the wound edges of each rat in the PRP group on days 1, 3 and 7. Each rat in the ozone group was systemically injected with 2.3–3.0 ml ozone gas on the 1st, 3rd and 7th days. The wounds of the rats in the control group were not performed anything. The rats in the HBO group were placed in the HBO pressure chamber and were treated with one session (2 h for each session) of 100% oxygen each day for 7 days. Rats in all groups were killed on the 15th day and the hard palates were excised for histopathological examination. Inflammation severity, neovascularization, fibroblast proliferation, collagen density and epithelization were evaluated. The rate of intense wound closure (epithelialization intensity) was significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group (p < 0.05). Fibroblast proliferation level was higher in PRP group (p < 0.05), followed by ozone, HBO and control groups, respectively. Histologically, inflammation was significantly higher in the control group than the treatment groups (p < 0.05). For the treatment groups; it was lowest in the PRP group, followed by the ozone and HBO groups, respectively. The rates of angiogenesis and collagenization were significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group (p < 0.05). In this study, no significance difference was found between the groups in terms of blood glucose levels (p = 0.21). In this study, all three treatment modalities were found to be effective in wound healing, and PRP was found to be more effective than the others.

Pınar Bulut - One of the best experts on this subject based on the ideXlab platform.

  • Investigation of the effects of Thrombocyte-Rich Plasma, systemic ozone and hyperbaric oxygen treatment on intraoral wound healing in rats: experimental study
    European Archives of Oto-Rhino-Laryngology, 2020
    Co-Authors: Kemal Uslu, Hasan Deniz Tansuker, Alper Tabaru, Selim Engin Egeren, Kemal Kutay Kulahci, Pınar Bulut, Funda Emre, Mehmet Faruk Oktay
    Abstract:

    Objective In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-Rich Plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats. Materials and methods In this study, thirty-six Wistar Hannover rats with weight of 250–350 g, fed with standard feeds, were anesthetized to create intraoral wound on the hard palate. Rats were divided into four groups as the following: control group, PRP, HBO and Ozone groups. 0.1 ml of PRP was injected on the wound edges of each rat in the PRP group on days 1, 3 and 7. Each rat in the ozone group was systemically injected with 2.3–3.0 ml ozone gas on the 1st, 3rd and 7th days. The wounds of the rats in the control group were not performed anything. The rats in the HBO group were placed in the HBO pressure chamber and were treated with one session (2 h for each session) of 100% oxygen each day for 7 days. Rats in all groups were killed on the 15th day and the hard palates were excised for histopathological examination. Inflammation severity, neovascularization, fibroblast proliferation, collagen density and epithelization were evaluated. Results The rate of intense wound closure (epithelialization intensity) was significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group ( p  

  • Investigation of the effects of Thrombocyte-Rich Plasma, systemic ozone and hyperbaric oxygen treatment on intraoral wound healing in rats: experimental study.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated wi, 2020
    Co-Authors: Kemal Uslu, Hasan Deniz Tansuker, Alper Tabaru, Selim Engin Egeren, Kemal Kutay Kulahci, Pınar Bulut, Funda Emre, Mehmet Faruk Oktay
    Abstract:

    In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-Rich Plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats. In this study, thirty-six Wistar Hannover rats with weight of 250–350 g, fed with standard feeds, were anesthetized to create intraoral wound on the hard palate. Rats were divided into four groups as the following: control group, PRP, HBO and Ozone groups. 0.1 ml of PRP was injected on the wound edges of each rat in the PRP group on days 1, 3 and 7. Each rat in the ozone group was systemically injected with 2.3–3.0 ml ozone gas on the 1st, 3rd and 7th days. The wounds of the rats in the control group were not performed anything. The rats in the HBO group were placed in the HBO pressure chamber and were treated with one session (2 h for each session) of 100% oxygen each day for 7 days. Rats in all groups were killed on the 15th day and the hard palates were excised for histopathological examination. Inflammation severity, neovascularization, fibroblast proliferation, collagen density and epithelization were evaluated. The rate of intense wound closure (epithelialization intensity) was significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group (p 

  • investigation of the effects of Thrombocyte Rich Plasma systemic ozone and hyperbaric oxygen treatment on intraoral wound healing in rats experimental study
    European Archives of Oto-rhino-laryngology, 2020
    Co-Authors: Kemal Uslu, Hasan Deniz Tansuker, Alper Tabaru, Selim Engin Egeren, Kemal Kutay Kulahci, Pınar Bulut, Funda Emre, Mehmet Faruk Oktay
    Abstract:

    In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-Rich Plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats. In this study, thirty-six Wistar Hannover rats with weight of 250–350 g, fed with standard feeds, were anesthetized to create intraoral wound on the hard palate. Rats were divided into four groups as the following: control group, PRP, HBO and Ozone groups. 0.1 ml of PRP was injected on the wound edges of each rat in the PRP group on days 1, 3 and 7. Each rat in the ozone group was systemically injected with 2.3–3.0 ml ozone gas on the 1st, 3rd and 7th days. The wounds of the rats in the control group were not performed anything. The rats in the HBO group were placed in the HBO pressure chamber and were treated with one session (2 h for each session) of 100% oxygen each day for 7 days. Rats in all groups were killed on the 15th day and the hard palates were excised for histopathological examination. Inflammation severity, neovascularization, fibroblast proliferation, collagen density and epithelization were evaluated. The rate of intense wound closure (epithelialization intensity) was significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group (p < 0.05). Fibroblast proliferation level was higher in PRP group (p < 0.05), followed by ozone, HBO and control groups, respectively. Histologically, inflammation was significantly higher in the control group than the treatment groups (p < 0.05). For the treatment groups; it was lowest in the PRP group, followed by the ozone and HBO groups, respectively. The rates of angiogenesis and collagenization were significantly higher in all the three treatment groups, the PRP group was the highest, than in the control group (p < 0.05). In this study, no significance difference was found between the groups in terms of blood glucose levels (p = 0.21). In this study, all three treatment modalities were found to be effective in wound healing, and PRP was found to be more effective than the others.