The Experts below are selected from a list of 180 Experts worldwide ranked by ideXlab platform
Vincent Larrue - One of the best experts on this subject based on the ideXlab platform.
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high rate of recanalization of middle cerebral artery occlusion during 2 mhz transcranial color coded doppler continuous monitoring without Thrombolytic Drug
Stroke, 2002Co-Authors: Pascal Cintas, Anne Pavy Le Traon, Vincent LarrueAbstract:Background and Purpose— Experimental evidence indicates that ultrasound can accelerate thrombolysis. We report our findings on early recanalization during transcranial color-coded Doppler (TCCD) continuous monitoring in acute stroke patients with middle cerebral artery (MCA) main stem occlusion. Methods— We performed continuous TCCD monitorings in 6 consecutive patients with acute MCA main stem occlusion using a 2-MHz transducer. Patients were not treated with recombinant tissue plasminogen activator. Results— Partial recanalization, defined as blunted waveforms, occurred during monitoring in 5 patients (83%). The mean time to beginning of recanalization was 17.2±9.6 minutes. Complete recanalization at 24 hours occurred in only 1 patient. The mean National Institutes of Health Stroke Scale score in the patients who recanalized during monitoring was 21.2±4.1 at baseline, 19.2±5 at 2 hours, and 15.6±3.4 at 24 hours (P=0.1). Conclusions— In this short series of patients with acute MCA main stem occlusion, no...
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High rate of recanalization of middle cerebral artery occlusion during 2-MHz transcranial color-coded doppler continuous monitoring without Thrombolytic Drug
Stroke, 2002Co-Authors: Pascal Cintas, Anne Pavy Le Traon, Vincent LarrueAbstract:BACKGROUND AND PURPOSE: Experimental evidence indicates that ultrasound can accelerate thrombolysis. We report our findings on early recanalization during transcranial color-coded Doppler (TCCD) continuous monitoring in acute stroke patients with middle cerebral artery (MCA) main stem occlusion. METHODS: We performed continuous TCCD monitorings in 6 consecutive patients with acute MCA main stem occlusion using a 2-MHz transducer. Patients were not treated with recombinant tissue plasminogen activator. RESULTS: Partial recanalization, defined as blunted waveforms, occurred during monitoring in 5 patients (83%). The mean time to beginning of recanalization was 17.2+/-9.6 minutes. Complete recanalization at 24 hours occurred in only 1 patient. The mean National Institutes of Health Stroke Scale score in the patients who recanalized during monitoring was 21.2+/-4.1 at baseline, 19.2+/-5 at 2 hours, and 15.6+/-3.4 at 24 hours (P=0.1). CONCLUSIONS: In this short series of patients with acute MCA main stem occlusion, not treated with recombinant tissue plasminogen activator, we found a high rate of early partial recanalization during continuous exposure to 2-MHz ultrasound.
Noel M. Elman - One of the best experts on this subject based on the ideXlab platform.
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Rapid Reconstitution Packages (RRPs) implemented by integration of computational fluid dynamics (CFD) and 3D printed microfluidics
Drug Delivery and Translational Research, 2014Co-Authors: Sebastian Curi, Kevin Clayton, David Luciano, Kameron Klauber, Alfredo Alexander-katz, Sebastian D’hers, Noel M. ElmanAbstract:Rapid Reconstitution Packages (RRPs) are portable platforms that integrate microfluidics for rapid reconstitution of lyophilized Drugs. Rapid reconstitution of lyophilized Drugs using standard vials and syringes is an error-prone process. RRPs were designed using computational fluid dynamics (CFD) techniques to optimize fluidic structures for rapid mixing and integrating physical properties of targeted Drugs and diluents. Devices were manufactured using stereo lithography 3D printing for micrometer structural precision and rapid prototyping. Tissue plasminogen activator (tPA) was selected as the initial model Drug to test the RRPs as it is unstable in solution. tPA is a Thrombolytic Drug, stored in lyophilized form, required in emergency settings for which rapid reconstitution is of critical importance. RRP performance and Drug stability were evaluated by high-performance liquid chromatography (HPLC) to characterize release kinetics. In addition, enzyme-linked immunosorbent assays (ELISAs) were performed to test for Drug activity after the RRPs were exposed to various controlled temperature conditions. Experimental results showed that RRPs provided effective reconstitution of tPA that strongly correlated with CFD results. Simulation and experimental results show that release kinetics can be adjusted by tuning the device structural dimensions and diluent Drug physical parameters. The design of RRPs can be tailored for a number of applications by taking into account physical parameters of the active pharmaceutical ingredients (APIs), excipients, and diluents. RRPs are portable platforms that can be utilized for reconstitution of emergency Drugs in time-critical therapies.
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Rapid Reconstitution Packages (RRPs) implemented by integration of computational fluid dynamics (CFD) and 3D printed microfluidics
Drug Delivery and Translational Research, 2014Co-Authors: Albert Chi, Sebastian Curi, Kevin Clayton, David Luciano, Kameron Klauber, Alfredo Alexander-katz, Sebastian D'hers, Noel M. ElmanAbstract:Rapid Reconstitution Packages (RRPs) are portable platforms that integrate microfluidics for rapid reconstitution of lyophilized Drugs. Rapid reconstitution of lyophilized Drugs using standard vials and syringes is an error-prone process. RRPs were designed using computational fluid dynamics (CFD) techniques to optimize fluidic structures for rapid mixing and integrating physical properties of targeted Drugs and diluents. Devices were manufactured using stereo lithography 3D printing for micrometer structural precision and rapid prototyping. Tissue plasminogen activator (tPA) was selected as the initial model Drug to test the RRPs as it is unstable in solution. tPA is a Thrombolytic Drug, stored in lyophilized form, required in emergency settings for which rapid reconstitution is of critical importance. RRP performance and Drug stability were evaluated by high-performance liquid chromatography (HPLC) to characterize release kinetics. In addition, enzyme-linked immunosorbent assays (ELISAs) were performed to test for Drug activity after the RRPs were exposed to various controlled temperature conditions. Experimental results showed that RRPs provided effective reconstitution of tPA that strongly correlated with CFD results. Simulation and experimental results show that release kinetics can be adjusted by tuning the device structural dimensions and diluent Drug physical parameters. The design of RRPs can be tailored for a number of applications by taking into account physical parameters of the active pharmaceutical ingredients (APIs), excipients, and diluents. RRPs are portable platforms that can be utilized for reconstitution of emergency Drugs in time-critical therapies. © 2014 Controlled Release Society.
Pascal Cintas - One of the best experts on this subject based on the ideXlab platform.
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high rate of recanalization of middle cerebral artery occlusion during 2 mhz transcranial color coded doppler continuous monitoring without Thrombolytic Drug
Stroke, 2002Co-Authors: Pascal Cintas, Anne Pavy Le Traon, Vincent LarrueAbstract:Background and Purpose— Experimental evidence indicates that ultrasound can accelerate thrombolysis. We report our findings on early recanalization during transcranial color-coded Doppler (TCCD) continuous monitoring in acute stroke patients with middle cerebral artery (MCA) main stem occlusion. Methods— We performed continuous TCCD monitorings in 6 consecutive patients with acute MCA main stem occlusion using a 2-MHz transducer. Patients were not treated with recombinant tissue plasminogen activator. Results— Partial recanalization, defined as blunted waveforms, occurred during monitoring in 5 patients (83%). The mean time to beginning of recanalization was 17.2±9.6 minutes. Complete recanalization at 24 hours occurred in only 1 patient. The mean National Institutes of Health Stroke Scale score in the patients who recanalized during monitoring was 21.2±4.1 at baseline, 19.2±5 at 2 hours, and 15.6±3.4 at 24 hours (P=0.1). Conclusions— In this short series of patients with acute MCA main stem occlusion, no...
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High rate of recanalization of middle cerebral artery occlusion during 2-MHz transcranial color-coded doppler continuous monitoring without Thrombolytic Drug
Stroke, 2002Co-Authors: Pascal Cintas, Anne Pavy Le Traon, Vincent LarrueAbstract:BACKGROUND AND PURPOSE: Experimental evidence indicates that ultrasound can accelerate thrombolysis. We report our findings on early recanalization during transcranial color-coded Doppler (TCCD) continuous monitoring in acute stroke patients with middle cerebral artery (MCA) main stem occlusion. METHODS: We performed continuous TCCD monitorings in 6 consecutive patients with acute MCA main stem occlusion using a 2-MHz transducer. Patients were not treated with recombinant tissue plasminogen activator. RESULTS: Partial recanalization, defined as blunted waveforms, occurred during monitoring in 5 patients (83%). The mean time to beginning of recanalization was 17.2+/-9.6 minutes. Complete recanalization at 24 hours occurred in only 1 patient. The mean National Institutes of Health Stroke Scale score in the patients who recanalized during monitoring was 21.2+/-4.1 at baseline, 19.2+/-5 at 2 hours, and 15.6+/-3.4 at 24 hours (P=0.1). CONCLUSIONS: In this short series of patients with acute MCA main stem occlusion, not treated with recombinant tissue plasminogen activator, we found a high rate of early partial recanalization during continuous exposure to 2-MHz ultrasound.
Anne Pavy Le Traon - One of the best experts on this subject based on the ideXlab platform.
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high rate of recanalization of middle cerebral artery occlusion during 2 mhz transcranial color coded doppler continuous monitoring without Thrombolytic Drug
Stroke, 2002Co-Authors: Pascal Cintas, Anne Pavy Le Traon, Vincent LarrueAbstract:Background and Purpose— Experimental evidence indicates that ultrasound can accelerate thrombolysis. We report our findings on early recanalization during transcranial color-coded Doppler (TCCD) continuous monitoring in acute stroke patients with middle cerebral artery (MCA) main stem occlusion. Methods— We performed continuous TCCD monitorings in 6 consecutive patients with acute MCA main stem occlusion using a 2-MHz transducer. Patients were not treated with recombinant tissue plasminogen activator. Results— Partial recanalization, defined as blunted waveforms, occurred during monitoring in 5 patients (83%). The mean time to beginning of recanalization was 17.2±9.6 minutes. Complete recanalization at 24 hours occurred in only 1 patient. The mean National Institutes of Health Stroke Scale score in the patients who recanalized during monitoring was 21.2±4.1 at baseline, 19.2±5 at 2 hours, and 15.6±3.4 at 24 hours (P=0.1). Conclusions— In this short series of patients with acute MCA main stem occlusion, no...
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High rate of recanalization of middle cerebral artery occlusion during 2-MHz transcranial color-coded doppler continuous monitoring without Thrombolytic Drug
Stroke, 2002Co-Authors: Pascal Cintas, Anne Pavy Le Traon, Vincent LarrueAbstract:BACKGROUND AND PURPOSE: Experimental evidence indicates that ultrasound can accelerate thrombolysis. We report our findings on early recanalization during transcranial color-coded Doppler (TCCD) continuous monitoring in acute stroke patients with middle cerebral artery (MCA) main stem occlusion. METHODS: We performed continuous TCCD monitorings in 6 consecutive patients with acute MCA main stem occlusion using a 2-MHz transducer. Patients were not treated with recombinant tissue plasminogen activator. RESULTS: Partial recanalization, defined as blunted waveforms, occurred during monitoring in 5 patients (83%). The mean time to beginning of recanalization was 17.2+/-9.6 minutes. Complete recanalization at 24 hours occurred in only 1 patient. The mean National Institutes of Health Stroke Scale score in the patients who recanalized during monitoring was 21.2+/-4.1 at baseline, 19.2+/-5 at 2 hours, and 15.6+/-3.4 at 24 hours (P=0.1). CONCLUSIONS: In this short series of patients with acute MCA main stem occlusion, not treated with recombinant tissue plasminogen activator, we found a high rate of early partial recanalization during continuous exposure to 2-MHz ultrasound.
Sebastian Curi - One of the best experts on this subject based on the ideXlab platform.
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Rapid Reconstitution Packages (RRPs) implemented by integration of computational fluid dynamics (CFD) and 3D printed microfluidics
Drug Delivery and Translational Research, 2014Co-Authors: Sebastian Curi, Kevin Clayton, David Luciano, Kameron Klauber, Alfredo Alexander-katz, Sebastian D’hers, Noel M. ElmanAbstract:Rapid Reconstitution Packages (RRPs) are portable platforms that integrate microfluidics for rapid reconstitution of lyophilized Drugs. Rapid reconstitution of lyophilized Drugs using standard vials and syringes is an error-prone process. RRPs were designed using computational fluid dynamics (CFD) techniques to optimize fluidic structures for rapid mixing and integrating physical properties of targeted Drugs and diluents. Devices were manufactured using stereo lithography 3D printing for micrometer structural precision and rapid prototyping. Tissue plasminogen activator (tPA) was selected as the initial model Drug to test the RRPs as it is unstable in solution. tPA is a Thrombolytic Drug, stored in lyophilized form, required in emergency settings for which rapid reconstitution is of critical importance. RRP performance and Drug stability were evaluated by high-performance liquid chromatography (HPLC) to characterize release kinetics. In addition, enzyme-linked immunosorbent assays (ELISAs) were performed to test for Drug activity after the RRPs were exposed to various controlled temperature conditions. Experimental results showed that RRPs provided effective reconstitution of tPA that strongly correlated with CFD results. Simulation and experimental results show that release kinetics can be adjusted by tuning the device structural dimensions and diluent Drug physical parameters. The design of RRPs can be tailored for a number of applications by taking into account physical parameters of the active pharmaceutical ingredients (APIs), excipients, and diluents. RRPs are portable platforms that can be utilized for reconstitution of emergency Drugs in time-critical therapies.
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Rapid Reconstitution Packages (RRPs) implemented by integration of computational fluid dynamics (CFD) and 3D printed microfluidics
Drug Delivery and Translational Research, 2014Co-Authors: Albert Chi, Sebastian Curi, Kevin Clayton, David Luciano, Kameron Klauber, Alfredo Alexander-katz, Sebastian D'hers, Noel M. ElmanAbstract:Rapid Reconstitution Packages (RRPs) are portable platforms that integrate microfluidics for rapid reconstitution of lyophilized Drugs. Rapid reconstitution of lyophilized Drugs using standard vials and syringes is an error-prone process. RRPs were designed using computational fluid dynamics (CFD) techniques to optimize fluidic structures for rapid mixing and integrating physical properties of targeted Drugs and diluents. Devices were manufactured using stereo lithography 3D printing for micrometer structural precision and rapid prototyping. Tissue plasminogen activator (tPA) was selected as the initial model Drug to test the RRPs as it is unstable in solution. tPA is a Thrombolytic Drug, stored in lyophilized form, required in emergency settings for which rapid reconstitution is of critical importance. RRP performance and Drug stability were evaluated by high-performance liquid chromatography (HPLC) to characterize release kinetics. In addition, enzyme-linked immunosorbent assays (ELISAs) were performed to test for Drug activity after the RRPs were exposed to various controlled temperature conditions. Experimental results showed that RRPs provided effective reconstitution of tPA that strongly correlated with CFD results. Simulation and experimental results show that release kinetics can be adjusted by tuning the device structural dimensions and diluent Drug physical parameters. The design of RRPs can be tailored for a number of applications by taking into account physical parameters of the active pharmaceutical ingredients (APIs), excipients, and diluents. RRPs are portable platforms that can be utilized for reconstitution of emergency Drugs in time-critical therapies. © 2014 Controlled Release Society.
